Thorne Emotion Balance Support Review

Emotion Balance Support is a multi-faceted formula of nutrients and botanicals that Thorne describes as designed to safely enhance mood and cognition. According to the page, it combines several mood-enhancing nutrients and botanicals to promote healthy neurotransmitter and adrenal function, and it is described as able to enhance cognition, modulate stress, and being non-habit forming. The product details state that Emotion Balance Support is safe and effective for mood enhancement and stress management. It combines neurotransmitter-supportive nutrients including L-tyrosine, 5-HTP, and GABA with two adrenal-supportive botanicals, Rhodiola and Eleutherococcus, which the page calls a well-known adaptogen that provides general adrenal support. The formula includes the active forms of folate (5-MTHF) and vitamin B12 (methylcobalamin) to support healthy neurological function and mood. GABA is provided as the patented, all natural-source PharmaGABA, which the page describes as an inhibitory neurotransmitter that helps alleviate stress and supports a calm, relaxed state of mind. The page states that the product contains no Hypericum (St. John's wort), which makes it suitable for individuals taking a medication metabolized by the CYP3A4 enzyme. It is also non-habit forming. Thorne notes that the product has been third-party tested and certified to verify that what is in the package matches the label and to confirm it contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. Serving size is 2 capsules, with 60 servings per container, and the listed price is $63 for 120 capsules, or $56.70 with a subscription at 10 percent off. The subscription options include delivery every 2 weeks, monthly, every 45 days, every 2 months, every 3 months, or every 4 months, with free shipping, and the page notes an additional 20 percent saving when subscribing to three or more different products. The page also lists HSA/FSA eligibility. Warnings on the page include that the product is contraindicated for anyone with a history of hypersensitivity to its ingredients, that iodine may occasionally cause an allergic reaction, and that it should not be used if pregnant or nursing. It also notes that 5-MTHF is not recommended concurrently with a med cancer therapy, that tyrosine is contraindicated with MAO inhibitor meds, and that 5-hydroxytryptophan should be used with caution alongside meds, MAO inhibitors, or other meds. Vitamin C in large doses can cause diarrhea in some individuals. The page recommends related products including Ashwagandha, FloraMend Prime Probiotic, Omega-3 with CoQ10, and Stress Balance.

Product Focus: MoodAlso covers:BrainHormones
Tier ⓘ
Tier 2 · Rank 6
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 6 within Tier 2 for Mood; 6 of 33 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
86 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
90% of 1,138
Biohacker Mentions
10 of 10
Cost per month
$95 at 3 servings

Study, Trial or Testing Result Summary

Members Only274 human studies · 137 improved

10 of these 274 human studies gave the ingredient by drip, injection or inhaler, not by mouth.

274 human studies137 improved88 no effect233,636 people studied

Several ingredients in this formula have human mood studies at the dose members take. Adding folate to a med medicine eased depression more than medicine alone in large pooled analyses [1][2], though one trial of 475 adults found no help [3]. Rhodiola, at the full dose of three servings a day, improved depression and emotional instability more than placebo in adults with mild to moderate depression [4], but another trial found no clear difference from placebo [5]. 5-hydroxytryptophan improved depression scores in older adults [6], yet did no better than placebo in a larger trial [7]. Vitamin C did not improve mood overall in pooled trials, with a small benefit only in people with mild depression [8], and it helped well-being in young adults low in vitamin C [9]. Results for vitamin B6 are mixed [10][11]. GABA showed benefits in small trials [12]. Vitamin B12 did not improve depression in people who are not deficient [13]. L-tyrosine is well below the studied dose. For pantothenic acid, iodine and Eleuthero there are no good trials of these ingredients alone [14][15][16]. Animal and cell studies are never counted.

See all 274 studies →Hide the studies

Review Totals and Summary

Members Only1,138 reviews · 90% positive
1,138 reviews · Amazon 378 · IHerb 365 · Store.mayoclinic 186 · Walmart 68 · Vitacost 65 · Thorne 42 · Google 34
90% positive6% neutral4% negative

Across the stores that sell it, Thorne Emotion Balance Support carries about 876 ratings, and the feedback is strongly positive. Buyers mostly describe steadier mood and better emotional balance, and a few mention sleep. A minority felt nothing. This summary covers the capsules only; reviews of other forms were left out. **What buyers say it did for them:** Most describe a more even mood. One says it "helps keep my mood positive and more level." Another, a postpartum buyer, says it "completely changed my mood" and that they can face the day "without snapping and feeling moody or overwhelmed." That buyer notices a difference after two or three days off it. Some mention sleep, with one saying it "helps balance my emotions and helps me sleep." Others use it alongside a med, with one calling it "a great addition for my a med" and another saying it gives "that boost I need" in winter. One buyer reports support during the luteal phase of PMDD. The store summaries add that some people notice changes within a few days, and that others describe calm without sedation, with enough energy left over. One reviewer felt more even-keeled and motivated after a few weeks. **What buyers complain about:** Complaints are few. One buyer gave one star, saying "I don't feel like it's working." Store summaries note that a minority saw no noticeable benefit, and one buyer on another page could not yet feel a change. Another reviewer said it helped mood and energy for a while but felt less necessary after they resumed eating meat. A buyer taking a prescription stimulant reported irritability and anger after two doses and said the combination should be avoided. That is one person's experience, and the page labels such accounts as not medical advice. One reviewer also noted that the product "doesn't come with the new name," which suggests a packaging or naming change. **Taste, smell, pill size and form:** Only one reviewer comments, calling it an "easy to swallow capsule." Nobody mentions taste or smell. The store summaries note no side effects on the Vitacost page. **Value for money:** Price comes up repeatedly in the store summaries. Many buyers call it expensive but think the quality justifies it. One says the price is a bit high but you are paying for good ingredients without harsh chemicals. Another calls the price very good for the quality and quantity. Buyers also trust the Thorne brand, and one reviewer notes "high quality ingredients." **Who it seems to suit and who it did not:** It seems to suit people looking for mood support through menopause, postpartum, premenstrual or seasonal changes, and people already on a med who want extra help. Some buyers say they prefer it to pharmaceutical options because of fewer side effects. Long-term users mention taking it for years, and some cycle off for a couple of days each week. It suited those who did not feel a change less well, and the one buyer on a prescription stimulant had a bad reaction. Several reviews are from people only a few weeks in, so longer-term results are less clear.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Vitamin C is the ingredient the panel talks about most, and most of them recommend or use it. They take it for collagen and joint support, often paired with collagen before a workout, and also for skin, immune support and inflammation. Doses mentioned run from 500 mg to 1 g up to 2 to 4 grams, though one panelist says the best dose is unclear and high amounts might blunt the benefits of exercise, and one person stopped a vitamin C skin serum because of its smell. Folate and rhodiola got less attention: a few recommend methylfolate as an active form the body can use directly, and a few use or recommend rhodiola for mood and stress. Iodine is a smaller ingredient in this product, and one panelist warns that high doses carry a risk to the thyroid.

See all 10 biohackers →Hide the biohackers
  • Ben Greenfield · Vitamin C · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Iodine · recommends · YouTube ↗
      Recommends taking sufficient iodine to ensure free T3 levels are right, which is important for the reverse calcium transport system.
    • 12 Oct 2026 · Folate · recommends · Facebook ↗
      Recommends methylfolate as an active form of folate that the body can use directly without conversion.
    • 24 Sep 2026 · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 25 Aug 2026 · neutral · X ↗
      Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
    • 15 Aug 2026 · Iodine · warns · YouTube ↗
      Warns that people can unknowingly take 20 times the amount of iodine they're supposed to because it's in different ingredient profiles.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends Vitamin C for skin repair post-tattoo.
    • 9 Jul 2026 · Folate · recommends · YouTube ↗
      Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
    • 9 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 30 Jun 2026 · Eleuthero · neutral · Facebook ↗
      Notes that eleuthero is an ingredient in MTE.
    • 23 May 2026 · Iodine · warns · YouTube ↗
      Warns that high iodine intakes can predispose people to autoimmune thyroid disease and advises caution with iodine for those with Hashimoto's or Graves' disease, suggesting seafood for sufficient intake.
    • 16 May 2026 · Rhodiola · uses · YouTube ↗
      Was already taking rhodiola, which they noted was an ingredient in the Novos product.
    • 18 Apr 2026 · Folate · recommends · YouTube ↗
      Recommends introducing methylfolate into the diet to address high homocysteine levels.
  • Siim Land · Vitamin C · recommends
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 14 Oct 2026 · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 30 Sep 2026 · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 27 Jul 2026 · neutral · X ↗
      Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
    • 27 Jul 2026 · neutral · X ↗
      States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
    • 27 Jul 2026 · recommends · YouTube ↗
      States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
    • 9 Jul 2026 · neutral · YouTube ↗
      Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
    • 4 Jul 2026 · uses · YouTube ↗
      Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
    • 12 Jun 2026 · Rhodiola · recommends · YouTube ↗
      States that Rhodiola rosea is not going to reduce fatigue if one is mentally or overall exhausted, and that there is not enough evidence yet to support claims of lowering stress and anxiety or increasing VO2 max.
    • 24 Apr 2026 · Vitamin B12 · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
    • 3 Apr 2026 · Iodine · neutral · YouTube ↗
      Mentions that the intake of certain nutrients, especially DHA and iodine, from seafood plays a powerful effect on intelligence for children and during pregnancy.
    • 24 Mar 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
  • Dr. Eric Berg · Vitamin C · neutral
    • 26 Oct 2026 · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 24 Oct 2026 · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 23 Oct 2026 · recommends · YouTube ↗
      States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
    • 21 Oct 2026 · Iodine · recommends · Podcast ↗
      Recommends applying a drop of iodine and covering the skin tag with a bandage twice a day for topical skin tag removal.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
    • 17 Oct 2026 · recommends · YouTube ↗
      Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
    • 10 Oct 2026 · Vitamin B6 · warns · Podcast ↗
      Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
    • 4 Oct 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
    • 4 Oct 2026 · Vitamin B6 · neutral · X ↗
      Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 4 Oct 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
    • 4 Oct 2026 · Vitamin B12 · neutral · X ↗
      Notes that Vitamin B12 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
    • 2 Oct 2026 · Iodine · recommends · YouTube ↗
      Recommends getting iodine from sea kelp regularly because it's packaged in a way that the body can better absorb it, is difficult to overdose on, and provides additional trace minerals, amino acids, and phytonutrients.
    • 20 Sep 2026 · recommends · Facebook ↗
      Recommends consuming foods high in vitamin C to block the effects of grains.
  • Thomas DeLauer · Vitamin C · recommends
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 4 Oct 2026 · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 18 Sep 2026 · neutral · Facebook ↗
      Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
    • 29 Aug 2026 · neutral · Instagram ↗
      States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
    • 25 Aug 2026 · recommends · YouTube ↗
      Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
    • 24 Aug 2026 · Iodine · recommends · YouTube ↗
      Recommends a small amount of iodine, explaining that it is the raw mineral from which T4 is built and is crucial for thyroid hormone production, but warns against high intake with low selenium.
    • 19 Aug 2026 · recommends · YouTube ↗
      Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
    • 8 Aug 2026 · neutral · YouTube ↗
      Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
    • 29 Jul 2026 · recommends · YouTube ↗
      Recommends using a multivitamin to ensure adequate micronutrient intake, especially when wholesome food is less available.
    • 18 Jul 2026 · Rhodiola · neutral · YouTube ↗
      Describes rhodiola as a great adaptogen primarily for pure stress mitigation, distinguishing it from salidrosides which also have mitochondrial effects.
    • 30 Jun 2026 · Vitamin B12 · neutral · YouTube ↗
      Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
  • Dave Asprey · Vitamin C · recommends
    • 24 Oct 2026 · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Folate · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 11 Oct 2026 · Rhodiola · neutral · Podcast ↗
      Dave discusses options like a med and Rhodiola rosea that support norepinephrine and dopamine, and how they compare.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 22 Aug 2026 · Rhodiola · uses · YouTube ↗
      Uses Rhodiola Rosea, an adaptogenic herb, to help keep norepinephrine at optimal levels in the prefrontal cortex, reduce cortisol, and improve mental performance under stress, noting it has somewhat similar but not as strong effects as a med.
    • 14 Aug 2026 · neutral · Podcast ↗
      Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
    • 5 Aug 2026 · Folate · recommends · Facebook ↗
      Recommends methylfolate as a better option than folic acid.
    • 25 Jul 2026 · neutral · Facebook ↗
      Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
    • 16 Jul 2026 · warns · YouTube ↗
      Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
    • 14 Jul 2026 · recommends · YouTube ↗
      Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
    • 9 Jul 2026 · warns · YouTube ↗
      Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
    • 1 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
    • 25 Jun 2026 · Eleuthero · neutral · Podcast ↗
      Dave Asprey discusses eleuthero as part of an adaptogen trio that works together for stress response and human performance.
    • 25 Jun 2026 · Eleuthero · neutral · YouTube ↗
      Mentions eleuthero (also known as ginseng) as an adaptogen in MTE that helps people respond to stress.
  • Dr. Mark Hyman · Rhodiola · recommends
    • 23 Oct 2026 · recommends · Facebook ↗
      Lists rhodiola rosea as an herb that can help lower anxiety or depression symptoms.
    • 23 Oct 2026 · 5-Hydroxytryptophan · recommends · Facebook ↗
      Lists 5-hydroxytryptophan, or 5-HTP, as a serotonin precursor that can help lower anxiety or depression symptoms.
    • 21 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 6 Oct 2026 · Vitamin C · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
    • 30 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
    • 14 Sep 2026 · Vitamin C · recommends · Facebook ↗
      Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
    • 9 Sep 2026 · Vitamin C · uses · YouTube ↗
      Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
    • 31 Aug 2026 · Folate · uses · YouTube ↗
      Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
    • 31 Aug 2026 · Vitamin B6 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
  • Dr. Rhonda Patrick · Folate · recommends
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 5 Jun 2026 · Vitamin C · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
    • 4 May 2026 · Vitamin C · uses · YouTube ↗
      Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
    • 5 Feb 2026 · Vitamin C · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · Vitamin C · neutral · Facebook ↗
      Notes that ~35% of Americans are low in vitamin C.
    • 29 Dec 2025 · Vitamin C · recommends · X ↗
      Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
    • 8 Oct 2025 · Vitamin B12 · warns · Facebook ↗
      Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
    • 9 Sep 2025 · Vitamin C · warns · YouTube ↗
      Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
    • 4 Sep 2025 · Vitamin C · neutral · Facebook ↗
      Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
    • 20 Aug 2025 · neutral · Instagram ↗
      Notes that dark leafy greens are a great source of folate.
    • 11 Aug 2025 · Vitamin C · uses · X ↗
      Currently takes the Pure Encapsulations O.N.E Multivitamin.
    • 26 Jun 2025 · Vitamin C · uses · Facebook ↗
      Rhonda's current supplement routine includes Vitamin C.
    • 8 May 2025 · Rhodiola · recommends · Facebook ↗
      Rhodiola rosea reliably boosts muscle endurance and reduces fatigue during intense exercise. Most benefits are seen around 150mg/day, with some studies testing doses as high as 800mg.
  • Andrew Huberman · Vitamin C · uses
    • 17 Jun 2026 · uses · X ↗
      Takes a multivitamin every day for longevity.
    • 2 Feb 2026 · recommends · YouTube ↗
      Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
    • 15 Dec 2025 · Vitamin B12 · neutral · YouTube ↗
      States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
    • 7 Jul 2025 · uses · YouTube ↗
      Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
    • 16 Jun 2025 · uses · YouTube ↗
      Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
    • 28 Apr 2025 · uses · YouTube ↗
      Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
    • 14 Apr 2025 · Iodine · neutral · Podcast ↗
      Mentions Iodine as an essential supplement.
    • 14 Apr 2025 · Iodine · neutral · YouTube ↗
      Notes that people are not eating iodized salt and that iodine supplementation can help with thyroid issues, which affect many people.
    • 31 Mar 2025 · Folate · recommends · YouTube ↗
      States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
    • 6 Mar 2025 · Iodine · neutral · Podcast ↗
      Explains how thyroid hormone levels are influenced by key nutrients, such as iodine, selenium, and L-tyrosine.
    • 6 Mar 2025 · Iodine · recommends · YouTube ↗
      States that iodine is absolutely key for the thyroid to produce thyroid hormone and recommends ensuring sufficient intake for healthy thyroid function.
    • 3 Feb 2025 · uses · YouTube ↗
      Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
    • 18 Nov 2024 · uses · YouTube ↗
      Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
    • 14 Oct 2024 · recommends · YouTube ↗
      Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
  • Bryan Johnson · Rhodiola · uses
    • 8 Jul 2025 · uses · YouTube ↗
      Drinks his Blueprint longevity mix with additional morning supplements, including rhodiola.
    • 5 Jun 2025 · uses · YouTube ↗
      States that Blueprint Rhodiola can be used to stabilize mood.
    • 5 Jun 2025 · Vitamin B12 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
    • 3 Feb 2025 · Vitamin C · neutral · YouTube ↗
      Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
    • 8 Jan 2025 · Vitamin C · uses · YouTube ↗
      Applies vitamin C after showering.
    • 26 Sep 2023 · Vitamin C · uses · YouTube ↗
      Takes 250 milligrams of Vitamin C.
    • Date not recorded · recommends · Website ↗
      Recommends Rhodiola Rosea during the luteal phase to help reduce stress, balance hormones, reduce PMS related fatigue, and combat water retention and bloating, and also for stress and mood management in perimenopausal and menopausal women.
    • Date not recorded · recommends · Website ↗
      Suggests rhodiola as an optional supplement to support calmness and resilience during stress, and to support the body's healthy response to stress.
    • Date not recorded · recommends · Source ↗
      During menopause, Bryan Johnson recommends adding rhodiola based on individual needs.
    • Date not recorded · Vitamin C · recommends · Website ↗
      Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
    • Date not recorded · Vitamin C · uses · Website ↗
      Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
    • Date not recorded · Vitamin C · uses · Website ↗
      He uses Vitamin C, typically in a serum, in the morning for skin health.
    • Date not recorded · Folate · recommends · Source ↗
      Recommends supplementing with folate for brain health for both the mother and the baby during pregnancy.
  • Peter Attia · Vitamin C · stopped
    • 3 Jul 2025 · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 17 Nov 2025 · Iodine · warns · Podcast ↗
      Discusses the dangers of supplementing with high levels of iodine.
    • 16 Nov 2025 · Iodine · warns · YouTube ↗
      Warns that high-dose iodine supplementation carries a risk of autoimmune thyroid disease, citing increased incidence in Japan due to higher dietary iodine intake.
    • 29 Jun 2025 · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 9 Sep 2024 · Vitamin B12 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 6 Sep 2024 · neutral · YouTube ↗
      States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
    • 19 Aug 2024 · recommends · YouTube ↗
      Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
    • 19 Aug 2024 · Folate · recommends · YouTube ↗
      Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
    • 24 Oct 2023 · Folate · uses · YouTube ↗
      Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
    • 23 Oct 2023 · Folate · uses · YouTube ↗
      Takes Jarrow methylfolate, a methylated version, once a day at the lower of two strengths, to keep homocysteine levels below nine.
    • 28 Aug 2023 · Folate · neutral · YouTube ↗
      Mentions that in a mouse model for obesity, the amount of folate given to the mother mouse during pregnancy affects the epigenetics of her offspring, leading to changes in coat color and obesity.
    • 26 Jun 2023 · Iodine · uses · YouTube ↗
      Mentions using iodine intraoperatively for infection prevention during penile prosthesis surgery.
    • 5 Jun 2023 · Folate · uses · YouTube ↗
      Personally takes methylfolate to help get homocysteine into the desired zone and prefers the Jarrow brand.
    • 7 Mar 2022 · neutral · YouTube ↗
      Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.

RAL Summary

Members OnlyTier 2 for Mood

Human studies of Vitamin C show a clear improvement in 2 meta-analyses, the largest of 91,966 people (22 of 44 human studies showed an improvement), and 90% of 1148 reviews are positive. The final check notes: The rule's reasoning rests on vitamin C meta-analyses, including one of 91,966 people, that are not in the evidence given, and the only vitamin C pooled review given found no overall mood benefit; the tier is still supported by folate, Rhodiola and the reviews.

Take 3 servings a day (6 capsules) to match the dose that worked in the studies.

Where the evidence disagrees: 88 of the 274 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Endocrine system

Combine with: For mood and emotional balance, this product pairs well with ashwagandha or rhodiola for stress resilience, omega-3 fatty acids (EPA/DHA) for brain and mood support, vitamin D if levels are low, and B-complex vitamins (methylfolate, B6, B12) for neurotransmitter synthesis. Taking glycine or additional magnesium glycinate in the evening may support relaxation and sleep. For occasional heartburn, use a product built for it instead, such as calcium carbonate or magnesium hydroxide antacids or an alginate for fast relief, or DGL licorice, zinc-carnosine, or aloe vera for longer-term mucosal support. Consult a healthcare provider if heartburn is frequent or persistent.

Possible side effects: Studies found folate side effects similar to placebo and very high-dose tyrosine raised anger in stressed soldiers. One buyer taking a prescription stimulant reported irritability and anger.

Supplement Facts

Vitamin C 250 mg · Vitamin B6 5 mg · Folate 667 mcg DFE
Supplement Facts
Serving Size Two Capsules
Servings Per Container 60
Amount Per Serving% Daily Value
Vitamin C250 mg
Vitamin B65 mg
Folate667 mcg DFE
Vitamin B12550 mcg
Pantothenic Acid130 mg
Iodine68 mcg
L-Tyrosine200 mg†
5-Hydroxytryptophan50 mg†
Eleuthero extract (root)50 mg†
Gamma-Aminobutyric Acid (GABA)††50 mg†
Rhodiola extract (root)50 mg†
† Daily Value not established.

Other ingredients: Hypromellose (derived from cellulose) capsule, Leucine, Calcium Laurate, Magnesium Citrate, Silicon Dioxide.

Directions: Take 2 capsules two times daily or as recommended by your health-care practitioner.

Label source: Reverseagelab · Report a label change

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Our articles on this subject

Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.