Nature Made SAM-e Complete 400 mg Review
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Study, Trial or Testing Result Summary
Members Only2 human studies · 0 improved
1 of these 2 human studies gave sam-e by drip, not by mouth.
Two small placebo-controlled trials tested this ingredient, and neither looked at muscle building in healthy people doing strength training. In 44 people with fibromyalgia, 800 milligrams a day by mouth for six weeks eased pain, fatigue and stiffness compared with a dummy pill. Muscle strength did not change [1]. In 34 people with fibromyalgia, 600 milligrams a day given by vein for 10 days did not change muscle strength or tender points compared with a dummy treatment [2]. Neither study measured muscle size or growth. This product gives 400 milligrams a day, half the dose used in the oral trial [1]. The other trial gave the ingredient by vein, not as a pill [2]. Taken together, these studies give no sign that it helps build muscle, but they were not designed to test that question. Animal and cell studies are never counted.
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- In 44 people with fibromyalgia, 800 mg a day of oral SAM-e for six weeks improved pain, fatigue and stiffness compared with placebo, but did not change muscle strength.Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation.
- In 34 people with fibromyalgia, 600 mg a day of SAM-e given by vein for 10 days had no effect on muscle strength or tender points compared with placebo in a crossover trial.Double-blind, placebo-controlled cross-over study of intravenous S-adenosyl-L-methionine in patients with fibromyalgia.
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
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RAL Summary
Members OnlyTier 4 for Muscle and Strength
The ineffective grade rests on two small trials in people with fibromyalgia that measured only muscle strength, not muscle growth in healthy people who train, so the evidence for this goal is thin rather than a clear showing that it does not work. So it is graded Tier 4, as the studies disagree.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 2 of the 2 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Nervous system
Possible side effects: No major side effects reported.
Supplement Facts
SAM-e 400 mg
| Protein | 1 g | |
| SAM-e | 400 mg | † |
Other ingredients: S-Adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Stearic Acid, Silicon Dioxide, Triethyl Citrate, Magnesium Stearate, Color added, Mannitol, Sodium Starch Glycolate.
Directions: Suggested use: Start with 1 tablet per day. For easier swallowing, take with water before and during ingestion. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablet (maximum 1600 mg/day) until benefits are achieved.
Barcode (UPC) 031604011000 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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