Thorne EnteroMend Orange Vanilla Flavored Review
Thorne Leaky Gut Support, formerly sold as EnteroMend, is presented as an optimal nutritional support powder for the gut. The product is described as helping maintain a healthy gut barrier, soothing mucus membranes, and supporting a healthy inflammatory and immune response in the GI tract. Its formula combines L-glutamine, curcumin phytosome, boswellia phytosome, aloe vera gel, and partially hydrolyzed guar gum. The page says these ingredients work together to promote overall intestinal health and bowel regularity, while also supporting healthy gut flora and normal butyrate levels for colon health. The recommended use is to mix one scoop with at least five to six ounces of water one to two times daily. The powder is described as orange vanilla flavored, easy to mix in water or a beverage, and NSF Certified for Sport. The page explains that curcumin is delivered as Meriva and boswellia as Casperome in phytosome form for enhanced absorption. Aloe is described as having soothing, tissue protective properties with no laxative effect. The fiber is Sunfiber partially hydrolyzed guar gum, described as a well-tolerated, soluble, prebiotic fiber with fewer reported GI side effects than other fiber supplements. The page lists the product as dairy free, gluten free, and soy free, and notes that it is third-party tested. Warnings include a California Proposition 65 lead notice, a contraindication for people with a history of hypersensitivity to any ingredient, advice for pregnant users to consult a health professional, and an interaction caution that curcumin may reduce the efficacy of cyclophosphamide and irinotecan.
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Study, Trial or Testing Result Summary
Members Only62 human studies · 40 improved
Curcumin, taken as a phytosome at 500 mg a day, matches the studied dose. In 79 adults with digestive complaints, 500 mg daily for 8 weeks reduced digestive symptoms more than placebo [1]. A curcumin and frankincense phytosome eased bloating and belly pain over 30 days [2]. But a pooled analysis of 326 people found no clear benefit [3], and healthy adults saw no change in bloating or gas [4]. The frankincense extract helped mild irritable bowel symptoms in two small studies without placebo, at an unclear dose here [5][6]. The guar gum fiber, at 2 grams a day, is below the 5 grams studied, where it eased pain, bloating and bowel habits [7][8]. Glutamine, at 5 grams a day, is well below the 15 grams that cut irritable bowel symptoms in trials [9][10]. Aloe vera showed no clear benefit over placebo in the largest review [11]. Animal and cell studies are never counted.
See all 62 studies →Hide the studies
- Pooling 60 studies of plant-based treatments for irritable bowel syndrome (6329 patients), the 3 aloe vera studies showed no clear symptom benefit over placebo, while peppermint oil and Chinese herbal medicine did help.Systematic Review and Meta-Analysis: Plant-Based Therapy for Irritable Bowel Syndrome.
- In a pooled analysis of 23 trials with 1919 patients having pelvic radiotherapy, glutamine did not reduce acute bowel side effects, though probiotics, synbiotics and polyphenols did.The role of dietary supplements, including biotics, glutamine, polyunsaturated fatty acids and polyphenols, in reducing …
- Pooling three trials of 326 people with irritable bowel syndrome, curcumin lowered symptom severity a little more than comparison, but the difference was not statistically significant.A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome (IBS).
- In a review of 33 placebo-controlled trials of Western herbal medicines for irritable bowel syndrome, pooled results found aloe vera reduced overall symptoms, though the evidence was limited.Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis.
- Across 21 studies of 1478 people with digestive diseases, four of seven irritable bowel studies showed benefit from curcumin or turmeric, though more controlled trials are needed.A Systematic Review of the Clinical Use of Curcumin for the Management of Gastrointestinal Diseases.
- An umbrella review of 58 meta-analyses found aloe vera improved irritable bowel symptoms, but the effects were small and the certainty of evidence was low to very low.Nutritional Interventions in Adult Patients With Irritable Bowel Syndrome: An Umbrella Review of Systematic Reviews and …
- A review of 26 studies found turmeric appeared safe with possible benefit in irritable bowel syndrome and inflammatory bowel disease, but most studies had high risk of bias so efficacy remains unclear.A systematic review of the efficacy and safety of turmeric in the treatment of digestive disorders.
- In 225 children with abdominal Henoch-Schönlein purpura, alanyl-glutamine nutritional support reduced a med use and weight loss but did not change hospital stay or recurrence of digestive symptoms.[Clinical effect of alanyl-glutamine-enriched nutritional support in the treatment of children with abdominal Henoch-Sch…
- In a combined analysis of two trials with 213 people with irritable bowel syndrome, 4 weeks of aloe extract eased symptoms in those with diarrhoea-type (58% responded vs 30% on control) but not in other types.Aloe barbadensis Mill. extract improves symptoms in IBS patients with diarrhoea: post hoc analysis of two randomized dou…
- In a pilot study of 207 randomized adults without a placebo group, about two thirds of participants reported better irritable bowel syndrome symptoms after 8 weeks of turmeric extract, with no significant difference between the one- and two-tablet groups.Turmeric extract may improve irritable bowel syndrome symptomology in otherwise healthy adults: a pilot study.
- In 190 stroke patients with lung infection, tube feeding with probiotics, glutamine and fish oil over up to 21 days reduced abdominal pain, bloating and diarrhoea and improved feeding tolerance versus standard feeding.Enteral ecoimmunonutrition reduced enteral permeability and serum ghrelin activity in severe cerebral stroke patients wi…
- In 188 adults with irritable bowel syndrome, 5 g a day of partially hydrolyzed guar gum improved pain and bowel habits about as well as 30 g of wheat bran, but was better tolerated and preferred, with a higher success rate in the intention-to-treat analysis (60% vs 40%).High-fiber diet supplementation in patients with irritable bowel syndrome (IBS): a multicenter, randomized, open trial c…
- In 160 people with irritable bowel syndrome, 4 weeks of aloe extract reduced symptoms but no more than the control (inulin); 39% responded on aloe vs 45% on control.Randomized clinical trial: Effects of Aloe barbadensis Mill. extract on symptoms, fecal microbiota and fecal metabolite …
- In 121 people with mild-to-moderate irritable bowel syndrome, curcumin with fennel oil for 30 days cut symptom scores about 50% versus 26% on placebo, and 25.9% became symptom-free versus 6.8%.Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome.
- In 110 people with irritable bowel syndrome (only 47 finished both treatment periods), aloe vera taken at 60 ml twice daily did not improve quality of life more than placebo.A Randomised, Cross-Over, Placebo-Controlled Study of Aloe vera in Patients with Irritable Bowel Syndrome: Effects on Pa…
- In 108 adults with irritable bowel syndrome, 6 g a day of partially hydrolyzed guar gum for 12 weeks reduced bloating and gas scores more than placebo, though other symptoms did not change.Randomized clinical study: Partially hydrolyzed guar gum (PHGG) versus placebo in the treatment of patients with irritab…
- In 106 adults with diarrhoea-type irritable bowel syndrome after an infection, 15 grams of glutamine a day for 8 weeks cut symptom scores by 50 points or more in 79.6% versus 5.8% on placebo, with fewer bowel movements and firmer stools.Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome.
- In 104 people with diarrhea-predominant irritable bowel syndrome, a Chinese herbal capsule outperformed a glutamine compound capsule over 3 weeks, but glutamine was only the comparator and was not tested against placebo.[Effects of Changjishu soft elastic capsule in treatment of diarrhea-predominant irritable bowel patients with liver-qi …
- In 100 patients on tube feeding, adding 20 g of soluble fiber per liter reduced diarrhea (6 vs 15 cases) but increased flatulence.Reduction in diarrhea incidence by soluble fiber in patients receiving total or supplemental enteral nutrition.
- In 79 people with acid reflux, 10 ml daily of aloe vera syrup for 4 weeks reduced the frequency of all assessed symptoms including flatulence and belching, compared against a med and ranitidine.Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive…
- In 79 adults with digestive complaints, 500 mg daily of curcumin extract for 8 weeks reduced digestive symptom scores and anxiety more than placebo, with no change in gut bacteria.Efficacy of a curcumin extract (Curcugen™) on gastrointestinal symptoms and intestinal microbiota in adults with self-re…
- In 69 otherwise healthy people with mild irritable bowel syndrome, one Casperome tablet daily for 6 months gave lower scores for almost all symptoms, less need for rescue medication and fewer side effects than standard care, and lowered oxidative stress.Oral administration of a lecithin-based delivery form of boswellic acids (Casperome®) for the prevention of symptoms of …
- In 68 adults with irritable bowel syndrome, 4 weeks of aloe extract led to 55% responders vs 31% on placebo, but the difference was not statistically significant and the main goal was not met.A Pilot Study of the Effect of Aloe barbadensis Mill. Extract (AVH200®) in Patients with Irritable Bowel Syndrome: a Ran…
- In 67 people with irritable bowel syndrome and small bowel dysbiosis, curcumin and boswellia phytosome plus a low-FODMAP diet for 30 days reduced bloating and abdominal pain more than the diet alone.Beneficial Effects on Abdominal Bloating with an Innovative Food-Grade Formulation of Curcuma longa and Boswellia serrat…
- In 61 constipated children, four weeks of partially hydrolyzed guar gum improved stool frequency, stool consistency and abdominal pain, working about as well as lactulose with fewer complaints of flatulence.Can partially hydrolyzed guar gum be an alternative to lactulose in treatment of childhood constipation?
- In 60 children and adults with cryptosporidium infection, all of whom received a glutamine-based rehydration drink for 2 weeks, adding paromomycin to mirazid improved symptoms more than either drug alone, but the glutamine drink was not tested separately.Mirazid alone or combined with Paromomycin in treating cryptosporidiosis parvum in immunocompetent hospitalized patients…
- In 60 constipated women, 15 g a day of an inulin and partially hydrolyzed guar gum mix for 3 weeks improved bowel movements no more than placebo, though it lowered Clostridium bacteria.Microbiota benefits after inulin and partially hydrolized guar gum supplementation: a randomized clinical trial in const…
- In 60 children with functional abdominal pain or irritable bowel syndrome, 5 g a day of partially hydrolyzed guar gum for 4 weeks reduced symptoms in 43% versus 5% with placebo and improved bowel habits more.Partially hydrolyzed guar gum in pediatric functional abdominal pain.
- In 60 healthy adults taking 1000 mg of a turmeric extract daily for 5 weeks, bloating, cramping, gas and stool habits did not differ from placebo, and the extract was well tolerated.Safety assessment and gastrointestinal tolerance of a novel highly bioavailable turmeric extract formulation: A randomis…
- In 58 hospital patients with irritable bowel syndrome, a month of aloe vera helped 35% (11 of 31) versus 22% (6 of 27) on placebo, a difference that was not statistically significant, though people with diarrhoea-predominant symptoms showed a possible trend.Randomised double-blind placebo-controlled trial of aloe vera for irritable bowel syndrome.
- In 50 adults with irritable bowel syndrome on a low FODMAP diet, 15 grams of glutamine a day for 6 weeks improved symptoms by more than 45% in 88% versus 60% with placebo.Glutamine Supplementation Enhances the Effects of a Low FODMAP Diet in Irritable Bowel Syndrome Management.
- In 50 people with constipation-type irritable bowel syndrome, two daily jelly drinks with curcumin, inulin and vitamin B6 for 2 weeks improved stool frequency, stool consistency, abdominal pain, bloating and quality of life, while the control group improved only in pain and bloating.[Dry jelly concentrate with vitamins and dietary fiber in patients with IBS with constipation: a comparative controlled …
- In 49 adults with irritable bowel syndrome and small bowel bacterial imbalance, 30 days of a curcumin and boswellia phytosome plus a low-FODMAP diet reduced bloating and abdominal pain more than diet plus placebo.Positive Outcomes of Supplementation with Lecithin-Based Delivery Formulation of Curcuma longa and Boswellia serrata in …
- In 47 people with irritable bowel syndrome, a blend of partially hydrolyzed guar gum, probiotics and fruit extracts for 2 months improved quality of life and some inflammation markers, but fiber's own effect could not be separated.Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers i…
- In 46 patients with acute radiation bowel inflammation, a nutrition mix with probiotics, fish oil and glutamine for 14 days gave better tolerance, with less abdominal pain, bloating and diarrhoea than controls.The impact of microbial immune enteral nutrition on the patients with acute radiation enteritis in bowel function and im…
- In 44 healthy adults with loose stools, 3 months of partially hydrolyzed guar gum normalized stool form compared with placebo, without changing stool frequency, and increased Bifidobacterium.Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomize…
- In 40 adults, a hydration drink with alanine and glutamine taken for 4 weeks was well tolerated at one to three packets a day, with only mild bloating and cramping changes noted.Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverag…
- In 32 people with diarrhoea-type irritable bowel syndrome, a herbal mix including turmeric taken twice daily for 4 weeks did not improve symptoms more than placebo.Efficacy and safety of Ayurvedic herbs in diarrhoea-predominant irritable bowel syndrome: A randomised controlled crosso…
- In 31 women with severe obesity, 1500 mg of curcumin daily for 13 weeks reduced overall gastrointestinal symptom scores more than placebo, with improvements in belching and constipation.Curcumin Supplementation Improves Gastrointestinal Symptoms in Women with Severe Obesity: A Double-Blind, Randomized, Pl…
- In 19 healthy young adults, a litre of drink with alanyl-glutamine and electrolytes led to less reported stomach bloating than plain water in a single-session crossover test.The Beverage Hydration Index: Influence of Electrolytes, Carbohydrate and Protein.
- In 14 healthy men, a single high dose of L-glutamine caused more stomach and digestive discomfort, nausea and belching over 24 hours than lower doses, though most symptoms were mild and the drink was generally well tolerated.Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilo…
- In 71 otherwise healthy people with mild irritable bowel syndrome, 4 weeks of Casperome improved abdominal pain, bowel habits, gas and cramps like the two drug treatments did, and only the Casperome group needed less medical attention, with fewer side effects.Supplementation with a lecithin-based delivery form of Boswellia serrata extract (Casperome®) controls symptoms of mild …
- In hemodialysis patients given the fiber alone or with a probiotic for four weeks, the combination improved stool form and bloating and raised Bifidobacterium, while the fiber alone mainly raised butyric acid; the abstract does not show a clear benefit of the fiber alone on stool or bloating.Synbiotics Improved Stool Form via Changes in the Microbiota and Short-Chain Fatty Acids in Hemodialysis Patients.
- In an open pilot study of 211 adults with irritable bowel syndrome, two months of a turmeric and fennel oil product reduced symptom severity and improved quality of life across all subtypes, though without a control group.Efficacy of bio-optimized extracts of turmeric and essential fennel oil on the quality of life in patients with irritabl…
- In 139 adults with knee osteoarthritis, 500 mg of curcumin three times daily for 28 days reduced episodes of flatulence more than diclofenac at day 7, while pain relief was similar between the two groups.Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study.
- In 86 adults with irritable bowel syndrome, 12 weeks of partially hydrolyzed guar gum at either 5 or 10 grams daily improved gut symptoms, quality of life and psychological distress, though some benefit faded after stopping.Treatment effects of partially hydrolyzed guar gum on symptoms and quality of life of patients with irritable bowel synd…
- In 49 adults with chronic constipation, 4 weeks of partially hydrolyzed guar gum (dose stated as 5 mg daily in the abstract) sped up colon transit, increased spontaneous bowel movements, reduced straining and laxative use, and improved stool form. The study had no placebo group.Partially hydrolyzed guar gum accelerates colonic transit time and improves symptoms in adults with chronic constipation…
- In 43 adults with digestive disorders, a herbal and nutrient gut formula containing glutamine, taken up to 10 g per day for 4 weeks after a control phase, improved upper and lower gut symptoms by 60% to 80% over 16 weeks in an uncontrolled before-and-after study.Herbal formula improves upper and lower gastrointestinal symptoms and gut health in Australian adults with digestive dis…
- In 20 cancer patients after bowel surgery, a feed containing glutamine dipeptides at 500 ml per day for 3 days was well tolerated with no product-related adverse events, and plasma glutamine rose; bowel symptoms were not shown to improve.Early enteral gut feeding with conditionally indispensable pharmaconutrients is metabolically safe and is well tolerated…
- In 14 patients after upper gut surgery, 30 g per day of glutamine dipeptides with antioxidants for 5 days was well tolerated, with only minor nausea, hiccups, or gas in 3 of 14; the study did not measure improvement in bowel symptoms.Safety and intestinal tolerance of high-dose enteral antioxidants and glutamine peptides after upper gastrointestinal su…
- In eight adults with HIV-associated diarrhea taking an average of 1,862 mg curcumin daily, all had diarrhea resolve within about two weeks, bowel movements fell from 7 to 1.7 per day, and most had less bloating and abdominal pain.Treatment of HIV-associated diarrhea with curcumin.
- Over 90 days of partially hydrolyzed guar gum, people with a diverse baseline gut microbiota had better irritable bowel symptom scores, quality of life and tolerance than those with low diversity.Role of Baseline Gut Microbiota on Response to Fiber Intervention in Individuals with Irritable Bowel Syndrome.
- In a 30-day single-group study of people with symptomatic diverticular disease, 500 mg of a curcumin and boswellia phytosome taken twice daily significantly reduced abdominal pain, with benefit seen by day 10.Symptomatic uncomplicated diverticular disease management: an innovative food-grade formulation of Curcuma longa and Bos…
- In a real-world study of 146 adults with irritable bowel syndrome, taking two tablets daily of a berberine and curcumin supplement (49 mg curcumin per tablet) for 2 months was followed by large drops in symptom severity, bloating, abdominal discomfort and stool frequency, and most patients reported improvement.The Possible Synergistic Pharmacological Effect of an Oral Berberine (BBR) and Curcumin (CUR) Complementary Therapy Alle…
- In 134 outpatients with irritable bowel syndrome, 5 grams per day of partially hydrolyzed guar gum for 24 weeks increased bowel movement frequency and reduced flatulence, with flatulence falling by about 56 percent after 3 weeks.[Partially hydrolyzed guar gum: a fiber as coadjuvant in the irritable colon syndrome].
- In 78 patients with severe acute pancreatitis, adding glutamine to standard treatment led to faster relief of bloating and abdominal pain and faster return of bowel function, along with lower inflammatory markers.Ulinastatin combined with glutamine improves liver function and inflammatory response in patients with severe acute panc…
- In 68 people with constipation-predominant irritable bowel syndrome, 4 weeks of partially hydrolyzed guar gum improved symptom scores, stool form and laxative use, with the bloating benefit varying by sex, age and body weight.Partially hydrolyzed guar gum in the treatment of irritable bowel syndrome with constipation: effects of gender, age, an…
- In a retrospective real-world group of 25 people with active Crohn's disease, a curcumin and QingDai combination taken for about 8 to 12 weeks produced clinical response in 76% and lowered fecal calprotectin, a gut inflammation marker; the study had no control group.Curcumin-QingDai combination for patients with active Crohn's disease: a retrospective, real-world multicenter cohort st…
- In 45 people with peptic ulcer symptoms, 3,000 mg per day of turmeric powder capsules for up to 12 weeks led to ulcer healing in a large share of patients, with abdominal pain easing within two weeks and no blood or liver changes; there was no control group.Phase II clinical trial on effect of the long turmeric (Curcuma longa Linn) on healing of peptic ulcer.
- In a small 30-day study of 44 adults with irritable bowel symptoms, 500 mg of a lecithin-based turmeric extract taken twice daily, together with a low-FODMAP diet, reduced bloating and abdominal pain in both the post-COVID and comparison groups, without a placebo group.Positive Effect of Lecithin-Based Delivery Form of Curcuma and Boswellia Extracts on Irritable Bowel Syndrome After COVI…
- In colon tissue samples taken from 12 people with diarrhea-predominant irritable bowel syndrome and incubated in the lab, higher glutamine concentrations increased the gut-lining protein claudin-1 compared with low glutamine.Glutamine Restores Tight Junction Protein Claudin-1 Expression in Colonic Mucosa of Patients With Diarrhea-Predominant I…
- Over six months, adding partially hydrolyzed guar gum to usual drug therapy in people with irritable bowel syndrome normalized stool form on the Bristol scale and shifted gut bacteria toward short-chain fatty acid producers.Changes in intestinal microbiota and biochemical parameters in patients with inflammatory bowel disease and irritable bo…
Review Totals and Summary
Members Only95 reviews · 84% positive
Thorne EnteroMend powder gets a mostly positive response, with about 95 ratings across the stores and most reviewers giving 4 or 5 stars. Buyers mainly credit it with calmer, more regular digestion, though a few report poor mixing, a delivery problem and one case of worse migraines. **What buyers say it did for them:** The strongest theme is gut relief. Several people describe a calmer, more settled gut, and some say they noticed it quickly. One says it "soothes the symptoms immediately" during diverticulosis flare-ups. Another says "Made a difference within the first week!" A parent describes a son's stool thickening and becoming regular within two weeks after bowel surgery. One reviewer says "Essentially all my GI troubles are gone" and that nothing else worked as well after years of fiber supplements. Another reports less bloating and being able to eat foods that used to cause stomach upset. One person says they have taken it for a year and it still helps. **What they complain about:** Complaints are few. One buyer gave three stars, said "I haven't seen any results yet," and found it "mixes very poorly." One reported "the intensity of my migraines increased on this powder." Another gave one star over delivery, not the product: a monthly shipment was split and this item never arrived, though they still called the product great. One store's summary says no written complaints about side effects appear in its visible reviews, though a small number of one- and two-star ratings exist. **Taste, smell and form:** Taste is generally liked. One reviewer says "Taste is very pleasing," and the store summary adds that people call it great-tasting. One buyer blends it into a smoothie with plain kefir and finds it "tasty and awesome," and adds fruit, juice or chia seeds. Mixing is where opinions split: one store's page describes it as mixing easily, while the three-star reviewer found it poor. Reviews of other forms of the product were left out; this summary covers the powder only. **Value for money:** Value is mentioned only lightly. One reviewer says "Well worth spending some effort and money," seeing it as worthwhile for healing and maintaining gut health. Nobody calls it overpriced in the reviews here. **Who it seems to suit and who it did not:** It seems to suit people with ongoing digestive trouble, such as diverticulosis flare-ups, bloating, irregular stools, or recovery after gut surgery. It also suits people who had only mild, irritating gut problems and wanted daily maintenance. One reviewer says a doctor prescribed it and it "helped me so very much." Others call it part of their daily routine. It did not suit the buyer who saw no results, and the person whose migraines worsened. Anyone relying on subscription delivery may want to watch for split or missing shipments. Results seem to come within days to a couple of weeks for many, but not everyone notices a benefit.
Biohacker Summary
Members Only10 of 10 recommend it
Curcumin is the main ingredient, and nine of the ten panelists spoke about it, with about half recommending or using it and the rest staying neutral or cautious. They take it mainly for lowering inflammation and for joint comfort, and some also mention brain health, mood, and blood sugar. Two of them prefer well-absorbed forms, one pointing to a phytosomal form and one to a nanoparticle form, and another says it barely absorbs without black pepper; one pairs it with high-dose omega-3, and one takes it before a late dinner to avoid overeating. Two of them urge caution: one does not suggest high-dose curcumin for general use and says to use it only for specific purposes with a doctor's guidance, and another advises avoiding it during pregnancy, while two stress that it cannot replace sleep, food, exercise, and stress care or stand in for other treatments. Glutamine is a smaller ingredient in this product, and several panelists take it for gut repair, immune support, or cutting sugar cravings.
See all 10 biohackers →Hide the biohackers
Dave Asprey · Curcumin · uses
- Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
- Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
- Asks what happens if you put glutamine in the skin, suggesting that manipulating amino acids in the skin and elsewhere is a fertile ground for more research.
- Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
- Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
- Dave Asprey mentions that supplements like curcumin support pain relief and mood.
- Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
- Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
- Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
- Recommends L-glutamine to support the gut barrier.
- Recommends aloe vera juice or liquids to strengthen the entire digestive tract.
- Mentions that curcumin also has anti-parasitic properties and is useful.
- Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
- Gave his yoga teacher glutamine to help with brain fog and autoimmune issues, which helped his energy return.
Dr. Eric Berg · Curcumin · neutral
- Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
- Notes that Curcumin barely absorbs without black pepper.
- Recommends taking glutamine or consuming foods high in glutamine to block the effects of grains.
- Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
- Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
- States that glutamine is an important amino acid for colon cells and is essential for intestinal permeability, greatly supporting the gut and benefiting inflammatory conditions.
- Lists curcumin as an epigenetic factor that may help with cancer prevention.
- Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
- States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
- Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
- States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
- Recommends increasing curcumin for best kidney health.
- Notes that glutamine is an amino acid that promotes gut healing.
- Mentions that carnivore can help increase glutamine, which is a healing amino acid for the gut.
Thomas DeLauer · Curcumin · recommends
- Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
- States that glutamine is the primary fuel source for intestinal cells, and its availability is crucial for the integrity of the gut barrier.
- Recommends supplementing with glutamine for a calming effect, especially when experiencing high stress, injury, illness, or increased training volume, as it acts as a precursor to GABA and helps the body produce more of it.
- Loads up on extra glutamine during muscle building phases.
- Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
- Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
- Recommends glutamine as one of the things that support the gut lining.
- Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
- Is familiar with glutamine being important for maintaining gut barrier function, though he has not done specific research on it in his lab.
- Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
- Recommends Glutamine as a great tool for gut cells when stressed or overworked, but advises not to take it every day.
- Mentions that glutamine is a main source of fuel for the gut and is also important for muscles, and a lack of it can lead to leaky gut during intense exercise.
- States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
- Recommends taking 5 to 10 grams of glutamine daily, stating that it directly feeds the cells lining the gut, thereby improving gut permeability and protecting the gut mucosal layer.
Siim Land · Curcumin · recommends
- Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Curcumin as one of 15 supplements backed by human studies.
- Thinks curcumin has some of the strongest evidence and is worth considering.
- Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
- Mentions that glutamine is one of the main precursors needed for glutathione.
- States that curcumin, unless contaminated, is not going to raise liver enzymes.
- Did not see a big extension from curcumin in their tests.
- Mentions that it is infeasible to obtain sufficient curcumin from food.
- Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
- States that glutamine is a good gut supplement that helps heal the gut lining, recommending it periodically for gut healing purposes.
- Mentions aloe vera as a natural agent with an SPF of 7, which can be used as a complementary ingredient in sunscreens but is insufficient as a primary sunscreen.
- Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
- Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
- Recommends supplementing glutamine to address intestinal inflammation and permeability, as it maintains tight junctions and intestinal permeability, with a meta-analysis showing 30 grams a day for less than two weeks reduced intestinal permeability.
Dr. Mark Hyman · Curcumin · recommends
- States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
- Mentions glutamine as something that might be helpful for gut repair.
- Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
- Recommends curcumin as an anti-inflammatory supplement that can be helpful.
- Recommends L-glutamine to help with gut barrier repair and healing leaky gut.
- States that curcumin helps to lower broader inflammatory levels in the body.
- Recommends glutamine to help repair the gut lining.
- Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
- Recommends glutamine for targeted support in healing the gut and recalibrating the immune system.
- Lists curcumin as a phytochemical that helps mitochondrial function.
- Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
- Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
- Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
- Recommends glutamine, an amino acid, for its ability to help soothe the gut lining.
Dr. Rhonda Patrick · Curcumin · neutral
- Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
- Asks if curcumin can slow aging.
- Supplements with glutamine.
- Always packs Glutamine when traveling, taking a baseline of 5 g/day and increasing to 15-20 g/day when sleep-deprived or exposed to illness, as it is an important fuel source for immune function.
- Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
- Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
- Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
- Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
- Warns that Glutamine has stimulating properties that increase arousal, interfering with sleep onset, and should be avoided too close to bedtime.
- Warns against taking glutamine at night for sleep because it is activating and can cause insomnia, citing examples of athletes who experienced this.
- Uses 5 grams of L-Glutamine to support gut-immune axis integrity and may reduce infection risk during travel.
- Says L-Glutamine has been added to their supplement stack recently, convinced by Dr. Rhonda Patrick on its benefits.
- Rhonda's current supplement routine includes Glutamine.
- Rhonda's regimen includes ~5.6g/day of L-glutamine with her morning coffee, upping it to 20g if she feels illness coming on.
Ben Greenfield · Curcumin · neutral
- Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
- States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
- Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
- Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
- Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
- Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
- Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
- Mentions curcumin as a polyphenol that can confer benefits when consumed.
- Mentions glutamine as a supplement that provides glucose to the brain, supporting neurotransmitter functions, as suggested by a guest.
- Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
- Recommends taking about five grams of L-glutamine with each meal for around four to eight weeks to help heal a leaky gut.
- Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
- Recommends taking about 5 grams of glutamine powder with each meal as a simple way to reduce IBS issues.
- Recommends topical aloe vera for hair growth, noting that dermarolling can enhance its absorption.
Andrew Huberman · Curcumin · neutral
- Discusses curcumin as a supplement for prenatal care and sperm health.
- Supplementing with L-glutamine may reduce sugar cravings, and anecdotally, it works.
- Discusses glutamine supplementation in relation to leaky gut and sugar cravings.
- Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
- Takes L-glutamine daily at 5g, increasing to 15-20g in 5g increments when her son is sick, she is exposed, during season, or when traveling, because she believes it helps her not get sick.
- He highlights specific nutrients, including glutamine, and discusses their recommended doses and dietary sources for offsetting sugar cravings.
- Recounts an anecdote about taking a teaspoon of L-glutamine in half-and-half twice a day, which he believes helped him wean off sugar, though he acknowledges it could be a placebo effect.
- Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
- Mentions that some people find ingesting a teaspoon of L-glutamine a few times a day helps with sugar cravings, noting that this method has anecdotal data but has not been peer-reviewed.
- Includes curcumin in his diet because it has been shown to stimulate GLP-1.
- Discusses L-glutamine supplementation for leaky gut, noting it is controversial with no randomized controlled trials, but some people swear by it, possibly due to increasing L cells.
- Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
- Mentions curcumin in the context of 5-alpha reductase.
- States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
Peter Attia · Curcumin · uses
- Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
- Says that patients can use an aloe vera plant if they have it for skin reactions from radiation.
- Notes that glutamine has been shown to increase the survival rate in ICU patients.
- States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
- Recommends glutamine as a nutrient the body needs to heal the gut.
- Warns that glutamine is essential for the immune system and gut health, so blocking it with drugs for cancer treatment must be done strategically to avoid compromising these systems. He also notes that tumor cells use glutamine as fuel, so it's a double-edged sword.
- Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
- Would make a smoothie with whey protein isolate, glutamine, glucosamine, and flaxseed oil for recovery after his run.
- Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
- Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
Bryan Johnson · Curcumin · warns
- Advises avoiding Curcumin during pregnancy.
RAL Summary
Members OnlyTier 3 for Digestion and Bloating
Tier 3 rests on 105 reviews, 81 percent positive, with some study support from curcumin at a full dose, where most trials helped bowel symptoms [1] but pooled results were not clearly significant [3].
Take 3 servings a day to match the dose that worked in the studies.
Where the evidence disagrees: 16 of the 62 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system
Combine with: For gut lining support, EnteroMend pairs well with a quality multi-strain probiotic (Lactobacillus and Bifidobacterium) and a prebiotic fiber such as partially hydrolyzed guar gum to feed beneficial bacteria. Zinc carnosine, aloe vera or DGL licorice can further soothe the mucosa, and omega-3 fish oil and vitamin D support a balanced inflammatory response. If the real goal is dental health, choose separate products: calcium with vitamin D3 and K2 for tooth and bone mineralization, magnesium, CoQ10 for gum tissue, and an oral probiotic such as Streptococcus salivarius K12 or a nano-hydroxyapatite toothpaste.
Possible side effects: High single doses of glutamine caused mild stomach discomfort, nausea and belching, and guar gum fiber increased gas in tube-fed patients. One reviewer reported worse migraines and another found it mixed poorly.
Supplement Facts
L-Glutamine 2.5 g · Sunfiber 1 g · Aloe vera, Dehydrate, Powder 250 mg
| L-Glutamine | 2.5 g | † |
| Sunfiber | 1 g | † |
| Aloe vera, Dehydrate, Powder | 250 mg | † |
| Meriva | 250 mg | † |
| Casperome | 250 mg | † |
Other ingredients: Flavors, Citric Acid, Rebaudioside A.
Directions: Suggested use: Mix 1 scoop with at least 5-6 ounces of water one to two times daily or as recommended by your health-care practitioner.
Barcode (UPC) 693749006251 · Label source: NIH label database · Report a label change
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- Best Probiotic for Bloating: The Strains With Human Trials, and How to Choose OneArticle · Oct 27, 2026
Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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