The Vitamin Shoppe Pantethine Complex 300 mg Review
Pantethine Complex 300 mg from The Vitamin Shoppe is listed in the NIH Dietary Supplement Label Database (DSLD ID 55237, entered 25 January 2016). The product is a tablet supplement with a net content of 120 tablets. The label gives a serving size of 2 tablets and lists Pantothenic Acid at 300 mg (as D-Calcium Pantothenate, 3,000% Daily Value) and Pantethine at 300 mg, with the Daily Value not established. The product type is listed as Vitamin, with the dietary claim being a structure/function claim. The label states that Pantethine Complex supports cholesterol levels already within the normal range. It is marked as vegetarian, gluten free, dairy free, and sugar free, and it is suitable for most vegetarians. Directions say to take two tablets twice daily, preferably with meals. The label warns to consult a healthcare provider before use if pregnant, nursing, taking medication, or having medical conditions. It carries a tamper evident seal and should be stored in a cool, dry place. The label also notes that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. Distributed by Vitamin Shoppe, Inc., Secaucus, NJ.
We don’t sell supplements. We help you make decisions and get the best price.
Lowest prices
We may earn a commission from some store links. How we choose.
Finding the lowest prices at the stores now. This takes a few seconds.
Study, Trial or Testing Result Summary
Members Only28 human studies · 22 improved
1 of these 28 human studies gave the ingredient by injection, not by mouth.
At two servings a day, this product gives 600 milligrams of pantethine, a full dose compared with the studies. In a placebo-controlled trial of 120 adults at low to moderate heart risk on a healthy diet, pantethine at 600 milligrams a day for 8 weeks and then 900 milligrams lowered total cholesterol by 3 percent and bad cholesterol by 4 percent more than placebo [1]. A smaller placebo-controlled trial of 32 adults found lower total, bad and other harmful cholesterol, with bad cholesterol down about 11 percent [2]. In adults with moderately high triglycerides, 600 milligrams a day for 8 weeks cut triglycerides by 16.5 percent [3]. A survey of 1045 people with high cholesterol taking about 900 milligrams a day found improved blood fats and very good tolerability [4], and older smaller studies also found lower cholesterol [5]. The product also gives 600 milligrams of pantothenic acid as calcium pantothenate. One older study in heart patients found calcium pantothenate had favourable effects on blood fats [6], but other trials of pantothenic acid, usually within milk or multivitamins or given with choline, found no cholesterol change [7][8][9]. Animal and cell studies are never counted.
See all 28 studies →Hide the studies
- In 105 adults with moderately high triglycerides given pantethine 600 units a day for 8 weeks, triglycerides fell 16.5% from baseline, but coenzyme A lowered them more than pantethine did.Efficacy and tolerability of coenzyme A vs pantethine for the treatment of patients with hyperlipidemia: A randomized, d…
- In 204 healthy older adults advised to drink 3 more cups of milk a day for 12 weeks, pantothenate intake rose but total and LDL cholesterol did not change and triglycerides rose within the normal range.Effects of increased consumption of fluid milk on energy and nutrient intake, body weight, and cardiovascular risk facto…
- In 120 women with type 2 diabetes and obesity on a low-calorie diet for 3 weeks, total cholesterol and triglycerides fell in both groups, with no stated extra benefit from a multivitamin-mineral complex containing pantothenic acid.[Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus …
- In 120 low-to-moderate heart risk adults on a healthy diet, pantethine (600 mg a day for 8 weeks then 900 mg for 8 weeks) lowered total cholesterol by 3% and LDL cholesterol by 4% more than placebo.Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein chol…
- In 32 people at low to moderate heart risk, taking pantethine (600 mg a day for 8 weeks, then 900 mg a day) for 16 weeks lowered total, LDL and non-HDL cholesterol compared with placebo, with LDL falling about 11%.Read the study on PubMed (24600231) →
- In a randomized placebo-controlled crossover study of 10 people with high cholesterol, 28 days of pantethine significantly lowered total cholesterol in plasma and platelets and shifted platelet fats in a favorable direction.Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia.
- In adults given supplemental pantothenate with choline, serum lipids did not change, and pantothenate alone did not change urinary carnitine excretion.Choline supplementation reduces urinary carnitine excretion in humans.
- In 182 patients with coronary heart disease and stable angina, pantethine and calcium pantothenate both had favourable effects on lipid metabolism and heart function, and pantethine at 500 mg a day was recommended for patients with clear high blood fats.[Therapeutic efficacy of pantothenic acid preparations in ischemic heart disease patients].
- In 48 people with moderately high cholesterol, pantethine 600 mg plus probucol for 8 weeks lowered total cholesterol but also lowered HDL (good) cholesterol and did not improve the atherogenic index, and pravastatin worked better.Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate hyperchole…
- In 29 people with high blood fats, pantethine 900 mg a day for 8 weeks cut total and LDL cholesterol by 13.5% in one patient type and lowered triglycerides by about 30% in some groups.Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoprot…
- In 27 diabetics with abnormal blood fats compared across three drugs for 6 months, pantethine 600 mg a day lowered triglycerides by 37.7%, while bezafibrate had the broadest effect on cholesterol.[Comparison of the efficacy of pantethine, acipimox, and bezafibrate on plasma lipids and index of cardiovascular risk i…
- In 72 children and adults with high cholesterol, taking pantethine at 900 to 1200 mg daily for 3 to 6 months lowered total cholesterol, bad cholesterol, triglycerides and apolipoprotein B, and raised good cholesterol and apolipoprotein A-I.Lipoprotein changes induced by pantethine in hyperlipoproteinemic patients: adults and children.
- In 37 people with high cholesterol or triglycerides, 600 mg of pantethine daily for 3 months steadily lowered cholesterol and triglycerides and raised good cholesterol, with values returning toward baseline after stopping.[Hyperlipidemia, diabetes and atherosclerosis: efficacy of treatment with pantethine].
- In 31 patients on chronic hemodialysis with blood fat problems, pantethine at an average of 970 mg daily for about 9 months reduced total cholesterol in those with high cholesterol and significantly lowered triglycerides, with no side effects reported.Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial.
- In 31 people with diabetes and high cholesterol, pantethine lowered total cholesterol from about 236 to 217 mg/dl and raised HDL cholesterol, and also normalized platelet fats and reduced platelet clumping.Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hy…
- In 24 women aged about 45 to 55 with high cholesterol, 900 mg of pantethine daily for 16 weeks significantly lowered total and bad cholesterol, with no reported side effects.[Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age].
- In 24 people with high blood fats not controlled by diet alone, one year of pantethine treatment consistently lowered total, bad and fatty cholesterol, while raising good cholesterol, with no side effects reported.Effectiveness of long-term treatment with pantethine in patients with dyslipidemia.
- In 22 diabetic people on dialysis with high cholesterol and triglycerides, 900 mg of pantethine daily lowered cholesterol, VLDL and triglycerides over 6 months with few side effects.Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance.
- In a pilot of 20 children and adolescents taking a daily 12-vitamin and 5-mineral supplement for 6 weeks, LDL fell in one subgroup of 10 while pantothenic acid levels rose, and the other subgroup's lipid profile did not change.Metabo groups in response to micronutrient intervention: Pilot study.
- In 18 people with high blood fats, 400 mg per day of pantethine given as injections for 20 days lowered cholesterol and triglycerides and raised HDL cholesterol, with excellent tolerability.[Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia].
- In 16 Japanese patients with fatty liver inflammation and high cholesterol, 600 mg daily of pantethine with 500 mg of probucol for 48 weeks significantly lowered total cholesterol along with liver enzymes, with no side effects reported.Combined pantethine and probucol therapy for Japanese patients with non-alcoholic steatohepatitis.
- In 16 people with diabetes and raised clotting marker levels, pantethine (600 mg for 3 months, then 1200 mg for 6 months) significantly lowered the clotting marker, triglycerides, total cholesterol and other blood fats over 9 months.Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus.
- In 12 male stroke survivors, 1000 mg of pantethine daily for 3 months tended to lower total cholesterol and LDL cholesterol and significantly raised HDL cholesterol and apolipoprotein A-I.The effects of pantethine on lipid and lipoprotein abnormalities in survivors of cerebral infarction.
- In 4 children with cystinosis given pantethine by mouth at 70 to 1,000 mg per kg daily, serum cholesterol fell by an average of 14%, but the drug was broken down quickly and was less effective than cysteamine for the cystinosis itself.Metabolism of pantethine in cystinosis.
- In a large post-marketing surveillance of 1045 people with high cholesterol, about 900 mg of pantethine per day improved lipid levels similarly in those with and without diabetes, with very good tolerability.[Pantethine, diabetes mellitus and atherosclerosis. Clinical study of 1045 patients].
- In a study of 176 adults over 50, long-term religious fasters who ate less pantothenic acid had higher LDL cholesterol than non-fasters, so this study does not show a cholesterol benefit from pantothenic acid.Does Religious Fasting Have a Protective Role against Metabolic Syndrome in Individuals Aged >50 Years?
- In 20 people with abnormal blood fats in a single-blind crossover study, pantethine lowered total cholesterol and triglycerides and raised HDL (good) cholesterol.Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment.
- Mouse and lab work plus a small investigator-run trial in psoriasis patients suggest pantethine calms overactive immune cells and eases psoriasis symptoms; cholesterol lowering was not measured as an outcome.Vanin-pantethine metabolic axis shapes dendritic cell function and affects inflammatory disorder progression.
Review Totals and Summary
Members Only25 reviews
Customers reviewing 300 mg pantethine products, not specifically The Vitamin Shoppe's, mostly buy them for cholesterol management. Many are a med-intolerant or want a gentler, more natural alternative to meds. Reviewers describe the supplement as well tolerated, with no side effects, and as a convenient daily option. They often cite the clean ingredients and the trust they place in established brands. Several say it fits alongside diet and lifestyle changes to support healthy lipids. A second group takes it for energy, adrenal and stress support. These reviewers say it relieves fatigue and helps them cope with stress. One person with an autoimmune condition took 300 mg twice daily. They reported more energy and better stress resilience, and planned to buy in larger quantities. Others describe feeling active and mentally clear within hours, or feeling more even-tempered and free of daytime crashes. Some of these reviewers had not tolerated a full B-complex and turned to pantethine instead of plain B5. Value and quality come up often, with several reviewers calling the price and quality good. There is some skepticism. One reviewer hoping to come off a med said they were also considering cheaper niacin (B3), and that it might work as well. Some users note that the 300 mg dose is on the low side, so reaching the studied 600 to 900 mg daily means taking several servings and buying more bottles. Beyond that, the feedback has few complaints about taste, pill size or side effects. Because the sample was small and drawn from other brands, check Vitamin Shoppe's own reviews before buying.
Biohacker Summary
Members Only5 of 10 recommend it
Only two of the ten panelists spoke about pantethine, the main ingredient, so there is little to go on. One recommends it as a form of vitamin B5, though the statement of what it helps with is unclear, and the other takes 600 mg twice a day for cholesterol. Neither mentioned a preferred form beyond pantethine itself, a pairing, or a caution about it. Pantothenic acid, a smaller ingredient in this product, drew comments from several panelists, who mostly recommend it for fat burning, adrenal support, fatigue and repairing the gut lining, while one warns that high doses can dry the skin and another says that taking it in massive single doses can create shortfalls in other nutrients such as biotin.
See all 5 biohackers →Hide the biohackers
Ben Greenfield · Pantethine · recommends
- Suggests pantethine, a derivative of vitamin B5, as something that can help lower Apple B.
- Recommends Vitamin B5 (pantothenic acid) as a critical nutrient for adrenal gland support, suggesting it can be obtained from a B complex or Vitamin B5 itself.
- Ben Greenfield uses Life Shots which contain 5000% of daily Pantothenic Acid needs.
- Recommends pantothenic acid cream, noting that many such lotions are rich in vitamin A and can be applied directly to the skin to help with various skin issues.
- Recommends Vitamin B5 (pantothenic acid) as a critical nutrient for supplying the adrenal gland, suggesting it can be obtained from a B complex or Vitamin B5 itself.
Peter Attia · Pantethine · uses
- Takes 600 mg of Pantethine twice a day for cholesterol.
Dr. Mark Hyman · Pantothenic Acid · recommends
- Mentions pantothenic acids as one of the things that can be used to repair mucosal membranes as part of the 'repair' step in the 4R program.
Thomas DeLauer · Pantothenic Acid · warns
- Explains that Vitamin B5, or pantothenic acid, is tremendous for fat metabolism and weight loss, but warns that taking it in high doses can cause skin dryness.
- Discusses the importance of pantothenic acid (vitamin B5) for fat metabolism, as it is crucial for forming coenzyme A, which is needed to break down fats.
- Notes that Vitamin B5 (Pantothenic acid) is important for the metabolism of the gut microbiome, but spontaneous deficiency is rare in healthy individuals, making supplementation generally unnecessary.
- Notes that cod provides vitamin B5 (pantothenic acid), which is needed to create adrenaline and cortisol, supporting adrenal glands and upregulating adrenaline for fat loss by activating fat-burning processes.
Dr. Eric Berg · Pantothenic Acid · recommends
- Dr. Berg recommends taking B5 (pantothenic acid) if experiencing fatigue, as it acts as a helper for fat-burning enzymes.
- Dr. Berg states that vitamin B5 (pantothenic acid) gives clear skin, but warns against taking it synthetically or in massive individual dosages, as it can create deficiencies in other things like biotin.
- Recommends taking vitamin B5 (pantothenic acid) to combat fatigue and lethargy when transitioning to a ketosis diet, as it supports fat metabolism and adrenal glands.
RAL Summary
Members OnlyTier 4 for Cholesterol
The review summary describes 300 mg pantethine products from other brands, not The Vitamin Shoppe's product, and no reviews of this product were counted. Its reviews are set aside, so it is graded on its studies alone. Human studies support Pantethine (22 of 23 human studies showed an improvement), but there are not yet enough reviews to confirm it (0).
Take 2 servings a day (4 tablets) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 3 of the 28 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Cardiovascular system, Metabolic system
Combine with: For cholesterol support, pantethine pairs well with omega-3 fish oil (EPA/DHA) for triglycerides, soluble fiber such as psyllium or beta-glucan for LDL, plant sterols, CoQ10 if on a med, and niacin or bergamot under medical guidance. For the regularity goal, use products designed for it: psyllium husk or partially hydrolyzed guar gum for long-term stool bulk and softness, magnesium citrate or oxide for gentle osmotic support, and probiotics like Bifidobacterium lactis BB-12 or B. lactis HN019. Also drink plenty of water and eat fiber-rich foods. Check with a healthcare provider before combining supplements, especially if you take lipid-lowering or other medications.
Possible side effects: A large survey reported very good tolerability for pantethine; no major side effects reported.
Supplement Facts
Pantothenic Acid 300 mg · Pantethine 300 mg
| Pantothenic Acid | 300 mg | |
| Pantethine | 300 mg | † |
Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, purified Water, Hydroxypropyl Methylcellulose, Polyethylene Glycol, Titanium Dioxide.
Directions: DIRECTIONS: As a dietary supplement, take two (2) tablets twice daily, preferably with meals.
Barcode (UPC) 766536010943 · Label source: NIH label database · Report a label change
Show entire label
More cholesterol products
Members OnlyThe highest ranked for the same goal
Read more
Our articles on this subject
- Best Diet for High Cholesterol: What to Eat, What to Cut, and What the Trials ShowArticle · Sep 13, 2026
- How to Lower LDL Cholesterol: A Practical Plan Based on Your Blood WorkArticle · Oct 27, 2026
Graded November 8, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
Privacy policyConsumer health dataAffiliate disclosureTermsDo Not Sell or Share My Personal InformationCookie settings