Thorne Collagen Plus Passion Berry Flavored Review
Product Focus: Muscle and StrengthAlso covers:Metabolism
Tier ⓘ
Tier 4 · Rank 40
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 40 within Tier 4 for Muscle and Strength; 78 of 86 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10
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Study, Trial or Testing Result Summary
Members Only49 human studies · 17 improved
49 human studies17 improved20 no effect9,737 people studied
Collagen peptides, at 13 grams a day in this product, are the main ingredient. A review pooling 19 trials in 768 healthy adults who trained for at least 8 weeks found small gains in fat-free mass, muscle structure and maximal strength compared with controls, with low to moderate certainty [1]. In 12-week training trials, 15 grams daily added more fat-free mass than placebo in middle-aged men [2], premenopausal women [3] and older men with muscle loss, who also gained leg strength [4]. In trained men, 10 grams daily added slightly more muscle than placebo over 8 weeks [5]. However, a one-year trial in 208 older adults who did not train found no change in muscle size or strength [6]. MitoHeal, a peat and apple extract blend, is at a full dose. Two small trials in 25 trained men found more muscle growth [7] and bigger squat, deadlift and jump gains than placebo [8]. Nicotinamide riboside showed no benefit for muscle mass or function in a pooled analysis of older adults [9]. Betaine is present only in a trace amount, far below the 2.5 grams studied [10], and its evidence is mixed [11]. HydroPeach has no human studies. Animal and cell studies are never counted.
See all 49 studies →Hide the studies
- Across 19 trials with 768 healthy adults who trained and took collagen peptides for at least 8 weeks, collagen gave small gains in fat-free mass, muscle structure, and maximal strength compared with controls, though the certainty of the evidence was low to moderate.Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous…
- A pooled analysis of placebo-controlled trials in adults averaging over 60 years found no benefit of nicotinamide riboside or its related compound for muscle mass or function; NR gave a longer walking distance in people with artery disease but worse physical performance scores in people with mild cognitive impairment.The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Met…
- A review of seven randomized trials in healthy people found only two reported greater strength or power with betaine, while five showed no change, so evidence for a clear benefit is lacking.Effects of Betaine Supplementation on Muscle Strength and Power: A Systematic Review.
- In 208 healthy older adults over 1 year, 20 g of collagen protein twice daily did not change muscle size, strength, or function compared with carbohydrate.The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, a…
- In 160 older adults with knee osteoarthritis doing resistance training for 24 weeks, collagen plus chicken essence gave more fat-free mass than placebo and more grip strength than glucosamine, while collagen alone mainly reduced pain early on.Randomized, double-blind, four-arm pilot study on the effects of chicken essence and type II collagen hydrolysate on joi…
- In 97 middle-aged untrained men doing resistance training for 12 weeks, 15 g of collagen peptides daily gave a bigger gain in fat-free mass and a bigger fat loss than placebo, though leg strength gains did not differ significantly.The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained …
- In 77 premenopausal women doing resistance training for 12 weeks, 15 g of collagen peptides daily led to greater fat-free mass, less body fat and greater hand-grip strength than placebo.Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength…
- In 60 people with knee osteoarthritis flares, adding collagen to a joint supplement combination for 8 weeks reduced pain more and improved walking function more; muscle building was not specifically reported.[Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].
- In 57 young recreationally active men doing resistance training for 12 weeks, 15 g of collagen peptides daily increased fat-free mass more than placebo, but muscle fiber growth and strength gains did not differ significantly between groups.Prolonged Collagen Peptide Supplementation and Resistance Exercise Training Affects Body Composition in Recreationally A…
- In 53 older men with sarcopenia doing resistance training for 12 weeks, 15 g of collagen peptides daily increased fat-free mass and leg strength and reduced fat mass more than placebo.Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle …
- In 50 healthy moderately active men doing resistance training for 14 weeks, 5 g of collagen peptides daily thickened the patellar tendon more than placebo, but muscle size and strength gains were similar in both groups.Specific collagen peptides increase adaptions of patellar tendon morphology following 14-weeks of high-load resistance t…
- In 50 healthy young sedentary men taking 10 g of collagen peptides daily for 16 weeks, muscle and tendon stiffness and explosive strength rose compared with placebo, but muscle size and maximal strength did not change.Collagen Peptide Supplementation Enhances Muscle-Tendon Stiffness and Explosive Strength: A 16-wk Randomized Controlled …
- In 40 healthy young men doing heavy resistance training for 14 weeks, 5 g daily collagen peptides led to a bigger increase in calf muscle thickness (7.3%) than placebo (2.7%), though strength gains were the same in both groups.Effects of specific collagen peptide supplementation combined with resistance training on Achilles tendon properties.
- In 40 resistance-trained men over 8 weeks, 10 g of collagen daily raised muscle mass by 0.46 kg versus 0.10 kg for placebo, and collagen with whey protein gave the largest gains (2.66 kg) and strength improvements.The combined effects of whey protein and collagen supplementation on bone mineral density and muscle mass in resistance-…
- In 39 young healthy men doing leg resistance training for 15 weeks, 15 g daily collagen peptides produced greater thigh muscle volume gains than placebo (quadriceps 15.2% vs 10.3%), but strength gains did not differ.The effect of specific bioactive collagen peptides on function and muscle remodeling during human resistance training.
- In 32 older adults given 1,000 mg nicotinamide riboside plus 200 mg pterostilbene daily versus placebo, muscle stem cell recruitment and other measures of muscle recovery after induced muscle injury were not improved.A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle …
- In 31 older adults during reduced calories and inactivity, collagen peptides (60 g daily) did not protect leg lean mass, and unlike whey protein did not help muscle regrowth during recovery.A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein sy…
- In 10 older men given an extra 50 g of collagen protein daily for about 8 days, muscle protein building did not increase, unlike with whey or pea protein.The effects of whey, pea, and collagen protein supplementation beyond the recommended dietary allowance on integrated my…
- In 30 older men doing low-load blood flow restriction training for 8 weeks, collagen hydrolysate gave a slightly larger muscle size gain (6.7% vs 5.7%) than placebo, but the difference was not statistically significant.Effects of Blood Flow Restriction Training with Protein Supplementation on Muscle Mass And Strength in Older Men.
- In 29 trained people doing CrossFit for 6 weeks, betaine did not improve muscle size or strength compared with placebo, though squat strength rose within the betaine group only.Betaine Supplementation Does Not Improve Muscle Hypertrophy or Strength Following 6 Weeks of Cross-Fit Training.
- In 29 young professional soccer players, 2 grams of betaine daily for 14 weeks raised testosterone and the testosterone to cortisol ratio but did not change lean mass or body fat compared with placebo.The effects of 14-week betaine supplementation on endocrine markers, body composition and anthropometrics in professiona…
- In 26 young adults doing 10 weeks of resistance training, a multi-ingredient supplement with whey and creatine produced larger lean mass gains than 20 grams of collagen peptides taken twice daily.The Effect of a Multi-ingredient Supplement on Resistance Training-induced Adaptations.
- In 26 people doing 10 weeks of resistance training, collagen served as the control and gave smaller gains in type II muscle fiber size than a multi-ingredient whey protein supplement, with similar satellite cell responses.The Effect of Multi-Ingredient Protein versus Collagen Supplementation on Satellite Cell Properties in Males and Females…
- In 25 young men over 12 weeks of hypertrophy training, 15 g a day of collagen peptides gave larger gains in body mass, fat-free mass and strength than placebo.Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Sk…
- In 25 resistance-trained men taking 150 mg daily of a peat and apple extract blend for 12 weeks of training, muscle cross-sectional area (+0.91 vs -0.08 cm2) and muscle thickness (+0.46 vs +0.04 cm) grew more than with placebo, with no change in fat mass.Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affectin…
- In 25 resistance-trained men taking 150 mg daily of a peat and apple extract blend for 12 weeks alongside supervised training, squat and deadlift maximum lifts and vertical jump power and velocity increased more than with placebo.Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men.
- In 12 young and 12 old men given a single dose of nicotinamide riboside versus placebo, older men had 8% higher isometric muscle torque and 15% better fatigue index, while maximal oxygen uptake and concentric torque were unchanged and young men saw no benefit.Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a do…
- In 23 experienced strength-trained men, 2.5 grams of betaine daily for 6 weeks improved body composition, arm size and bench press workload compared with placebo, but not strength.Effects of betaine on body composition, performance, and homocysteine thiolactone.
- In 23 untrained young women doing resistance training for 8 weeks, 2.5 grams of betaine daily did not improve lean mass, muscle thickness or strength more than placebo, but fat mass and body fat percentage fell more.The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind…
- In 22 untrained young adults over 10 weeks of resistance training, 35 gram doses of leucine-matched collagen peptides increased muscle thickness less than whey protein, though strength and power gains were similar.Whey Protein Supplementation Is Superior to Leucine-Matched Collagen Peptides to Increase Muscle Thickness During a 10-W…
- In 20 middle-aged men on a crossover design lasting 33 days, 10 g of collagen peptides daily reduced muscle soreness and fatigue after a squat workout and left leg strength higher 48 hours later than placebo.Dietary collagen peptides alleviate exercise-induced muscle soreness in healthy middle-aged males: a randomized double-b…
- In a retrospective subgroup of 20 overweight or obese older men over 12 weeks, a collagen and safflower oil supplement gave smaller gains in lean mass and strength than a whey and casein supplement.Obesity and Metabolic Disease Impair the Anabolic Response to Protein Supplementation and Resistance Exercise: A Retrosp…
- In 20 middle-aged men doing 12 weeks of resistance training, 30 g of hydrolysed collagen increased patellar tendon size and stiffness more than placebo, but muscle thickness and strength gains were the same in both groups.Hydrolysed Collagen Supplementation Enhances Patellar Tendon Adaptations to 12 Weeks' Resistance Training in Middle-Aged…
- In 18 trained men, 6 grams of betaine daily for 14 days did not increase leg press repetitions compared with placebo but did produce a larger rise in the growth factor IGF-1.The Impacts of Combined Blood Flow Restriction Training and Betaine Supplementation on One-Leg Press Muscular Endurance,…
- In 17 female under-21 soccer players over 10 weeks of training, 30 g a day of collagen hydrolysate did not change knee muscle strength or muscle thickness compared with placebo, although it increased patellar tendon stiffness more than placebo.Collagen supplementation augments changes in patellar tendon properties in female soccer players.
- In 15 post-intensive care patients given 22 g of collagen peptides twice daily for 6 weeks, the trial was stopped early and no group differences in physical strength could be determined.Feasibility challenges in protein supplementation research: Insights from the convalescence of functional outcomes after…
- In 12 young adults given a single protein drink after a resistance workout, collagen hydrolysate produced far less whole-body protein retention than a dileucine amino acid blend or branched-chain amino acids, and no placebo group was included.Dileucine-supplemented essential amino acids support whole-body anabolism after resistance exercise and serum-stimulated…
- In 11 professional female soccer players over 10 weeks of training, 30 g of collagen before sessions increased patellar tendon stiffness more than placebo, with no added gain in tendon size.High-intensity resistance training and collagen supplementation improve patellar tendon adaptations in professional fema…
- In 9 older women over two 15-day diet periods, a fortified collagen protein supplement kept nitrogen balance and lean body mass unchanged, while a whey supplement lowered body weight.Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older…
- In 8 older men, a single 20 g feed of a collagen and milk protein blend built muscle protein at the same rate as milk protein alone, though the blend produced lower blood amino acid levels.A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend…
- In patients with Werner syndrome taking 1,000 mg nicotinamide riboside daily for 26 weeks in a crossover trial, arterial stiffness and skin ulcers improved, but the abstract reports no clear muscle benefit (sarcopenia was only listed as a secondary endpoint).Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Pla…
- In untrained people, 2 grams of betaine daily for 10 days did not raise muscle creatine stores, strength or power compared with placebo, unlike creatine.Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance.
- A pre-workout blend containing betaine, taken for six weeks alongside resistance training, did not improve body composition or objective exercise performance compared with a comparator, though users reported more energy and focus.Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of …
- In 12 resistance-trained men, 14 days of betaine taken twice daily increased bench throw power and bench press force compared with placebo, though repetitions did not change.Ergogenic effects of betaine supplementation on strength and power performance.
- In 3214 adults in Newfoundland, higher dietary betaine intake was linked to less body fat and higher lean mass in a single cross-sectional survey.Higher Dietary Choline and Betaine Intakes Are Associated with Better Body Composition in the Adult Population of Newfou…
- In 1938 middle-aged and older Chinese adults followed for 3 years, higher blood betaine levels were linked to less muscle loss and less fat gain, mainly in people with low starting levels.Association between serum choline and betaine concentrations and longitudinal changes of body composition in community-d…
- In 1242 middle-aged adults followed for 3 years, higher dietary betaine intake was linked to less loss of leg and limb muscle mass.Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou …
- In 1081 adults, higher blood betaine levels were linked to better body composition in men but not in women.Higher serum choline and betaine levels are associated with better body composition in male but not female population.
- In a laboratory study of muscle cells taken from people after repeated disuse, nicotinamide riboside increased the size of cultured muscle fibers, but this was not tested in living people.Repeated Disuse Atrophy Imprints a Molecular Memory in Skeletal Muscle: Transcriptional Resilience in Young Adults and S…
Review Totals and Summary
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Biohacker Summary
Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it
Most of the panel backs collagen: four of the ten recommend it and four more say they use it, while two are neutral and one has stopped taking it. People take it mainly for joints, tendons and ligaments, skin elasticity, and muscle, and a few mention gut, sleep, or recovery. Doses cluster around 10 grams a day, taken in the morning by three of them, while one suggests 15 grams and two suggest 2.5 to 5 grams of hydrolyzed peptides for at least 8 weeks for skin; two advise taking it an hour before exercise, one of them with vitamin C. Cautions come from two panelists: one says it is an incomplete protein that should be paired with another protein and is poor as a sole protein for muscle, and another says it will not repair a damaged gut wall. Nicotinamide riboside is a smaller ingredient in this product, and the panel's views on it are mixed, with one using it and others skeptical or noting limited evidence.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Collagen · recommends
- Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
- Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
- Mentions that grass-fed liver is loaded with collagen.
- States he added 500 mg of betaine to his creatine product because it helps the body make more creatine.
- States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
- Recommends betaine hydrochloride for constant bloating and gas, especially if it's due to low stomach acid.
- Recommends increasing collagen intake because a lack of it can make it harder for the body to repair itself.
- Recommends taking betaine hydrochloride if an antacid was taken.
- Discusses collagen in relation to changes in joints, skin, hair, nails, and recovery, suggesting these could be signs of needing more collagen.
- Uses one scoop of collagen in their coffee every single morning, noting that the average person needs between 10 and 15 grams minimum daily for benefits like improved joints, nails, hair, gut health, and youthful skin.
- Warns against consuming collagen powder while fasting.
- Recommends betaine hydrochloride for heartburn or indigestion, stating it increases stomach acidification and can be taken in multiple pills before a meal.
- States that Betaine hydrochloride can help to restore stomach acid, but warns it should be avoided if one has a stomach ulcer.
- Recommends increasing collagen intake instead of a glycine supplement, suggesting adding it to coffee or a shake and pairing it with vitamin C to support absorption.
Siim Land · Collagen · recommends
- Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
- Nicotinamide riboside failed to improve clinical outcomes in people with early Parkinson’s disease. In a randomized trial of 410 participants, 1,000 mg/day of NR for 52 weeks showed no benefit over placebo.
- Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Collagen as one of 15 supplements backed by human studies.
- Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
- 30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
- Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
- Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Mentions that glycine makes up one-third of collagen.
- Recommends taking Collagen one hour before exercise with a vitamin.
- States that nicotinamide can protect the skin against UV radiation.
- Takes 200 mg of Nicotinamide every morning for 2 weeks to support baseline NAD levels, recover from lost sleep, and protect skin against UV damage.
- Mentions that nicotinamide is used in a stack to increase NAD.
Thomas DeLauer · Collagen · uses
- Says he takes collagen to take care of his gut.
- Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
- Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
- Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
- Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
- Recommends taking 15 grams of collagen about 30 minutes before bed, especially on rest days, for its glycine content to aid sleep onset and for connective tissue repair.
- Recommends opting for foods rich in collagen because modern diets lack it compared to traditional nose-to-tail eating.
- Recommends 15 grams of collagen before bed, as it provides 3 grams of glycine and supports connective tissue repair, which peaks during sleep, making it a good way to get glycine for testosterone production.
- Wanted a smoothie option for their kids that included collagen.
- Recommends collagen, found in bone broth, to directly feed goblet cells and enterocytes.
- Would start taking trimethylglycine (TMG), also known as betaine, due to increasing evidence of its benefits for insulin resistance and its ability to increase fat oxidation.
- Mentions a pilot trial showing that supplementation with NR, an NAD precursor, combined with CoQ10, improved mitochondrial bioenergetic health and reduced oxidative stress, and later suggests taking it to support NAD availability.
- Recommends TMG (trimethylglycine or betaine) for improving body composition and insulin sensitivity, and for supporting methylation pathways that keep the endothelium healthy, complementing the shear stress benefits of walking.
- Recommends TMG, also known as betaine, to aid the liver's ability to clear excess cortisol from the system.
Dave Asprey · Collagen · uses
- States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
- Recommends taking collagen for better skin health.
- Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
- Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
- Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
- Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
- Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
- Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
- Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
- Dave Asprey warns that collagen supplements have small, short-term effects on skin, mostly from industry-funded studies, and explains that the body breaks it down into amino acids, not directly targeting skin; he suggests taking cheaper protein if protein-deficient.
- A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, a med, pitavastatin, and ketamine, while nicotinamide riboside, a med, and senolytics showed no detected clock improvement in the studies reviewed.
- Recommends taking betaine HCL (stomach acid) with meals to improve protein absorption, as stomach acid decreases with age.
- Takes stomach acid, betaine HCL, and enzymes to help digest food, which he says speeds healing and resilience.
- Takes nicotinamide riboside (NR), a precursor of NAD, to replenish NAD levels which start to decline after age 50-55.
Ben Greenfield · Collagen · recommends
- Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
- Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
- Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
- Recommends starting with collagen for body remodeling.
- Is currently experimenting with NR again and feels better on it than NMN, noting it raises her energy floor.
- A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
- The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
- Recommends collagen for skin repair post-tattoo.
- Says he personally uses Niagen, which is a precursor to NAD, and found that his energy levels increased almost immediately after taking it.
- Notes that collagen is not a complete protein, so while it can be added to things, it should not be relied upon as the sole protein source.
- Ben Greenfield's clinic sometimes gives Niagen as part of preparing the body for stem cell therapy, noting that it causes fewer symptoms than NAD.
- Ben Greenfield's guest states that using Niagen (NR) as an IV has the same issues as other precursors, as it provides raw material without fixing the salvage pathway, which is the main reason for NAD decline.
- Recommends collagen peptides or essential amino acids to support the dermal matrix that anchors hair follicles, considering them important for hair health.
- Takes 10 grams of collagen in the morning.
Bryan Johnson · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Consumes collagen peptides at 4:55 am.
- Uses collagen peptides as an ingredient in Nutty Pudding.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 g of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Mentions extra virgin olive oil is better than NR.
- Advises avoiding Nicotinamide Riboside during pregnancy.
Dr. Mark Hyman · Collagen · neutral
- Dr. Hyman mentions collagen supplements in the context of skin aging.
- Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
- Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- States that collagen powder may modestly improve elasticity and hydration of the skin.
- Notes that most people focus on collagen powders for skin aging, but healthy skin is built inside the body.
- Takes 10 grams of Collagen in the morning for muscle.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Recommends supplementing with high-quality collagen because the body produces less after age 20, and it supports skin health and joint comfort.
- Recommends supplementing with high-quality collagen, as it is the most abundant protein in the body, supporting skin, joints, bones, and connective tissues, and its production decreases after age 20.
- Has long recommended brands like TruNiagen.
- Notes that NR reestablishes NAD levels and that while animal models show remarkable effects, the amounts sold as supplements are much lower than what is used in the lab, and he personally takes a gram.
- Uses Betaine HCl to provide stomach acid, which helps digest food and reduce SIBO.
- Takes NR, having found it as effective as NMN in getting his intracellular NAD levels to the same place after 90-day trials of each.
Andrew Huberman · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of collagen in the morning for muscle.
- Takes 10-20 grams of Collagen every day for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- He takes 10 grams of Collagen in the morning for skin health.
- Discusses NAD/NR as a supplement for prenatal care and sperm health.
- Notes that animal data suggests NR can be advantageous for unexplained infertility, but does not recommend it universally due to a lack of human data.
- Takes nicotinamide riboside (NR), specifically True Niagen, and is cautiously experimenting with it for its effects on mitochondrial health, fertility, energy, and recovery, despite some concerns about cancer cell growth and insulin sensitivity. They are not convinced it will directly lead to living longer but find it interesting.
- Tried oral NR supplements but couldn't tell if they got the same or different effect because they were taking them together with NMN, and did not continue.
Dr. Rhonda Patrick · Collagen · stopped
- Is no longer taking collagen.
- Mentions that professional sports organizations have reportedly experimented with NR for performance and recovery, but at this point, it's anecdotal.
- Notes that supplementing with NAD precursors like nicotinamide riboside (NR) to enhance performance or recovery is mechanistically plausible, but strong evidence from controlled human trials is not yet available.
- Recommends Nicotinamide Riboside (NR) as the most evidence-backed way to boost cellular NAD, stating it is a cleaner, better studied way to support the NAD network.
- Supplementation with nicotinamide riboside (NR), a key NAD precursor, can effectively lower inflammation. In multiple randomized controlled trials, roughly one gram per day of NR reduced inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-10 (IL-10).
- Supplementing with nicotinamide riboside (NR), a precursor to NAD, may support faster exercise recovery. By replenishing NAD, NR could help sustain these repair and adaptation processes so you can come back stronger session to session.
- Mentions that his technology turned into the nicotinamide riboside and NAD boosting industry.
- Considers nicotinamide riboside to be the premium NAD precursor because the NR kinase pathway gets upregulated in many conditions of metabolic stress, such as in a failing heart or damaged neuron, making it more effective than nicotinamide in certain mouse models.
- Mentions that emerging research suggests NR for lowering inflammation and improving recovery.
- Takes nicotinamide riboside (NR) in the evening.
- Rhonda includes Tru Niagen (NR) in her supplement routine.
- Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
- Dr. Rhonda Patrick, who was previously unconvinced, now recommends hydrolyzed collagen powder prophylactically for connective tissue and ligaments, especially if someone has a soft tissue injury history, to be taken 30 to 60 minutes pre-exercise with 50 milligrams of vitamin C.
- Discusses whether collagen can actually strengthen tendons.
Peter Attia · Collagen · neutral
- Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
- Is skeptical that NR and NMN really change NAD levels that much, and their mice don't respond in studies with NR. He has never noticed anything personally when taking NR.
- Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
- References a small study where patients with Parkinson's disease were given nicotinamide riboside, which showed some change in a movement disorder rating scale, though the study had confounders.
- Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
- States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
- States that NR did not extend mouse lifespan in their tests. However, he is not a 'non-believer' for NR and the whole nicotinamide modulating family, believing the book is still open and there's a reasonable chance for good results, possibly in combination with another drug or a different form.
- Reports that NR by itself did not extend mouse lifespan, but he remains open to the possibility that it could work in combination with another drug or in a different form to modulate NAD availability.
- Discusses Nicotinamide riboside (NR) as an expensive, over-the-counter supplement that some believe might increase lifespan, but for which there is virtually no evidence indicating efficacy, and suggests there might be risks beyond wasting money.
- Believes that for general use for longevity, the small, possible benefits of Nicotinamide riboside (NR) do not outweigh the small, possible risks.
- Discusses nicotinamide riboside (NR) as an NAD precursor that has been shown in some studies to lead to benefits associated with healthy aging and lifespan extension in mice, though these results are not always reproducible.
- Peter Attia mentions that another finding close to publication is around nicotinamide riboside, a popular supplement and precursor to NAD.
- Recommends collagen supplements, in either pill or powder form, for hair, skin, nails, bones, and for putting on and maintaining healthy muscle, as it's difficult to get enough from diet alone.
- Notes that the ITPs are looking at nicotinamide riboside.
RAL Summary
Members OnlyTier 4 for Muscle and Strength
Collagen peptides at a full dose have some human trial support for muscle building, including a pooled review showing small gains with training [1]. However, there are no counted reviews, so the product stays at emerging.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 20 of the 49 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Metabolic system
Possible side effects: No major side effects reported.
Supplement Facts
Total Carbohydrates 2 g · Bovine Collagen Peptides 13 g · MitoHeal 500 mg
Supplement Facts
Serving Size 16.5 Gram(s)
Servings Per Container 30
Amount Per Serving% Daily Value
| Calories | 61 | |
| Total Carbohydrates | 2 g | |
| Protein | 12 g | |
| Sodium | 65 mg | |
| Bovine Collagen Peptides | 13 g | † |
| MitoHeal | 500 mg | † |
| Nicotinamide Riboside Hydrogen Malate | 125 mg | † |
| Betaine Anhydrous | 50 mg | † |
| HydroPeach | 20 mg | † |
† Daily Value not established.
Other ingredients: Flavors, Citric Acid, Rebaudioside A.
Directions: Suggested Use: Mix 1 scoop with at least 8-12 ounces of water daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749013112 · Label source: NIH label database · Report a label change
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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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