Thorne Curcumin Phytosome Review
Thorne's Curcumin Phytosome is presented as a well-absorbed curcumin supplement for joint stiffness, muscle soreness, and a healthy inflammatory response. The page states that Thorne's Curcumin Phytosome provides the most clinically studied curcumin on the market, helping maintain a healthy inflammatory response in the joints, muscles, GI tract, liver, brain, and nerves. The product page describes turmeric as extensively researched for its health-promoting properties, with a history of use in traditional Chinese and Ayurvedic medicine for more than 2,000 years. It explains that curcuminoids, the most active components in turmeric, are linked to promoting joint health and flexibility, supporting the liver and digestive system, and aiding cardiovascular health, and that curcumin acts as a powerful antioxidant. The page says the formula is built exclusively with Meriva, a phytosome complex that the page says provides superior absorption over other curcumin extracts, with a human study showing 29-times greater absorption than ordinary curcumin. The Sustained Release version uses Time-Sorb, described as a patented combination of high- and low-viscosity hydroxypropyl methylcellulose with magnesium citrate laurate, which the page says delays absorption and helps protect the active curcumin compounds as they pass through the stomach. Listed benefits include easing joint stiffness, encouraging flexibility, alleviating minor aches and muscle soreness, shielding muscles from exercise-related stress, and helping guard muscle tissue from age-related decline. The page also lists support for a balanced inflammatory response, healthy cholesterol processing, liver enzyme activity, and normal blood sugar levels. The product is third-party tested to verify that contents match the label and to confirm it contains no unsafe levels of heavy metals, pesticides, or microorganisms. The warnings state the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, that pregnant users should consult a health-care practitioner, and that curcumin may reduce the therapeutic efficacy of cyclophosphamide and may interfere with irinotecan, so concurrent use with these agents should be avoided. The FAQ notes that Thorne does not use black pepper or piperine in its curcumin products because it can irritate the gut mucosa, and that the phospholipids are extracted from sunflower oil, so people with a sunflower allergy are not advised to use it. The page also says results vary by individual, with some people noticing changes in a few days and others needing a few weeks of consistent use.
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Study, Trial or Testing Result Summary
Members Only21 human studies · 18 improved
Curcumin, the main ingredient here, is taken at a full dose, well above the 250 milligrams a day that worked in a trial. A 2024 pooled analysis of 23 trials with 2175 people with knee osteoarthritis found curcumin reduced pain, joint symptom scores and use of rescue meds compared with placebo, with fewer side effects than meds [1]. A 2021 analysis of 15 trials with 1621 people found turmeric extract and curcumin eased pain and stiffness and improved function, working about as well as meds, and the authors suggest taking it for more than 12 weeks [2]. A large 2025 analysis of 39 trials with 4599 adults found curcumin showed potential for improving knee function, with no increase in side effects [3]. In rheumatoid arthritis, six studies with 539 people showed fewer tender and swollen joints and lower inflammation [4]. In 106 adults with knee pain, 250 milligrams a day of a turmeric extract for 90 days lowered walking pain more than placebo [5]. Many trials were small and of low quality [6]. Animal and cell studies are never counted.
See all 21 studies →Hide the studies
- Across 39 trials with 4599 adults with knee osteoarthritis, curcumin along with several other supplements showed benefits in some outcomes compared with placebo, with Boswellia ranking best and curcumin showing potential for improving function, and no increase in side effects.Comparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis.
- Pooling 47 trials with 3852 people with rheumatoid arthritis, dietary polyphenols including curcumin improved disease activity, lowered inflammation markers and oxidative stress without more side effects.Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomiz…
- In 29 randomized trials with 2396 people with different types of arthritis, taking 120 to 1500 mg of curcumin or turmeric extract for 4 to 36 weeks eased pain and inflammation, but the trials were small and low in quality.Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-An…
- Across 23 trials with 2175 people with knee osteoarthritis, curcumin reduced pain scores and total WOMAC scores and the use of rescue medication compared with placebo, and caused fewer adverse reactions than meds.Efficacy and safety of curcumin therapy for knee osteoarthritis: A Bayesian network meta-analysis.
- In 15 randomized trials with 1621 people with osteoarthritis, turmeric extract and curcumin reduced pain and stiffness and improved function versus placebo, worked similarly to meds with fewer side effects, and the authors suggest using them for more than 12 weeks.The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and met…
- Across 12 studies with 724 curcumin users and 714 controls with osteoarthritis, curcumin improved pain and function compared with placebo but not compared with active treatments such as meds.A Meta-Analysis of the Impact of Nutritional Supplementation on Osteoarthritis Symptoms.
- Across 5 randomized trials with 599 people with osteoarthritis, curcumin lowered joint pain and stiffness scores, and caused no more side effects than a med.Efficacy and side effect of curcumin for the treatment of osteoarthritis: A meta-analysis of randomized controlled trial…
- Across six studies with 539 people with rheumatoid arthritis, curcumin lowered disease activity, the number of tender and swollen joints, and a blood marker of inflammation compared with controls.Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.
- In 8 randomized trials, turmeric extract (about 1000 mg a day of curcumin) lowered arthritis pain and joint symptom scores versus placebo and matched meds, though the trials were too few and small to be definitive.Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta…
- In a review of 69 placebo-controlled trials of supplements for osteoarthritis, curcumin and turmeric extract gave large short-term pain relief, though the overall evidence quality was very low and no supplement helped over the long term.Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.
- Across 21 randomized trials (14 on joint health), turmeric extract and curcumin supplements were judged effective add-on options for musculoskeletal health with few side effects, and a water-dispersible extract at 250 mg a day appeared most effective, though doses and durations varied widely.Safety and Efficacy of Turmeric (Curcuma longa) Extract and Curcumin Supplements in Musculoskeletal Health: A Systematic…
- Pooling 11 meta-analyses of trials, curcumin significantly reduced pain, stiffness and difficulty with movement in people with knee osteoarthritis.The efficacy of curcumin in relieving osteoarthritis: A meta-analysis of meta-analyses.
- This review found mostly laboratory and animal studies and only one human study, in which curcumin improved morning stiffness, walking time and joint swelling in people with rheumatoid arthritis.Curcumin and rheumatoid arthritis: A systematic review of literature.
- Across 17 randomized trials lasting 4 weeks to 8 months, various curcumin formulations significantly improved pain and overall WOMAC scores in people with osteoarthritis without severe side effects, with better-absorbed forms tending to work better.A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.
- An overview of 161 meta-analyses of trials found that ginger-family plants and curcumin clearly relieved osteoarthritis pain and were generally safe, though better-quality research is still needed.Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and met…
- In 139 people with knee osteoarthritis, 1500 mg curcumin daily for 28 days relieved pain about as well as the drug diclofenac, with fewer side effects (13% vs 38%), and this was an open-label comparison without placebo.Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.
- In 106 healthy adults with chronic knee pain, 250 mg a day of a turmeric extract (150 mg curcuminoids) for 90 days cut walking pain scores more than placebo (1.5 vs 0.6 points) and improved walking and stair-climb times.A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Assessing Efficacy and Safety of a Novel Low-Dose Turm…
- In 84 adults with knee osteoarthritis, a combination including 500 mg curcumin daily for 12 weeks reduced knee pain no more than placebo (difference 0.16 mm on a 100 mm scale).Effect of an oral complementary medicine combination for symptomatic knee osteoarthritis: A double-blind, randomized, pl…
- In 70 people with knee osteoarthritis and joint swelling, turmeric extract for 12 weeks reduced knee pain more than placebo (9.1 mm on a 100 mm scale) but did not reduce joint swelling or change cartilage.Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A R…
- In 60 people with chronic knee osteoarthritis, a turmeric, black pepper and ginger mix taken for 4 weeks lowered an inflammation chemical (PGE2) similarly to the drug a med, with no difference between groups.Read the study on PubMed (32180294) →
- In 48 women with rheumatoid arthritis, 500 mg curcumin daily for 8 weeks reduced tender and swollen joints, pain and disease activity scores more than placebo and raised antioxidant capacity.The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in w…
Review Totals and Summary
Members Only2,734 reviews · 92% positive
Across the stores it is sold in, Thorne Curcumin Phytosome carries about 1,863 ratings, and feedback is mostly positive. Buyers mainly talk about joint and pain relief and good quality, while price and uneven results are the main drawbacks. **What buyers say it did for them:** The most common story is relief from joint pain and inflammation. One person with hip osteoarthritis said it "allowed me to stop taking OTC pain killers," though it took about two weeks to start working. Another wrote that it "works better than a med shots I was getting." Others describe more modest effects, such as feeling it "seems to decrease the pains I typically get from exercising" and "feel like it is helping my arthritis pain." Some users report gradual onset, and one says they "need to give it time." The page's own summary notes that some users see big differences and others notice nothing. **What they complain about:** The complaints are few. One reviewer saw no change ("Have not seen any difference so far"). Another tried it for a few days, had stomach issues, and was unsure whether it works. One buyer's order was cancelled by the vendor, and another had a hard time ordering a bottle and suggested the store test its ordering process. Those are store issues rather than product issues. **Taste, smell, pill size or form:** Reviewers did not comment on taste, smell or capsule size. One does give a dosing example: two capsules in the morning and two in the evening. Reviews of other forms of this product were left out, and this summary covers the capsules only. **Value for money:** Price is the main drawback raised. One reviewer called it "Very good quality but expensive." The store summary also names cost as the chief downside. No one says it was poor value, but nobody calls it cheap either. **Who it seems to suit and who it did not:** It appears to suit people looking for support with arthritis, joint pain or exercise soreness, especially those who want an alternative to over-the-counter pain relievers. One buyer liked it as a "Healthy alternative to meds" and said it "doesn't upset stomach." Long-term users are also happy, with one saying they have "Used this product for years." Buyers who researched the brand liked its reputation for testing and quality. It did not suit the reviewer who had stomach trouble, and it did nothing noticeable for the person who saw no difference. Anyone expecting quick results should note that several reports describe a wait of a couple of weeks or more, and that individual results vary.
Biohacker Summary
Members Only9 of 10 recommend it
Curcumin gets a mostly favorable but mixed response from the panel: about half recommend or use it, several stay neutral, and two give cautions. Most take it for inflammation, with joint comfort, mood, brain health and blood sugar also mentioned. One panelist prefers the phytosomal form because standard curcumin is poorly absorbed, and he takes 500 mg a day; others point to well-absorbed versions, adding black pepper, or getting it in turmeric or curries, and one pairs it with omega-3 while another uses it alongside sulforaphane. Doses given include 500 mg daily and a range of 500 to 1000 mg, while one panelist warns against high doses and says to check sourcing for lead contamination, and another advises avoiding it in pregnancy. One panelist stopped taking it for longevity because he did not see enough evidence, and another says it does not replace sleep, food, exercise and stress care.
See all 10 biohackers →Hide the biohackers
Dave Asprey · Curcumin · uses
- Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
- Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
- Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
- Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
- Dave Asprey mentions that supplements like curcumin support pain relief and mood.
- Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
- Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
- Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
- Mentions that curcumin also has anti-parasitic properties and is useful.
- Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
Dr. Eric Berg · Curcumin · neutral
- Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
- Notes that Curcumin barely absorbs without black pepper.
- Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
- Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
- Lists curcumin as an epigenetic factor that may help with cancer prevention.
- Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
- States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
- Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
- States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
- Recommends increasing curcumin for best kidney health.
Thomas DeLauer · Curcumin · recommends
- Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
- Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
- Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
- Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
- Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
- States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
- Recommends curcumin, especially when stacked with ginger, noting its anti-inflammatory efficacy and its ability to increase antioxidant defense systems and reduce oxidative stress. He emphasizes taking it with black pepper or piperine, or in a liposomal form, for bioavailability.
- Recommends curcumin with black pepper for general inflammation, explaining it blocks the primary transcription factor nuclear factor kappa B, shutting down the master regulatory at a genetic level for inflammation genes.
- Curcumin with black pepper shuts down the NF-κB inflammatory pathway at the source, with pepper making it absorbable.
- Cites a study showing that curcumin can shift gene expression in microglial cells, increasing anti-inflammatory genes and reducing pro-inflammatory signaling and migration, thereby slowing the snowball effect of inflammation.
Siim Land · Curcumin · recommends
- Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Curcumin as one of 15 supplements backed by human studies.
- Thinks curcumin has some of the strongest evidence and is worth considering.
- Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- States that curcumin, unless contaminated, is not going to raise liver enzymes.
- Did not see a big extension from curcumin in their tests.
- Mentions that it is infeasible to obtain sufficient curcumin from food.
- Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
- Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
- Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
Dr. Mark Hyman · Curcumin · recommends
- States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
- Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
- Recommends curcumin as an anti-inflammatory supplement that can be helpful.
- States that curcumin helps to lower broader inflammatory levels in the body.
- Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
- Lists curcumin as a phytochemical that helps mitochondrial function.
- Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
- Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
- Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
- Mentions that curcumin can modify the expression of genes, which in turn affects stress response and mental health.
Dr. Rhonda Patrick · Curcumin · neutral
- Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
- Asks if curcumin can slow aging.
- Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
- Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
- Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
- Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
- Took Meriva, a phytosomal curcumin, which has been shown to help with DOMS in some small studies.
- States that curcumin, found in turmeric root, also activates antioxidant defenses.
- Suggests that if someone is an 'immuno-ager,' they might want to take curcumin to help with their immune system.
- Rhonda mentions curcumin as a xenohormetic compound that, in a small dose, is slightly toxic and activates cellular stress response pathways, helping the body deal with stress better.
Ben Greenfield · Curcumin · neutral
- Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
- States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
- Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
- Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
- Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
- Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
- Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
- Mentions curcumin as a polyphenol that can confer benefits when consumed.
- Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
- Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
Andrew Huberman · Curcumin · neutral
- Discusses curcumin as a supplement for prenatal care and sperm health.
- Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
- Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
- Includes curcumin in his diet because it has been shown to stimulate GLP-1.
- Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
- Mentions curcumin in the context of 5-alpha reductase.
- States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
- Warns that some people, including himself, are very sensitive to curcumin because it can potently reduce DHT, leading to decreased libido and drive, though these effects reverse quickly after stopping.
- Warns against taking high dosages of curcumin, such as 8000 milligrams per day, because it can alter hormonal pathways, specifically inhibiting dihydrotestosterone (DHT) synthesis, which can lead to undesirable effects like reduced libido.
- Notes that if there's a strong genetic predisposition to enlarged prostates or early, fast-growing prostate cancers, individuals could consider taking curcumin as an anti-androgen, if they can tolerate it.
Peter Attia · Curcumin · uses
- Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
- States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
- Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
- Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
- Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
Bryan Johnson · Curcumin · warns
- Advises avoiding Curcumin during pregnancy.
RAL Summary
Members OnlyTier 2 for Joints and Mobility
Many pooled analyses, including 23 trials in 2175 people with knee osteoarthritis, show curcumin reduces joint pain and improves function, and 92% of 2744 reviews are positive, which meets the tier 2 rules.
Where the evidence disagrees: 3 of the 21 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system, Immune system
Combine with: For joint and inflammation support, curcumin phytosome pairs well with omega-3 fish oil (EPA/DHA), boswellia (AKBA-standardized), and collagen peptides or glucosamine/chondroitin. Vitamin D3/K2 and magnesium support musculoskeletal health. If you still want digestive comfort alongside it, consider ginger root extract, a broad-spectrum digestive enzyme with meals, artichoke leaf extract, or peppermint/caraway oil. Take curcumin with a meal containing some fat, and consult a healthcare provider if you take meds, have gallstones or bile duct obstruction, or have persistent upper-abdominal symptoms.
Possible side effects: Studies found fewer side effects than meds and no increase over placebo. One buyer reported stomach trouble after a few days.
Supplement Facts
Curcumin Phytosome 1 g
| Curcumin Phytosome | 1 g | † |
Other ingredients: Hypromellose (derived from cellulose) capsule, Leucine, Calcium Laurate, Silicon Dioxide, Calcium Citrate, Microcrystalline Cellulose.
Directions: Take 1-2 capsules two times daily or as recommended by your health-care practitioner.
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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