ProCaps Essential 1 with 5000 IU Vitamin D3 Review

Product Focus: Thyroid HealthAlso covers:HormonesImmune systemRanked among:Multivitamins
Tier ⓘ
Tier 2 · Rank 7
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 7 within Tier 2 for Thyroid Health; 7 of 62 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
69 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
96% of 6,302
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only292 human studies · 67 improved

4 of these 292 human studies gave the ingredient by drip, not by mouth.

292 human studies67 improved161 no effect776,737 people studied

Selenium is in this product at a full dose. In people with autoimmune thyroid disease, pooled trials found it lowered thyroid antibodies and thyroid-stimulating hormone [1][2]. In one trial it restored normal thyroid function in 31% of people with a mildly underactive thyroid, compared with 3% of controls [3]. One review still judged the evidence too weak for routine use [4]. Zinc reaches the studied dose at two servings a day. A pooled analysis of people with an underactive thyroid found that zinc added to meds raised active thyroid hormone, though certainty was low [5]. Other zinc reviews call the results inconsistent [6]. Vitamin D is at a full dose, which is above the daily recommended limit. Results are mixed: one pooled analysis found lower antibodies [7], another found no clear effect [8]. Vitamin A and coenzyme Q10 are present only in trace amounts, well below the doses studied [9][10]. Biotin can distort thyroid blood test results [11]. Chromium and magnesium can reduce how well meds is absorbed, so take the two apart [12][13]. Animal and cell studies are never counted.

See all 292 studies →Hide the studies

Review Totals and Summary

Members Only6,302 reviews · 96% positive
6,302 reviews · Amazon 6,302
96% positive3% neutral1% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Zinc is the main ingredient here, and the panel is broadly positive on it: of the ten, eight spoke about zinc, and four of them use it, two recommend it, and one warns. Reasons given include wound healing and tissue repair, supporting testosterone, gut lining support in the form of zinc carnosine, helping the body absorb vitamin C for fall and winter immunity, and possible help with sleep alongside magnesium. One panelist takes 15 mg in the morning for longevity, while another uses a much larger amount for a short stretch around surgery. The one caution is that overshooting zinc can lead to a copper deficiency. Selenium also came up, with two panelists saying it supports immune regulation or may help with thyroid problems, and magnesium for sleep was the most common smaller ingredient in this product mentioned, along with vitamin D3 taken in the morning with fat.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Selenium · neutral
    • 8 Nov 2026 · neutral · Facebook ↗
      Notes that sardines are rich in selenium, which binds with mercury.
    • 8 Nov 2026 · Vitamin D · neutral · Facebook ↗
      Lists Vitamin D as an ingredient found in sardines.
    • 8 Nov 2026 · Vitamin B12 · neutral · Facebook ↗
      Mentions that one can of sardines provides 348% of the daily Vitamin B12.
    • 8 Nov 2026 · Calcium · neutral · Facebook ↗
      States that one can of sardines contains 382 mg of calcium.
    • 8 Nov 2026 · Vitamin A · neutral · Facebook ↗
      Mentions that the body relies on healthy fats to absorb essential vitamins like A, D, E, and K, which help support skin health, moisture, and normal cell function.
    • 7 Nov 2026 · recommends · Facebook ↗
      Recommends selenium as a trace mineral, noting that modern farming practices deplete it from the soil, leading to low levels in crops.
    • 7 Nov 2026 · Zinc · recommends · Facebook ↗
      Recommends zinc as a trace mineral, noting that modern farming practices deplete it from the soil, leading to low levels in crops.
    • 7 Nov 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
    • 7 Nov 2026 · Vitamin D · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Vitamin B12 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Calcium · warns · Facebook ↗
      Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
    • 7 Nov 2026 · Vitamin A · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
    • 7 Nov 2026 · Vitamin E · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
    • 7 Nov 2026 · Vitamin C · warns · Facebook ↗
      Warns against generic multivitamins, stating they are often full of fillers and synthetics.
  • Dr. Rhonda Patrick · Zinc · neutral
    • 6 Nov 2026 · neutral · Instagram ↗
      Mentions that getting too little zinc may play a role in declining testosterone levels, and that zinc helps the body make testosterone.
    • 8 Nov 2026 · Vitamin D · neutral · Instagram ↗
      Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
    • 8 Nov 2026 · Magnesium · recommends · Instagram ↗
      Explains that magnesium helps the body activate and metabolize vitamin D, and that magnesium intake has been associated with lower odds of vitamin D deficiency and insufficiency.
    • 6 Nov 2026 · Magnesium · neutral · Instagram ↗
      Mentions that getting too little magnesium may play a role in declining testosterone levels.
    • 4 Nov 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
    • 3 Nov 2026 · Magnesium · recommends · X ↗
      Recommends getting enough magnesium, around 300–400 mg daily from diet and supplements, as it is an essential cofactor for vitamin D metabolism. Magnesium glycinate is a good form.
    • 1 Nov 2026 · Magnesium · neutral · YouTube ↗
      Mentions magnesium as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
    • 1 Nov 2026 · Folate · neutral · YouTube ↗
      Mentions folate as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
    • 31 Oct 2026 · Magnesium · neutral · YouTube ↗
      Explains that magnesium helps control blood pressure by boosting the production of substances that relax blood vessels and improve cardiovascular health, citing a meta-analysis that found magnesium supplementation at an average dose of 368 mg per day notably lowers both systolic and diastolic blood pressure.
    • 29 Oct 2026 · Magnesium · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 28 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
    • 16 Oct 2026 · Magnesium · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
  • Andrew Huberman · Zinc · neutral
    • 5 Nov 2026 · neutral · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 4 Nov 2026 · Magnesium · recommends · Instagram ↗
      Notes that Les Spellman's team includes 'Magnesium timed right' as part of their game plan to optimize recovery in unfavorable conditions.
    • 29 Oct 2026 · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 22 Oct 2026 · Magnesium · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 19 Oct 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 14 Sep 2026 · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 7 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
  • Ben Greenfield · Zinc · warns
    • 29 Oct 2026 · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Copper · neutral · YouTube ↗
      Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
    • 29 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 29 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · Magnesium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · Selenium · recommends · YouTube ↗
      Recommends taking sufficient selenium to ensure free T3 levels are right, which is important for the reverse calcium transport system.
    • 15 Oct 2026 · Magnesium · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · Magnesium · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
  • Dr. Mark Hyman · Zinc · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Explains that zinc is important for the body's repair crew, helping to heal damaged tissue, and a deficiency can lead to cuts and wounds taking longer to heal.
    • 4 Nov 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium breakthrough advanced ten from Biooptimizers, which is their most complete magnesium formula with 10 bioavailable forms and 550 milligrams of elemental magnesium, designed to support restful restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 4 Nov 2026 · Vitamin D · uses · YouTube ↗
      Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
    • 1 Nov 2026 · Magnesium · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 29 Oct 2026 · Magnesium · neutral · YouTube ↗
      Explains that a lack of magnesium can cause muscles and nerves to malfunction, resulting in muscle weakness, twitching, and cramps.
    • 29 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 14 Oct 2026 · Magnesium · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
  • Thomas DeLauer · Zinc · uses
    • 23 Oct 2026 · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 6 Nov 2026 · Vitamin C · recommends · YouTube ↗
      Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
    • 5 Nov 2026 · Magnesium · recommends · YouTube ↗
      Recommends taking magnesium glycinate and threonate at night to act as a brake on the nervous system, block excitatory signaling, help wind down, and support serotonin and melatonin production for better sleep.
    • 5 Nov 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
    • 4 Nov 2026 · Magnesium · neutral · YouTube ↗
      Mentions that magnesium glycinate also helps a lot with sleep.
    • 2 Nov 2026 · Magnesium · neutral · YouTube ↗
      Mentions that restless leg syndrome is often treated with magnesium, but states that the sensation is actually coming from three other issues.
    • 28 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 24 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
  • Dave Asprey · Zinc · uses
    • 7 Oct 2026 · uses · YouTube ↗
      Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
    • 6 Nov 2026 · Manganese · neutral · X ↗
      Mentions that algae provides manganese.
    • 3 Nov 2026 · Magnesium · uses · Instagram ↗
      Looks at magnesium alongside protein to keep muscle for the long run.
    • 3 Nov 2026 · Magnesium · recommends · YouTube ↗
      Suggests adding magnesium to help keep potassium in the system longer, as they work hand in hand.
    • 3 Nov 2026 · Biotin · warns · YouTube ↗
      Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
    • 3 Nov 2026 · Vitamin C · neutral · YouTube ↗
      Recounts a doctor telling him in his 20s that vitamin C would kill him.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 31 Oct 2026 · Magnesium · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · Magnesium · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Magnesium · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 17 Oct 2026 · Folate · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
  • Siim Land · Selenium · recommends
    • 5 Aug 2026 · recommends · YouTube ↗
      States that deficiencies in nutrients such as selenium can impair normal immune regulation.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 25 Oct 2026 · Magnesium · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 24 Oct 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 14 Oct 2026 · Copper · neutral · Instagram ↗
      Mentions that copper is a mineral necessary for making collagen.
    • 12 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 8 Oct 2026 · Boron · neutral · Instagram ↗
      Boron is a mineral that helps with bone density and vitamin D utilization, and also helps to increase free testosterone by reducing SHBG.
    • 7 Oct 2026 · Magnesium · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Magnesium · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
    • 3 Oct 2026 · Boron · neutral · Instagram ↗
      States that boron is a superstar when it comes to hormone and bone optimization.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
  • Bryan Johnson · Zinc · uses
    • 4 May 2026 · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 22 Oct 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 22 Oct 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 3 Jul 2026 · Vitamin D · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 4 May 2026 · Boron · uses · X ↗
      Takes 2 mg of Boron in the morning for longevity.
    • 2 May 2026 · Vitamin D · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 2 May 2026 · Magnesium · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 15 Apr 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
  • Peter Attia · Zinc · recommends
    • 4 Jan 2026 · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 1 Jun 2026 · Magnesium · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · Magnesium · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 15 Sep 2025 · Magnesium · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 20 Jul 2025 · Vitamin A · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
    • 10 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · Magnesium · recommends · YouTube ↗
      Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.

RAL Summary

Members OnlyTier 2 for Thyroid Health

Tier 2 holds because selenium at a full dose lowered thyroid antibodies and thyroid-stimulating hormone in pooled trials of people with autoimmune thyroid disease, and zinc showed added benefit in a pooled analysis of 3,508 people. In addition, 96% of 6,302 reviews are positive.

Take 4 servings a day (4 capsules) to match the dose that worked in the studies.

Where the evidence disagrees: 161 of the 292 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Endocrine system, Immune system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: Biotin can distort thyroid blood test results, and chromium and magnesium can reduce how well meds is absorbed. One selenium review noted a higher risk of side effects, and the vitamin D dose is above the daily recommended limit.

Supplement Facts

Vitamin A 200 mcg RAE · Vitamin C 200 mg · Vitamin D3 125 mcg
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 360
Amount Per Serving% Daily Value
Vitamin A200 mcg RAE
Vitamin C200 mg
Vitamin D3125 mcg
Vitamin E40 mg
Vitamin B110 mg
Vitamin B210 mg
Niacin20 mg
Pantothenic Acid20 mg
Vitamin B610 mg
Vitamin B12100 mcg
Folate400 mcg DFE
Biotin1,200 mcg
Calcium80 mg
Magnesium80 mg
Zinc15 mg
Selenium150 mcg
Copper1 mg
Manganese2.3 mg
Chromium120 mcg
Molybdenum75 mcg
Coenzyme Q-1010 mg†
Vitamin K240 mcg
Boron100 mcg†
Vanadium50 mcg†
Lutein1 mg†
Lycopene1 mg†
Zeaxanthin500 mcg†
† Daily Value not established.

Other ingredients: Plant Cellulose, Natural, Proprietary Protected Methyl B12 Matrix.

Directions: Suggested use Consume one capsule daily with food, preferably a complete meal. Once daily

Label source: NIH label database · Report a label change

Show entire label

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Our articles on this subject

Graded November 10, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.