Thorne Curcumin Phytosome - Sustained Release Review

Thorne's Curcumin Phytosome - Sustained Release is a capsule supplement that pairs curcumin with a phospholipid complex from sunflower. The page describes turmeric as extensively researched, noting that curcuminoids, the most active components in turmeric, are associated with promoting joint health and flexibility, supporting the liver and digestive system, and aiding cardiovascular health, and that curcumin acts as a powerful antioxidant. The product is presented as helping with a healthy inflammatory response, which the page says makes it especially helpful for those dealing with intermittent physical discomfort, and it states that curcumin can help ease tension in muscles and joints caused by overuse. The page also says a balanced inflammatory response is vital for the brain, eyes, liver, digestive tract, kidneys, and cardiovascular system. Thorne states that its curcumin is formulated exclusively with Meriva, which it describes as the most clinically studied curcumin on the market. As a phytosome complex, Meriva is described as providing superior absorption over other curcumin extracts, and the page cites a human study showing 29-times greater absorption of Meriva than ordinary curcumin. The Sustained Release formula uses Time-Sorb, described as a patented combination of high- and low-viscosity hydroxypropyl methylcellulose with magnesium citrate laurate, which the page says is designed to delay absorption and help protect the active curcumin compounds as they pass through the stomach. Listed benefits include easing joint stiffness, encouraging flexibility, alleviating minor aches and muscle soreness, shielding muscles from exercise-related stress and possibly helping reduce delayed onset muscle soreness, possibly lessening cellular damage from intense training, and helping guard muscle tissue from age-related decline. For metabolic health, the page lists encouraging healthy cholesterol processing, boosting liver enzyme activity, and helping support normal blood sugar levels. The page notes that the product does not use black pepper or piperine, because black pepper can irritate the gut mucosa. The serving size is 2 capsules with 60 servings per container, and the listed curcumin phytosome amount is 500mg per serving. The product is stated to be third-party tested and certified to verify that what is in the package matches the label and contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. The warnings section states the product is contraindicated in individuals with a history of hypersensitivity to its ingredients, advises pregnant users to consult a health-care practitioner, and notes curcumin may reduce the efficacy of cyclophosphamide and interact with irinotecan, so concurrent use with these agents should be avoided. The phospholipid complex is extracted from sunflower oil, and the page advises against use for people with a sunflower allergy.

Product Focus: Joints and MobilityAlso covers:Immune system
Tier ⓘ
Tier 2 · Rank 18
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 18 within Tier 2 for Joints and Mobility; 18 of 62 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
85 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
92% of 3,362
Biohacker Mentions
9 of 10

Study, Trial or Testing Result Summary

Members Only21 human studies · 18 improved
21 human studies18 improved3 no effect17,726 people studied

This product gives curcumin in a phospholipid complex at 1000 milligrams a day, which is above the 250 milligrams that worked in studies. Curcumin has strong support for joint health. A large pooled analysis of 23 trials with 2175 people with knee osteoarthritis found curcumin reduced pain, joint symptom scores and the use of rescue meds compared with placebo, with fewer side effects than meds [1]. Another analysis of 15 trials with 1621 people found turmeric extract and curcumin eased pain and stiffness and improved function, working about as well as meds. The authors suggest taking it for more than 12 weeks [2]. In rheumatoid arthritis, six studies with 539 people showed fewer tender and swollen joints and lower inflammation [3]. A trial in 106 adults with knee pain found 250 milligrams a day of a turmeric extract for 90 days lowered walking pain more than placebo [4]. A pooled look at 39 trials found curcumin showed potential for improving function, though another herb ranked higher [5]. Many trials were small and of low quality, so the size of the benefit is less certain [6]. Animal and cell studies are never counted.

See all 21 studies →Hide the studies

Review Totals and Summary

Members Only3,362 reviews · 92% positive
3,362 reviews · Amazon 2,286 · Store.mayoclinic 871 · Thorne 133 · Walmart 66 · Google 6
92% positive4% neutral4% negative

Across the stores, Thorne Curcumin Phytosome Sustained Release carries about 2,485 ratings, and most are positive. Buyers mainly report relief from joint pain and inflammation, though some notice no change, and a few had stomach trouble or ordering problems. This summary covers the capsules only; no other forms appear in the material, so none were left out. **What buyers say it did for them:** The strongest praise is for joint and exercise-related pain. One osteoarthritis sufferer says it took about two weeks to work and then "allowed me to stop taking OTC pain killers" for hip pain. Another says it "seems to decrease the pains I typically get from exercising." A third simply says it "seems to reduce inflation" (inflammation, presumably). The Thorne page summary adds that reviewers describe relief for arthritis and knee discomfort, with one saying it worked better than a med shots they had been getting, and another feeling it helps after more than a month and planning to continue. One long-term user says "Used this product for years. . . . Love it." **What buyers complain about:** Complaints are few. One buyer found it hard to order, saying "I had a heck of a time ordering my last bottle." Another reports that an order was cancelled by the vendor. One reviewer gave 2 stars after "a few days" because of stomach issues. Another says "Have not seen any difference so far." The page's own AI summary also says some users report significant differences in health while others notice no change. **Taste, smell, pill size and form:** The reviews say little here. They do not describe taste, aftertaste or pill size. One buyer mentions taking 2 capsules in the morning and 2 in the evening, which suggests a multi-capsule daily routine. **Value for money:** Price comes up only on the Thorne page summary, where one reviewer calls the product very good quality but expensive. That is the only criticism in that page's visible written feedback. **Quality and trust:** Several buyers value the brand. One calls Thorne a "top-tier company" and says the products are well tested. The Thorne page summary mentions reviewers who are very happy with the quality and results. **Who it seems to suit and who it did not:** It seems to suit people looking for a supplement for joint pain, arthritis or exercise soreness, including those who want an alternative to over-the-counter painkillers. One reviewer calls it a "Healthy alternative to meds" and says it "doesn't upset stomach," although another buyer had stomach problems. Buyers who expect fast results may be disappointed: one needed about two weeks, another says "Need to give it time," and a couple saw no clear difference. Those who struggled with stomach upset or ordering were the least satisfied. Of the reviews with star ratings, about 89% gave 4 or 5 stars. The Thorne page's histogram is similarly favorable, but its written reviews are a small sample.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Curcumin gets a mostly positive but mixed reception from the panel: about five of the ten recommend it, several use it, and a few stay neutral. The main reason people take it is to calm inflammation, with joint comfort, mood, brain health and blood sugar support also mentioned. One panelist prefers the phytosomal form because plain curcumin is poorly absorbed and quickly broken down, and that person takes 500 mg daily; another cited 500 to 1000 mg in trials, and others pointed to black pepper or other well-absorbed forms, and some pair it with omega-3 or sulforaphane. On the caution side, one panelist warns against high doses and says to check sourcing for lead contamination, one says to avoid it during pregnancy, one stopped taking it because he saw too little evidence, and another says it should not replace other treatments or healthy habits.

See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Curcumin · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
    • 4 Jun 2026 · recommends · YouTube ↗
      Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
    • 5 May 2026 · uses · YouTube ↗
      Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
    • 6 Nov 2025 · recommends · Podcast ↗
      Dave Asprey mentions that supplements like curcumin support pain relief and mood.
    • 6 Nov 2025 · recommends · YouTube ↗
      Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
    • 16 Oct 2025 · neutral · YouTube ↗
      Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
    • 4 Sep 2025 · recommends · Podcast ↗
      Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
    • 22 Sep 2024 · uses · YouTube ↗
      Mentions that curcumin also has anti-parasitic properties and is useful.
    • 1 Aug 2024 · recommends · YouTube ↗
      Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
  • Dr. Eric Berg · Curcumin · neutral
    • 25 Oct 2026 · neutral · Facebook ↗
      Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
    • 17 Oct 2026 · neutral · Instagram ↗
      Notes that Curcumin barely absorbs without black pepper.
    • 6 Sep 2026 · recommends · Facebook ↗
      Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
    • 3 Sep 2026 · neutral · X ↗
      Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
    • 2 Sep 2026 · recommends · Facebook ↗
      Lists curcumin as an epigenetic factor that may help with cancer prevention.
    • 21 Aug 2026 · neutral · Facebook ↗
      Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
    • 4 Jul 2026 · recommends · Instagram ↗
      States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
    • 8 Apr 2026 · recommends · YouTube ↗
      Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
    • 28 Jan 2026 · recommends · Podcast ↗
      States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
    • 19 Dec 2025 · recommends · Podcast ↗
      Recommends increasing curcumin for best kidney health.
  • Thomas DeLauer · Curcumin · recommends
    • 14 Oct 2026 · recommends · YouTube ↗
      Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
    • 11 Oct 2026 · recommends · YouTube ↗
      Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
    • 4 Oct 2026 · uses · YouTube ↗
      Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
    • 6 Sep 2026 · neutral · YouTube ↗
      Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
    • 16 Aug 2026 · recommends · YouTube ↗
      States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
    • 15 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin, especially when stacked with ginger, noting its anti-inflammatory efficacy and its ability to increase antioxidant defense systems and reduce oxidative stress. He emphasizes taking it with black pepper or piperine, or in a liposomal form, for bioavailability.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends curcumin with black pepper for general inflammation, explaining it blocks the primary transcription factor nuclear factor kappa B, shutting down the master regulatory at a genetic level for inflammation genes.
    • 4 Mar 2026 · neutral · Facebook ↗
      Curcumin with black pepper shuts down the NF-κB inflammatory pathway at the source, with pepper making it absorbable.
    • 17 Feb 2026 · neutral · YouTube ↗
      Cites a study showing that curcumin can shift gene expression in microglial cells, increasing anti-inflammatory genes and reducing pro-inflammatory signaling and migration, thereby slowing the snowball effect of inflammation.
  • Siim Land · Curcumin · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Curcumin as one of 15 supplements backed by human studies.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks curcumin has some of the strongest evidence and is worth considering.
    • 7 Aug 2026 · neutral · YouTube ↗
      Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 7 Jul 2026 · neutral · YouTube ↗
      States that curcumin, unless contaminated, is not going to raise liver enzymes.
    • 6 Mar 2026 · neutral · YouTube ↗
      Did not see a big extension from curcumin in their tests.
    • 30 Jan 2026 · neutral · Instagram ↗
      Mentions that it is infeasible to obtain sufficient curcumin from food.
    • 28 Dec 2025 · neutral · YouTube ↗
      Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
    • 11 Dec 2025 · recommends · YouTube ↗
      Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
    • 10 Oct 2025 · recommends · YouTube ↗
      Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
  • Dr. Mark Hyman · Curcumin · recommends
    • 5 Oct 2026 · recommends · YouTube ↗
      States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
    • 24 Aug 2026 · neutral · YouTube ↗
      Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin as an anti-inflammatory supplement that can be helpful.
    • 13 Jul 2026 · neutral · YouTube ↗
      States that curcumin helps to lower broader inflammatory levels in the body.
    • 27 May 2026 · neutral · YouTube ↗
      Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
    • 8 Oct 2025 · neutral · YouTube ↗
      Lists curcumin as a phytochemical that helps mitochondrial function.
    • 14 May 2025 · neutral · YouTube ↗
      Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
    • 26 Feb 2025 · neutral · YouTube ↗
      Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
    • 29 Nov 2024 · recommends · YouTube ↗
      Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
    • 16 Oct 2024 · neutral · YouTube ↗
      Mentions that curcumin can modify the expression of genes, which in turn affects stress response and mental health.
  • Dr. Rhonda Patrick · Curcumin · neutral
    • 5 Aug 2026 · neutral · Facebook ↗
      Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
    • 5 Aug 2026 · neutral · TikTok ↗
      Asks if curcumin can slow aging.
    • 24 Jun 2026 · neutral · Facebook ↗
      Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
    • 22 May 2026 · uses · Facebook ↗
      Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
    • 15 May 2026 · uses · Instagram ↗
      Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
    • 30 Apr 2026 · uses · Facebook ↗
      Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
    • 31 Jul 2024 · uses · Instagram ↗
      Took Meriva, a phytosomal curcumin, which has been shown to help with DOMS in some small studies.
    • 7 Oct 2021 · recommends · YouTube ↗
      States that curcumin, found in turmeric root, also activates antioxidant defenses.
    • 8 Jun 2021 · recommends · YouTube ↗
      Suggests that if someone is an 'immuno-ager,' they might want to take curcumin to help with their immune system.
    • 5 Apr 2017 · neutral · YouTube ↗
      Rhonda mentions curcumin as a xenohormetic compound that, in a small dose, is slightly toxic and activates cellular stress response pathways, helping the body deal with stress better.
  • Ben Greenfield · Curcumin · neutral
    • 13 Jun 2026 · neutral · Facebook ↗
      Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
    • 13 Jun 2026 · uses · YouTube ↗
      States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
    • 2 May 2026 · uses · YouTube ↗
      Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
    • 26 Mar 2026 · recommends · YouTube ↗
      Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
    • 20 Nov 2025 · recommends · Facebook ↗
      Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
    • 30 Oct 2025 · neutral · Podcast ↗
      Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
    • 30 Oct 2025 · uses · YouTube ↗
      Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
    • 26 Jun 2025 · neutral · YouTube ↗
      Mentions curcumin as a polyphenol that can confer benefits when consumed.
    • 3 May 2025 · recommends · YouTube ↗
      Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
    • 27 Feb 2025 · recommends · YouTube ↗
      Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
  • Andrew Huberman · Curcumin · neutral
    • 13 Apr 2026 · neutral · Podcast ↗
      Discusses curcumin as a supplement for prenatal care and sperm health.
    • 13 Apr 2026 · warns · YouTube ↗
      Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
    • 12 May 2025 · neutral · YouTube ↗
      Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
    • 6 May 2024 · uses · YouTube ↗
      Includes curcumin in his diet because it has been shown to stimulate GLP-1.
    • 29 Feb 2024 · warns · YouTube ↗
      Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
    • 10 Apr 2023 · neutral · Podcast ↗
      Mentions curcumin in the context of 5-alpha reductase.
    • 10 Apr 2023 · stopped · YouTube ↗
      States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
    • 22 Feb 2023 · warns · YouTube ↗
      Warns that some people, including himself, are very sensitive to curcumin because it can potently reduce DHT, leading to decreased libido and drive, though these effects reverse quickly after stopping.
    • 6 Feb 2023 · warns · YouTube ↗
      Warns against taking high dosages of curcumin, such as 8000 milligrams per day, because it can alter hormonal pathways, specifically inhibiting dihydrotestosterone (DHT) synthesis, which can lead to undesirable effects like reduced libido.
    • 11 Apr 2022 · warns · YouTube ↗
      Notes that if there's a strong genetic predisposition to enlarged prostates or early, fast-growing prostate cancers, individuals could consider taking curcumin as an anti-androgen, if they can tolerate it.
  • Peter Attia · Curcumin · uses
    • 23 Nov 2020 · uses · YouTube ↗
      Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
    • 26 Oct 2020 · recommends · YouTube ↗
      States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
    • 31 Dec 2019 · uses · YouTube ↗
      Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
    • Date not recorded · stopped · Website ↗
      Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
    • Date not recorded · neutral · Website ↗
      Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
  • Bryan Johnson · Curcumin · warns
    • Date not recorded · warns · Website ↗
      Advises avoiding Curcumin during pregnancy.

RAL Summary

Members OnlyTier 2 for Joints and Mobility

Many pooled analyses of human trials, including 23 trials in knee osteoarthritis, show curcumin reduces joint pain and improves function [1][2]. Over 3,000 reviews are 92% positive, which meets tier 2.

Where the evidence disagrees: 3 of the 21 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Musculoskeletal system, Immune system

Combine with: For joint and inflammation support, curcumin phytosome pairs well with omega-3 fish oil (EPA/DHA), which has complementary anti-inflammatory effects, and with glucosamine/chondroitin or collagen peptides for cartilage support. Boswellia serrata offers additional joint comfort support through a different inflammatory pathway, and vitamin D3 with K2 supports bone and joint health. Taking it with a meal containing some fat helps absorption, and a small amount of black pepper extract is unnecessary with the phytosome form. If the real goal is post-meal upper-abdominal comfort, consider instead a combination of ginger root extract, broad-spectrum digestive enzymes, artichoke leaf extract, or a peppermint/caraway oil blend, and consult a healthcare provider if symptoms persist, especially if you take meds or have gallbladder disease, since curcumin can affect bile flow and platelet function.

Possible side effects: Studies found fewer side effects than meds. A few buyers reported stomach upset.

Supplement Facts

Curcumin Phytosome 500 mg
Supplement Facts
Serving Size Two Capsules
Servings Per Container 60
Amount Per Serving% Daily Value
Curcumin Phytosome500 mg†
† Daily Value not established.

Other ingredients: High and low viscosity hydroxypropyl methylcellulose, Calcium Citrate, and Calcium Laurate (Time-Sorb††), Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide, Microcrystalline Cellulose.

Directions: Take 1-2 capsules two times daily or as recommended by your health-care practitioner.

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.