Nordic Naturals Ultimate Omega Review
Nordic Naturals Ultimate Omega is a high-quality fish oil supplement rich in EPA and DHA, formulated to provide advanced support for heart and brain health.
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Study, Trial or Testing Result Summary
Members Only136 human studies · 57 improved
For blood pressure, the research on fish oil omega-3 fats is mixed, and the rules rate this product as not working for this goal. All three listed ingredients reach a studied dose when taken as members are told. A 2022 review of 71 trials in 4973 adults found that 2 to 3 grams a day lowered the top number by about 2.6 points and the bottom number by about 1.6 to 1.8 points, with bigger effects in people with high blood pressure and older adults [1]. A 1993 review of 31 trials found a drop of about 3 over 1.5 points, but no effect in healthy people [2]. A much larger 2020 review of 86 trials with about 162,800 adults found little or no effect on blood pressure [3]. A 3 year trial of 2157 adults aged 70 or older taking 1 gram a day found no meaningful change [4]. For the eicosapentaenoic acid part, 1800 milligrams a day lowered blood pressure in 24 adults with high cholesterol [5]. For the docosahexaenoic acid part, some small trials found drops [6], but a review of 61 trials found purified docosahexaenoic acid had no effect [7]. Animal and cell studies are never counted.
See all 136 studies →Hide the studies
- Across 86 trials with about 162,800 adults followed for 12 to 88 months, increasing omega-3 intake had little or no effect on blood pressure, though it lowered triglycerides by about 15%.Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.
- In 11 trials with over 5000 pregnant women, fish oil in the second or third trimester did not lower the risk of pregnancy-induced high blood pressure, pre-eclampsia or gestational diabetes.Fish Oil Supplementation does not Reduce Risks of Gestational Diabetes Mellitus, Pregnancy-Induced Hypertension, or Pre-…
- In 71 trials with 4973 adults, omega-3 at 2 to 3 grams a day lowered systolic blood pressure by about 2.6 mm Hg and diastolic by about 1.6 to 1.8 mm Hg, with larger effects in people with high blood pressure, high blood lipids and older adults.Omega-3 Polyunsaturated Fatty Acids Intake and Blood Pressure: A Dose-Response Meta-Analysis of Randomized Controlled Tr…
- In 21 trials with about 1950 adults with metabolic syndrome, there was not enough data to pool blood pressure results, and the authors say blood pressure benefits are not consistent, though triglycerides fell substantially.Marine-Based Omega-3 Fatty Acids and Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled …
- In 16 trials with 1,852 people with leg artery disease, omega-3 lowered triglycerides but had no significant effect on blood pressure or the other secondary outcomes.Omega-3 Polyunsaturated Fatty Acid Supplementation in Patients with Lower Extremity Arterial Disease.
- In 15 trials with 1830 people with leg artery blockage pain, omega-3 made no difference to blood pressure compared with placebo.Omega-3 fatty acids for intermittent claudication.
- In 31 placebo-controlled trials with 1356 people, fish oil lowered blood pressure by an average of 3.0 over 1.5 mm Hg, with the biggest effect at higher doses and in people with high blood pressure, but no effect in healthy people.Does fish oil lower blood pressure? A meta-analysis of controlled trials.
- In 20 trials with 1,208 people with heart disease, omega-3 at 0.3 to 4.7 g a day did not change arterial stiffness (pulse wave velocity) but improved wave reflection and blood vessel widening, with the best results around 1,650 mg EPA and 750 mg DHA.Omega-3 Fatty Acid Supplementation and Vascular Health Biomarkers - A Systematic Review and Meta-Analysis.
- In 12 studies with 759 people with leg artery disease, EPA or EPA plus DHA did not change blood pressure compared with placebo.The effectiveness of intervention with omega-3 fatty acids, eicosapentaenoic and docosahexenoic acid in peripheral arter…
- In 10 trials with 344 people with diabetes, omega-3 lowered systolic blood pressure slightly compared with control, but the difference was not statistically significant.The effects of omega-3 fatty acids on diabetic nephropathy: A meta-analysis of randomized controlled trials.
- Across 20 randomized trials, EPA lowered systolic blood pressure by 2.6 mmHg (3.8 mmHg in people with abnormal blood fats), and EPA also lowered a blood marker of inflammation (C-reactive protein).Effects of EPA and DHA on blood pressure and inflammatory factors: a meta-analysis of randomized controlled trials.
- This review of 61 trials and 37 observational studies found moderate to high confidence that marine omega-3 oils do not affect blood pressure, though they lower triglycerides.Omega-3 Fatty Acids and Cardiovascular Disease: An Updated Systematic Review.
- In 23 observational studies of healthy Asian adults, higher blood levels of total omega-3 fats were linked with lower risk of high blood pressure, while other blood pressure links were inconclusive and EPA specifically was tied to lower heart attack risk.Biomarkers of PUFA and cardiovascular risk factors and events in healthy Asian populations: a systematic review.
- A review of trials and other studies found omega-3 fats (EPA and DHA) were linked with slight drops in blood pressure, mainly in people with high blood pressure or high heart risk, but results varied and best doses are unclear.OMEGA-3 POLYUNSATURATED FATTY ACIDS AND HYPERTENSION: A REVIEW OF VASOACTIVE MECHANISMS AND IMPLICATIONS FOR CARDIOVASCU…
- A review of 26 studies of diet components found good but not conclusive evidence that DHA helps lower blood pressure.Bioactive Compounds and Their Effect on Blood Pressure-A Review.
- In a machine-learning analysis of 25,871 adults without heart disease followed for 5 years, omega-3 lowered heart disease risk by 0.47% on average, with larger benefit in some people (1.21% in the top third) and none in those with a low score; this did not measure blood pressure directly.Identification of individuals who benefit from omega-3 fatty acid supplementation to prevent coronary heart disease: a m…
- In 2,157 adults aged 70 or older given 1 g a day of omega-3 for 3 years, there was no statistically significant change in systolic blood pressure (-0.8 mm Hg) or diastolic blood pressure (-0.5 mm Hg) compared with no omega-3.Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clin…
- In 2,157 older adults given 1 g a day of omega-3 for 3 years, omega-3 did not reduce new high blood pressure or major cardiovascular events, and it raised HDL, total and LDL cholesterol while lowering triglycerides.Effects of vitamin D, omega-3 and a simple strength exercise programme in cardiovascular disease prevention: The DO-HEAL…
- In 851 pregnant women with a prior preterm birth, omega-3 lowered preterm delivery and low birth weight in smokers, and the abstract reported no significant difference between smokers and nonsmokers in pregnancy-related high blood pressure.The effect of omega-3 supplementation on pregnancy outcomes by smoking status.
- Premature infants fed high-DHA milk feeds had no difference in blood pressure at age 7 compared with standard-DHA feeds, although high-DHA children were more likely to be classed as obese.Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure …
- In 563 elderly Norwegian men at high heart risk given 2.4 g daily of omega-3 (EPA and DHA) or corn oil for 3 years, death and heart events were not significantly reduced, though deaths showed a borderline trend lower.A randomized clinical trial on n-3 polyunsaturated fatty acids supplementation and all-cause mortality in elderly men at…
- In 550 pregnant women with gestational diabetes, cod-liver oil for 12 to 16 weeks lowered blood sugar, blood fats, inflammation and pregnancy complications compared with placebo, though the 4-week primary outcomes showed no difference; blood pressure was not reported separately, only pregnancy-induced hypertension as a complication.Cod-Liver Oil Improves Metabolic Indices and hs-CRP Levels in Gestational Diabetes Mellitus Patients: A Double-Blind Ran…
- In 312 heart attack patients given high-dose omega-3 for 6 months, only those with a specific gene variant had lower heart volumes and natriuretic peptide levels compared with placebo; blood pressure was not reported.Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatt…
- In 262 people with heart disease over one year, omega-3 supplements (1.86 g EPA and 1.5 g DHA daily) prevented the rise in urine albumin in people with type 2 diabetes but had no effect in people without diabetes, and the abstract reports no direct effect on blood pressure.Eicosapentaenoic and Docosahexaenoic Acids Attenuate Progression of Albuminuria in Patients With Type 2 Diabetes Mellitu…
- In 224 healthy men, 4 g a day of purified fish-derived omega-3 ethyl esters did not change blood pressure compared with corn oil over the study period.Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans.
- In pregnant women, taking 800 mg of DHA daily lowered resting heart rate and improved vagal heart control compared with taking 200 mg daily.DHA Supplementation During Pregnancy Enhances Maternal Vagally Mediated Cardiac Autonomic Control in Humans.
- In 199 Danish children aged 8 to 9, eating about 300 grams of oily fish a week for 12 weeks did not change diastolic blood pressure compared with poultry.Effects of oily fish intake on cardiometabolic markers in healthy 8- to 9-y-old children: the FiSK Junior randomized tri…
- In a placebo-controlled trial, mothers who took 600 mg of DHA daily during pregnancy had children with overweight or obesity whose blood pressure was lower at ages 4 to 6 than children whose mothers took placebo.Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesi…
- In 161 healthy adults eating omega-3 enriched chicken and eggs for 6 months, diastolic blood pressure fell by about 3 mmHg compared with those eating control foods.Omega-3 index and blood pressure responses to eating foods naturally enriched with omega-3 polyunsaturated fatty acids: …
- In 152 older overweight adults, 2400 mg per day of fish oil for 16 weeks lowered heart rate but did not clearly change blood pressure compared with placebo.Effects of fish oil and curcumin supplementation on cerebrovascular function in older adults: A randomized controlled tr…
- In 152 adults over 65 with prediabetes, eating about 200 grams of sardines per week for a year lowered blood pressure more than the control diet.Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An int…
- In 126 Chinese adults with high blood pressure, 2 g per day of fish oil lowered systolic blood pressure and blood levels of angiotensin II compared with corn oil placebo.Lowering Effects of n-3 Fatty Acid Supplements on Blood Pressure by Reducing Plasma Angiotensin II in Inner Mongolia Hyp…
- In 120 adults with leg artery disease taking a gamma-linolenic and eicosapentaenoic acid combination for 2 years, systolic blood pressure was significantly lower than in the placebo group.Randomized controlled trial of gamma-linolenic acid and eicosapentaenoic acid in peripheral arterial disease.
- In 120 men at increased heart risk, fish or fish oil over 12 weeks lowered blood pressure more than control, but the difference between groups was not statistically significant.Effects on blood pressure of omega 3 fats in subjects at increased risk of cardiovascular disease.
- In 120 adults with metabolic syndrome, a daily 1 gram fish oil capsule (containing 120 mg DHA) for 6 months lowered systolic blood pressure, LDL cholesterol and inflammatory markers compared with no supplement.Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including ma…
- In 108 Chinese adults with high blood pressure and belly fat, 2 g a day of fish oil (EPA and DHA combined) for 12 weeks lowered a combined heart risk score more than corn oil, with lower LDL cholesterol and waist size.Effects of n-3 fatty acid supplements on cardiometabolic profiles in hypertensive patients with abdominal obesity in Inn…
- In 99 adults over 50, about 1.5 g per day of fish oil omega-3 from either liquid fish oil meals or microencapsulated powder for 4 weeks lowered systolic blood pressure by about 7 mmHg compared with a control group.Blood pressure-lowering effects of long chain n-3 fatty acids from meals enriched with liquid fish oil and from microenc…
- In 97 overweight or obese women on a calorie-restricted diet for 10 weeks, 1.3 g daily of EPA was tested against placebo; blood pressure was measured, but the abstract reports no blood pressure difference between groups.Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
- In 90 kidney transplant recipients, taking 9 g or 18 g of eicosapentaenoic acid daily for 26 weeks lowered diastolic blood pressure by about 9 to 10 mmHg, while the corn oil placebo group rose by about 2 mmHg.Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study.
- In 87 healthy men, 8 weeks of 4 g daily omega-3 fats in bakery products lowered mean arterial blood pressure.Trans, and n-3 polyunsaturated fatty acids and vascular function-a yin yang situation?
- In 86 healthy young adults taking about 3 grams a day for 12 weeks, pure EPA lowered blood pressure less than pure DHA or olive oil did, and EPA raised heart rate relative to DHA.Docosahexaenoic acid reduces resting blood pressure but increases muscle sympathetic outflow compared with eicosapentaen…
- In 84 adults at moderate heart disease risk, 8 weeks of 1.5 g daily long-chain omega-3 fats did not significantly change blood pressure.Fish-oil supplementation alters numbers of circulating endothelial progenitor cells and microparticles independently of …
- In 83 healthy 9-month-old infants given 5 mL of fish oil daily for 3 months, systolic blood pressure was about 6 mmHg lower at 12 months than in infants not given fish oil.Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants.
- In 80 obese middle-aged adults at high heart failure risk, taking 1.6 grams of omega-3 daily for one year did not improve heart structure, heart function, blood vessel stiffness or body composition beyond exercise or placebo.1 Year HIIT and Omega-3 Fatty Acids to Improve Cardiometabolic Risk in Stage-A Heart Failure.
- In 80 healthy adults taking a curcumin, eicosapentaenoic acid, astaxanthin and gamma-linolenic acid blend for 4 weeks, systolic blood pressure fell by about 5 mmHg more than with placebo.A combined effect of Cavacurcumin, Eicosapentaenoic acid (Omega-3s), Astaxanthin and Gamma -linoleic acid (Omega-6) (CEA…
- In 80 adults with coronary artery narrowing and high triglycerides taking meds, 4 grams a day of icosapent ethyl for 18 months reduced fatty plaque in the heart arteries compared with placebo, where plaque grew.Read the study on PubMed (32860032) →
- In 80 adults with cardiovascular risk factors, 3 grams a day of fish oil for 2 months raised adiponectin and lowered some cholesterol measures compared with sunflower oil, with benefit depending on starting adiponectin levels; blood pressure results were not reported.The benefits of ω-3 supplementation depend on adiponectin basal level and adiponectin increase after the supplementation…
- In 78 slightly overweight adolescent boys, 1.5 grams a day of fish oil for 16 weeks lowered systolic blood pressure by about 3.8 mm Hg and diastolic by about 2.6 mm Hg compared with vegetable oil.Effects of fish oil supplementation on markers of the metabolic syndrome.
- In 77 middle-aged and older adults with high blood pressure, 90 days of fish oil at 2 grams a day lowered inflammatory markers TNF-alpha and CRP more than corn oil did; blood pressure itself was not reported as an outcome.Lowering effects of fish oil supplementation on proinflammatory markers in hypertension: results from a randomized contr…
- Mothers given 4.5 g a day of fish oil for the first 4 months of breastfeeding did not change their children's blood pressure at age 2.5 years compared with olive oil.Diet and blood pressure in 2.5-y-old Danish children.
- In older adults with mild memory impairment, 12 months of a daily fish oil supplement providing about 1,491 mg DHA and 351 mg EPA lowered systolic blood pressure compared with placebo, though it did not improve cognition.The effects of docosahexaenoic acid supplementation on cognition and well-being in mild cognitive impairment: A 12-month…
- In 67 adults without high blood pressure, 8 weeks of fish oil did not change blood pressure reaction to mental stress, although it blunted heart rate reaction to stress.Fish oil and neurovascular reactivity to mental stress in humans.
- In healthy adults aged 50 to 75 taking 2.2 grams of fish oil omega-3 per day for 26 weeks, diastolic blood pressure improved compared with placebo, along with better executive thinking skills.Long-chain omega-3 fatty acids improve brain function and structure in older adults.
- In 65 healthy college students in China, 2.5 g daily fish oil did not show a blood pressure effect, but it gave some benefits on blood inflammation and oxidative stress markers during air pollution exposure.Cardiovascular Benefits of Fish-Oil Supplementation Against Fine Particulate Air Pollution in China.
- In 65 adults with high LDL cholesterol, adding fish oil to a diet plan for 20 weeks lowered diastolic blood pressure about 8%, the same as the diet plan alone, so the fish oil added no extra blood pressure benefit.Reduction of cardiovascular risk factors by the diet - Evaluation of the MoKaRi concept by a parallel-designed randomize…
- In 60 children receiving doxorubicin chemotherapy, taking 1000 mg of omega-3 fatty acids daily for six months lowered a marker of cell damage, raised antioxidant levels and preserved heart pumping function compared with usual care.Omega 3 fatty acids can reduce early doxorubicin-induced cardiotoxicity in children with acute lymphoblastic leukemia.
- In 59 overweight men with mildly high lipids, 4 g a day of purified fish-derived omega-3 for six weeks did not change 24-hour blood pressure compared with olive oil placebo, although the companion fish oil component lowered it.Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans.
- In 57 overweight young adults, 1.7 g per day of emulsified fish oil for 4 weeks did not lower blood pressure or arterial stiffness compared with safflower oil placebo.A randomized trial of fish oil omega-3 fatty acids on arterial health, inflammation, and metabolic syndrome in a young h…
- In 55 patients recovering from a heart attack, 12 weeks of 5.2 g daily omega-3 fats did not improve heart pumping function compared with placebo.N-3 fatty acids and cardiac function after myocardial infarction in Denmark.
- In 52 overweight adults with high blood pressure, 3 g of fish oil daily for 8 weeks improved large artery stretchiness but did not lower blood pressure compared with placebo.Fish oil supplementation improves large arterial elasticity in overweight hypertensive patients.
- In a 12-week double-blind trial of 45 people with lung disease and weight loss, a drink with 2 g of omega-3 fatty acids lowered systolic blood pressure more than an isocaloric comparator drink.Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: a randomized, controlled trial.
- In 45 hypertensive heart transplant recipients, 3.4 grams a day of omega-3 fatty acids for 1 year prevented the blood pressure rise seen with placebo and preserved kidney function.Omega-3 fatty acids improve blood pressure control and preserve renal function in hypertensive heart transplant recipien…
- In 45 hypertensive adults, 8 weeks of omega-3 capsules reduced oxidative stress in platelets of people with diabetes, but the abstract does not report a blood pressure change.Platelet redox balance in diabetic patients with hypertension improved by n-3 fatty acids.
- In healthy older adults taking 3.9 grams of omega-3 per day for 6 months, blood pressure (systolic) was reduced compared with corn oil placebo, alongside lower triglycerides.A Randomized Trial of ω-3 Fatty Acid Supplementation and Circulating Lipoprotein Subclasses in Healthy Older Adults.
- In 40 adults with diabetes and high cholesterol, fish oil or corn oil taken for 12 weeks produced no significant difference in blood pressure.A comparison of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDM.
- Eating eggs enriched with docosahexaenoic acid, vitamin E, lutein and selenium daily for 8 weeks did not change blood pressure compared with normal table eggs in 40 healthy adults.Designer egg evaluation in a controlled trial.
- In 39 adults with abdominal obesity, seven weeks of 3 to 4 g a day of fish oil lowered systolic blood pressure by about 1.8% while safflower oil raised it by about 2.6%, a significant difference between the two groups.Inflammatory markers after supplementation with marine n-3 or plant n-6 PUFAs: A randomized double-blind crossover study…
- In 38 dyslipidemic adults, 3 g a day of purified fish-derived omega-3 for seven weeks increased arterial elasticity by about 36% versus placebo, while blood pressure readings tended to fall without reaching statistical significance.The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans.
- In 38 mildly hypertensive older adults taking fish oil for 20 weeks, blood flow responses in the brain improved in women and in men with a different response, but blood pressure was not reported and mood and memory did not change.Effects of Long Chain Omega-3 Polyunsaturated Fatty Acids on Brain Function in Mildly Hypertensive Older Adults.
- In healthy middle-aged men and women, 0.7 grams of docosahexaenoic acid per day for 3 months lowered diastolic blood pressure by 3.3 points compared with placebo.Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women.
- In young healthy adults eating omega-3-enriched eggs providing about 777 mg omega-3 per day for 3 weeks, blood pressure and inflammation marker CRP fell from baseline, while the control egg group showed no change.Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy ind…
- In 36 normotensive adults with type 1 diabetes and kidney disease, 4.6 grams of fish oil daily for one year did not change 24-hour blood pressure compared with olive oil placebo.Fish oil in diabetic nephropathy.
- In 36 overweight or obese adults, 2 grams per day of algal docosahexaenoic acid for about 4.5 months did not change blood pressure compared with placebo.Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults.
- In overweight healthy adults, about 1 g of EPA daily for 16 weeks raised omega-3 levels in red blood cells but did not change blood pressure compared with control oil.Stearidonic acid-enriched soybean oil increased the omega-3 index, an emerging cardiovascular risk marker.
- In 32 patients with leg claudication taking 3 grams of fish oil per day for 4 months, mean blood pressure fell similarly in the fish oil and corn oil groups, with no meaningful improvement in walking distance.Fish oil supplementation in patients with stable claudication.
- In 32 people with Raynaud's phenomenon, 6.6 g of daily fish oil delayed attacks triggered by cold and raised finger blood pressure in the cold, though these benefits appeared only in primary Raynaud's.Fish-oil dietary supplementation in patients with Raynaud's phenomenon: a double-blind, controlled, prospective study.
- In a 6-month placebo-controlled trial of 28 heart transplant recipients, 4 g of omega-3 fatty acids daily prevented the blood pressure rise seen with corn oil, with systolic pressure falling 2 mm Hg versus rising 17 mm Hg in the placebo group.Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients.
- In 26 normal and hypertensive men, 30 days of 5 g fish oil did not change blood pressure, but in hypertensive men it raised LDL cholesterol.Fish oil produces an atherogenic lipid profile in hypertensive men.
- In 26 patients with lupus nephritis, a year of 15 g daily fish oil, compared with olive oil placebo, did not change blood pressure or kidney function, though it lowered triglycerides.Fish oil in lupus nephritis: clinical findings and methodological implications.
- In 26 adults, 8 weeks of 3.4 grams a day of marine omega-3 lowered resting blood pressure compared with placebo, and the reductions tracked with higher omega-3 levels in red blood cells.Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.
- In 25 adolescents with high triglycerides, about 3360 mg daily of omega-3 for six months did not change blood pressure compared with placebo, and the triglyceride drop was not significantly different from placebo.Using high-dose omega-3 fatty acid supplements to lower triglyceride levels in 10- to 19-year-olds.
- In 24 healthy older women taking 3 g per day of fish oil for 12 weeks, resting blood pressure was measured, but the abstract reports no blood pressure change; triglycerides fell by 29% compared with placebo.Omega-3 Fatty Acid Supplementation for 12 Weeks Increases Resting and Exercise Metabolic Rate in Healthy Community-Dwell…
- In 21 men, 3 weeks of fish oil increased blood flow speed in nailfold capillaries, while blood pressure was not changed by fish oil.Fish oil increases peripheral capillary blood cell velocity in humans.
- In an 8-week placebo-controlled trial of 21 men with poorly controlled hypertension, 4.5 g a day of fish oil did not lower blood pressure more than placebo, though blood pressure fell within both groups.Fish oil as an adjuvant in the treatment of hypertension.
- In a small trial of 20 normal volunteers over 4 weeks, marine oil capsules did not change blood pressure or forearm blood flow compared with placebo.Read the study on PubMed (2339203) →
- In 20 adults with type 1 diabetes, 3.3 grams of omega-3 daily for 6 months did not change blood pressure compared with corn oil placebo.Omega-3 polyunsaturated fatty acid supplementation versus placebo on vascular health, glycaemic control, and metabolic p…
- In 20 postmenopausal women doing resistance training, fish oil for 8 weeks lowered blood pressure, triglycerides, and inflammation and oxidative stress markers, while the training-plus-placebo group showed no such changes.Fish Oil Supplementation with Resistance Exercise Training Enhances Physical Function and Cardiometabolic Health in Post…
- In 19 healthy men taking 860 mg EPA and DHA per day for 8 weeks, fish oil did not prevent sitting-induced decline in leg blood vessel function, and blood pressure was measured but not reported as improved.Eight weeks of fish oil supplementation does not prevent sitting-induced leg endothelial dysfunction.
- In adults with mild high blood pressure taking 50 grams of marine oil per day for 6 weeks, diastolic blood pressure fell from 96 to 89 mm Hg, while vegetable oil did not change it.Effects of n-3 fatty acids in essential hypertension.
- In 8 normotensive men, a moderate dose of dietary fish oil did not change 24-hour blood pressure compared with safflower oil, although it reduced blood vessel response to angiotensin II.Effect of omega-3 fatty acids on the vascular response to angiotensin in normotensive men.
- A randomized trial in people with high normal diastolic blood pressure found that a novel fatty acid supplement did not significantly lower blood pressure.A trial of omega-3 fatty acids for prevention of hypertension.
- In overweight postmenopausal women, a 16-week DHA-rich omega-3 supplement lowered diastolic blood pressure and triglycerides compared with olive oil placebo, while exercise training gave the larger body composition gains.Effects of DHA-Rich n-3 Fatty Acid Supplementation and/or Resistance Training on Body Composition and Cardiometabolic Bi…
- In healthy young and older men given 1.35 to 4.05 g per day of an EPA-rich oil for 12 weeks, blood pressure did not change compared with placebo.Age- and dose-dependent effects of an eicosapentaenoic acid-rich oil on cardiovascular risk factors in healthy male subj…
- In adults aged 50 to 80 with overweight or obesity, 16 weeks of fish oil providing 400 mg daily of EPA and 2000 mg of DHA improved processing speed and brain blood flow response in men only versus placebo, while the abstract reports no direct group effect on blood pressure, which was only linked to processing speed through correlation.Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with…
- In people with type 2 diabetes and kidney involvement, 900 mg a day of purified fish-derived omega-3 for 12 months reduced albumin leakage in urine but did not affect blood pressure.Long-term effect of eicosapentaenoic acid ethyl (EPA-E) on albuminuria of non-insulin dependent diabetic patients.
- In 84 adults with dyslipidemia followed for 12 months, those given 1,800 mg per day of eicosapentaenoic acid showed no rise in arterial stiffness, while the diet-only control group's stiffness increased.Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia…
- In 67 adults with normal or elevated blood pressure taking 9 g of fish oil daily for 8 weeks, mean blood pressure did not change compared with olive oil placebo.Fish oil and neurovascular control in humans.
- In 67 overweight or obese adults taking 2 to 6 g per day of fish oil for 12 weeks, blood pressure did not change compared with sunflower oil control, although heart rate variability and large artery compliance improved.Dose-dependent increases in heart rate variability and arterial compliance in overweight and obese adults with DHA-rich …
- In girls with typical Rett syndrome, 12 months of high-dose omega-3 supplementation improved heart muscle pumping function and lowered oxidative stress markers compared with untreated girls.Effects of ω-3 PUFAs supplementation on myocardial function and oxidative stress markers in typical Rett syndrome.
- In 60 people with type 2 diabetes, a diet with 8 g per day of fish oil improved essential hypertension and blood fats more than diet alone, without worsening blood sugar.[Effects of diet therapy including eiconol on clinical and metabolic parameters in patients with type 2 diabetes mellitu…
- In 43 healthy young adults taking 3 g of fish oil daily for 4 weeks, lung function loss after ozone exposure was reduced, but fish oil did not change blood pressure, whereas olive oil blunted the blood pressure rise.Fish oil blunts lung function decrements induced by acute exposure to ozone in young healthy adults: A randomized trial.
- In 30 healthy adults, 2.52 grams of omega-3 daily from fish oil for 5 weeks lowered systolic blood pressure compared with placebo, while the lower 1.26 gram dose was not reported as significant for blood pressure.Effects of fish oil capsules in two dosages on blood pressure, platelet functions, haemorheological and clinical chemist…
- In 29 healthy young and older adults, 4 g per day of fish oil for 12 weeks reduced the rise in blood pressure during handgrip exercise in both age groups.Omega-3 polyunsaturated fatty acid supplementation attenuates blood pressure increase at onset of isometric handgrip exe…
- In 25 obese teenagers taking 1.2 g of omega-3 daily for 3 months, blood pressure did not change compared with placebo, though inflammation markers fell and blood vessel function improved.Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents.
- In 24 adults with high cholesterol, 1800 mg of EPA daily for 3 months lowered both central and arm blood pressure, while pravastatin did not change blood pressure.Effect of eicosapentaenoic acid on central systolic blood pressure.
- In 20 healthy elderly people, a daily capsule with 30 mg EPA and 150 mg DHA for 42 days significantly lowered systolic blood pressure and malondialdehyde compared with placebo.The influence of low intake of n-3 fatty acids on platelets in elderly people.
- In 20 adults with a genetic cholesterol disorder taking meds, 4 g a day of fish oil for eight weeks lowered systolic and diastolic blood pressure by about 6% each and improved large artery elasticity.Read the study on PubMed (27614801) →
- In 18 children with dilated cardiomyopathy taking 10 mL of fish oil daily for about 6.6 months, heart pumping function improved, while a comparison group not taking fish oil showed no significant change.Fish oil supplementation improves left ventricular function in children with idiopathic dilated cardiomyopathy.
- In a small crossover study of 15 volunteers, two weeks of a mackerel-rich diet was followed by a marked drop in blood pressure, linked to lower noradrenaline levels; a herring-rich diet did not produce the same drop.Clinical studies on lipid and blood pressure lowering effect of eicosa-pentaenoic acid-rich diet.
- In 13 healthy adults, 6 weeks of fish oil at 3 grams a day did not change mean blood pressure or heart rate, though it improved blood flow in the upper arm artery during exercise.Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm…
- In a small 12-week open study of 21 obese men with metabolic syndrome, blood pressure fell in both the calorie-restricted diet group and the group that also took fish oil, with no separate fish oil effect reported.n-3 PUFA and caloric restriction diet alters lipidomic profiles in obese men with metabolic syndrome: a preliminary open…
- In people with familial hypercholesterolemia on standard cholesterol treatment, 4 g per day of omega-3 ethyl esters for 8 weeks lowered systolic and diastolic blood pressure by about 6% each, along with triglycerides and postprandial lipemia.ω-3 Fatty Acid Ethyl Esters Diminish Postprandial Lipemia in Familial Hypercholesterolemia.
- Among 427,678 UK adults followed for about 8 years, regular fish oil users had lower risk of cardiovascular death and cardiovascular events, and the link was stronger in people with high blood pressure.Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a …
- In a long-term study of about 38,000 women without prior heart disease, dietary omega-3 fats and fish intake were not linked to the risk of heart attack, stroke or heart-related death.Fish Consumption, Omega-3 Fatty Acids, and Risk of Cardiovascular Disease.
- In over 30,000 UK adults with several heart and metabolic conditions, those who used fish oil had about 17% lower risk of death from any cause and about 19% lower risk of heart-related death over about 12 years of follow-up.Use of fish oil and mortality of patients with cardiometabolic multimorbidity: A prospective study of UK biobank.
- In 6,944 children followed to age 7.5, a weak link between mother's omega-3 intake in late pregnancy and child blood pressure disappeared after adjusting for other factors.Maternal diet in pregnancy and offspring blood pressure.
- Across 7 European birth cohorts of 2188 children, breast milk omega-3 levels, including docosahexaenoic acid, were not linked to childhood blood pressure.Breast milk n-3 long-chain polyunsaturated fatty acids and blood pressure: an individual participant meta-analysis.
- In 1666 middle-aged and older Finnish adults, blood levels of long-chain omega-3 fats such as DHA were not linked to orthostatic hypotension (a blood pressure drop on standing), except for an inverse link with DPA.Serum long-chain omega-3 polyunsaturated fatty acids and risk of orthostatic hypotension.
- Tanzanian adults eating a freshwater fish diet had lower blood pressure than adults eating a mainly vegetarian diet, with higher blood levels of eicosapentaenoic acid.Blood pressure, serum lipids, and fatty acids in populations on a lake-fish diet or on a vegetarian diet in Tanzania.
- In 899 hospitalized heart failure patients, low blood levels of omega-3 fats were linked to some heart measures but did not predict death over three years of follow-up.The omega-3 index in patients with heart failure: A prospective cohort study.
- A dietary survey of 853 Bosnian adults found low intakes of omega-3 fats DHA and EPA, and more than half had elevated blood pressure, but the survey did not test whether DHA changes blood pressure.Fueling an epidemic of non-communicable disease in the Balkans: a nutritional survey of Bosnian adults.
- In a cross-sectional comparison of 596 hypertensive adults, a fishing village with higher blood omega-3 levels had less heart wall thickening and artery thickening than a farming village, though this does not prove cause.Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan.
- In 404 patients with a type of heart failure, higher blood omega-3 levels (EPA plus DHA) were linked to better metabolic markers, better exercise capacity, and higher heart pumping function, but not to diastolic function markers.Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-D…
- In 321 hemodialysis patients, the ratio of EPA to arachidonic acid was not significantly linked to cardiovascular disease after adjusting for other risk factors.Eicosapentaenoic Acid and Prevalence of Cardiovascular Disease in Hemodialysis Patients.
- In 308 patients with heart failure, lower blood DHA was linked to a more enlarged heart chamber, and a DHA level of about 1.24% or higher helped rule out severe enlargement.Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the hear…
- In 265 healthy American adults not taking meds, higher blood DHA was modestly linked to lower diastolic blood pressure, with about 2 mm Hg lower readings per two standard deviations higher DHA.Long-chain omega-3 fatty acids and blood pressure.
- In children followed to age 9, umbilical cord DHA levels at birth were not associated with blood pressure, while higher arachidonic acid levels were linked to lower diastolic blood pressure.Neonatal fatty acid status and cardiometabolic health at 9years.
- In pregnant women, the fatty acid changes seen in pregnancy-induced high blood pressure appeared late in pregnancy and were unlikely to cause the condition.The essential fatty acid status of mother and child in pregnancy-induced hypertension: a prospective longitudinal study.
- In 47 overweight middle-aged men, those with higher blood omega-3 levels had better insulin sensitivity, lower nighttime blood pressure, and lower inflammation marker CRP than those with lower levels.Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-ag…
- A population-level study of heart disease deaths in 27 European Union countries found that low intake of omega-3 fats was among the largest dietary contributors to higher heart disease death burden, especially in women in Austria, Greece and Malta; this was not a direct supplement trial.Diet and sex inequities in ischemic heart disease mortality across Europe: findings from the global burden of disease st…
- In Iranian schoolchildren aged 7 to 12, regular eating of a seafood-rich diet high in omega-3 fats was associated with lower blood pressure, though this cross-sectional study cannot show cause.The intake assessment of diverse dietary patterns on childhood hypertension: alleviating the blood pressure and lipidemi…
- In 55 people with heart disease, high cholesterol and hypertension, a diet with 20 g of fish oil for 55 days lowered lipids and changed clotting-related markers; the abstract does not report blood pressure results.[Effect of atherosclerotic diet containing polyunsaturated omega-3 fatty acids on level of natural antibodies to prostag…
- In 22 people with type 2 diabetes, 8 weeks of fish oil lowered systolic blood pressure from 142 to 128 and diastolic from 88 to 80, but raised apolipoprotein B and temporarily worsened blood sugar control.Effects of omega-3 fish oils on lipid metabolism, glycemic control, and blood pressure in type II diabetic patients.
- Maximal treadmill exercise raised blood pressure in healthy volunteers but did not change omega-3 levels in their red blood cells; no omega-3 supplement was given.Maximal exercise and erythrocyte fatty-acid status: a lipidomics study.
- A diet with 20 g of fish oil for 4 weeks, repeated 2 to 3 times a year, was recommended for people with heart disease, familial high cholesterol and hypertension; the abstract gives no blood pressure numbers.[Clinico-biochemical validation of the use of PUFA omega-3 in patients with ischemic heart disease, familial hyperlipopr…
- A genetic analysis (Mendelian randomization) linked higher genetically predicted blood EPA levels to a higher risk of ischemic stroke, alongside higher blood pressure; no supplement was tested.Exploring Genetic Associations of 3 Types of Risk Factors With Ischemic Stroke: An Integrated Bioinformatics Study.
Review Totals and Summary
Members Only870 reviews · 70% positive
Nordic Naturals Ultimate Omega receives largely positive feedback from real users across several major retailers. Many reviewers mention noticing tangible benefits after consistent use, especially when it comes to overall wellness and energy levels. Several customers express satisfaction with the quality of the product, often citing the brand’s reputation and the perception that the supplement feels more trustworthy than alternatives. A widely shared sentiment among positive reviews is the pleasant or at least tolerable taste, with some users pointing out that the softgels do not have the strong fishy aftertaste commonly associated with omega supplements. Ease of swallowing and lack of unpleasant burps are recurring highlights, with people appreciating the convenience of adding it to their daily routines without discomfort. Despite the overall favorable response, neutral reviews make up a significant portion as well, with many users reporting results that are either subtle or take time to become noticeable. Some express uncertainty about whether the supplement makes a significant difference, especially for those already maintaining a healthy lifestyle or taking similar products. A few customers mention that while Nordic Naturals Ultimate Omega fits easily into their regimen, the effects are difficult to measure directly, and they continue to take it based on trust or a healthcare provider’s recommendation rather than dramatic personal outcomes. On the downside, a smaller group of negative reviews surfaces around issues of cost and packaging. Price is a fairly common concern, with several reviewers stating that while they like the product, they find it expensive compared to other options. There are also occasional complaints about a mild aftertaste or the pills being larger than average, which can be uncomfortable for those who have trouble swallowing supplements. A handful of negative comments mention digestive upset or mild nausea, although these are not the dominant themes. In terms of customer service and shipping, most feedback is neutral to positive, but a few customers express disappointment with shipping times or minor packaging issues upon arrival. Overall, sentiment for Nordic Naturals Ultimate Omega is predominantly positive, with about seven out of ten customers rating their experience favorably. Most users feel confident in the quality and consistency of the product, and many highlight improvements in their sense of well-being or routine blood work. Neutral remarks generally stem from the supplement’s perceived subtlety or the inability to quantify benefits easily, but rarely from dissatisfaction with the product itself. Negative reviews, while present, are relatively sparse and center mainly on price, pill size, and isolated reports of digestive discomfort. All told, the consensus suggests that Nordic Naturals Ultimate Omega is regarded as a reliable, high-quality supplement that meets the expectations of most users, with only a minority expressing notable reservations.
Biohacker Summary
Members Only7 of 10 recommend it
Seven of the ten panelists recommend omega-3 fatty acids, one uses them, and two are neutral, so the panel is broadly in favor. They take them for heart and brain health, lower triglycerides, less inflammation, mood and focus, skin, and fertility, including sperm health. Several point to fatty fish like salmon and sardines as a food source, and one says fish oil may matter more than plant-based omega-3s if seed oils are in your diet. Doses mentioned are 1 to 3 grams a day of EPA and DHA, 1 gram a day, and about 2 grams a day to raise a low omega-3 index; one panelist warns most people underdose because standard capsules hold little EPA and DHA. For cautions, one advises buying from a brand with independent third-party testing and a recent certificate of analysis, another prefers the triglyceride form for absorption and to avoid oxidation, one pairs it with vitamin D and strength training, and one says the research on hard heart disease outcomes is not very strong.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Omega-3 Fatty Acids · neutral
- Explains why omega-3s are important for brain, mood, and healthy aging.
- Eats Zetopia's Atlantic salmon for Omega-3s and Vitamin D, especially in winter, noting that one serving provides as much EPA and DHA as two standard fish oil capsules.
- Mentions omega-3 fats as existing biomarkers that play a role in mental health, which Function Health includes in their measurements.
- Mentions that omega-3s are anti-inflammatory and helpful.
- Tries to supplement with omega-3s for psoriasis and considers them the one clearly clinically effective skin nutrient for skin, hair, and nails.
- Emphasizes the importance of focusing on omega-3s, noting that a national crisis of omega-3 deficiency exists and that low omega-3 levels are a significant problem, more so than omega-6s.
- Consumes omega-3 fats through salmon at dinner.
- Notes that omega-3s are important nutrients for brain performance and aging, and that many people have gaps in these nutrients.
- Recommends omega-3 fats from wild fish, seafood, and certain nuts and seeds to fight inflammation.
- Mentions omega-3 fats as something that might be helpful for gut repair.
Dr. Eric Berg · Omega-3 Fatty Acids · neutral
- Notes that one can of sardines contains 900 mg of omega-3s (EPA and DHA).
- Recommends Omega-3s from fish oil or cod liver oil to improve the omega-6 to omega-3 ratio, which should be around 2:1 or 1:1 but is often 10:1 or 20:1 for most people.
- Suggests that taking cod liver oil can help with flaky skin around the nose or forehead, which usually means too much omega-6 fat relative to omega-3 fat.
- Recommends fatty fish like salmon, sardines, and mackerel, which are high in omega-3 fatty acids (EPA and DHA) that reduce liver inflammation and prevent scarring.
- Recommends wild-caught salmon as a healthy food to eat every day, noting it contains about 2000 mg of omega-3s in just 3 ounces.
- Recommends wild salmon as it is rich in omega-3 fatty acids, which help reduce inflammation and support brain health and cognitive function, especially important as one ages.
- Recommends DHA, an omega-3 fatty acid, as a natural remedy that, along with sweet wormwood, can trigger iron into an explosion to hit cancer.
- Dr. Eric Berg mentions that sardines are packed with omega-3 fatty acids, which support brain health and metabolism.
- Mentions that wild salmon, specifically half a fillet, has 970 mg of potassium, zero carbohydrates, a good amount of magnesium, and is loaded with omega-3 fatty acids.
- Discusses what would happen if one consumed omega-3 fatty acids every day for 30 days, highlighting their benefits for brain health, heart health, and various conditions like dry eyes, dermatitis, and high blood pressure, as well as supporting calcium absorption and promoting better sleep.
Thomas DeLauer · Omega-3 Fatty Acids · recommends
- Recommends eating more omega-3s to turn over cell membranes more quickly.
- Recommends fish oil supplements as an omega-3 source for gut health, as they help reduce inflammatory signaling while tissue repairs.
- Recommends high-dose omega-3s, specifically 2 to four grams of combined EPA and DHA daily, to lower hepatic fat output and improve chylomicron clearance, which helps with non-fasting triglycerides.
- Recommends omega-3s, specifically 4 grams a day, to boost the muscle building response by making muscle cell membranes work better for the mTor switch to fire, and specifically mentions Pury for their clean, third-party tested omega-3s.
- Recommends consuming more omega-3s to help balance the mitochondrial membrane, as it will absorb more omega-3s instead of omega-6s.
- Recommends consuming more omega-3s to drive down inflammation.
- Recommends omega-3s, stating that a meta-analysis found 1,000 mg significantly reduced liver fat by shutting down inflammatory signals that promote fat storage, and advises looking for a triglycerol form for better absorption and to avoid oxidation.
- Recommends fatty fish like salmon and sardines, aiming for two to three servings per week, especially around a workout, because their omega-3s, particularly DHA, increase BDNF expression.
- Considers omega-3s a fundamental for brain protection, recommending both dietary sources and supplementation for EPA and DHA, as they produce pro-resolving mediators to limit inflammation.
- Recommends timing omega-3 intake around workouts because they directly help build and keep muscle by making muscle more responsive to growth signals and fighting anabolic resistance as one ages.
Dr. Rhonda Patrick · Omega-3 Fatty Acids · neutral
- Notes that Omega-3s (EPA and DHA) are important for neuronal membranes, brain function, and resolving inflammation, and higher levels are associated with lower dementia risk.
- Highlights omega-3 fatty acids as important for cell membranes, neurons, supporting brain cells, the blood-brain barrier, and regulating inflammation, which can contribute to memory problems.
- Mentions that EPA is an omega-3 examined in mortality analysis and found primarily in seafood.
- States that Omega-3 fatty acids are very important for sperm health.
- Omega-3s may help slow biological aging, with added benefits when combined with vitamin D and strength training. In a 3-year randomized trial of healthy, mostly active older adults, omega-3 alone slowed several DNA-based aging clocks.
- Recommends regular intake of omega-3 rich seafood and supplementation with omega-3 fatty acids if it's appropriate for one's lifestyle, as they are beneficial for the heart by resolving inflammation and preserving membrane fluidity.
- Notes that a 100 mg per day increase in omega-3 fatty acids was associated with lowering the risk of Alzheimer's disease and cognitive decline by 10%, and that it takes about two grams a day to get to a high omega-3 index if one has a low index.
- Practical habits to help keep chronic inflammation in check include getting enough omega-3s.
- States that Omega-3s, specifically EPA and DHA, may be the most potent naturally occurring dietary compounds for reducing inflammation, and that about 2 g/day of combined EPA and DHA can raise a low omega-3 index.
- Recommends fatty fish as a source of healthy fats for muscle gain.
Andrew Huberman · Omega-3 Fatty Acids · recommends
- Mentions that AG1 is giving away a free bottle of omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- AG1 is giving away a free bottle of omega-3 coenzyme Q10 with your first subscription.
- Mentions that AG1 is giving away a free bottle of Omega-3 co-enzyme Q10 with the first subscription to AG1 Pro.
- Discusses Omega-3 Fatty Acids and EPA.
- Mentions that AG1 is offering a free bottle of Omega-3 co-enzyme Q10 with a first subscription to AG1 Pro.
- Recommends a free bottle of Omega-3 co-enzyme Q10 with the first AG1 Pro subscription.
- Mentions Omega-3s in the context of the microbiome and processed foods.
- Recommends Omega-3 co-enzyme Q10, which is offered as a free bottle with the first AG1 Pro subscription.
- States that getting 1 to 3 grams of EPA essential fatty acid per day can improve mood and cognitive function, supporting focus and concentration.
- Discusses Omega-3 Fatty Acids.
Siim Land · Omega-3 Fatty Acids · recommends
- Recommends taking omega-3s, including EPA and DHA, with a fat-containing meal to increase absorption.
- Increased his omega-3 intake to achieve a higher omega-3 index, which is associated with greater insulin sensitivity and better metabolic health markers.
- Increased his omega-3 index to 9.5% and notes that omega-3s have strong evidence for reducing elevated triglycerides.
- Mentions that EPA and DHA Omega-3s support heart and brain function and can lower triglycerides, with a higher omega-3 index associated with lower heart disease, Alzheimer's and mortality risk.
- Recommends Omega-3s for triglycerides and cardiovascular health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends choosing an omega-3 supplement from a brand that uses independent third-party testing and publishes a recent certificate of analysis, verifying EPA and DHA amounts, and testing for heavy metals, contaminants, and oxidation markers.
- Lists Omega-3s as one of 15 supplements backed by human studies.
- Explains that omega-3s can alter mitochondrial membranes and have broader cardiometabolic effects, making mitochondria more responsive to cellular signaling and oxidative stress from exercise, but they don't increase maximal mitochondrial respiration.
- Notes that 75% of people aren't meeting the daily recommendation for omega-3s and that Japanese people eat 2-3x more omega-3s per day than Americans or Europeans, which reflects in their higher omega-3 index.
- Thinks omega-3s have some of the strongest evidence and are worth considering.
Dave Asprey · Omega-3 Fatty Acids · recommends
- Suggests that omega-3s may help slow aging and support cellular repair.
- Recommends omega-3s, noting that 1 gram a day slowed epigenetic aging by up to 4 months in a randomized trial of people over 70.
- Dave Asprey recommends Omega-3, citing a randomized trial showing 1g a day slowed epigenetic aging in older adults, but warns that most people underdose due to low EPA and DHA content in standard capsules.
- A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, a med, pitavastatin, and ketamine.
- Recommends getting nutrients like omega-3s from real food or Vision 101 for eyesight.
- Recommends adding omega-3 fats to improve how neurons absorb and use nutrients like vitamin C.
- States that Fatty15 supports cells better than omega-3s or fish oil, but he uses both.
- Notes that Inuit people consumed very high levels of omega-3s, specifically EPA and DHA, which contributed to their health on a whale blubber diet.
- Lists Omega-3s as a nutrient that forms the structure and different parts of the brain.
- Uses both C15 and omega-3s, noting that C15 supports cells better than omega-3s or fish oil with three times more benefits.
Ben Greenfield · Omega-3 Fatty Acids · neutral
- Notes that omega-3s have solid research behind them for fertility.
- Recommends omega-3 fatty acids, specifically EPA and DHA, at 1 to 3 grams per day for better sperm morphology and motility, noting that sperm membranes are rich in polyunsaturated fatty acids.
- Recommends getting Omega-3 from oily fish such as sardines, anchovies, mackerel, herring, and salmon with skin.
- Discusses why fatty fish or fish oil may matter more than plant-based omega-3s if seed oils are in one's diet.
- Says that omega-3 fatty acids are a great way to feed the system and help with stress.
- Recommends testing for and replenishing omega-3 fatty acids if levels are low, as they can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
- Recommends including EPA from fatty fish or fish oil in one's diet, especially if seed oils are present in the diet.
- Notes that B vitamins and Omega-3s work as a pair to support the brain, but not independently.
- Notes that the DO-Health study showed omega-3 had good effects, and it's a supplement people commonly take.
- Mentions that omega-3, vitamin D, and exercise all had good effects in the DO-Health study.
Peter Attia · Omega-3 Fatty Acids · neutral
- Peter and Michael explore the benefits of omega-3 fatty acids for cardiovascular trials and the challenge of delivering DHA to the brain.
- Mentions that some trials showing a benefit to PUFA were confounded by the inclusion of omega-3s, and argues that the literature on omega-3s is not super strong for decreasing hard cardiovascular disease endpoints.
- Took big doses of omega-3 postpartum to help maintain when she wasn't sitting down to eat full meals.
- Mentions consuming fatty fish, specifically sardines, as part of their diet, noting their high fat and protein content.
- Peter discusses how omega-3s from fish oil impact inflammation, heart health, and brain function, as well as the strengths and limitations of current research.
- Mentions the importance of DHA omega-3 fatty acids for neuronal membranes, which are concentrated in synapses and crucial for communication between neurons.
- Highlights the importance of DHA omega-3 fatty acids for neuronal membranes and communication between neurons, as they are concentrated in synapses.
- Discusses the mfsd2a transporter, which is specific to DHA in phospholipid form, and its role in blood-brain barrier integrity, noting that animal studies show disruption of this transporter causes significant breakdown of the blood-brain barrier and loss of omega-3 in the brain.
- States that there is a very strong clinical impression that high doses of omega-3s help with dry eye, primarily from an anti-inflammatory standpoint.
- Recommends omega-3 fatty acids, specifically DHA and EPA, for brain protection, especially for individuals with the APOE4 gene, stating that they require higher doses.
Bryan Johnson · Omega-3 Fatty Acids · uses
- Lists Omega-3 as a customer favorite.
- Recommends Omega 3 fatty acids as a supplement for skin health, noting they are in the Blueprint stack.
- During menopause, Bryan Johnson recommends ensuring adequate omega-3s for brain health.
RAL Summary
Members OnlyTier 5 for Blood Pressure
Rated ineffective because the largest review, 86 trials with about 162,800 adults, found little or no effect on blood pressure [3], and a 3 year trial in older adults found no meaningful change [4]. Smaller reviews showing modest drops mostly involved higher doses and people with high blood pressure [1].
- Not endorsed.
Where the evidence disagrees: 65 of the 136 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system
Combine with: Not compulsory, but can be taken with a meal to improve absorption.
Possible side effects: In one large trial, 1 gram a day raised total and bad cholesterol while lowering triglycerides, and one trial of high dose docosahexaenoic acid noted increased nerve activity that tightens blood vessels.
Supplement Facts
Total Omega-3s 1280 mg · EPA 650 mg · DHA 450 mg
| Calories | 20 | |
| Calories from fat | 20 | |
| Total Fat | 2 g | 3% |
| Saturated Fat | 0.1 g | 1% |
| Trans Fat | 0 g | † |
| Total Omega-3s | 1,280 mg | † |
| EPA (Eicosapentaenoic Acid) | 650 mg | † |
| DHA (Docosahexaenoic Acid) | 450 mg | † |
| Other Omega-3s | 180 mg | † |
Directions: Take two soft gels daily, with food, or as directed by your health care professional or pharmacist.
Label source: the brand's label · Report a label change
Sizes and barcodes: 8 fl. Oz.; 237 mL, UPC 7 68990 02793 2 (off market); 120 Softgel(s), UPC 7 68990 02790 1 (off market)
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Graded October 23, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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