Nature's Life Super Cal-Mag Review
Nature's Life Super Cal-Mag is listed on this King Soopers page as a 250 tablet container, with the UPC 0004064700573 printed beside the product name. The page presents the product as a calcium and magnesium supplement. The product details state that regular exercise and a healthful diet or dietary supplements providing enough calcium help women maintain good bone health and may reduce their high risk of osteoporosis later in life. The page further explains that calcium maintains healthy bones better when taken with other minerals, such as magnesium, and that calcium also supports the normal function of a healthy cardiovascular system. The product is labeled suitable for vegetarians. A standard statement on the page notes that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. The Nutrition Information section lists 125.0 servings per container. The calorie, fat, carbohydrate, sugar, and protein values are all shown as zero, and the serving size field is blank in the scraped text. The page notes that the % Daily Value tells how much a nutrient in a serving of food contributes to a daily diet, based on 2,000 calories a day for general nutrition advice. The Ingredients section lists Vitamin D (Ergocalciferol), Calcium (Calcium Carbonate, aspartate, Citrate), Magnesium (Magnesium Oxide, Citrate, aspartate), Cellulose, Maltodextrin, Acacia, Stearic Acid and Silica. The Allergen Info section states that the product contains corn and its derivatives and is free from declared obligatory allergens. The page shows the item as pickup at Bennett and lists availability as unavailable for pickup, Kroger delivery, and all delivery at the time of capture. No price is shown, only the note that prices may vary. The page also includes a disclaimer that actual product packaging may contain different ingredient, nutritional, or usage information, and that shoppers should read the physical label before use. A section promoting the FoodHealth Score, a 0 to 100 nutrition rating developed with FoodHealth Company, appears on the page, but it is a site-wide feature and not a property of this supplement specifically. The ratings and reviews section on this page contains only a prompt inviting shoppers to submit a rating and a link to terms and conditions. No star rating, rating count, histogram, or written customer review appears in the scraped text, so no review statistics are reported for this product here.
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Study, Trial or Testing Result Summary
Members Only25 human studies · 7 improved
For bone health, the human evidence on this formula's ingredients is mixed. Vitamin D is at a full dose here. In older adults, 700 to 800 units a day cut hip fractures by about a quarter, while 400 units did not help [1]. Other reviews found no clear drop in fractures [2][3]. In women with thinning bones after menopause, calcium plus vitamin D slightly improved pelvic bone density but not spine or hip density, and did not reduce fractures [4]. For calcium alone, small trials of 1 gram and 1200 milligrams a day found no clear gain in bone mineral, though bone stayed stable [5][6]. Surveys linked more dietary calcium with denser bones, sometimes only in women [7][8], but a six-year study found no link with bone loss [9]. Magnesium has no human studies for bone here. The only support comes from magnesium implants and scaffolds in animals, not supplements [10][11]. The 500 milligrams of magnesium is above the daily recommended limit for supplements, so members may choose to take less. Animal and cell studies are never counted.
See all 25 studies →Hide the studies
- In 11 trials of 43,869 postmenopausal women with osteoporosis, calcium plus vitamin D modestly improved pelvic bone density but not spine, neck of femur or total hip density, and did not reduce fractures.The effects of combined calcium and vitamin D supplementation on bone mineral density and fracture risk in postmenopausa…
- This review of smartphone apps for osteoporosis self-management did not test vitamin D supplements and found no significant effect on vitamin D intake.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- In trials of older adults, 700 to 800 IU a day of vitamin D cut hip fracture risk by 26% and other nonvertebral fractures by 23%, while 400 IU a day gave no significant benefit.Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials.
- Across nine studies, vitamin D3 did not significantly reduce nonvertebral or vertebral fractures versus placebo or calcium alone, with only a borderline trend toward fewer falls.The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis.
- In 23 trials of 1,209 kidney transplant recipients, vitamin D analogues (2 trials, 51 patients) improved lumbar spine and femoral neck bone density versus no treatment, but no trial showed fewer fractures.Interventions for preventing bone disease in kidney transplant recipients: a systematic review of randomized controlled …
- In 18 small trials of 576 children with chronic kidney disease, vitamin D preparations lowered parathyroid hormone levels, but there were few data on growth or bone deformities and no clear differences between preparations.Interventions for metabolic bone disease in children with chronic kidney disease.
- One small trial of 39 people with sickle cell disease found vitamin D3 for six weeks raised blood vitamin D and reduced pain days versus placebo, but no bone outcomes were reported and the evidence was low quality.Vitamin D supplementation for sickle cell disease.
- In nine trials of postmenopausal women without osteoporosis, vitamin D raised blood vitamin D and improved some bone remodeling measures, but only one study found fewer fractures, so a fracture benefit could not be confirmed.Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal wom…
- In a review of 25 observational studies of healthy men aged 50 or older, evidence linking calcium intake to bone density or bone loss was inconsistent or weak.Risk factors for low BMD in healthy men age 50 years or older: a systematic review.
- In 500 elderly women with Alzheimer disease who all took 1000 IU of vitamin D2 plus calcium, adding risedronate for 18 months raised bone density 4.1% and cut hip fracture risk compared with placebo, but vitamin D itself was not tested alone and the paper was retracted.The prevention of hip fracture with risedronate and ergocalciferol plus calcium supplementation in elderly women with Al…
- Children whose mothers took 1000 IU of vitamin D3 daily during pregnancy had higher whole-body bone mineral content and density at ages 6-7 than children whose mothers took placebo.Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled…
- In 242 elderly men with Parkinson disease who all took 1000 IU of vitamin D2, adding risedronate for 2 years raised bone density, but vitamin D was not compared against placebo and the paper was retracted.Risedronate and ergocalciferol prevent hip fracture in elderly men with Parkinson disease.
- In 39 older women with severe osteoporosis, 1200 mg of calcium daily with or without 25-hydroxyvitamin D for two years kept bone mineral content stable in both groups, with improved bone mineralization rate in both groups.Histomorphometric effects of calcium or calcium plus 25-hydroxyvitamin D3 therapy in senile osteoporosis.
- In 40 postmenopausal women with wrist fracture, 1 g of calcium daily for one year had no significant effect on femur bone mineral content compared with placebo.Bone mineral content in women with Colles' fracture: effect of calcium supplementation.
- In 2904 US adults aged 60 and over, higher dietary calcium was linked with higher lumbar bone density, but this link held in women and not in men.Association between Dietary Calcium Intake and Bone Mineral Density in Older Adults.
- In 1479 elderly Japanese men, greater milk intake was linked with higher hip and femoral neck bone density and lower bone turnover, though this link weakened after accounting for calcium intake.Greater milk intake is associated with lower bone turnover, higher bone density, and higher bone microarchitecture index…
- In 1098 adults aged 65 and over, higher dietary calcium intake was linked with higher bone density at the hip and spine, while higher urinary sodium was linked with lower bone density.Dietary intake, blood pressure and osteoporosis.
- In 698 placebo-group women over 65 with osteopenia, averaging 886 mg of dietary calcium a day over 6 years, calcium intake was unrelated to bone loss at any site.Dietary Calcium Intake and Bone Loss Over 6 Years in Osteopenic Postmenopausal Women.
- In a survey of 452 women in Alaska, dietary calcium intake was low (about 306 mg a day on average), but the survey did not test calcium supplements, so it shows no effect of calcium on bone.Risk factors for osteoporosis in Alaska Native women: a cross-sectional survey.
- In Tuscany, Italy, most people who broke a hip from 2011 to 2015 were not taking vitamin D supplements, and only 30-35% were on cholecalciferol one year after the fracture; no bone outcome was measured against a comparison group.The use of cholecalciferol in patients with hip fracture.
- Among 173 adults aged 35 to 50, about a quarter had osteopenia; bone density correlated with exercise in women and in the opposite direction in men, and no calcium-specific result was reported.Bone Mineral Density Among Men and Women Aged 35 to 50 Years.
- In a 2-year cross-sectional study of 116 pre- and post-menopausal obese and non-obese women, daily vitamin D and calcium intake was low and osteoporosis was less common in obese women, though blood vitamin D levels were within normal range.Dietary Pattern and Bone Health in Pre and Post-menopausal Obese Women.
- In 52 Parkinson's patients compared with 52 matched controls, lower bone density was seen, and insufficient calcium intake was among the factors related to low bone density.Prevalence and risk factors of osteoporosis in patients with Parkinson's disease.
- In 70 people taking meds, a dedicated bone clinic found many with bone loss; early results showed bone density rose 3 to 5 percent with drug and lifestyle measures, including calcium and/or vitamin D in 44 people.Read the study on PubMed (10678299) →
- In 42 Iranian adults with hemophilia, low bone density was very common, and only cigarette smoking was significantly linked to it, not calcium intake.Bone mineral density in hemophilia patients.
Review Totals and Summary
Members Only4 reviews
Public review volume for this exact product is small, so these themes come from limited feedback across Amazon, retailer pages and related Nature's Life listings. Treat them as indicative only. The strongest theme is satisfaction with muscle and sleep benefits. The top Amazon review describes taking two tablets before bed, sleeping soundly and having leg cramps controlled. A reviewer of a related Nature's Life calcium-magnesium product said nightly ankle and shin cramps improved by roughly 70%, though not completely. That shows some users see partial relief rather than a full fix. A second theme is value and reliability. Reviewers mention the price is right, that they keep it on hand, and that they have used it for years. Several describe it as a great source of calcium and vitamin D with a good calcium-to-magnesium balance. One endorsement calls it the best calcium-magnesium-D product the customer had used. Loyalty and long-term repeat use stand out more than any dramatic effect. A third theme is that people see it as a general wellness and bone-support staple. Some credit it with better mobility, and others with fewer symptoms they link to low calcium or magnesium, such as lack of sleep or brain fog. These are personal impressions rather than verified outcomes. The critical side is thin. Ratings on Amazon show most buyers are happy, and a minority (roughly one in five) give middling or low scores. Because the full text of critical reviews could not be retrieved, I can't say for certain what drives them. Plausible reasons are tablet size, since a 1,000 mg calcium serving needs two sizable tablets, and the need to split doses. One review title says the product is good regardless of size, which hints that size comes up. Another reviewer of a related liquid product complained that the taste changed after a stock gap, which suggests customers notice formulation or supply changes. I found no widespread reports of serious side effects in the available text. Overall, buyers are pleased by cramp and sleep support, affordability and dependability, while the complaints that appear are mild and mostly about pill size or consistency.
Biohacker Summary
Members Only8 of 10 recommend it
Magnesium is the main ingredient, and most of the panel recommends or uses it, mainly for sleep. Four of them take it before bed or recommend it for deeper sleep, and two named forms: glycinate for one, and threonate for two who take 400 mg before bed, with one more suggesting threonate and similar types. Others use it in electrolyte drinks for hydration and workouts, one uses it during surgery, and one suggests getting red blood cell levels to the high end of the range. One person said it does not fix waking in the night, and another warned that labels can make a dose look larger than it is. Vitamin D is a smaller ingredient in this product, and the panel mostly supports it, with several taking it daily.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
- Notes that vitamin D plays a role in immune function.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
- States that vitamin D supplementation can help with oxidative stress.
- Mentions vitamin D as a key nutrient for supporting immune function.
- States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Takes Vitamin DAKE from Suppgrade Labs.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Suggests that vitamin D supports brain health, muscle function, and focus.
- States that magnesium can affect how the body responds to a supplement.
- Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
- States that currently, he is only taking vitamin C and vitamin D.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
- Dave Asprey recommends Magnesium Glycinate for sleep, noting human studies show it helps people fall asleep faster, is safe, and works on a fundamental aspect of health, unlike magnesium oxide which acts as a laxative.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
- Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
- Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
- Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
- Recommends increasing vitamin D to restore balance and support healthy blood pressure.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- States that a lack of vitamin D can potentially cause achy bones or crashing mood.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions vitamin D as part of a bare-minimum protocol.
- Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
- Recommends supplementing with magnesium threonate if one is low in magnesium, as it crosses the blood-brain barrier and is demonstrated to increase hippocampus plasticity, theoretically making one smarter and improving memories.
- Uses Magnesium Breakthrough from BIOptimizers as part of their daily stack, taking four capsules in the evening to support relaxation, recovery, and a good night of sleep.
- Has been taking Vitamin D3 K2 for over a decade.
- Recommends Celtic Sea Salt's new electrolyte drink "Hydrate" for replacing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, plus magnesium, taurine, and potassium.
- Had heart palpitations when he was really overdoing magnesium, not knowing what he was taking.
- Recommends taking magnesium as a co-factor to increase vitamin D absorption.
- Notes that sunlight influences more than just vitamin D production.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
- Mentions that vitamin D also plays a role in maintaining muscle mass.
- Mentions magnesium as an important nutrient component for testosterone.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- Recommends ensuring adequate vitamin D intake for men's sperm health.
- Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
- Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
- Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
- Recommends taking Vitamin D with fat for better absorption.
- States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists dairy and sardines as sources of Calcium.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Thinks vitamin D has some of the strongest evidence and is worth considering.
- Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
- Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Confirms that magnesium is absolutely important for cognitive function, noting studies show those with lower magnesium intakes tend to perform less well on cognitive function tests, and it's related to brain changes over time and dementia risk.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning.
- He takes 400 mg of Magnesium L-Threonate from Double Wood before bed for sleep.
- He takes 5,000 IU of Vitamin D3 in the morning for overall health.
- Takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for longevity.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- He takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 5000 IU of Vitamin D3 in the morning for general health.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 5,000 IU of Vitamin D3 in the morning for longevity.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Lists vitamin D as one of her staple supplements.
- Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
- Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
- In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
- Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
RAL Summary
Members OnlyTier 4 for Bone Health
The review summary mixes in feedback from related Nature's Life products, including a different calcium-magnesium product and a liquid product, while no reviews of this exact product were counted or read. Its reviews are set aside, so it is graded on its studies alone. Human studies support Calcium (5 of 15 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 9 of the 25 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skeletal system
Combine with: For bone health, pair Super Cal-Mag with vitamin D3 to improve calcium absorption and vitamin K2 (MK-7) to help direct calcium into bone rather than soft tissue. Boron, zinc, and collagen peptides can support bone matrix and mineral balance. Take with meals if using calcium carbonate-type forms, and separate high-dose calcium from iron, zinc, and meds by a few hours. For actual fast heartburn relief, a dedicated antacid such as calcium carbonate chewables, or an alginate product, is a better choice. Talk to a healthcare provider if heartburn is frequent.
Possible side effects: No major side effects reported.
Supplement Facts
Vitamin D 800 IU · Calcium 1000 mg · Magnesium 500 mg
| Vitamin D | 800 IU | |
| Calcium | 1,000 mg | |
| Magnesium | 500 mg |
Other ingredients: Cellulose, Maltodextrin, Acacia, Stearic Acid, Silica.
Directions: 2 daily Directions: Use only as directed. Take two (2) tablets daily with food.
Barcode (UPC) 040647005730 · Label source: NIH label database · Report a label change
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- When Is the Best Time to Take Vitamins and Supplements?Article · Jun 15, 2026
Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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