Ancient Nutrition Multi Collagen Protein Review
Multi Collagen Protein is described on this page as a 6-in-1 daily collagen peptide supplement that supports skin, hair, nails, joint, gut and immune health. The product is presented as a research-driven formula that combines responsibly sourced collagen, lipid-enhanced vitamin C and gut-resilient probiotics, designed to help people look, feel and move their best as they age. The page states that as the body's natural collagen production declines with age, this can contribute to wrinkles, such as crow's feet, joint stiffness and other issues. The formula is positioned as supporting collagen production, utilization and whole-body wellness. The collagen comes from pasture-raised, grass-fed cattle, wild-caught fish, U.S.-raised chickens and upcycled eggshell membrane. Each scoop provides 9g of protein, 10g of Multi Collagen Complex and 90mg of vitamin C from lipid metabolite ascorbate, which the page lists as 100% of the daily value. Each serving also includes 2 billion CFU of Bacillus coagulans, a soil-based organism probiotic that the page says may support gut health, digestive function and healthy bowel transit time. The unflavored powder is listed at 45 servings, with a serving size of one scoop (10.1g) and 35 calories per scoop. The label also lists the product as raised without hormones, non-GMO, raised without meds, and made without grains, dairy, soy and gluten. Adults are directed to mix one scoop with 8 ounces of cold or hot liquid using a blender, hand frother or shaker cup, and the page suggests adding it to coffee, smoothies, pancakes, oatmeal and baked goods. The FAQ states that collagen is generally safe for most healthy adults when used as directed, and that people who are pregnant, breastfeeding, allergic to fish or eggs, or have medical conditions should consult a healthcare professional first. The page says the product is manufactured in USA-based facilities audited by third parties for cGMP compliance and tested for ingredient identification, purity, heavy metals and safety. The product is not vegan or vegetarian because collagen comes from animal sources. The page also notes that results are gradual, with the brand describing possible changes in joint comfort after about 30 days, probiotic-related gut benefits after eight weeks, and hair, skin and nail improvements after 12 weeks of consistent daily use. The page also explains the difference between this powder and related Ancient Nutrition products, noting that Multi Collagen Protein offers four collagen sources and multiple flavors, while Multi Collagen Advanced offers ten sources and specific superfood blends.
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Study, Trial or Testing Result Summary
Members Only47 human studies · 36 improved
7 of these 47 human studies gave the ingredient by injection, not by mouth.
The main ingredient, a 10 gram collagen blend, is at or above the doses used in studies. A review pooling 26 placebo-controlled trials with 1721 people found that collagen taken by mouth improved skin hydration and elasticity [1]. Another review of 19 trials, mostly in women, found that about 90 days of collagen improved hydration, elasticity and wrinkles [2]. In 114 women aged 45 to 65, 2.5 grams a day for 8 weeks cut eye wrinkle volume by 20 percent compared with placebo [3]. Trials in 114 women and 100 adults also found better elasticity, smoothness and wrinkles than with placebo [4][5]. However, a 2025 review of 23 trials found that the highest-quality studies, and those not paid for by companies, showed no clear effect [6]. The 90 milligrams of vitamin C has unclear support. Most vitamin C skin studies used creams or serums applied to the skin, not pills or powders [7][8]. When vitamin C was taken by mouth at 500 milligrams a day for 12 weeks, it did not improve hydration or elasticity. Animal and cell studies are never counted.
See all 47 studies →Hide the studies
- Across 26 randomized trials with 1721 people, hydrolyzed collagen improved skin hydration and elasticity compared with placebo.Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.
- Across 23 randomized trials with 1474 people, collagen improved hydration, elasticity and wrinkles overall, but studies without pharmaceutical funding and high-quality studies showed no significant effect.Effects of Collagen Supplements on Skin Aging: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Across 19 randomized trials with 1125 people (95% women), hydrolyzed collagen for about 90 days improved skin hydration, elasticity and wrinkles compared with placebo.Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.
- In a review of 30 trials for sun-damaged skin, one small study showed benefit from vitamin C applied to skin compared with placebo, while tretinoin had the strongest evidence.Interventions for photodamaged skin.
- A review of 32 studies with 1236 people found vitamin C and retinol products earned the top recommendation grade for anti-aging skin care, with few side effects.Cosmeceuticals for antiaging: a systematic review of safety and efficacy.
- Across 11 placebo-controlled trials with 805 people, oral collagen at 2.5 to 10 grams daily for 4 to 24 weeks increased skin elasticity, hydration and dermal collagen density.Oral Collagen Supplementation: A Systematic Review of Dermatological Applications.
- A review of seven trials with 139 volunteers found skin treated with vitamin C looked smoother, less wrinkled and lighter, but hydration improved as much with placebo.Efficacy of topical vitamin C in melasma and photoaging: A systematic review.
- A review of seven studies found that all used vitamin C with other ingredients or treatments, so its own effect on wrinkles could not be clearly determined.Clinical Efficacy of Topical Vitamin C on the Appearance of Wrinkles: A Systematic Literature Review.
- A review of 10 publications found that almost all reported oral collagen improved skin health.Collagen supplementation for skin health: A mechanistic systematic review.
- In 439 people with nasolabial folds, injected bovine collagen filler gave shorter-lasting correction than hyaluronic acid fillers over up to 24 weeks; this tested an injected filler, not a collagen supplement.Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked,…
- In 149 people with nasolabial folds, an injected porcine collagen filler improved wrinkle scores for 6 months, about the same as a hyaluronic acid filler; this was an injection, not a collagen supplement.A randomized, multicenter study of the safety and efficacy of Dermicol-P35 and non-animal-stabilized hyaluronic acid gel…
- In 149 people given an injected porcine collagen filler for nasolabial wrinkles, 95.3% kept the improvement at 9 months and 76.5% at 12 months; this was an injection, not a collagen supplement.Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler.
- In 120 people, a daily collagen drink combined with vitamins and other ingredients for 90 days raised skin elasticity by 40% versus placebo and improved skin structure and joint pain.Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin ela…
- In 114 women aged 45-65, 2.5 grams of collagen peptides daily for 8 weeks reduced eye wrinkle volume by 20% versus placebo and raised skin procollagen and elastin.Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.
- In 114 women aged 20-50, 1000 mg of low-molecular-weight collagen peptide daily for 24 weeks improved cellulite, skin roughness and skin elasticity versus placebo.Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diame…
- In 100 healthy adults taking low-molecular-weight collagen peptides for 12 weeks, wrinkles, elasticity and hydration improved significantly more than with placebo, with no related side effects.Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-control…
- In 87 women aged 40-65 taking collagen with 80 mg vitamin C daily for 16 weeks, skin density, texture and wrinkles improved, but elasticity and hydration did not change significantly.The Effects of Dietary Supplementation with Collagen and Vitamin C and Their Combination with Hyaluronic Acid on Skin De…
- In 77 healthy women, 5000 mg per day of bioactive collagen peptides for 12 weeks improved skin hydration, water loss, and dermal density compared with placebo, and the gains held through a 4-week washout.The Sustained Effects of Bioactive Collagen Peptides on Skin Health: A Randomized, Double-Blind, Placebo-Controlled Clin…
- In 72 women aged 35 or older, a daily collagen and vitamin C drink for 12 weeks improved skin hydration, elasticity, roughness and density more than placebo.A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Cont…
- In 69 women using a vitamin C derivative cream twice daily for 8 weeks on one side of the face, wrinkles around the eyes improved compared with placebo cream on the other side.Evaluation of the anti-wrinkle effect of a lipophilic pro-vitamin C derivative, tetra-isopalmitoyl ascorbic acid.
- In 69 women aged 35 to 55, 2.5 g or 5 g of collagen peptides daily for 8 weeks significantly improved skin elasticity compared with placebo, with no side effects noted.Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, plac…
- In 64 patients after laser treatment for acne scars, an antioxidant serum with vitamin C used for 14 days improved healing and skin hydration compared with saline on the other side of the face.Reparative Effects of a Topical Antioxidant Serum Containing Vitamin C, Vitamin E, and Ferulic Acid After Ablative Fract…
- In 64 people, 1000 mg of low-molecular-weight collagen peptide daily for 12 weeks improved skin hydration, wrinkling and elasticity compared with placebo, with no related side effects.Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Rand…
- In 61 Asian adults with nasolabial folds, a porcine collagen filler improved wrinkle scores over 12 months, with results not significantly different from a bovine collagen filler and no serious side effects.Efficacy and safety of porcine collagen filler for nasolabial fold correction in Asians: a prospective multicenter, 12 m…
- In 60 women aged 20-50 with facial melasma, a multi-ingredient serum containing a small amount of vitamin C used for 5 months reduced pigmentation about as much as 4% hydroquinone, with better hydration, skin barrier function and tolerance in the serum group.Evaluation of the Efficacy of a Serum Containing Niacinamide, Tranexamic Acid, Vitamin C, and Hydroxy Acid Compared to 4…
- In 54 Chinese adults with photoaging, injected collagen combined with a collagen serum produced better skin satisfaction, fine lines, and firmness than injection alone by 12 weeks, with no related side effects; this was an injection study, not an oral supplement.Effectiveness and Safety of Recombinant Type III Humanized Collagen Solution Injection Combined With Collagen-III Multi-…
- In 50 women aged 30-65, a serum with vitamin C, vitamin E and raspberry leaf extract applied to one side of the face for 8 weeks improved skin color, elasticity, radiance, smoothness, scaliness and wrinkles compared with the untreated side.Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell cultu…
- In 50 healthy adults, 12 weeks of green tea catechins plus vitamin C twice daily protected only one skin elastic fiber protein (fibulin-5) from sun-simulating light damage, with no difference from placebo for other collagen and elastic components.Ultraviolet radiation-induced degradation of dermal extracellular matrix and protection by green tea catechins: a random…
- In 32 healthy volunteers, 500 mg daily vitamin C for 12 weeks did not improve skin hydration or elasticity beyond baseline, and adding it to collagen peptides did not enhance the collagen effect.Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study.
- In 31 adults aged 30 to 65, applying a vitamin C, E and ferulic acid serum daily for 12 weeks after microneedle treatment reduced neck wrinkles more (29.9% vs 18.0%) and improved elasticity (12.9% vs 2.3%) compared with placebo on the other side of the neck.Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuven…
- In 24 Korean women, a vitamin C microneedle patch applied twice daily for 12 weeks produced significant reductions in crow's feet wrinkle roughness, with no side effects reported.Novel cosmetic patches for wrinkle improvement: retinyl retinoate- and ascorbic acid-loaded dissolving microneedles.
- In 20 adults with acne scars, a porcine collagen filler and a subcision procedure both improved scars over 6 months, and blinded evaluators found no significant difference between them.Subcuticular incision versus naturally sourced porcine collagen filler for acne scars: a randomized split-face compariso…
- In a randomized, double-blind study of 19 adults with sun-damaged facial skin, applying a vitamin C serum daily for 3 months improved skin texture and wrinkling more than the vehicle serum on the other side of the face, as shown by skin surface measurements and clinical grading.Use of topical ascorbic acid and its effects on photodamaged skin topography.
- In 15 women aged 19-40 exposed to air pollution particles for 4 days, a vitamin C, ferulic acid and vitamin E serum applied to the back protected collagen and elastin and reduced markers of inflammation and oxidative stress in skin biopsies.Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.
- In a double-blind trial of women with sun-aged skin, a 5% vitamin C cream applied daily for 6 months improved overall skin appearance and surface texture compared with the vehicle cream and was well tolerated.Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. …
- In women aged 45 to 60, a hydrolyzed marine collagen supplement for 12 weeks reduced wrinkle scores by 35% from baseline and gave greater improvements in wrinkles, elasticity, hydration, and firmness than placebo.A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen …
- In 33 women, a cream with 3% vitamin C applied daily to the forearm for four months increased the density of dermal papillae, the small skin structures that carry capillaries, from 4 weeks onward compared with the cream base alone.Topically applied vitamin C increases the density of dermal papillae in aged human skin.
- In a half-face study of 27 Japanese women with dark sun spots, a vitamin C derivative lotion applied twice daily for 24 weeks gave a weak lightening effect on the spots, but pigmentation scores did not differ from the placebo lotion.Whitening effect of L-ascorbate-2-phosphate trisodium salt on solar lentigos.
- In placebo-controlled tests including 25 volunteers for one month and a 12-week usage study, a face cream with 3% vitamin C lowered skin oxidative stress, increased the number of dermal papillae, and significantly reduced facial wrinkles.Topical activity of ascorbic acid: from in vitro optimization to in vivo efficacy.
- In a split-face trial of 24 adults with sun-damaged skin, using a handheld device to push vitamin C into the skin twice a week for 8 weeks improved pore tightening and skin hydration on the treated side compared with baseline, with no adverse reactions recorded.Efficacy of handheld iontophoresis device in enhancing transdermal vitamin C delivery: A split-face clinical trial.
- A hydrogel carrying ascorbyl palmitate, a vitamin C form, moisturized skin better than a placebo gel in both short-term and long-term tests.Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nan…
- Creams containing 1% of a fat-soluble vitamin C derivative increased skin moisture and improved skin smoothness in volunteers over 15 days of use.Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: stability studies and in vivo efficacy.
- In 31 women aged 43 to 65 without a control group, a vitamin C, vitamin E and green tea serum applied twice daily for 12 weeks improved wrinkles, smoothness, radiance and skin density.Novel Vitamin C and E and Green Tea Polyphenols Combination Serum Improves Photoaged Facial Skin.
- In 8 people, an injected collagen filler improved nasolabial folds over 12 weeks with no reported side effects, in an open-label pilot without a control group.A Two-Phase Pilot Study to Evaluate the Safety and Tolerability of an In Situ Polymerizing Collagen.
- In a 1984 questionnaire of people who had collagen injections for wrinkles, many reported benefit, but it lasted under a year, about 6 months; most nonresponders gave no follow-up, and this was an injection study, not a supplement.Collagen injections for aging skin lines (wrinkles).
- In lab and skin models, a type V collagen peptide increased collagen production and fiber density, and a preliminary clinical trial found improved skin barrier, density, and elastic recovery; the human evidence is preliminary.The Human-Like Collagen Alpha-1 Type V Peptides Strengthen the Dermal Fiber Network and Improve the Regeneration Ability…
- In a study in mice with sun-damaged skin, a tilapia collagen gel containing cerium oxide nanoparticles, injected into the skin, reduced skin oxidative stress, decreased wrinkles and skin thickening, and increased collagen, with effects lasting seven months. This was an animal study, not a human trial, and it tested an injected filler, not a collagen supplement.Autocatalytic Ceria Nanoparticle-Embedded Tilapia Collagen Hydrogels as Enhanced Antioxidative and Long-Lasting Dermal F…
Review Totals and Summary
Members Only79,470 reviews · 89% positive
Ancient Nutrition Multi Collagen Protein powder has garnered approximately 79470 ratings across various stores, with 71% of reviewers giving it 4 or 5 stars. The overall picture is largely positive, with many users reporting noticeable benefits, though some significant complaints exist. **Benefits Reported** Many customers report positive changes, particularly in hair, skin, and nails. Reviewers mention "thicker stronger hair," "hair get darker," and "nails really strong and healthy." For skin, users observed it becoming "more hydrated" and even "scars I have are fading." Older individuals often note improved mobility, with one saying they "can put my pants on without holding on" and another no longer waking up stiff. Some also experienced increased "energy levels up and less aches in my joints," and a general feeling of being "much better!" The product is also valued for providing "additional protein in our diet." **Complaints** While many praise the product, a notable number of complaints focus on taste and smell, especially concerning recent batches. Some describe the taste as "horrendous," "foul smell which tastes equally bad," or "tastes like leather. Gross leathery undertaste." A few users reported a gritty texture, with one saying "the last sip is like swallowing sand." Other issues include feeling "bloated all the time" and experiencing "joints ache more then they ever have." Practical complaints include receiving "damaged goods" and unauthorized subscription shipments. **Taste, Smell, and Form** The product is an unflavored powder, and many positive reviews highlight its ability to mix "easily into morning coffee, tea, and smoothies without changing the taste or texture," often being "barely notice[d]." However, a significant concern is inconsistency in taste and smell, with some recent containers described as having a "strong, foul smell" and an "equally bad" taste, or a "gross leathery undertaste." Some batches also leave "grit in the bottom of the glass." The product is exclusively sold as a powder, with other forms like gummies or capsules not included in this summary. **Value for Money** Opinions on value are mixed. While one reviewer considered it "a good value for the price," several others noted that it "was expensive for both of us" and can be "high for the daily cost" over time. The perceived benefits often outweigh the cost for loyal users, but price remains a consideration for some. **Who It Suits and Who It Did Not** The powder appears to suit individuals seeking support for age-related changes, with many older reviewers (including those in their 70s and 80s) reporting significant improvements in hair, skin, nails, and joint comfort. Active individuals and athletes also found it beneficial for body support and stiffness. Those who use it "consistently daily over a period of weeks" tend to see the best results. It is also favored by those who appreciate an unflavored powder that mixes conveniently into drinks. Conversely, it did not suit those who experienced adverse reactions like bloating or increased joint aches. Customers sensitive to taste and smell were also disappointed by "bad batch[es]" that had an unpleasant flavor or gritty texture. Those who experienced issues with damaged deliveries or unauthorized subscriptions also had negative experiences.
Biohacker Summary
Members Only9 of 10 recommend it
Most of the panel backs collagen: five recommend it, three take it (two of those as a regular morning habit), two are neutral, and one has stopped. People take it mainly for skin, with others citing joints, connective tissue, muscle and sleep, and the usual doses are 10 grams a day for muscle or 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least eight weeks for skin elasticity, while one panelist suggests 15 grams an hour before working out. Some add it to coffee or a pudding, and several pair it with vitamin C because the body needs it to make collagen. Cautions came from one panelist who said collagen will not repair a damaged gut wall, and another who said its mix of amino acids makes it less effective for building muscle than whey. Vitamin C is a smaller ingredient in this product, and the panel mostly recommends it for skin and immune support.
See all 10 biohackers →Hide the biohackers
Bryan Johnson · Collagen · uses
- Bryan Johnson states that he eats collagen peptides.
- Takes 10 grams of Collagen in the morning for muscle.
- Consumes collagen peptides at 4:55 am.
- Uses collagen peptides as an ingredient in Nutty Pudding.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 g of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of collagen in the morning for muscle.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 250 milligrams of Vitamin C.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
Dr. Eric Berg · Collagen · recommends
- Recommends focusing on collagen to support stronger bones if a neck hump is associated with osteoporosis.
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
- Mentions that grass-fed liver is loaded with collagen.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- States that the body is begging for collagen if one experiences weak ligaments and tendons, joint pain, wrinkles or saggy skin, thin dry fragile hair, brittle slow growing nails, loss of muscle, increased need for longer repair after exercise, and bone loss.
- Recommends increasing collagen intake because a lack of it can make it harder for the body to repair itself.
- Recommends consuming foods high in vitamin C to block the effects of grains.
Dave Asprey · Collagen · uses
- States that no one used collagen for health; it was previously used as a packing aid for pills.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
- Recommends taking collagen for better skin health.
- Recommends taking vitamin C for better skin health.
- Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
- States that currently, he is only taking vitamin C and vitamin D.
- Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
- Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
- Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
- Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
- Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
- Recommends increasing collagen intake, specifically about 20 grams of collagen protein, for individuals with hypermobility, but warns against exceeding this amount due to oxalate concerns.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
Thomas DeLauer · Collagen · recommends
- Recommends taking collagen peptides in the morning for tendon tensile effects and 5 or 10 grams at night before bed to couple with the body's natural growth hormone pulse for skin and connective tissue repair.
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Would add more collagen to his protein shakes, believing it helps connective tissue protein synthesis and works synergistically with whey protein for muscle protein synthesis.
- Says he takes collagen to take care of his gut.
- Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
- Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
- Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Recommends taking 15 grams of collagen about 30 minutes before bed, especially on rest days, for its glycine content to aid sleep onset and for connective tissue repair.
Siim Land · Collagen · recommends
- Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Collagen as one of 15 supplements backed by human studies.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
- 30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
- Notes that Vitamin C is one of several supplements with human evidence.
- Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
- Mentions that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Notes that taking 15 grams of collagen before bed has been seen to reduce the number of awakenings during the night.
- Mentions that glycine makes up one-third of collagen.
- Recommends taking Collagen one hour before exercise with a vitamin.
Ben Greenfield · Collagen · recommends
- Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
- Mentions vitamin C as part of a bare-minimum protocol.
- Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
- Recommends starting with collagen for body remodeling.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- A new meta-analysis reviewed the existing evidence on collagen supplementation and found that collagen peptides may support several aspects of health, including skin aging, osteoarthritis symptoms, fat-free mass, tendon quality, and markers of metabolic health.
- The latest meta-analysis on collagen backs up collagen benefits for skin aging, osteoarthritis, fat-free mass, tendon quality, and overall metabolic health, with effective doses ranging from 5 to 15g.
- Recommends collagen for skin repair post-tattoo.
- Recommends Vitamin C for skin repair post-tattoo.
- Notes that collagen is not a complete protein, so while it can be added to things, it should not be relied upon as the sole protein source.
- Recommends collagen peptides or essential amino acids to support the dermal matrix that anchors hair follicles, considering them important for hair health.
Dr. Mark Hyman · Collagen · neutral
- Dr. Hyman mentions collagen supplements in the context of skin aging.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Adds Peak's Carrera Marine Collagen to their morning ritual for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
- States that collagen powder may modestly improve elasticity and hydration of the skin.
- Notes that most people focus on collagen powders for skin aging, but healthy skin is built inside the body.
Andrew Huberman · Collagen · uses
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- Takes 10 grams of collagen in the morning for muscle.
- Takes 10-20 grams of Collagen every day for muscle.
- Takes a multivitamin every day for longevity.
- Takes 10 grams of Collagen in the morning for muscle.
- He takes 10 grams of Collagen in the morning for muscle.
- Takes 10 grams of Collagen in the morning for skin health.
- He takes 10 grams of Collagen in the morning for skin health.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
Dr. Rhonda Patrick · Collagen · stopped
- Is no longer taking collagen.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Uses Hydrolyzed Collagen Peptides as a source of glycine and proline to support connective tissue and skin health.
- Rhonda's current supplement routine includes Vitamin C.
- Dr. Rhonda Patrick, who was previously unconvinced, now recommends hydrolyzed collagen powder prophylactically for connective tissue and ligaments, especially if someone has a soft tissue injury history, to be taken 30 to 60 minutes pre-exercise with 50 milligrams of vitamin C.
- Discusses whether collagen can actually strengthen tendons.
Peter Attia · Collagen · neutral
- Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Advises that collagen protein is not a very complete protein and suggests supplementing it with something else if consumed, despite his wife's preference for it.
- Says that based on current data, there is no benefit in myofibrillar or muscle connective tissue protein synthesis using collagen versus whey or casein, especially in exercising individuals. He warns that using collagen as a sole supplemental protein source compromises myofibrillar muscle protein synthesis due to its poor amino acid balance.
- States that as a scientist, he hasn't seen evidence that collagen leads to greater connective tissue protein synthesis rates in muscle, but if he were recovering from a hip or knee injury, he would take a protein supplement with some collagen to ensure enough glycine and proline for ligaments, tendons, bone, and cartilage.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
- Recommends collagen supplements, in either pill or powder form, for hair, skin, nails, bones, and for putting on and maintaining healthy muscle, as it's difficult to get enough from diet alone.
- Expresses skepticism about 'panacea treatments' for cancer, specifically mentioning a 'twenty thousand dollars of vitamin C' treatment, implying it's an example of something he's 'squirrely' about due to cost and unproven claims.
- Asks if vitamin C matters for immune function, suggesting a need for a definitive study.
- Warns against the "total nonsense" of taking excessive amounts of vitamin C, especially in specific forms like liposomal vitamin C, for immunity, stating that it is idiotic and potentially dangerous to think it will offer immunity.
RAL Summary
Members OnlyTier 2 for Younger-Looking Skin for Women
Three reviews pooling many placebo-controlled trials show that collagen taken by mouth improves skin hydration, elasticity and wrinkles [1][2]. Over 79,000 ratings are mostly positive, so tier 2 stands, although the highest-quality studies are less convincing [6].
Where the evidence disagrees: 5 of the 47 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Skin, Musculoskeletal system, Digestive system
Combine with: To maximize the benefits of collagen for skin health, consider combining it with Vitamin C, which is crucial for collagen synthesis. Hyaluronic acid can further enhance skin hydration and plumpness, complementing collagen's structural support. Additionally, antioxidants like Vitamin E or astaxanthin can help protect collagen from oxidative damage, while omega-3 fatty acids may support overall skin barrier function and reduce inflammation.
Possible side effects: The collagen studies reported no related side effects, and vitamin C skin products had few side effects. The review summary mentions some users reporting bloating, more joint aches and an unpleasant taste in some batches.
Supplement Facts
Vitamin C 90 mg · Multi Collagen Complex 10 g
| Calories | 35 | |
| Protein | 9 g | |
| Vitamin C (from Lipid Metabolite Ascorbate) | 90 mg | 100% |
| Multi Collagen Complex | 10 g |
Directions: Adults mix one scoop with 8 ounces of liquid, and enjoy. Adults add one scoop of Multi Collagen Protein to 8 ounces of cold or hot liquid using a blender, hand frother or shaker cup.
Label source: Ancientnutrition · Report a label change
Sizes and barcodes: 16 Ounce(s); 1 Pound(s); 454.5 Gram(s), UPC 8 58109 00611 5 (on market); 8.6 Ounce(s); 242.4 Gram(s), UPC 8 16401 02217 2 (not checked yet); 0.36 Ounce(s); 10.1 Gram(s), UPC 8 58109 00633 7 (off market); 4.28 Ounce(s); 121.2 Gram(s), UPC 8 16401 02533 3 (off market); 21.38 Ounce(s); 606 Gram(s), UPC 8 16401 02539 5 (off market)
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More younger-looking skin for women products
Members OnlyThe highest ranked for the same goal
Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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