Shaklee Optiflora DI Review

Optiflora DI is a probiotic supplement sold by Shaklee, delivering 10 billion CFUs from a proprietary formula with four bacterial strains, including Bifidobacterium lactis HN019, which the page says was proven in clinical studies to support digestive and immune health. The page lists three benefits: it helps support intestinal flora balance and adds good bacteria, helps maintain regularity, and helps reduce occasional gas, bloating, and constipation. It also states that at least 70% of the immune system is in the gut and that Optiflora DI adds good bacteria to the gut to support immune health. A section on digestive balance says it helps maintain digestive health and regularity and reduces the likelihood of occasional gas, bloating, and constipation. The page says B. lactis HN019 is laboratory tested to survive stomach acid and is shown to survive passage through the digestive tract to reach the large intestine. Optiflora DI is listed as gluten free, soy free, and dairy free, and the product requires no refrigeration. The frequently asked questions name the four strains as Bifidobacterium lactis HN019, Lactobacillus acidophilus La-14, Lactobacillus rhamnosus GG and Lactobacillus plantarum Lp-115, with the blend delivering 10 billion CFUs per serving. The directions say to take one capsule daily. The product type is listed as a probiotic complex capsule. The dietary icons show gluten free, Star-K Kosher and vegan. The page notes that Optiflora DI contains no artificial flavors, sweeteners, colors, or preservatives, and describes it as vegetarian. A Did you know section says the B. lactis HN019 strain was tested to improve gut transit time, the speed at which food is digested, and that leading researchers believe healthy gut transit time supports better gut metabolism. The retail price is $39.40 with a member price of $33.40, and the page notes a $1.31 per day figure, with members receiving 15% off all orders and monthly delivery options. A 100% money back guarantee is also stated, even if the product is 100% used up. The page carries the disclaimer that these statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure, or prevent any disease. Two references are cited for the clinical claims, a 2001 study on immunity in the elderly and a 2011 study on whole gut transit time and functional gastrointestinal symptoms.

Product Focus: Digestion and BloatingAlso covers:Immune system
Tier ⓘ
Tier 4 · Rank 5
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 5 within Tier 4 for Digestion and Bloating; 33 of 45 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
55 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
91% of 359
Biohacker Mentions
7 of 10
Cost per month
$39

Study, Trial or Testing Result Summary

Members OnlyHuman studies

We found no human studies on this product's ingredients for sensitive bowels, gas, bloating or irregularity, so there is no study evidence to report for this goal. The label lists a single proprietary blend of 96 milligrams called the Digestive and Immune Enhanced Proprietary Blend. The store listing describes 10 billion live bacteria from four strains, including Bifidobacterium lactis, but does not name the other strains. Because the strains sit inside a blend, the amount of each one is hidden. That means it cannot be compared with doses used in research, even where research exists for similar bacteria. Shoppers rate the product warmly: 359 ratings, 91 percent positive and 4 percent negative. No written reviews could be read, so we do not know what buyers say it did for them. Any benefit for digestion therefore rests on buyer ratings and the maker's own claims, not on clinical evidence we could check. Anyone with ongoing bowel symptoms should treat this as an unproven option. Animal and cell studies are never counted.

Review Totals and Summary

Members Only359 reviews · 91% positive
359 reviews · Amazon 318 · Shaklee 38 · Google 3
91% positive5% neutral4% negative

Shaklee Optiflora DI capsules get consistently warm feedback. Across the stores that sell them they carry about 356 ratings, and every written review that gives stars is 4 or 5. The written feedback is thin, though, so most of the picture comes from a handful of personal testimonials rather than detailed reports. **What buyers say it did for them:** The clearest benefit reported is better digestion. One buyer "saw immediate improvement in digestion" after adding it to a daily routine. Another calls the capsules "very good for supporting my body." A third says gut health affects their energy and mood, and that the product leaves their gut feeling supported. Most praise is general rather than specific, and the reviews don't report measured outcomes. **What buyers complain about:** No complaints appear in the reviews or the store summary. Nobody describes a side effect, a taste problem, a delivery problem or a disappointing result. One review title misspells the name as "Optoflora DI," which is trivial. The lack of criticism partly reflects how few written reviews there are, so it shouldn't be read as proof that nobody has had a problem. **Taste, smell, pill size and form:** Little is said on this. One reviewer who uses the capsule alongside Shaklee's prebiotic powder notes that "The pearl is small," so they take it slowly and gently. The same reviewer says the powder "mixes right into water," but that refers to the separate prebiotic powder, not the capsule. The store summary says no reviewer mentions taste or size problems. Reviews of other forms of the product were left out of this summary. **Value for money:** Nobody comments on price or value, so there is nothing here to go on. **Who it seems to suit:** Several of the reviewers are daily users who plan to keep taking it. One is "even getting a friend on it." Another treats it as a "number #1 defense" against the additives and preservatives they believe are hidden in grocery food. A third pairs it with the prebiotic powder as a daily gut routine. It seems to appeal to people who want a steady, everyday digestive and general wellness habit, and to those who like using it together with the prebiotic. No reviewer says it did not suit them. Note that at least one enthusiastic reviewer identifies as a Shaklee ambassador, so some of the praise comes from people with a connection to the brand. **Overall:** The feedback is positive but sparse and anecdotal. It suggests happy daily users and some digestive benefit, without detail on taste, price or downsides. Treat these as individual testimonials, not clinical evidence. The clinical claims on the store page come from the manufacturer.

Biohacker Summary

Members Only7 of 10 recommend it
7 of 10 biohackers on our panel recommend it

The only ingredient the panel spoke about is the probiotic blend, a smaller ingredient in this product, so the panel has nothing to say on a main ingredient. Of the four who commented, three recommend or use probiotics, and one is neutral, noting only that another product includes a full blend for the gut. Their reasons are better gut health, less bloating and gas, more regular digestion, and help when changing diets, and one suggests taking it a couple of hours apart from fermented foods. They favor combined prebiotic and probiotic capsules, and one pairs it with honey. One panelist also recommends one specific strain, Bifidobacterium lactis, another smaller ingredient here, and no doses, cautions or people who stopped were mentioned.

See all 4 biohackers →Hide the biohackers
  • Thomas DeLauer · Probiotic Blend · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Recommends Seed probiotic, stating it's the only probiotic he would ever recommend due to its scientific approach and multi-stage delivery system.
    • 7 Jul 2026 · recommends · YouTube ↗
      Highly recommends Seed Daily Synbiotic, a prebiotic and probiotic, to capitalize on the beneficial effects of fermented foods and improve gut health, suggesting it be taken a couple of hours apart from fermented foods.
    • 26 Jun 2025 · recommends · YouTube ↗
      Recommends Seed Daily Synbiotic, a prebiotic and probiotic in one, especially when changing diet or acclimating to a new diet style, and offers a discount code.
    • 13 Jun 2025 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which is a prebiotic and probiotic in one capsule, as a great tool to use in conjunction with honey to shift and alter the microbiome rapidly.
    • 4 Jan 2025 · uses · YouTube ↗
      Is a huge fan of Seed Daily Symbiotic and states it's the only probiotic he personally uses, appreciating their transparency in publishing clinical trials, even when results aren't in their favor.
    • 14 Oct 2024 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for good digestive health and notes the brand's commitment to microbiome research.
    • 22 Sep 2024 · recommends · YouTube ↗
      Recommends Seed Daily Synbiotic, stating it's the only probiotic he would ever recommend, especially when in a caloric deficit or changing one's diet, due to its unique capsule-in-capsule technology for better colonization of bacteria in the gut.
    • 25 Jul 2023 · recommends · YouTube ↗
      Recommends Seed's daily symbiotic, which contains a prebiotic and probiotic in one capsule, for those looking to improve their gut microbiome, noting its unique technology and the company's funding of microbiome research.
    • 18 May 2022 · recommends · YouTube ↗
      Recommends Seed, a synbiotic that combines a probiotic and prebiotic, for people who are intermittent fasting and may not be getting a wide variety of food, to help support their gut biome.
    • 13 Feb 2022 · uses · YouTube ↗
      Likes that Ample includes a probiotic blend, specifically mentioning L-rhamnosus as a highly researched strain.
  • Dr. Mark Hyman · Probiotic Blend · uses
    • 7 Oct 2026 · uses · YouTube ↗
      Continues to recommend and take Seed's DS-01 Daily Synbiotic, highlighting its 24 unique probiotic strains, capsule-in-capsule technology, and clinical evidence for reducing bloating, alleviating gas, and improving regularity.
    • 16 Aug 2021 · Bifidobacterium lactis · recommends · YouTube ↗
      Recommends Bifidobacterium lactis, a specific strain of bacteria found to be low in IBD patients, which, when combined with xyloglucan, showed significant healing and symptom resolution in ulcerative colitis patients.
    • 10 May 2021 · uses · YouTube ↗
      Gave a good general probiotic blend to a patient to improve gut health.
  • Ben Greenfield · Probiotic Blend · neutral
    • 23 Jun 2026 · neutral · Facebook ↗
      Notes that IM8health includes a full probiotic blend for the gut.
    • 12 Nov 2022 · recommends · Podcast ↗
      Recommends Seed's Daily Synbiotic for those who want to add a probiotic + prebiotic to their daily routine, noting that gut health affects whole-body health.
    • Date not recorded · uses · Website ↗
      Uses probiotic blends APO-808™ and APO-19™ as part of Dr. John Lieurance's Travel Hacking Kit, which are designed to assist in gut health by placing probiotics in the lower intestine.
  • Dr. Eric Berg · Bifidobacterium lactis · recommends
    • Date not recorded · recommends · Website ↗
      Dr. Berg lists Bifidobacterium lactis as one of the best probiotics for type 2 diabetes.

RAL Summary

Members OnlyTier 4 for Digestion and Bloating

Tier 3 requires some study support, but no ingredient findings or human studies on digestion were provided for this product's ingredients, so only the thin-evidence tier is supported. So it is graded Tier 4, lower than the rules alone gave.

  • Emerging: not enough evidence to rank higher yet.
  • No human studies on this goal for its ingredients.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system, Immune system

Combine with: For digestive support, pair it with a prebiotic fiber such as inulin, partially hydrolyzed guar gum, or acacia fiber to feed the probiotic strains. Digestive enzymes or L-glutamine can support gut lining comfort, and magnesium citrate may help regularity. Zinc carnosine can support gut barrier integrity, and omega-3 fish oil may help calm gut inflammation. If the real goal is cellular and DNA repair, consider adding separate targeted agents such as NMN or NR with resveratrol or pterostilbene, CoQ10 or PQQ, alpha-lipoic acid, and vitamin D3/K2. Consult a healthcare provider before starting a new regimen.

Possible side effects: No major side effects reported.

Supplement Facts

Digestive & Immune Enhanced Proprietary Blend 96 mg
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 30
Amount Per Serving% Daily Value
Digestive & Immune Enhanced Proprietary Blend96 mg†
† Daily Value not established.

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Water.

Directions: Directions: Take 1 capsule daily.

Label source: NIH label database · Report a label change

Show entire label

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Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.