Thorne EnteroMend Orange Vanilla Flavored Review

Thorne Leaky Gut Support, formerly sold as EnteroMend, is presented as an optimal nutritional support powder for the gut. The product is described as helping maintain a healthy gut barrier, soothing mucus membranes, and supporting a healthy inflammatory and immune response in the GI tract. Its formula combines L-glutamine, curcumin phytosome, boswellia phytosome, aloe vera gel, and partially hydrolyzed guar gum. The page says these ingredients work together to promote overall intestinal health and bowel regularity, while also supporting healthy gut flora and normal butyrate levels for colon health. The recommended use is to mix one scoop with at least five to six ounces of water one to two times daily. The powder is described as orange vanilla flavored, easy to mix in water or a beverage, and NSF Certified for Sport. The page explains that curcumin is delivered as Meriva and boswellia as Casperome in phytosome form for enhanced absorption. Aloe is described as having soothing, tissue protective properties with no laxative effect. The fiber is Sunfiber partially hydrolyzed guar gum, described as a well-tolerated, soluble, prebiotic fiber with fewer reported GI side effects than other fiber supplements. The page lists the product as dairy free, gluten free, and soy free, and notes that it is third-party tested. Warnings include a California Proposition 65 lead notice, a contraindication for people with a history of hypersensitivity to any ingredient, advice for pregnant users to consult a health professional, and an interaction caution that curcumin may reduce the efficacy of cyclophosphamide and irinotecan.

Product Focus: Digestion and Bloating
Tier ⓘ
Tier 3 · Rank 12
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 12 within Tier 3 for Digestion and Bloating; 26 of 43 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
70 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
84% of 95
Biohacker Mentions
10 of 10
Cost per month
$150 at 3 servings

Study, Trial or Testing Result Summary

Members Only62 human studies · 40 improved
62 human studies40 improved16 no effect14,220 people studied

Curcumin, taken as a phytosome at 500 mg a day, matches the studied dose. In 79 adults with digestive complaints, 500 mg daily for 8 weeks reduced digestive symptoms more than placebo [1]. A curcumin and frankincense phytosome eased bloating and belly pain over 30 days [2]. But a pooled analysis of 326 people found no clear benefit [3], and healthy adults saw no change in bloating or gas [4]. The frankincense extract helped mild irritable bowel symptoms in two small studies without placebo, at an unclear dose here [5][6]. The guar gum fiber, at 2 grams a day, is below the 5 grams studied, where it eased pain, bloating and bowel habits [7][8]. Glutamine, at 5 grams a day, is well below the 15 grams that cut irritable bowel symptoms in trials [9][10]. Aloe vera showed no clear benefit over placebo in the largest review [11]. Animal and cell studies are never counted.

See all 62 studies →Hide the studies

Review Totals and Summary

Members Only95 reviews · 84% positive
95 reviews · Thorne 58 · Walmart 37
84% positive5% neutral11% negative

Thorne EnteroMend powder gets a mostly positive response, with about 95 ratings across the stores and most reviewers giving 4 or 5 stars. Buyers mainly credit it with calmer, more regular digestion, though a few report poor mixing, a delivery problem and one case of worse migraines. **What buyers say it did for them:** The strongest theme is gut relief. Several people describe a calmer, more settled gut, and some say they noticed it quickly. One says it "soothes the symptoms immediately" during diverticulosis flare-ups. Another says "Made a difference within the first week!" A parent describes a son's stool thickening and becoming regular within two weeks after bowel surgery. One reviewer says "Essentially all my GI troubles are gone" and that nothing else worked as well after years of fiber supplements. Another reports less bloating and being able to eat foods that used to cause stomach upset. One person says they have taken it for a year and it still helps. **What they complain about:** Complaints are few. One buyer gave three stars, said "I haven't seen any results yet," and found it "mixes very poorly." One reported "the intensity of my migraines increased on this powder." Another gave one star over delivery, not the product: a monthly shipment was split and this item never arrived, though they still called the product great. One store's summary says no written complaints about side effects appear in its visible reviews, though a small number of one- and two-star ratings exist. **Taste, smell and form:** Taste is generally liked. One reviewer says "Taste is very pleasing," and the store summary adds that people call it great-tasting. One buyer blends it into a smoothie with plain kefir and finds it "tasty and awesome," and adds fruit, juice or chia seeds. Mixing is where opinions split: one store's page describes it as mixing easily, while the three-star reviewer found it poor. Reviews of other forms of the product were left out; this summary covers the powder only. **Value for money:** Value is mentioned only lightly. One reviewer says "Well worth spending some effort and money," seeing it as worthwhile for healing and maintaining gut health. Nobody calls it overpriced in the reviews here. **Who it seems to suit and who it did not:** It seems to suit people with ongoing digestive trouble, such as diverticulosis flare-ups, bloating, irregular stools, or recovery after gut surgery. It also suits people who had only mild, irritating gut problems and wanted daily maintenance. One reviewer says a doctor prescribed it and it "helped me so very much." Others call it part of their daily routine. It did not suit the buyer who saw no results, and the person whose migraines worsened. Anyone relying on subscription delivery may want to watch for split or missing shipments. Results seem to come within days to a couple of weeks for many, but not everyone notices a benefit.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Curcumin is the main ingredient, and nine of the ten panelists spoke about it, with about half recommending or using it and the rest staying neutral or cautious. They take it mainly for lowering inflammation and for joint comfort, and some also mention brain health, mood, and blood sugar. Two of them prefer well-absorbed forms, one pointing to a phytosomal form and one to a nanoparticle form, and another says it barely absorbs without black pepper; one pairs it with high-dose omega-3, and one takes it before a late dinner to avoid overeating. Two of them urge caution: one does not suggest high-dose curcumin for general use and says to use it only for specific purposes with a doctor's guidance, and another advises avoiding it during pregnancy, while two stress that it cannot replace sleep, food, exercise, and stress care or stand in for other treatments. Glutamine is a smaller ingredient in this product, and several panelists take it for gut repair, immune support, or cutting sugar cravings.

See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Curcumin · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
    • 16 Jul 2026 · Glutamine · recommends · YouTube ↗
      Asks what happens if you put glutamine in the skin, suggesting that manipulating amino acids in the skin and elsewhere is a fertile ground for more research.
    • 4 Jun 2026 · recommends · YouTube ↗
      Recommends CurcuLite, a curcumin product, for turning up AMPK, which is foundational to energy, longevity, and detox.
    • 5 May 2026 · uses · YouTube ↗
      Takes curcumin, an extract of turmeric, to bypass the oxalate content while still getting the benefits.
    • 6 Nov 2025 · recommends · Podcast ↗
      Dave Asprey mentions that supplements like curcumin support pain relief and mood.
    • 6 Nov 2025 · recommends · YouTube ↗
      Notes that adding curcumins to a med can make it work significantly better, and it is included in their "happy saffron" product. They also recommend a combination of curcumins and omega-3 fatty acids for pain.
    • 16 Oct 2025 · neutral · YouTube ↗
      Notes that turmeric curcumin is also an NRF2 activator, though less bioavailable than sulforaphane.
    • 4 Sep 2025 · recommends · Podcast ↗
      Dave Asprey and his guests reveal how curcumin can rival meds, delivering natural ways to improve metabolism and regulate dopamine.
    • 1 Apr 2025 · Glutamine · recommends · YouTube ↗
      Recommends L-glutamine to support the gut barrier.
    • 1 Apr 2025 · Aloe Vera · recommends · YouTube ↗
      Recommends aloe vera juice or liquids to strengthen the entire digestive tract.
    • 22 Sep 2024 · uses · YouTube ↗
      Mentions that curcumin also has anti-parasitic properties and is useful.
    • 1 Aug 2024 · recommends · YouTube ↗
      Recommends combining specific nutrients like curcumin with red meat consumption to bind to iron and pull it out, rather than absorb it.
    • 13 Feb 2024 · Glutamine · uses · YouTube ↗
      Gave his yoga teacher glutamine to help with brain fog and autoimmune issues, which helped his energy return.
  • Dr. Eric Berg · Curcumin · neutral
    • 25 Oct 2026 · neutral · Facebook ↗
      Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
    • 17 Oct 2026 · neutral · Instagram ↗
      Notes that Curcumin barely absorbs without black pepper.
    • 20 Sep 2026 · Glutamine · recommends · Facebook ↗
      Recommends taking glutamine or consuming foods high in glutamine to block the effects of grains.
    • 6 Sep 2026 · recommends · Facebook ↗
      Recommends curcumin, stating it delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health and mental well-being.
    • 3 Sep 2026 · neutral · X ↗
      Dr. Eric Berg states that curcumin may support blood sugar, but it should not be treated as an equivalent substitute for other treatments.
    • 3 Sep 2026 · Glutamine · recommends · Facebook ↗
      States that glutamine is an important amino acid for colon cells and is essential for intestinal permeability, greatly supporting the gut and benefiting inflammatory conditions.
    • 2 Sep 2026 · recommends · Facebook ↗
      Lists curcumin as an epigenetic factor that may help with cancer prevention.
    • 21 Aug 2026 · neutral · Facebook ↗
      Curcumin is a compound that delivers powerful antioxidant and anti-inflammatory effects.
    • 4 Jul 2026 · recommends · Instagram ↗
      States that curcumin, found in turmeric, delivers powerful antioxidant and anti-inflammatory effects linked to cardiovascular health, mental well-being, and more.
    • 8 Apr 2026 · recommends · YouTube ↗
      Suggests that curcumin can be beneficial to counter some of the effects of a hypoxic state in cancer and inflammation.
    • 28 Jan 2026 · recommends · Podcast ↗
      States that curcumin, a potent compound in turmeric, can naturally alleviate pain and inflammation, and a study found that 1500 mg of turmeric with black pepper produced results comparable to a med without side effects.
    • 19 Dec 2025 · recommends · Podcast ↗
      Recommends increasing curcumin for best kidney health.
    • 13 Nov 2025 · Glutamine · neutral · Podcast ↗
      Notes that glutamine is an amino acid that promotes gut healing.
    • 5 Nov 2025 · Glutamine · neutral · YouTube ↗
      Mentions that carnivore can help increase glutamine, which is a healing amino acid for the gut.
  • Thomas DeLauer · Curcumin · recommends
    • 14 Oct 2026 · recommends · YouTube ↗
      Notes that PET scans showed a significant reduction in amyloid plaque build-up in the group taking curcumin, suggesting fewer instances of Alzheimer's and dementia.
    • 27 Oct 2026 · Glutamine · neutral · YouTube ↗
      States that glutamine is the primary fuel source for intestinal cells, and its availability is crucial for the integrity of the gut barrier.
    • 16 Oct 2026 · Glutamine · recommends · YouTube ↗
      Recommends supplementing with glutamine for a calming effect, especially when experiencing high stress, injury, illness, or increased training volume, as it acts as a precursor to GABA and helps the body produce more of it.
    • 14 Oct 2026 · Glutamine · uses · YouTube ↗
      Loads up on extra glutamine during muscle building phases.
    • 11 Oct 2026 · recommends · YouTube ↗
      Discusses a UCLA study where curcumin led to a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup, suggesting less instance of Alzheimer's and dementia. He also mentions a study where curcumin helped mood as much as a med.
    • 4 Oct 2026 · uses · YouTube ↗
      Uses Curcumin Gold in their recipe, stating it is amazing because it contains ginger oil, DHA, and curcumin, which work in harmony for the body to operate at its best, helping with inflammation and brain energy.
    • 28 Sep 2026 · Glutamine · recommends · YouTube ↗
      Recommends glutamine as one of the things that support the gut lining.
    • 6 Sep 2026 · neutral · YouTube ↗
      Discusses a UCLA study where participants taking 90 milligrams of curcumin daily for 18 months showed a 28% increase in cognitive function and a significant reduction in amyloid plaque buildup.
    • 5 Sep 2026 · Glutamine · neutral · YouTube ↗
      Is familiar with glutamine being important for maintaining gut barrier function, though he has not done specific research on it in his lab.
    • 1 Sep 2026 · recommends · Instagram ↗
      Recommends Curcumin, stating that 500-1000mg lowers CRP and IL-6 in trials and has over 2000 studies.
    • 1 Sep 2026 · Glutamine · recommends · Instagram ↗
      Recommends Glutamine as a great tool for gut cells when stressed or overworked, but advises not to take it every day.
    • 22 Aug 2026 · Glutamine · neutral · YouTube ↗
      Mentions that glutamine is a main source of fuel for the gut and is also important for muscles, and a lack of it can lead to leaky gut during intense exercise.
    • 16 Aug 2026 · recommends · YouTube ↗
      States that curcumin plus vitamin D is probably the most powerful brain booster and brain protector, explaining that curcumin helps macrophages enlarge to gobble up more amyloid beta.
    • 12 Aug 2026 · Glutamine · recommends · YouTube ↗
      Recommends taking 5 to 10 grams of glutamine daily, stating that it directly feeds the cells lining the gut, thereby improving gut permeability and protecting the gut mucosal layer.
  • Siim Land · Curcumin · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Curcumin as one of 15 supplements backed by human studies.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks curcumin has some of the strongest evidence and is worth considering.
    • 7 Aug 2026 · neutral · YouTube ↗
      Mentions curcumin as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 23 Jul 2026 · Glutamine · neutral · X ↗
      Mentions that glutamine is one of the main precursors needed for glutathione.
    • 7 Jul 2026 · neutral · YouTube ↗
      States that curcumin, unless contaminated, is not going to raise liver enzymes.
    • 6 Mar 2026 · neutral · YouTube ↗
      Did not see a big extension from curcumin in their tests.
    • 30 Jan 2026 · neutral · Instagram ↗
      Mentions that it is infeasible to obtain sufficient curcumin from food.
    • 28 Dec 2025 · neutral · YouTube ↗
      Mentions curcumin as a supplement that has been shown to lower CRP and improve metabolic health.
    • 28 Dec 2025 · Glutamine · recommends · YouTube ↗
      States that glutamine is a good gut supplement that helps heal the gut lining, recommending it periodically for gut healing purposes.
    • 28 Dec 2025 · Aloe Vera · neutral · YouTube ↗
      Mentions aloe vera as a natural agent with an SPF of 7, which can be used as a complementary ingredient in sunscreens but is insufficient as a primary sunscreen.
    • 11 Dec 2025 · recommends · YouTube ↗
      Recommends curcumin for metabolic health, especially for insulin resistance and dyslipidemia.
    • 10 Oct 2025 · recommends · YouTube ↗
      Places Curcumin in the 'god tier' for longevity, based on its ability to extend lifespan in a few animal models and consistent human study findings of lower inflammation, better lipid profiles, and improved metabolic health.
    • 20 Aug 2025 · Glutamine · recommends · YouTube ↗
      Recommends supplementing glutamine to address intestinal inflammation and permeability, as it maintains tight junctions and intestinal permeability, with a meta-analysis showing 30 grams a day for less than two weeks reduced intestinal permeability.
  • Dr. Mark Hyman · Curcumin · recommends
    • 5 Oct 2026 · recommends · YouTube ↗
      States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
    • 2 Sep 2026 · Glutamine · neutral · YouTube ↗
      Mentions glutamine as something that might be helpful for gut repair.
    • 24 Aug 2026 · neutral · YouTube ↗
      Mentions that curcumin has been studied for its anti-inflammatory effects, but emphasizes that no supplement can replace the daily signals created by sleep, nutrition, exercise, stress management, and metabolic health.
    • 27 Jul 2026 · recommends · YouTube ↗
      Recommends curcumin as an anti-inflammatory supplement that can be helpful.
    • 27 Jul 2026 · Glutamine · recommends · YouTube ↗
      Recommends L-glutamine to help with gut barrier repair and healing leaky gut.
    • 13 Jul 2026 · neutral · YouTube ↗
      States that curcumin helps to lower broader inflammatory levels in the body.
    • 22 Jun 2026 · Glutamine · recommends · YouTube ↗
      Recommends glutamine to help repair the gut lining.
    • 27 May 2026 · neutral · YouTube ↗
      Explains that curcumin is the key compound in turmeric, a polyphenol that research shows supports the body against conditions like cancer, cardiovascular stress, and neurogenic diseases like dementia, and can also help with inflammation, metabolic balance, joint comfort, and mood.
    • 6 Apr 2026 · Glutamine · recommends · YouTube ↗
      Recommends glutamine for targeted support in healing the gut and recalibrating the immune system.
    • 8 Oct 2025 · neutral · YouTube ↗
      Lists curcumin as a phytochemical that helps mitochondrial function.
    • 14 May 2025 · neutral · YouTube ↗
      Mentions curcumin from turmeric as an example of a powerful phytochemical that affects the body.
    • 26 Feb 2025 · neutral · YouTube ↗
      Notes that curcumin is an amazing NRF2 activator, but its bioavailability is only 5% compared to sulforaphane from home-grown broccoli sprouts.
    • 29 Nov 2024 · recommends · YouTube ↗
      Recommends a curcumin supplement with black pepper (piperine) for indigestion, including reflux, noting that a recent trial found it as effective as a med.
    • 29 Nov 2024 · Glutamine · recommends · YouTube ↗
      Recommends glutamine, an amino acid, for its ability to help soothe the gut lining.
  • Dr. Rhonda Patrick · Curcumin · neutral
    • 5 Aug 2026 · neutral · Facebook ↗
      Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
    • 5 Aug 2026 · neutral · TikTok ↗
      Asks if curcumin can slow aging.
    • 31 Jul 2026 · Glutamine · uses · TikTok ↗
      Supplements with glutamine.
    • 14 Jul 2026 · Glutamine · uses · X ↗
      Always packs Glutamine when traveling, taking a baseline of 5 g/day and increasing to 15-20 g/day when sleep-deprived or exposed to illness, as it is an important fuel source for immune function.
    • 24 Jun 2026 · neutral · Facebook ↗
      Curcumin may be one of the most effective natural compounds for lowering age-related inflammation. The phytosomal form matters because standard curcumin is poorly absorbed and rapidly metabolized, while phytosomal delivery makes it much more bioavailable.
    • 22 May 2026 · uses · Facebook ↗
      Takes phytosomal curcumin daily because it is much more bioavailable than standard curcumin and human evidence suggests it is potent for lowering TNF-α, a major inflammatory cytokine linked to biological aging.
    • 15 May 2026 · uses · Instagram ↗
      Rhonda takes 500 mg of liposomal Curcumin daily for inflammation.
    • 30 Apr 2026 · uses · Facebook ↗
      Uses Phytosomal curcumin, stating it is one of the only naturally occurring compounds shown to meaningfully lower TNF-alpha, a master inflammatory cytokine that accelerates aging.
    • 8 Oct 2025 · Glutamine · warns · Facebook ↗
      Warns that Glutamine has stimulating properties that increase arousal, interfering with sleep onset, and should be avoided too close to bedtime.
    • 6 Oct 2025 · Glutamine · warns · YouTube ↗
      Warns against taking glutamine at night for sleep because it is activating and can cause insomnia, citing examples of athletes who experienced this.
    • 3 Jul 2025 · Glutamine · uses · Facebook ↗
      Uses 5 grams of L-Glutamine to support gut-immune axis integrity and may reduce infection risk during travel.
    • 28 Jun 2025 · Glutamine · uses · X ↗
      Says L-Glutamine has been added to their supplement stack recently, convinced by Dr. Rhonda Patrick on its benefits.
    • 26 Jun 2025 · Glutamine · uses · Facebook ↗
      Rhonda's current supplement routine includes Glutamine.
    • 1 May 2025 · Glutamine · neutral · Facebook ↗
      Rhonda's regimen includes ~5.6g/day of L-glutamine with her morning coffee, upping it to 20g if she feels illness coming on.
  • Ben Greenfield · Curcumin · neutral
    • 13 Jun 2026 · neutral · Facebook ↗
      Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
    • 13 Jun 2026 · uses · YouTube ↗
      States that their curcumin product affects the Nrf2 pathway by activating PKC delta, which phosphorylates Nrf2, allowing it to go into the nucleus, and works synergistically with sulforaphane.
    • 2 May 2026 · uses · YouTube ↗
      Ben Greenfield's clinic photoactivates curcumin before use, finding it to be very anti-cancer when photoactivated.
    • 26 Mar 2026 · recommends · YouTube ↗
      Says curcumin at low doses, such as sprinkled turmeric onto food, acts as a hormetic stressor, increasing internal defense systems, antioxidants, and repair pathways, leading to overall reductions in inflammation.
    • 20 Nov 2025 · recommends · Facebook ↗
      Recommends MitoQ +Curcumin, a Mitoquinol-enhanced blend with Longvida Curcumin for antioxidant and joint health synergy.
    • 30 Oct 2025 · neutral · Podcast ↗
      Gets nerdy about curcumin and explains which longevity supplements actually work, according to the science in mammals.
    • 30 Oct 2025 · uses · YouTube ↗
      Uses curcumin, taking Keon Flex at night on an empty stomach and a heaping tablespoon of Row Nutrition's liposomal curcumin at some point during the day, but not right after a workout due to its mTor signaling inhibition.
    • 26 Jun 2025 · neutral · YouTube ↗
      Mentions curcumin as a polyphenol that can confer benefits when consumed.
    • 12 Jun 2025 · Glutamine · neutral · YouTube ↗
      Mentions glutamine as a supplement that provides glucose to the brain, supporting neurotransmitter functions, as suggested by a guest.
    • 3 May 2025 · recommends · YouTube ↗
      Recommends curcumin to reduce inflammation, especially when combined with the Weber laser treatment.
    • 20 Mar 2025 · Glutamine · recommends · YouTube ↗
      Recommends taking about five grams of L-glutamine with each meal for around four to eight weeks to help heal a leaky gut.
    • 27 Feb 2025 · recommends · YouTube ↗
      Tells people to take curcumin to block the secondary function of cancer pulling other things like glutamate and converting it through gluconeogenesis.
    • 22 Feb 2025 · Glutamine · recommends · YouTube ↗
      Recommends taking about 5 grams of glutamine powder with each meal as a simple way to reduce IBS issues.
    • 22 Feb 2025 · Aloe Vera · recommends · YouTube ↗
      Recommends topical aloe vera for hair growth, noting that dermarolling can enhance its absorption.
  • Andrew Huberman · Curcumin · neutral
    • 13 Apr 2026 · neutral · Podcast ↗
      Discusses curcumin as a supplement for prenatal care and sperm health.
    • 1 May 2026 · Glutamine · recommends · X ↗
      Supplementing with L-glutamine may reduce sugar cravings, and anecdotally, it works.
    • 30 Apr 2026 · Glutamine · neutral · Podcast ↗
      Discusses glutamine supplementation in relation to leaky gut and sugar cravings.
    • 13 Apr 2026 · warns · YouTube ↗
      Does not recommend high-dose curcumin supplements for general use, suggesting it's only for specific purposes under a doctor's guidance to target excess inflammation.
    • 23 Mar 2026 · Glutamine · warns · YouTube ↗
      Takes L-glutamine daily at 5g, increasing to 15-20g in 5g increments when her son is sick, she is exposed, during season, or when traveling, because she believes it helps her not get sick.
    • 11 Sep 2025 · Glutamine · recommends · Podcast ↗
      He highlights specific nutrients, including glutamine, and discusses their recommended doses and dietary sources for offsetting sugar cravings.
    • 7 Jul 2025 · Glutamine · neutral · YouTube ↗
      Recounts an anecdote about taking a teaspoon of L-glutamine in half-and-half twice a day, which he believes helped him wean off sugar, though he acknowledges it could be a placebo effect.
    • 12 May 2025 · neutral · YouTube ↗
      Notes that people are excited about the possible health benefits of curcumin, which is found in turmeric.
    • 1 Feb 2025 · Glutamine · neutral · Instagram ↗
      Mentions that some people find ingesting a teaspoon of L-glutamine a few times a day helps with sugar cravings, noting that this method has anecdotal data but has not been peer-reviewed.
    • 6 May 2024 · uses · YouTube ↗
      Includes curcumin in his diet because it has been shown to stimulate GLP-1.
    • 6 May 2024 · Glutamine · neutral · YouTube ↗
      Discusses L-glutamine supplementation for leaky gut, noting it is controversial with no randomized controlled trials, but some people swear by it, possibly due to increasing L cells.
    • 29 Feb 2024 · warns · YouTube ↗
      Warns against taking high doses of curcumin, noting potential negative effects like limiting dihydrotestosterone production, and advises checking sourcing carefully due to lead contamination concerns.
    • 10 Apr 2023 · neutral · Podcast ↗
      Mentions curcumin in the context of 5-alpha reductase.
    • 10 Apr 2023 · stopped · YouTube ↗
      States he once took curcumin in high dosages (1-2 gram capsules) and felt terrible, vowing never to take it again due to his sensitivity to its effects on the DHT pathway.
  • Peter Attia · Curcumin · uses
    • 23 Nov 2020 · uses · YouTube ↗
      Uses a specific nanoparticle version of curcumin at a reasonable dose, which may have anti-TNF alpha effects and help with inflammation.
    • 6 Apr 2025 · Aloe Vera · recommends · YouTube ↗
      Says that patients can use an aloe vera plant if they have it for skin reactions from radiation.
    • 28 Mar 2022 · Glutamine · recommends · YouTube ↗
      Notes that glutamine has been shown to increase the survival rate in ICU patients.
    • 26 Oct 2020 · recommends · YouTube ↗
      States that a well-absorbed curcumin with high-dose omega-3 is as good as or better than any a med and helps improve brain function, mood, cognition, and may reduce dementia.
    • 7 Jul 2020 · Glutamine · recommends · YouTube ↗
      Recommends glutamine as a nutrient the body needs to heal the gut.
    • 6 Jan 2020 · Glutamine · warns · YouTube ↗
      Warns that glutamine is essential for the immune system and gut health, so blocking it with drugs for cancer treatment must be done strategically to avoid compromising these systems. He also notes that tumor cells use glutamine as fuel, so it's a double-edged sword.
    • 31 Dec 2019 · uses · YouTube ↗
      Says that for a 27-year-old woman with an early-onset Alzheimer's gene, they would be "loading her up with curcumin" to prevent symptoms for 25 years.
    • 31 Dec 2019 · Glutamine · uses · YouTube ↗
      Would make a smoothie with whey protein isolate, glutamine, glucosamine, and flaxseed oil for recovery after his run.
    • Date not recorded · stopped · Website ↗
      Used to take Curcumin for longevity but stopped because he didn't see enough evidence.
    • Date not recorded · neutral · Website ↗
      Mentions curcumin as another example of a niche compound with numerous RCTs, reinforcing the point that research can be done without pharma sponsorship.
  • Bryan Johnson · Curcumin · warns
    • Date not recorded · warns · Website ↗
      Advises avoiding Curcumin during pregnancy.

RAL Summary

Members OnlyTier 3 for Digestion and Bloating

Tier 3 rests on 105 reviews, 81 percent positive, with some study support from curcumin at a full dose, where most trials helped bowel symptoms [1] but pooled results were not clearly significant [3].

Take 3 servings a day to match the dose that worked in the studies.

Where the evidence disagrees: 16 of the 62 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system

Combine with: For gut lining support, EnteroMend pairs well with a quality multi-strain probiotic (Lactobacillus and Bifidobacterium) and a prebiotic fiber such as partially hydrolyzed guar gum to feed beneficial bacteria. Zinc carnosine, aloe vera or DGL licorice can further soothe the mucosa, and omega-3 fish oil and vitamin D support a balanced inflammatory response. If the real goal is dental health, choose separate products: calcium with vitamin D3 and K2 for tooth and bone mineralization, magnesium, CoQ10 for gum tissue, and an oral probiotic such as Streptococcus salivarius K12 or a nano-hydroxyapatite toothpaste.

Possible side effects: High single doses of glutamine caused mild stomach discomfort, nausea and belching, and guar gum fiber increased gas in tube-fed patients. One reviewer reported worse migraines and another found it mixed poorly.

Supplement Facts

L-Glutamine 2.5 g · Sunfiber 1 g · Aloe vera, Dehydrate, Powder 250 mg
Supplement Facts
Serving Size 5.6 Gram(s)
Servings Per Container 30
Amount Per Serving% Daily Value
L-Glutamine2.5 g†
Sunfiber1 g†
Aloe vera, Dehydrate, Powder250 mg†
Meriva250 mg†
Casperome250 mg†
† Daily Value not established.

Other ingredients: Flavors, Citric Acid, Rebaudioside A.

Directions: Suggested use: Mix 1 scoop with at least 5-6 ounces of water one to two times daily or as recommended by your health-care practitioner.

Barcode (UPC) 693749006251 · Label source: NIH label database · Report a label change

Show entire label

More digestion and bloating products

Members OnlyThe highest ranked for the same goal

Read more

Our articles on this subject

Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.