Thorne Curcumin Phytosome 1000 mg Review

THORNE Curcumin Phytosome, 1,000 mg Curcumin Supplement, 60 Capsules is a curcumin supplement from the brand THORNE. The page describes it as supporting joint stiffness, muscle soreness and a healthy inflammatory response, and it is listed as clinically studied and NSF Contents Certified. The listed item form is capsule, with 60 count in one bottle and a package size of 60 Capsules, weighing 3.36 ounces with dimensions of 2.09 x 2.09 x 3.72 inches. The Primary Supplement Type is Curcumin Phytosome, the special ingredient is listed as Curcumin, and the flavor is unflavored. The diet type is gluten free. Product benefits are listed as Bone and Joint Health and Liver and Detox. The allergen information on the page says dairy free, egg free, fish free, gluten free, peanut free, soy free and tree nut free. The material features list GMO free and gluten free. Recommended uses include brain health, healthy inflammatory response and liver. The About this item section explains several points. Muscle mobility: the product is said to ease joint stiffness to promote flexibility and to shield muscles from exercise-related stress and soreness. Whole-body wellness: it is said to help maintain a healthy inflammatory response in the joints, muscles, GI tract, liver, brain, eyes and nerves. Well-absorbed: the formula uses Meriva, described as the most clinically studied curcumin, with 29-times greater absorption than ordinary curcumin. Third-party certified: the page says the product has been third-party tested and certified to verify that what is in the package matches the label and to confirm it contains no unsafe levels of contaminants. Trusted: the page says Thorne is trusted by 100-plus professional sports teams and is named the number one most recommended clinical brand by consumers and health-care practitioners, based on a 2026 independent survey of US supplement consumers and health-care practitioners as cited on the page. The product is sold by Pattern. and ships from Amazon, with a one-time purchase price of $36.00 and a Subscribe and Save option. The item is listed under Health and Household, in the Curcumin Herbal Supplements category. The manufacturer is listed as Thorne Research with model number SF813 and ASIN B0797FSF89. The page also lists related Thorne products in a 120-capsule and 500 mg size, which are separate listings.

Product Focus: Joints and MobilityAlso covers:Immune system
Tier ⓘ
Tier 2
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
77 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
92% of 3,278
Biohacker Mentions
5 of 10
Cost per month
$25

Study, Trial or Testing Result Summary

Members Only21 human studies · 18 improved
21 human studies18 improved3 no effect17,726 people studied

Curcumin, given here in the Meriva phytosome form at a full daily amount, has strong human study support for joint health. A pooled analysis of 23 trials with 2175 people with knee osteoarthritis found curcumin reduced pain, joint symptom scores and the use of rescue meds compared with placebo, with fewer side effects than meds [1]. Another pooled analysis of 15 trials with 1621 people found turmeric extract and curcumin eased pain and stiffness and improved function, working about as well as meds, and suggested use for more than 12 weeks [2]. In rheumatoid arthritis, six studies with 539 people showed fewer tender and swollen joints and lower inflammation [3]. A trial in 106 adults with knee pain found 250 milligrams a day of a turmeric extract for 90 days lowered walking pain more than placebo and improved walking and stair times [4]. A large analysis of 39 trials found curcumin may help knee function, though another herb ranked higher [5]. Reviewers caution that many trials were small and of low quality [6]. Animal and cell studies are never counted.

See all 21 studies →Hide the studies

Review Totals and Summary

Members Only3,278 reviews · 92% positive
3,278 reviews · Amazon 1,664 · Mayo Clinic Store 871 · Vitacost 361 · Thorne 324 · Walmart 58
92% positive4% neutral4% negative

Buyers are largely happy with Thorne Curcumin Phytosome capsules, mostly for joint comfort and easing inflammation, and about 1,722 ratings across the stores back that up. The main complaints are about price and third-party sellers, not the supplement itself. Reviews of other forms of the product were left out. **What buyers say it did for them:** Joint relief is the most common benefit. One buyer wrote, "It works better than a med shots I was getting." Another reported "significant improvement in my knee and joint pain" after mountain biking. Others mention less muscle soreness after exercise, with one using it after badminton and runs. A few go further, citing better mood, focus, skin tone, or general wellbeing: "overall better mood and focus after just a couple of weeks." Patience matters, as one says, "must take for atleast 2 weeks to see results." A few reviewers weren't sure what to look for, and one took it alongside several other supplements, so it's hard to credit the curcumin alone. **What they complain about:** The complaints concern buying through third-party sellers on Walmart, not how the capsules work. One buyer says shipping was delayed "at least twice" and took about three weeks. Another was unhappy that the seller was in China and the order shipped from abroad. The most serious is a one-star review from a user of seven years. The bottle from the seller Titan Techies had a different ingredient list (no silicon dioxide, microcrystalline cellulose listed twice), different pill color, and a different bottle size. That reviewer urges Walmart to check the seller. Other buyers reported fast, trouble-free delivery. **Taste, smell, pill size, form:** Reviews don't mention taste, smell, or pill size much. The capsules are called "easy to take," and one buyer says it is "gentle on the stomach and doesn't cause any aftertaste." Several others say it is easy on digestion compared with other curcumin products. One likes it as a "natural alternative for turmeric without Pipirín" (the black pepper extract). Buyers credit the phytosome (Meriva) form with better absorption. **Value for money:** Opinions are mixed and depend on where you buy. One reviewer calls it "a little bit pricy" but worth it for the quality, and another says "Very good quality but expensive." On Walmart, several buyers praise the price, with one saying it is "better than Amazon." One buyer repeat-purchases the 120-count bottle. **Who it seems to suit and who it did not:** It suits active people with sore joints or muscles after exercise, and people in their 40s and 50s looking for antioxidant and recovery support. Some with arthritis or knee pain say it helps, and some who want to avoid piperine or who dislike how other turmeric products sit in the stomach. One buyer follows a physician's recommendation. Another hopes it will help a skin condition, but that was only an expectation, not a result. It did not suit buyers who ended up with delayed, foreign-shipped, or mismatched bottles from marketplace sellers. Those who want the genuine product should check the seller carefully.

Biohacker Summary

Members Only5 of 10 recommend it
5 of 10 biohackers on our panel recommend it

Most of the panel speaks well of curcumin: four recommend it and several others use it, mainly to lower inflammation and ease joint discomfort, with some also citing mood, brain health and blood sugar. Two panelists prefer a phytosomal or other well-absorbed form because plain curcumin is poorly absorbed, and one notes it barely absorbs without black pepper. Doses are rarely given: one panelist takes 500 mg daily, and another cites 500 to 1000 mg in trials. Others take it as a blend with omega-3, sulforaphane or ginger oil and DHA. On the cautious side, one panelist warns against high doses and says to check the sourcing for lead contamination, one advises avoiding it during pregnancy, one says it should not replace other treatments, and one stopped taking it for longevity because he saw too little evidence.

See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Curcumin · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
    • 4 Jun 2026 · recommends · YouTube ↗
      Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
    • 5 May 2026 · uses · YouTube ↗
      Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
    • 6 Nov 2025 · recommends · Podcast ↗
      Dave Asprey mentions that supplements like curcumin support pain relief and mood.
    • 6 Nov 2025 · recommends · YouTube ↗
      Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
    • 16 Oct 2025 · neutral · YouTube ↗
      Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
    • 4 Sep 2025 · recommends · Podcast ↗
      Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
    • 22 Sep 2024 · uses · YouTube ↗
      Mentions that curcumin also has anti-parasitic properties and is useful.
    • 1 Aug 2024 · recommends · YouTube ↗
      Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
  • Dr. Eric Berg · Curcumin · neutral
    • 25 Oct 2026 · neutral · Facebook ↗
      Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
    • 17 Oct 2026 · neutral · Instagram ↗
      Notes that Curcumin barely absorbs without black pepper.
    • 6 Sep 2026 · recommends · Facebook ↗
      Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
    • 3 Sep 2026 · neutral · X ↗
      Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
    • 2 Sep 2026 · recommends · Facebook ↗
      Lists curcumin as an epigenetic factor that may help with cancer prevention.
    • 21 Aug 2026 · neutral · Facebook ↗
      Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
    • 4 Jul 2026 · recommends · Instagram ↗
      States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
    • 8 Apr 2026 · recommends · YouTube ↗
      Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
    • 28 Jan 2026 · recommends · Podcast ↗
      States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
    • 19 Dec 2025 · recommends · Podcast ↗
      Recommends increasing curcumin for best kidney health.
  • Thomas DeLauer · Curcumin · recommends
    • 14 Oct 2026 · recommends · YouTube ↗
      Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
    • 11 Oct 2026 · recommends · YouTube ↗
      Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
    • 4 Oct 2026 · uses · YouTube ↗
      Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
    • 6 Sep 2026 · neutral · YouTube ↗
      Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
    • 16 Aug 2026 · recommends · YouTube ↗
      States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
    • 15 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin, especially when stacked with ginger, noting its anti-inflammatory efficacy and its ability to increase antioxidant defense systems and reduce oxidative stress. He emphasizes taking it with black pepper or piperine, or in a liposomal form, for bioavailability.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends curcumin with black pepper for general inflammation, explaining it blocks the primary transcription factor nuclear factor kappa B, shutting down the master regulatory at a genetic level for inflammation genes.
    • 4 Mar 2026 · neutral · Facebook ↗
      Curcumin with black pepper shuts down the NF-κB inflammatory pathway at the source, with pepper making it absorbable.
    • 17 Feb 2026 · neutral · YouTube ↗
      Cites a study showing that curcumin can shift gene expression in microglial cells, increasing anti-inflammatory genes and reducing pro-inflammatory signaling and migration, thereby slowing the snowball effect of inflammation.
  • Siim Land · Curcumin · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Curcumin as one of 15 supplements backed by human studies.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks curcumin has some of the strongest evidence and is worth considering.
    • 7 Aug 2026 · neutral · YouTube ↗
      Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 7 Jul 2026 · neutral · YouTube ↗
      States that curcumin, unless contaminated, is not going to raise liver enzymes.
    • 6 Mar 2026 · neutral · YouTube ↗
      Did not see a big extension from curcumin in their tests.
    • 30 Jan 2026 · neutral · Instagram ↗
      Mentions that it is infeasible to obtain sufficient curcumin from food.
    • 28 Dec 2025 · neutral · YouTube ↗
      Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
    • 11 Dec 2025 · recommends · YouTube ↗
      Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
    • 10 Oct 2025 · recommends · YouTube ↗
      Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
  • Dr. Mark Hyman · Curcumin · recommends
    • 5 Oct 2026 · recommends · YouTube ↗
      States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
    • 24 Aug 2026 · neutral · YouTube ↗
      Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin as an anti-inflammatory supplement that can be helpful.
    • 13 Jul 2026 · neutral · YouTube ↗
      States that curcumin helps to lower broader inflammatory levels in the body.
    • 27 May 2026 · neutral · YouTube ↗
      Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
    • 8 Oct 2025 · neutral · YouTube ↗
      Lists curcumin as a phytochemical that helps mitochondrial function.
    • 14 May 2025 · neutral · YouTube ↗
      Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
    • 26 Feb 2025 · neutral · YouTube ↗
      Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
    • 29 Nov 2024 · recommends · YouTube ↗
      Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
    • 16 Oct 2024 · neutral · YouTube ↗
      Mentions that curcumin can modify the expression of genes, which in turn affects stress response and mental health.
  • Dr. Rhonda Patrick · Curcumin · neutral
    • 5 Aug 2026 · neutral · Facebook ↗
      Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
    • 5 Aug 2026 · neutral · TikTok ↗
      Asks if curcumin can slow aging.
    • 24 Jun 2026 · neutral · Facebook ↗
      Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
    • 22 May 2026 · uses · Facebook ↗
      Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
    • 15 May 2026 · uses · Instagram ↗
      Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
    • 30 Apr 2026 · uses · Facebook ↗
      Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
    • 31 Jul 2024 · uses · Instagram ↗
      Took Meriva, a phytosomal curcumin, which has been shown to help with DOMS in some small studies.
    • 7 Oct 2021 · recommends · YouTube ↗
      States that curcumin, found in turmeric root, also activates antioxidant defenses.
    • 8 Jun 2021 · recommends · YouTube ↗
      Suggests that if someone is an 'immuno-ager,' they might want to take curcumin to help with their immune system.
    • 5 Apr 2017 · neutral · YouTube ↗
      Rhonda mentions curcumin as a xenohormetic compound that, in a small dose, is slightly toxic and activates cellular stress response pathways, helping the body deal with stress better.
  • Ben Greenfield · Curcumin · neutral
    • 13 Jun 2026 · neutral · Facebook ↗
      Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
    • 13 Jun 2026 · uses · YouTube ↗
      States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
    • 2 May 2026 · uses · YouTube ↗
      Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
    • 26 Mar 2026 · recommends · YouTube ↗
      Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
    • 20 Nov 2025 · recommends · Facebook ↗
      Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
    • 30 Oct 2025 · neutral · Podcast ↗
      Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
    • 30 Oct 2025 · uses · YouTube ↗
      Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
    • 26 Jun 2025 · neutral · YouTube ↗
      Mentions curcumin as a polyphenol that can confer benefits when consumed.
    • 3 May 2025 · recommends · YouTube ↗
      Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
    • 27 Feb 2025 · recommends · YouTube ↗
      Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
  • Andrew Huberman · Curcumin · neutral
    • 13 Apr 2026 · neutral · Podcast ↗
      Discusses curcumin as a supplement for prenatal care and sperm health.
    • 13 Apr 2026 · warns · YouTube ↗
      Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
    • 12 May 2025 · neutral · YouTube ↗
      Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
    • 6 May 2024 · uses · YouTube ↗
      Includes curcumin in his diet because it has been shown to stimulate GLP-1.
    • 29 Feb 2024 · warns · YouTube ↗
      Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
    • 10 Apr 2023 · neutral · Podcast ↗
      Mentions curcumin in the context of 5-alpha reductase.
    • 10 Apr 2023 · stopped · YouTube ↗
      States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
    • 22 Feb 2023 · warns · YouTube ↗
      Warns that some people, including himself, are very sensitive to curcumin because it can potently reduce DHT, leading to decreased libido and drive, though these effects reverse quickly after stopping.
    • 6 Feb 2023 · warns · YouTube ↗
      Warns against taking high dosages of curcumin, such as 8000 milligrams per day, because it can alter hormonal pathways, specifically inhibiting dihydrotestosterone (DHT) synthesis, which can lead to undesirable effects like reduced libido.
    • 11 Apr 2022 · warns · YouTube ↗
      Notes that if there's a strong genetic predisposition to enlarged prostates or early, fast-growing prostate cancers, individuals could consider taking curcumin as an anti-androgen, if they can tolerate it.
  • Peter Attia · Curcumin · uses
    • 23 Nov 2020 · uses · YouTube ↗
      Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
    • 26 Oct 2020 · recommends · YouTube ↗
      States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
    • 31 Dec 2019 · uses · YouTube ↗
      Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
    • Date not recorded · stopped · Website ↗
      Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
    • Date not recorded · neutral · Website ↗
      Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
  • Bryan Johnson · Curcumin · warns
    • Date not recorded · warns · Website ↗
      Advises avoiding Curcumin during pregnancy.

RAL Summary

Members OnlyTier 2 for Joints and Mobility

Many pooled analyses, including 23 trials with 2175 people with knee osteoarthritis, show curcumin reduces joint pain and improves function, and 92% of 3288 reviews are positive, meeting tier 2.

Where the evidence disagrees: 3 of the 21 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Immune system

Combine with: For joint and inflammation support, pair with omega-3 fish oil (EPA/DHA), glucosamine and chondroitin or undenatured type II collagen, and vitamin D3 with K2. Black pepper extract (piperine) is unnecessary with the phytosome form but harmless. If the broader goal is cellular aging and DNA repair, stack it with NAD+ precursors (nicotinamide riboside or NMN), trans-resveratrol or pterostilbene, quercetin and fisetin for senescence support, and alpha-lipoic acid, CoQ10 or ubiquinol and glutathione or NAC for mitochondrial and antioxidant defense. Take with a meal containing fat, and consult a clinician if you use meds, have gallbladder disease, or have liver concerns.

Possible side effects: Studies found fewer side effects than meds and no increase in side effects compared with placebo. No major side effects reported.

Supplement Facts

Meriva 1 g
Supplement Facts
Serving Size 1-2 Capsule(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Meriva1 g†
† Daily Value not established.

Other ingredients: Hypromellose, Leucine, Calcium Laurate, Silicon Dioxide, Calcium Citrate, Microcrystalline Cellulose.

Directions: Suggested use: Take 1-2 capsules two times daily or as recommended by your health-care practitioner.

Barcode (UPC) 693749004790 · Label source: NIH label database · Report a label change

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Graded November 5, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.