Nestmann Avena Sativa Review

This Nestmann Avena Sativa label, DSLD ID 25221, is a liquid herbal extract supplement listed as a Botanical product with supplement form Liquid. The label was entered into DSLD on 25 September 2013 and is marked On Market. The net contents are 1.69 fl. Oz. (50 mL), the serving size is 0.15-0.9 mL, and there are 55 servings per container. The supplement facts list Mugwort, Valerian, European Vervain, St. John's Wort, Heather, White Nettle, Hops, Cowslip, Peppermint, Lemon Balm, Dill, Pulsatilla, Oat and Red Squill, each with Daily Value not established. Other ingredients are water and ethyl alcohol. The FDA statement of identity is Herbal Liquid Extract Supplement and the seal shown is MPI. Suggested use for adults is 30 drops in tepid water three times daily, with up to 1 teaspoon before bedtime. Children 6 years or older take 10 drops in water three to five times daily, and children up to 6 years old take 5 drops in water three to five times daily. Precautions include checking that the tamper evident ring is intact, keeping the product out of reach of children, and consulting a health professional if pregnant or breast-feeding. The label notes that cloudiness or sediment can occur in herbal products without altering effectiveness. It states Made in Germany by Nestmann Pharma in Zapfendorf/Bamberg and is distributed by Marco Pharma Int'l, Roseburg, OR.

Product Focus: Stress and CalmAlso covers:BrainDigestion
Tier ⓘ
Tier 4 · Rank 9
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 9 within Tier 4 for Stress and Calm; 20 of 26 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
27 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 7 reviews
Biohacker Mentions
6 of 10

Study, Trial or Testing Result Summary

Members Only124 human studies · 71 improved

9 of these 124 human studies gave the ingredient by inhaler, not by mouth.

124 human studies71 improved28 no effect35,833 people studied

This is a 14-herb liquid blend, and every ingredient amount is hidden, so no one can tell whether any herb reaches the dose used in studies. Lemon balm has the most consistent support: pooled trials found it lowered anxiety more than placebo [1], and 400 milligrams daily for 3 weeks eased stress and anxiety in distressed adults [2]. Valerian lowered anxiety over 8 weeks in adults with sleep complaints [3], but a pooled analysis found too little evidence that it reduces anxiety [4], and one 4-week trial in stressed adults found no difference from placebo [5]. St. John's wort lowered anxiety scores at 600 to 1050 milligrams daily, mostly in people with depression [6][7]. Hops extract at 200 milligrams daily lowered anxiety and stress in young adults [8], though a multi-ingredient product with hops did no better than placebo [9]. Oat extract eased the body's stress response only at the highest dose, with no change in mood [10]. Peppermint mainly helped as an inhaled oil before surgery [11]. Cowslip and dill each have only one weak study [12][13]. Pulsatilla has only mouse studies [14]. Mugwort, vervain, heather, white nettle and red squill have no human studies. Animal and cell studies are never counted.

See all 124 studies →Hide the studies

Review Totals and Summary

Members Only7 reviews
7 reviews · Boiron USA 6 · Marco Pharma 1

If you retry the search, or send me the product label or a retailer URL, I can write both sections from real sources.

Biohacker Summary

Members Only6 of 10 recommend it
6 of 10 biohackers on our panel recommend it

For St. John's wort, the main ingredient, five of the ten panelists spoke, and the group is split. One recommends it for low mood, citing a better benefit to harm balance than meds. Three are neutral: one mentions it as a herbal option some people use for sleep, one went through a phase of using it for people who did not want pharmaceutical options, and one calls it a good supplement but doubts the body needs it without testing. One warns that it can make birth control and meds work less well, so that is the main caution, and no doses or preferred forms were given. Valerian, a smaller ingredient in this product, drew mixed views on sleep, with some recommending it and others warning of next morning grogginess.

See all 9 biohackers →Hide the biohackers
  • Dr. Eric Berg · St. John's Wort · recommends
    • 29 Apr 2026 · recommends · Podcast ↗
      Recommends St. John's wort as a natural a med to help improve the symptoms of depression.
    • 29 Apr 2026 · recommends · YouTube ↗
      Suggests St. John's Wort as an alternative for depression, highlighting its better benefit-to-harm ratio compared to a med drugs.
    • 12 Jan 2026 · Lemon Balm · recommends · Podcast ↗
      Recommends lemon balm tea as it works well when quitting coffee.
    • 8 Jan 2026 · Lemon Balm · recommends · YouTube ↗
      Recommends adding lemon balm tea in the morning as another awesome thing when transitioning off coffee.
    • 5 Jan 2026 · Lemon Balm · recommends · Podcast ↗
      Recommends lemon balm tea as one of the best weight loss drinks, noting it contains rosmarinic acid which increases GABA.
    • 3 Jan 2026 · Lemon Balm · recommends · YouTube ↗
      Recommends consuming lemon balm tea 60 minutes before bed to lower cortisol, calm the nervous system, and promote better sleep, which in turn aids in fat burning.
    • 8 Nov 2025 · Dill · neutral · YouTube ↗
      Notes that Wikipedia states there is insufficient evidence to recommend the use of dill for treating dysmenorrhea.
    • 12 Oct 2025 · recommends · YouTube ↗
      Notes that St. John's wort works better than meds for depression, with 70% results compared to 60% for the drug, and fewer side effects.
    • 7 Oct 2025 · Peppermint · recommends · Podcast ↗
      Recommends peppermint oil as a natural 5 alpha-reductase inhibitor for hair loss.
    • 7 Jul 2025 · Peppermint · recommends · Podcast ↗
      Recommends smelling peppermint oil, noting it can increase sustained attention, improve reaction time, improve respiratory efficiency, and decrease tension headaches.
    • 12 May 2025 · neutral · Podcast ↗
      Notes that St. John's wort affects both serotonin and dopamine, is an anti-inflammatory, and reduces cortisol, but doctors often recommend against it despite its few side effects.
    • 14 Jan 2024 · Peppermint · recommends · YouTube ↗
      Recommends adding three drops of peppermint oil to a homemade anti-tartar toothpaste.
    • 17 Nov 2023 · Lemon Balm · recommends · Podcast ↗
      Recommends trying lemon balm to help lose belly fat after menopause.
    • 12 Nov 2023 · Lemon Balm · recommends · YouTube ↗
      Lists lemon balm as a really good adaptogen herb for menopause symptoms.
  • Dr. Mark Hyman · St. John's Wort · warns
    • 14 May 2025 · warns · YouTube ↗
      Mentions that St. John's wort can reduce the effectiveness of birth control and meds.
    • 24 Jun 2026 · Lemon Balm · recommends · YouTube ↗
      Recommends lemon balm as an ingredient in Besper that helps the body relax.
    • 27 May 2026 · Lemon Balm · neutral · YouTube ↗
      Mentions that ingredients like lemon balm in Vesper help the body relax.
    • 15 Apr 2026 · Valerian · neutral · YouTube ↗
      Notes that Valerian binds to separate allosteric sites on the GABA receptor, increasing the amount of GABA to bind.
    • 12 Nov 2025 · Peppermint · uses · YouTube ↗
      Uses peppermint oil in her products for its therapeutic effect of helping with sebum production.
    • 29 Nov 2024 · Peppermint · warns · YouTube ↗
      Lists peppermint essential oils as one of the substances that can weaken the lower esophageal sphincter, leading to acid reflux.
    • 15 Nov 2024 · Lemon Balm · recommends · YouTube ↗
      Recommends adaptogenic herbs like ashwagandha, particularly at night, rhodiola, lemon balm, and catclaw for stress relief.
    • 1 Nov 2024 · Lemon Balm · recommends · YouTube ↗
      Recommends lemon balm as an herbal supplement for deep sleep and relaxation, especially for those who are tired, wired, and stressed.
    • 1 Nov 2024 · Valerian · recommends · YouTube ↗
      Recommends valerian root as an herbal supplement for deep sleep and relaxation, especially for those who are tired, wired, and stressed.
    • 27 May 2024 · Valerian · recommends · YouTube ↗
      Mentions valerian root as an herb that can be helpful for sleep.
    • 19 Apr 2024 · Valerian · uses · YouTube ↗
      Sometimes takes a supplement with herbs like valerian root to wind down before bed.
    • 4 Mar 2024 · neutral · YouTube ↗
      Discusses a study funded by a pharmaceutical company that claimed St. John's Wort didn't work, but upon reading the study, it did work for all but the most severely depressed people.
    • 1 Aug 2023 · Dill · uses · TikTok ↗
      Uses fresh dill as an ingredient in a salmon recipe.
    • 5 May 2023 · Valerian · recommends · YouTube ↗
      Suggests trying valerian root as an herb that can be very helpful for sleep.
  • Ben Greenfield · St. John's Wort · neutral
    • 29 Mar 2025 · neutral · YouTube ↗
      Mentions St. John's Wort as a natural herbal approach some people utilize for sleep.
    • 29 Sep 2026 · Peppermint · neutral · X ↗
      Notes that a recent study showed peppermint oil improved symptoms of irritable bowel syndrome by more than 63% compared to a placebo group.
    • 23 Jul 2026 · Peppermint · uses · YouTube ↗
      Says they like to put a little peppermint oil in the sauna for the aroma and for the lungs.
    • 6 Nov 2025 · Peppermint · uses · YouTube ↗
      Learned from Dr. John Morat to put peppermint oil on his taint right before breathwork.
    • 2 Sep 2025 · Dill · uses · Facebook ↗
      Stuffs the trout with herbs like dill.
    • 6 Mar 2025 · Valerian · recommends · YouTube ↗
      Suggests using valerian root as a compound to help shut down hardwired dopamine firing pathways for those with ruminating thoughts at night.
    • 22 Feb 2025 · Peppermint · uses · YouTube ↗
      Uses peppermint oil, rubbing a little on his stomach and putting a few drops in his water, finding it fantastic for problematic gut issues, especially when traveling.
    • 4 Jan 2025 · Peppermint · neutral · YouTube ↗
      Notes that essential oil-based mouthwashes, such as those with peppermint, that do not contain antibacterial compounds would probably be okay.
    • 5 Oct 2024 · Valerian · recommends · YouTube ↗
      Ben Greenfield recommends valerian as an herbal supplement for insomnia.
    • 23 Aug 2024 · Hops · uses · YouTube ↗
      Tried Kolkurb, an active ingredient called Mar from hops extract, an hour before a meal and found it worked effectively to induce satiety, despite its extremely bitter taste.
    • 6 Jun 2024 · Hops · uses · YouTube ↗
      Ben Greenfield has tried Calocurb, an extract of bitter hops, multiple times after lunch and found he had to force himself to eat dinner due to appetite suppression.
    • 16 Mar 2024 · neutral · Podcast ↗
      Mentions St. John's Wort as something that can help with quelling tobacco/nicotine addiction.
    • 8 Mar 2024 · uses · YouTube ↗
      Ben Greenfield and his sons harvest St. John's Wort to make a tincture, which he calls the "happy flower" and notes it contains compounds similar to meds without the side effects.
    • 7 Mar 2024 · Lemon Balm · recommends · YouTube ↗
      Ben recommends lemon balm as an ideal herb for making tea, especially when combined with hot water, mint, and sage. He considers mint and lemon balm to be the two quintessential herbal medicines for tea.
  • Dave Asprey · St. John's Wort · neutral
    • 25 Mar 2025 · neutral · YouTube ↗
      Went through a phase of using St. John's Wort, especially for people who didn't want to try pharmaceutical agents for depression.
    • 6 Jul 2026 · Peppermint · recommends · Instagram ↗
      Recommends peppermint as a midwife remedy to help with nausea during pregnancy.
    • 6 Feb 2025 · neutral · YouTube ↗
      Mentions that one can make an argument for St. John's Wort but emphasizes focusing on what the body needs.
    • 21 Sep 2024 · Lemon Balm · recommends · YouTube ↗
      Recommends using lemon balm to aggressively prevent recurrent cold sores.
    • 10 Sep 2024 · Lemon Balm · recommends · YouTube ↗
      Recommends using lemon balm to aggressively prevent recurrent cold sores associated with herpes simplex 1, especially for those at risk of Alzheimer's.
    • 1 Feb 2024 · Valerian · uses · YouTube ↗
      Says he takes valerian root in capsule form before bed as one of his four natural sleep aids, noting that it smells bad but works.
    • 11 Jan 2024 · uses · YouTube ↗
      Dave Asprey's grandma and great-grandma would pick St. John's Wort from the side of the highway, dry it, and make tea, which he later learned is good for depression.
    • 4 Apr 2023 · Peppermint · recommends · YouTube ↗
      Suggests taking enteric coated peppermint oil to reduce gas in the belly.
    • Date not recorded · Valerian · recommends · Website ↗
      Dave suggests that valerian root might increase deep sleep.
  • Thomas DeLauer · St. John's Wort · neutral
    • 13 May 2024 · neutral · YouTube ↗
      Mentions St. John's Wort as a good supplement but questions if the body actually needs it without proper testing.
    • 5 Aug 2026 · Valerian · warns · YouTube ↗
      Warns that valerian, like other common sleep supplements, does not directly address the physiological issues of body temperature and brain restlessness, instead only sedating the user.
    • 18 Dec 2025 · Valerian · warns · YouTube ↗
      Warns against Valerian root for sleep, rating it as "decent" but not making his list, because while it can make one feel tired by inhibiting GABA breakdown, it often leads to grogginess and lack of motivation the next morning, essentially sedating rather than promoting true sleep.
    • 17 Apr 2025 · Lemon Balm · recommends · YouTube ↗
      Recommends chamomile and lemon balm as hugely beneficial for a sedative-like effect that can make one feel calmer, especially if tart cherry juice is avoided due to sugar content.
    • 4 Dec 2024 · Peppermint · warns · YouTube ↗
      Warns that peppermint can trigger reflux because it soothes and relaxes the lower esophageal sphincter, allowing reflux to occur, despite being good for irritable bowel syndrome.
    • 26 Jun 2024 · Peppermint · recommends · YouTube ↗
      Recommends peppermint, noting it contains the antioxidant luteolin, which has been shown to help brain fog.
    • 3 May 2024 · Hops · recommends · YouTube ↗
      Recommends Hop Water, which contains water, hops, and nootropics like 5-HTP, as a solution for those who want to reduce alcohol consumption.
    • 8 Jan 2024 · Hops · recommends · YouTube ↗
      Recommends Hop Water, a drink made from hops with nootropics, as a substitute for alcohol to give a buzz without the alcohol, and notes it is carried by Thrive Market.
    • 10 Dec 2023 · Hops · uses · YouTube ↗
      Drinks hop water, which is water made from hops that tastes a bit like beer and contains 5-HTP and nootropics to provide a fun buzz without damaging the body.
    • 6 Mar 2023 · Valerian · warns · YouTube ↗
      Notes that while valerian root is interesting and somewhat powerful for sleep, he has seen data suggesting it can disrupt sleep after the first few hours.
    • 14 Dec 2022 · Valerian · neutral · YouTube ↗
      Mentions that some people lean into valerian root for sleep, and studies show tart cherry juice is comparable to it.
    • 22 Nov 2022 · Lemon Balm · uses · YouTube ↗
      Notes that the Bomar sleep product includes lemon balm, which almost instantly helps one feel calm.
    • 26 Jun 2021 · Valerian · recommends · YouTube ↗
      Recommends taking valerian root in a concentrated form over melatonin for improving deeper sleep.
    • 18 Apr 2021 · Peppermint · recommends · YouTube ↗
      Recommends peppermint tea as tremendous for digestion and having powerful blood sugar modulating effects, suggesting it's perfect to help come down from a big carbohydrate meal.
  • Siim Land · Valerian · neutral
    • 17 Apr 2026 · neutral · YouTube ↗
      Notes that there isn't much long-term research on substances like valerian root for sleep and anxiety, and replication is a problem due to varying product formulations. He also points out a lack of follow-up on people after they discontinue supplementation.
    • 17 Apr 2026 · Lemon Balm · neutral · YouTube ↗
      Notes that there isn't much long-term research on substances like lemon balm for sleep and anxiety, and replication is a problem due to varying product formulations. He also points out a lack of follow-up on people after they discontinue supplementation.
    • 30 May 2024 · Peppermint · recommends · YouTube ↗
      Recommends using essential oil mouthwashes, such as those with peppermint oil, rosemary oil, or clove oil, to improve the oral microbiome and fight bad bacteria and periodontal pathogens.
    • 30 Oct 2023 · Peppermint · neutral · YouTube ↗
      Suggests adding a drop of peppermint or lemon essential oil to coconut oil pulling for good breath.
    • 7 Sep 2023 · Peppermint · uses · YouTube ↗
      Added a couple of drops of peppermint oil to his mouthwash because it has been shown to kill off P. gingivalis in vitro.
    • 22 Sep 2021 · neutral · YouTube ↗
      Mentions valerian as a recommendation for stress management, but states he does not use it.
    • 22 Sep 2021 · Lemon Balm · neutral · YouTube ↗
      Mentions lemon balm as a recommendation for anxiety.
    • 22 Sep 2021 · Peppermint · neutral · YouTube ↗
      Mentions peppermint oil as a recommendation for IBS.
    • 25 Oct 2017 · Peppermint · recommends · YouTube ↗
      States that peppermint tea improves digestion, reduces inflammation, and muscle pain.
  • Andrew Huberman · Valerian · uses
    • 17 Nov 2025 · uses · YouTube ↗
      Mentions valerian root as one of the clinically supported ingredients that can help you fall asleep, stay asleep, and wake up feeling more refreshed, and he has worked with AG1 to create a product that includes it.
    • 10 Nov 2025 · recommends · YouTube ↗
      Mentions Valerian root as a clinically supported ingredient that can help people fall asleep, stay asleep, and wake up feeling more refreshed.
    • 27 Oct 2025 · recommends · YouTube ↗
      States that valerian root is a clinically supported ingredient that can help one fall asleep, stay asleep, and wake up feeling more refreshed.
    • 20 Oct 2025 · neutral · YouTube ↗
      Mentions valerian root as one of several clinically supported ingredients that can help people fall asleep, stay asleep, and wake up feeling more refreshed.
    • 1 May 2025 · Peppermint · neutral · Podcast ↗
      Discusses peppermint as a tool for alertness.
    • 1 May 2025 · Peppermint · uses · YouTube ↗
      Huberman notes that sniffing peppermint and other minty scents can increase attention and create an arousal response, similar to ammonia salts but less intensely.
    • 8 May 2024 · warns · YouTube ↗
      States that Valerian root does not seem to hold up in terms of any sleep benefit whatsoever based on the data.
    • 10 Apr 2023 · Peppermint · neutral · YouTube ↗
      Huberman mentions peppermint oil as something people suggest to massage into the scalp to increase blood flow for hair growth.
    • 6 Feb 2023 · Peppermint · neutral · Podcast ↗
      Explains the evidence and mechanisms supporting the use of peppermint oil for headaches.
    • 6 Feb 2023 · Peppermint · recommends · YouTube ↗
      Andrew Huberman, initially skeptical, found that essential plant oil preparations containing peppermint oil, with or without eucalyptus oil, significantly reduced the intensity of pain and increased cognitive performance during headaches when applied to the temples and forehead.
    • 2 Aug 2021 · warns · YouTube ↗
      States that the evidence is quite against Valerian root being a beneficial sleep aid, with most good studies finding no benefits on sleep metrics.
    • 26 Jul 2021 · Peppermint · recommends · Podcast ↗
      Recommends peppermint for reducing nausea.
    • 21 Jun 2021 · Peppermint · neutral · YouTube ↗
      Notes that the smell of peppermint can increase attention and create an arousal response, though not as intensely as ammonia salts.
    • 12 Apr 2021 · neutral · YouTube ↗
      Notes that Valeriana officinalis has shown some improvement in hot flash symptoms and associated insomnia during menopause, based on double-blind placebo-controlled studies.
  • Dr. Rhonda Patrick · Valerian · recommends
    • 15 Oct 2025 · recommends · Facebook ↗
      Recommends valerian as a better option for a sleep-promoting supplement.
    • 8 Oct 2025 · recommends · Facebook ↗
      Recommends Valerian as a sleep supplement that promotes relaxation and reduces nighttime awakenings, offering meaningful improvements to sleep quality.
    • 6 Oct 2025 · neutral · YouTube ↗
      States that Valerian is sedating and calming, and while it came closest to beating placebo for insomnia, the data still shows it does not.
  • Bryan Johnson · Peppermint · uses
    • 25 Jun 2024 · uses · YouTube ↗
      Is currently in the Penalty Box on doctor's orders to rest, and has made himself some peppermint tea.

RAL Summary

Members OnlyTier 4 for Stress and Calm

Several herbs here have human studies showing calmer mood, but all doses are hidden in a blend and there are no counted reviews, so the evidence for this product is thin. Emerging fits.

  • Emerging: not enough evidence to rank higher yet.
  • Valerian: amount hidden in a blend
  • St. John's Wort: amount hidden in a blend
  • Hops: amount hidden in a blend
  • Cowslip: amount hidden in a blend
  • Peppermint: amount hidden in a blend
  • Lemon Balm: amount hidden in a blend
  • Dill: amount hidden in a blend
  • Pulsatilla: amount hidden in a blend
  • Oat: amount hidden in a blend

Where the evidence disagrees: 28 of the 124 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Digestive system

Combine with: For calm and focus, pair oat straw with L-theanine for relaxed alertness, magnesium glycinate for nervous system and sleep support, and ashwagandha or rhodiola to help modulate stress response. Bacopa monnieri or lion's mane can add cognitive support, and B-complex vitamins (especially B6, B12, folate) support neurotransmitter synthesis. If the underlying aim is cellular and DNA repair, add targeted longevity ingredients separately: NMN or NR with resveratrol or pterostilbene, CoQ10 or PQQ for mitochondrial support, alpha-lipoic acid, and spermidine, along with omega-3s and vitamin D3/K2.

Possible side effects: Studies reported no serious side effects for valerian or lemon balm, and side effects were rare with St. John's wort. No reviews were available to add anything.

Supplement Facts

Mugwort 0 · Valerian 0 · European Vervain 0
Supplement Facts
Serving Size 0.15-0.9 mL
Servings Per Container 55
Amount Per Serving% Daily Value
Mugwort0†
Valerian0†
European Vervain0†
St. John's Wort0†
Heather0†
White Nettle0†
Hops0†
Cowslip0†
Peppermint0†
Lemon Balm0†
Dill0†
Pulsatilla0†
Oat0†
Red Squill0†
† Daily Value not established.

Other ingredients: Water, ethyl alcohol.

Directions: Suggested Use: Adults take 30 drops in tepid water three times daily. If needed, may take up to 1 teaspoon before bedtime. Children 6 years or older take 10 drops in water three to five times daily. Children up to 6 years old take 5 drops in water three to five times daily.

Label source: NIH label database · Report a label change

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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.