Nature Made Fish Oil 1000 mg Review
Nature Made Fish Oil 1000 mg Softgels are presented as a heart health supplement. Each softgel provides 1000 mg of fish oil with 300 mg of Omega-3 per softgel, so two daily softgels deliver a total of 2000 mg of fish oil and 600 mg of Omega-3 fatty acids per serving. The brand says the Omega-3s from EPA and DHA in fish oil help support a healthy heart, and the page notes that supportive but not conclusive research shows that consumption of EPA and DHA Omega-3 fatty acids may reduce the risk of coronary heart disease. The product is described as purified to remove mercury and other contaminants, with the page stating that it has been purified to remove PCBs, dioxins and furans, and mercury to ensure levels below 0.09 ppm, 2 ppt WHO TEQs, and 0.1 ppm respectively. The ingredient panel lists 2000 mg Fish Oil per serving, providing 600 mg Total Omega-3 Fatty Acids including 500 mg Omega-3 EPA and DHA. The softgel contains no color added and no artificial flavors and is gluten free. The brand calls itself the number one pharmacist recommended vitamin and supplement brand, based on a survey of pharmacists who recommend branded vitamins and supplements. The product carries a USP Verified mark, and the page explains that USP has tested and verified ingredients, potency and manufacturing process. Suggested use is two softgels daily with water and a meal. The page advises that people who are pregnant, nursing, taking medications, or who have blood clotting issues should consult a physician before use. It also warns that fish oil should be used with caution when combined with meds such as meds, nonsteroidal meds such as meds, and meds. The page explains that many U.S. adults do not consume enough EPA and DHA in their diet, noting that over two thirds of adults (68%) fall short. It suggests that heart health experts recommend at least two servings of fatty fish per week, roughly 250 to 500 mg of EPA and DHA per day, and says the fish oil comes from wild-caught ocean fish rather than farm-raised fish. The page offers count options of 90 and 250 softgels, but it displays this listing as discontinued and states that the product is no longer available, so the purchase options shown may not be available to buy. A subscription option with a two-pack is also shown, offering ten percent off and free shipping on subscription orders. The statements on the page have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure, or prevent any disease.
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Lowest cost per month first, in stock, at 2 softgels a day. Checked Nov 8.
- TargetLowest$9.69 a bottle of 104 softgels$5.59/moBuy at Target (opens in a new tab)
- Walmart$14.54 a bottle$9.69/moBuy at Walmart (opens in a new tab)
- CVS$24.49 a bottle of 145 softgels$10.13/moBuy at CVS (opens in a new tab)
Also at: Nature Made · iHerb · Vitacost · Walgreens
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Study, Trial or Testing Result Summary
Members Only53 human studies · 21 improved
2 of these 53 human studies gave fish oil by drip, not by mouth.
Fish oil mainly lowers blood fats called triglycerides, with smaller and mixed effects on cholesterol itself. A review of 64 trials found each gram of fish oil omega-3 lowered triglycerides by about 9 points [1]. A large review of marine oils found the strongest effect on triglycerides, with small rises in both good and bad cholesterol [2]. In people with diabetes, a review of 26 trials found triglycerides fell while bad cholesterol rose slightly [3], and a 12 week trial of 4 grams daily lowered triglycerides more than corn oil [4]. In kidney transplant patients, fish oil modestly raised good cholesterol [5]. However, in 190 adults at heart risk, four weeks of fish oil did not lower bad cholesterol compared with a dummy pill, while meds did [6]. The label lists 2000 milligrams of fish oil per serving, but our ingredient record marks the amount as not clearly given. That serving is below the 4 grams daily used in one of the trials above [4]. Overall, expect help with triglycerides more than with bad cholesterol. Animal and cell studies are never counted.
See all 53 studies →Hide the studies
- In 15 small trials of 733 kidney transplant recipients, fish oil taken for more than six months modestly raised HDL (good) cholesterol compared with placebo, and lowered diastolic blood pressure, but the changes were too small to recommend routine use.Fish oil for kidney transplant recipients.
- In 8 trials of 483 premature newborns given fish oil lipid emulsions through a vein, blood triglycerides and C-reactive protein did not differ from control emulsions, though omega-3 levels in the blood rose.Safety and efficacy of parenteral fish oil-containing lipid emulsions in premature neonates.
- Across 64 trials, each gram of omega-3 in fish oil lowered triglycerides by about 9 mg/dL, and krill oil and fish oil did not differ in effects on triglycerides, LDL, HDL or total cholesterol.Lipid-modifying effects of krill oil vs fish oil: a network meta-analysis.
- A review of combined trials in women with polycystic ovary syndrome found omega-3 reduced triglycerides with moderate certainty, and fish oil lowered insulin and insulin resistance.Effects of nutrition on metabolic and endocrine outcomes in women with polycystic ovary syndrome: an umbrella review of …
- Across 26 trials in people with diabetes, fish oil lowered triglycerides by about 0.60 mmol/l but slightly raised LDL (bad) cholesterol by 0.18 mmol/l, with no change in long-term blood sugar (HbA1c).Fish oil and glycemic control in diabetes. A meta-analysis.
- A literature review reported omega-3 fats may lower heart-related death and triglycerides, but can cause a slight rise in LDL (bad) cholesterol.Evidence for the cardioprotective effects of omega-3 Fatty acids.
- A review of many trials found marine oils lowered triglycerides most strongly, with small increases in both HDL (good) and LDL (bad) cholesterol, and no effect on blood pressure.Omega-3 Fatty Acids and Cardiovascular Disease: Summary of the 2016 Agency of Healthcare Research and Quality Evidence R…
- A review of meta-analyses on metabolic syndrome reported that adding 3 to 4 grams of omega-3 fats lowers triglycerides and blood pressure and reduces the share of people with metabolic syndrome.Metabolic Syndrome-Role of Dietary Fat Type and Quantity.
- A review of 21 studies in women with polycystic ovary syndrome found omega-3 supplements lowered total cholesterol and triglycerides and raised HDL cholesterol, though doses and durations varied and more studies are needed.Omega-3 supplementation in the treatment of polycystic ovary syndrome (PCOS) - a review of clinical trials and cohort.
- In 309 Chinese adults with type 2 diabetes and high triglycerides, 4 g of fish oil daily for 12 weeks lowered triglycerides more than corn oil (about 1.51 vs 0.66 mmol/L drop).Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes.
- In 282 people with high cholesterol, a spread with plant sterols plus 0.9 to 1.8 g of fish oil omega-3s for 4 weeks lowered VLDL cholesterol and triglycerides in a dose-dependent way, but did not lower LDL cholesterol beyond plant sterols alone.The effect of plant sterols and different low doses of omega-3 fatty acids from fish oil on lipoprotein subclasses.
- In 259 older adults with memory complaints, DHA-rich fish oil plus cocoa flavanols for 12 months raised the HDL to total cholesterol ratio and lowered triglycerides versus control, but did not improve thinking and slightly worsened some measures.A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adu…
- In 190 adults at increased heart disease risk, 28 days of fish oil did not lower LDL cholesterol more than placebo, while a med 5 mg lowered it much more.Read the study on PubMed (36351465) →
- In 93 adults with high triglycerides taking 2.4 g a day of algal DHA and EPA oil for 14 weeks, triglycerides fell while LDL cholesterol rose 4.6 percent and HDL cholesterol rose 4.3 percent; fish oil raised LDL 6.8 percent and HDL 6.9 percent, compared with a corn and soy oil control.A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols in adults with mild-to-moderate hypertriglyceridem…
- In 86 adults with high triglycerides, MaxEPA fish oil lowered triglycerides compared with placebo over 3 months, but total cholesterol did not change in either group.Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study.
- In 84 adults at moderate heart disease risk, 1.5 grams a day of omega-3 fish oil for eight weeks did not significantly change blood lipids compared with placebo.Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of …
- In healthy 9-month-old infants given 5 mL of fish oil daily for 3 months, total and bad (low-density lipoprotein) cholesterol were higher at 12 months than in infants not given fish oil.Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants.
- In HIV patients on antiretroviral therapy, 3 g of fish oil daily did not change cholesterol or triglycerides compared with soy oil placebo.Effects of fish oil on lipid profile and other metabolic outcomes in HIV-infected patients on antiretroviral therapy: a …
- In 80 adults with type 2 diabetes, 10 grams a day of fish oil for six weeks lowered triglycerides but did not change total cholesterol compared with olive oil.Effects of fish oil supplements in NIDDM subjects. Controlled study.
- In 73 adults with abdominal obesity, 12 weeks of 2 grams a day of DHA-enriched fish oil lowered fasting insulin and insulin resistance compared with corn oil; cholesterol results were not reported in the abstract.DHA-enriched fish oil reduces insulin resistance in overweight and obese adults.
- In 59 healthy adults over 50, 8 weeks of about 2 grams a day of fish oil did not change a blood marker of inflammation linked to heart disease compared with olive oil.Omega-3 fatty acids and lipoprotein associated phospholipase A(2) in healthy older adult males and females.
- In 55 men with an atherogenic lipid pattern, 3 grams a day of EPA and DHA for six weeks lowered fasting triglycerides by 35% and small dense LDL by 26% compared with olive oil, though HDL cholesterol did not change.ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype.
- In 48 adults given 3.5 to 10.6 grams of omega-3 fatty acids daily for 4 weeks, triglycerides fell in a dose-dependent way, but lipoprotein(a) did not change compared with placebo.Fish oil treatment and apolipoprotein(a).
- In 45 healthy men taking 1.5, 3 or 6 g of fish oil omega-3 daily for 12 weeks, triglycerides fell and the larger good cholesterol (HDL2) rose, but bad cholesterol (LDL) did not change; 3 g performed about as well as 6 g.Dose-response effects of fish-oil supplementation in healthy volunteers.
- In 45 people with severe acute pancreatitis, a daily intravenous omega-3 fish oil fat emulsion (0.2 g per kg body weight) for 14 days lowered inflammation markers and shortened time to negative fluid balance compared with standard care alone, but the abstract reports no cholesterol result.[The effects of ω-3 fish oil lipid emulsion on inflammation-immune response and organ function in patients with severe a…
- In 41 adults with insulin-dependent diabetes, 15 g per day of a fish oil supplement raised bad (LDL) cholesterol compared with the control group.Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabet…
- In 40 obese women on a 3-week low-calorie diet, adding 790 mg of fish oil via yogurt raised omega-3 levels in serum lipids and limited some unfavorable fatty acid changes; cholesterol was not reported as an outcome.Change in fatty acid composition of serum lipids in obese females after short-term weight-reducing regimen with the addi…
- In 40 adults with cholesterol above 200, taking fish oil with garlic powder for one month lowered total cholesterol by 11%, triglycerides by 34% and LDL cholesterol by 10% compared with placebo.Modulation of lipid profile by fish oil and garlic combination.
- In 32 people with leg claudication, 4 months of fish oil capsules (3 grams EPA and DHA daily) raised HDL cholesterol and lowered triglycerides compared with corn oil, though walking distance did not improve.Fish oil supplementation in patients with stable claudication.
- In women with breast cancer starting chemotherapy, 4 grams of fish oil daily for 60 days kept HDL cholesterol stable and lowered triglycerides, while HDL fell in the control group.Fish Oil Supplementation Enhances Pulmonary Strength and Endurance in Women Undergoing Chemotherapy.
- In 31 healthy men taking a purified fish oil concentrate for 7 weeks, total cholesterol and triglycerides were not changed differently by the ethyl ester or triglyceride forms.Comparative effects of prolonged intake of highly purified fish oils as ethyl ester or triglyceride on lipids, haemostas…
- In 29 people with type 1 diabetes and kidney disease, a year of fish oil (4.6 grams of omega-3 a day) did not change albumin leakage or a clotting marker compared with olive oil placebo.Lack of effect of fish oil supplementation on coagulation and transcapillary escape rate of albumin in insulin-dependent…
- In 29 people with type 1 diabetes and kidney disease, a year of fish oil (4.6 grams of omega-3 a day) lowered triglycerides and VLDL cholesterol compared with olive oil, but total and LDL cholesterol rose.Fish oil in diabetic nephropathy.
- In 13 men with hypertension, 5 grams of fish oil daily for 30 days raised total cholesterol, LDL cholesterol and apolipoprotein B compared with placebo, while normotensive men showed no change.Fish oil produces an atherogenic lipid profile in hypertensive men.
- In 26 people with lupus nephritis, 15 grams of fish oil daily for one year lowered triglycerides and VLDL cholesterol compared with olive oil placebo, with no effect on kidney function.Fish oil in lupus nephritis: clinical findings and methodological implications.
- In 25 healthy men, a single meal containing 9 grams of fish oil improved blood vessel widening four hours after eating compared with a meal using placebo oil, but the study did not measure cholesterol.Fish oil fatty acids improve postprandial vascular reactivity in healthy men.
- In 21 men, three weeks of fish oil lowered triglycerides compared with olive oil, while blood pressure fell in the olive oil group.Fish oil increases peripheral capillary blood cell velocity in humans.
- In 20 overweight adults, 3.7 grams a day of fish oil for six weeks lowered several harmful fat species in the blood, while total cholesterol was not reported as lowered by fish oil, unlike fenofibrate.Comparative Analysis of the Effects of Fish Oil and Fenofibrate on Plasma Metabolomic Profiles in Overweight and Obese I…
- In 16 adults on dialysis, 3.6 g of fish oil omega-3 for 4 weeks produced a non-significant trend toward lower triglycerides compared with olive oil placebo.Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients.
- In 15 healthy men on a controlled diet, 20 grams a day of fish oil for five weeks lowered triglycerides by 30% but did not change total or HDL cholesterol.Effects of fish oil on serum lipids in men during a controlled feeding trial.
- In 11 healthy women taking fish oil for 30 days, blood fat profiles changed in both directions compared with krill oil, and the study did not report a clear effect on cholesterol.Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in He…
- In 10 adults with mild type 2 diabetes, 10 g of fish oil daily for 3 weeks did not significantly change total, good (high-density lipoprotein) or bad (low-density lipoprotein) cholesterol compared with baseline.Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM.
- In 9 men with high triglycerides, fish oil lowered triglycerides by about half but did not change cholesterol production, while increasing bile acid synthesis.Fish oil increases bile acid synthesis in male patients with hypertriglyceridemia.
- In 8 healthy volunteers, 4 weeks of fish oil lowered after-meal blood fat (chylomicron triglyceride) by about 40% compared with olive oil, without speeding its clearance.Fish oil reduces postprandial triglyceride concentrations without accelerating lipid-emulsion removal rates.
- In five boys with nephrotic syndrome, 4 grams of tuna fish oil for 8 weeks did not change cholesterol or triglycerides compared with placebo.Effects of tuna fish oil on hyperlipidemia and proteinuria in childhood nephrotic syndrome.
- In heart attack survivors with high triglycerides, 4 g a day of omega-3 ethyl ester for 12 weeks lowered triglycerides 24 percent compared with placebo but raised LDL cholesterol about 7 percent.Omega-3 Ethyl Ester Concentrate Decreases Total Apolipoprotein CIII and Increases Antithrombin III in Postmyocardial Inf…
- In people with combined high cholesterol and high triglycerides, marine oil with or without a med improved triglycerides, non-good cholesterol and good (HDL) cholesterol.Read the study on PubMed (9315596) →
- In 72 volunteers taking about 3.3 grams of EPA plus DHA daily for 2 weeks, absorption differed by form: re-esterified triglycerides were better absorbed than natural fish oil, and ethyl esters were less well absorbed; cholesterol was not reported as an outcome.Bioavailability of marine n-3 fatty acid formulations.
- In seven adults with type 2 diabetes, a 4-week combination of sardine oil, evening primrose oil and vitamin E lowered total cholesterol more than in 11 untreated patients, though the oils were given together.Evening primrose oil and fish oil in non-insulin-dependent-diabetes.
- In 10 young healthy men taking 3 g a day of fish oil for 3 months, triglycerides fell and the HDL cholesterol share of total cholesterol rose, though prostaglandin and thromboxane levels also increased.Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men.
- In over 400,000 UK Biobank participants, people taking fish oil supplements had a lower genetic tendency toward high total cholesterol, LDL cholesterol and triglycerides, and a higher genetic tendency toward HDL cholesterol.Fish oil supplementation modifies the genetic potential for blood lipids.
- In healthy men taking 3 g a day of MaxEPA fish oil for 30 days, total cholesterol and LDL cholesterol decreased significantly.The effects of dietary marine fish oils (omega-3 fatty acids) on coagulation profiles in men.
- In women taking 3 g a day of marine fish oil for 30 days, triglycerides fell in oral contraceptive users, cholesterol and LDL rose in non-users, and LDL fell in menopausal women on estrogen.Effects of marine fish oil (omega-3 fatty acids) on lipid profiles in women.
Review Totals and Summary
Members Only52,965 reviews · 95% positive
Nature Made Fish Oil 1000 mg has garnered approximately 52965 ratings across various retail platforms, with the vast majority of feedback being highly positive. Customers generally express strong satisfaction with this product. **What it did for buyers** Many users report noticeable health improvements after taking this fish oil. Some experienced relief from joint discomfort, noting "not hearing &feeling so much popping &pain in my neck." Others highlight its "anti inflammatory effects and good benefits for brain, heart and skin." Customers also mentioned improved skin quality, balanced cholesterol, and reduced hair frizz, with one stating, "my hair is no frizzy anymore, cholesterol feels balanced." The product is frequently cited for supporting "heart-healthy omega-3s" and boosting overall energy, with one user feeling it was "helping with my heart health and overall energy. My skin also looks healthier." **Complaints** While overall satisfaction is high, a few points of concern emerged. Some customers reported issues with order delays and delivery, though these were related to the seller or retailer rather than the product itself. A common product-specific complaint is the large size of the capsules, with one reviewer stating, "If you have a hard time swallowing, you may have an issue." Additionally, some users found it necessary to "take with food to avoid stomach upset." **Taste, Smell, and Pill Form** The product is generally well-regarded for its lack of unpleasant fishy attributes. Many reviewers appreciate that there is "no fishy taste" or "no fishy aftertaste or fish burp afterwards." The scent is often described as minimal. While some find the "capsules are very large," many others report the "soft gels that it is easy to swallow," indicating a mixed experience depending on individual swallowing ability. **Value for Money** Customers frequently praise Nature Made Fish Oil for its affordability and value. It's often described as a "Great Price" and "Well worth the money." Many appreciate the option to purchase in "bulk size at a great price," finding it "more economically convenient" to buy larger bottles. Reviewers consistently note its "Great quality and affordable." **Who it suits and who it did not** This fish oil appears particularly suitable for adults seeking general wellness and those looking to supplement omega-3s without the taste of fish, with one user recommending it for "people that run at the smell of fish." It is "highly recommended for all adult ages." However, it may not be ideal for individuals who "have a hard time swallowing" large pills or those with sensitive stomachs who might experience discomfort if not taken with food.
Biohacker Summary
Members Only7 of 10 recommend it
Our biohacker panel has not discussed this product’s ingredients yet.
RAL Summary
Members OnlyTier 3 for Cholesterol
Tier 3 because 92% of 554 reviews are positive, while the studies give only some support: fish oil reliably lowers triglycerides but has mixed or slightly unfavorable effects on bad cholesterol [1][6].
- Fish Oil: amount hidden in a blend
Where the evidence disagrees: 18 of the 53 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Digestive system
Combine with: To further support heart health and cholesterol management alongside Fish Oil, consider supplementing with Plant Sterols, which can help block the absorption of dietary cholesterol. Red Yeast Rice is another option, known for its natural compounds that may help reduce cholesterol production. Additionally, Coenzyme Q10 (CoQ10) can support overall cardiovascular function and energy production in heart cells. Soluble fiber, such as psyllium husk, can also be beneficial by helping to reduce the absorption of cholesterol in the digestive tract.
Possible side effects: Studies found bad cholesterol can rise slightly with fish oil. The review summary mentions stomach upset, diarrhea and large softgels that are hard to swallow.
Supplement Facts
Polyunsaturated Fat 0.5 g · Fish Oil 2000 mg · Total Omega-3 Fatty Acids 600 mg
| Calories | 20 | |
| Total Fat | 2 g | 3% |
| Polyunsaturated Fat | 0.5 g | |
| Cholesterol | 20 mg | 7% |
| Total Carbohydrate | 0 g | <1% |
| Protein | 0 g | |
| Fish Oil | 2,000 mg | † |
| Total Omega-3 Fatty Acids | 600 mg | † |
| Omega-3 EPA and DHA | 500 mg | † |
Other ingredients: Gelatin, Glycerin, Tocopherols.
Directions: SUGGESTED USE: Adults, take 2 softgels daily with water and a meal.
Label source: Naturemade · Report a label change
Sizes and barcodes: 90 Softgel(s), UPC 0 31604 02662 2 (on market); 250 Softgel(s), UPC 0 31604 02659 2 (off market); 175 Softgel(s), UPC 0 31604 04293 6 (off market); 320 Softgel(s), UPC 0 31604 04167 0 (off market); 100 Softgel(s), UPC 0 31604 04083 3 (off market); 80 Softgel(s), UPC 0 31604 02954 8 (off market); 200 Softgel(s), UPC 0 31604 02663 9 (off market)
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- Best Diet for High Cholesterol: What to Eat, What to Cut, and What the Trials ShowArticle · Sep 13, 2026
- How to Lower LDL Cholesterol: A Practical Plan Based on Your Blood WorkArticle · Oct 27, 2026
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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