Basic Vitamins B-Complex 100 Time Released Review

Product Focus: Occasional Heartburn: Fast ReliefAlso covers:DigestionBrainRanked among:Vitamin B complex
Tier ⓘ
Tier 4 · Rank 6
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 6 within Tier 4 for Occasional Heartburn: Fast Relief; 15 of 29 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
43 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 9,100
Biohacker Mentions
0 of 10
Cost per month
$3

Study, Trial or Testing Result Summary

Members Only17 human studies · 9 improved

3 of these 17 human studies gave the ingredient by drip or injection, not by mouth.

17 human studies9 improved7 no effect16,670 people studied

No study has tested this B-complex, or any single B vitamin in it, for fast relief of occasional heartburn. The strongest human evidence is indirect. A large diet survey linked more riboflavin, vitamin B6 and folic acid from food to lower odds of one type of reflux, but this shows only an association [1]. A smaller study linked more riboflavin and folate from food to less inflammation of the food pipe [2]. A trial in people with reflux found a blend of melatonin, vitamin B6, folic acid, vitamin B12 and other nutrients worked better than an acid-reducing drug over about 40 days, but this product has no melatonin and the vitamins' own share is unknown [3]. Other studies disagree: one linked more vitamin B6 to more reflux [4], and folic acid did worse than an herbal remedy for upper-stomach pain [5]. Thiamine helped indigestion only when injected into acupuncture points [6]. Vitamin B12 here is 100 micrograms, below the 1000 micrograms studied for indigestion [7]. Choline evidence is from animals only [8]. Animal and cell studies are never counted.

See all 17 studies →Hide the studies

Review Totals and Summary

Members Only9,100 reviews · 95% positive
9,100 reviews · Google Shopping 9,100
95% positive0% neutral5% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Folate is the main ingredient, and the panel leans positive: five of the ten recommend it and the other five are neutral, with no one warning against it or stopping it. The two who named a form both prefer methylfolate, described as an active form the body can use directly, and one links it to mitochondrial function. People mainly take it to lower homocysteine, to cover low intake from food, and to support brain health during pregnancy, with one noting it helped reduce spina bifida and another using it to correct a child's low folate levels. No one gave a folate dose, and the only pairing mentioned was a prenatal vitamin for women preparing for IVF. Among the smaller ingredients in this product, inositol drew the most attention, with several panelists taking 900 mg before bed for sleep.

See all 10 biohackers →Hide the biohackers
  • Dr. Rhonda Patrick · Folate · neutral
    • 1 Nov 2026 · neutral · YouTube ↗
      Mentions folate as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 18 Jun 2026 · Choline · neutral · Facebook ↗
      States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
    • 30 Dec 2025 · Choline · neutral · Instagram ↗
      Choline plays a critical role in fetal brain development, and the form and dose matter. Pregnant women who supplemented with twice the RDA for choline (900 mg/day) had children with higher intelligence scores than women taking 450 mg/day.
    • 23 Dec 2025 · Choline · recommends · Facebook ↗
      Recommends that pregnant women supplement with choline, specifically phosphatidylcholine, to potentially have smarter babies, citing a randomized controlled trial where mothers who nearly doubled their choline intake had children who scored higher on IQ and cognitive tests.
    • 8 Oct 2025 · Vitamin B12 · warns · Facebook ↗
      Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
    • 9 Sep 2025 · Biotin · warns · YouTube ↗
      Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
    • 2 Sep 2025 · Inositol · uses · Instagram ↗
      Has found myo-inositol helps calm "mental chatter" before bed, although it is not strongly evidenced as a sleep aid.
    • 20 Aug 2025 · neutral · Instagram ↗
      Notes that dark leafy greens are a great source of folate.
    • 5 Aug 2025 · Choline · neutral · Podcast ↗
      Discusses which choline supplement won't raise TMAO.
    • 5 Aug 2025 · Inositol · uses · Podcast ↗
      Discusses why and how much myo-inositol they took.
    • 8 Jul 2025 · Choline · neutral · Facebook ↗
      Choline is vital for brain function and development, and even slight deficiencies can elevate homocysteine levels, which is linked to cardiovascular disease and cognitive decline.
    • 26 Jun 2025 · Inositol · uses · Facebook ↗
      Rhonda's current supplement routine includes Myo-inositol.
    • 31 Oct 2024 · Choline · recommends · Instagram ↗
      Recommends that pregnant women consume 900 mg of choline per day for greater outcomes in a child’s cognitive, attention, and possibly social development.
  • Dr. Mark Hyman · Folate · neutral
    • 21 Oct 2026 · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 23 Oct 2026 · Inositol · recommends · Facebook ↗
      Lists inositol as a supplement that helps balance neurotransmitters and can help lower anxiety or depression symptoms.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 30 Sep 2026 · Niacin · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 31 Aug 2026 · uses · YouTube ↗
      Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
    • 31 Aug 2026 · Vitamin B6 · uses · YouTube ↗
      Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
    • 28 Jul 2026 · neutral · Facebook ↗
      Notes that a med depletes folate.
    • 22 Jul 2026 · recommends · YouTube ↗
      States that folate is a nutritional deficiency that impacts mental health.
    • 22 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 is a nutritional deficiency that impacts mental health.
    • 20 Jul 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 8 Jul 2026 · uses · YouTube ↗
      Recounts giving a patient with MCI high-dose methylfolate, along with B12 shots and B6, which completely cured her MCI.
    • 29 Jun 2026 · recommends · Facebook ↗
      Recommends folate with vitamin B6 and B12 as supplements with strong evidence for PMS.
    • 29 Jun 2026 · Vitamin B6 · recommends · Facebook ↗
      Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
    • 29 Jun 2026 · Vitamin B12 · recommends · Facebook ↗
      Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
  • Dr. Eric Berg · Folate · neutral
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
    • 8 Nov 2026 · Vitamin B12 · neutral · Facebook ↗
      Mentions that one can of sardines provides 348% of the daily Vitamin B12.
    • 7 Nov 2026 · Vitamin B12 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
    • 6 Nov 2026 · Vitamin B1 · neutral · Instagram ↗
      Notes that irritability, overthinking, and nightmares can point to low vitamin B1, which is depleted by refined grains and sugar.
    • 6 Nov 2026 · Vitamin B1 · warns · YouTube ↗
      Explains that vitamin B1 is needed to support the autonomic nervous system and metabolize glucose.
    • 6 Nov 2026 · Vitamin B2 · neutral · Instagram ↗
      States that cracked corners on the mouth are often a B2 vitamin issue, which is also behind cracked heels and chapped lips.
    • 5 Nov 2026 · Vitamin B1 · recommends · Podcast ↗
      Suggests that increasing vitamin B1 may help address the underlying problem of bruxism.
    • 5 Nov 2026 · Choline · recommends · YouTube ↗
      Recommends ensuring adequate choline intake, as a deficiency can make one susceptible to liver fat, and it's important for preventing fat accumulation in the liver.
    • 1 Nov 2026 · Vitamin B6 · neutral · YouTube ↗
      States that vitamin B6 is needed to absorb magnesium.
    • 27 Oct 2026 · Choline · recommends · YouTube ↗
      Recommends choline for brain health, noting that consuming two eggs provides 300 mg of choline, which is essential for brain communication.
    • 21 Oct 2026 · Vitamin B1 · recommends · YouTube ↗
      States that taking Vitamin B1 might help with swollen legs and ankles.
    • 19 Oct 2026 · Niacin · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 18 Oct 2026 · Vitamin B1 · recommends · Instagram ↗
      Dr. Eric Berg states that vitamin B1 supports the nerve function and energy production involved in the brain's response to changes in hearing, which plays a major role in tinnitus.
    • 16 Oct 2026 · Choline · neutral · YouTube ↗
      Mentions that egg yolks contain choline, which helps the brain and prevents a fatty liver.
  • Dave Asprey · Folate · neutral
    • 17 Oct 2026 · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 3 Nov 2026 · Biotin · warns · YouTube ↗
      Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
    • 3 Nov 2026 · Inositol · recommends · YouTube ↗
      Suggests trying inositol for PCOS before going on a med, to see if it helps with sex binding globulin and anorobes.
    • 29 Sep 2026 · Choline · recommends · YouTube ↗
      Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
    • 12 Sep 2026 · Choline · recommends · YouTube ↗
      Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
    • 13 Aug 2026 · Choline · recommends · Podcast ↗
      Dave explains how to stack racetams with choline for smarter cognitive enhancement.
    • 13 Aug 2026 · Choline · recommends · YouTube ↗
      Recommends taking choline donors, especially if over 35, to prevent headaches and muscle tension that can occur when taking racetams due to increased demand on the acetylcholine system.
    • 5 Aug 2026 · recommends · Facebook ↗
      Recommends methylfolate as a better option than folic acid.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 1 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
    • 11 Jun 2026 · recommends · YouTube ↗
      Dave Asprey notes that 80% of their clients have a problem absorbing certain forms of folate, and when the exact form of folate or folinic acid is dialed in, clients experience shifts, with the brain waking up as one of the first improvements.
    • 30 May 2026 · Niacin · recommends · YouTube ↗
      Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
    • 16 May 2026 · Inositol · uses · X ↗
      He takes 900 mg of Inositol before bed for sleep.
    • 15 May 2026 · Niacin · neutral · X ↗
      Notes that niacin has been a standard longevity ingredient since the 1990s.
  • Ben Greenfield · Folate · recommends
    • 12 Oct 2026 · recommends · Facebook ↗
      Recommends methylfolate as an active form of folate that the body can use directly without conversion.
    • 21 Sep 2026 · Inositol · neutral · Facebook ↗
      Notes that inositol has solid research behind it for fertility.
    • 19 Sep 2026 · Inositol · recommends · YouTube ↗
      Recommends Inositol at 1 to 5 grams per day for women, noting its involvement in FSH signaling and citing trials showing fewer immature oocytes and more high-quality embryos in women undergoing IVF.
    • 19 Sep 2026 · Inositol · neutral · Podcast ↗
      He discusses inositol for female fertility.
    • 9 Sep 2026 · Inositol · neutral · X ↗
      Myo-inositol has the same insulin-sensitivity mechanism as in men and is tied to egg quality.
    • 8 Sep 2026 · Inositol · neutral · X ↗
      Mentions Inositol with a dose of 1-5 grams/day.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 20 Aug 2026 · Choline · uses · YouTube ↗
      Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
    • 9 Jul 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
    • 25 Apr 2026 · Niacin · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 18 Apr 2026 · recommends · YouTube ↗
      Recommends introducing methylfolate into the diet to address high homocysteine levels.
    • 18 Apr 2026 · Niacin · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
    • 25 Mar 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
  • Thomas DeLauer · Folate · recommends
    • 29 Jun 2026 · recommends · YouTube ↗
      Recommends taking methylfolate as a methylated form of B vitamin for mitochondrial function.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 25 Sep 2026 · Choline · neutral · Facebook ↗
      Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 5 Aug 2026 · Vitamin B2 · warns · Instagram ↗
      Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
    • 5 Aug 2026 · Vitamin B1 · warns · Instagram ↗
      Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
    • 30 Jun 2026 · Vitamin B12 · neutral · YouTube ↗
      Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
    • 29 Jun 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
    • 24 Jun 2026 · Niacin · neutral · YouTube ↗
      Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
    • 13 Jun 2026 · Biotin · warns · YouTube ↗
      Thinks biotin is a little overhyped, suggesting that consuming adequate protein is probably more effective for hair, skin, and nails. He notes that some people might be deficient, especially if consuming a lot of eggs with avidin, but doesn't consider it the 'Mecca of perfect hair'.
    • 10 Jun 2026 · recommends · YouTube ↗
      Recommends methylfolate as a runner-up for insulin resistance, especially for individuals with the MTHFR variant, as it directly enters the methylation cycle without conversion.
    • 20 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
    • 10 May 2026 · Choline · recommends · YouTube ↗
      Explains that choline is the direct precursor to acetylcholine, a neurotransmitter tied to memory, attention, and learning speed, and that most adults don't get enough of it.
    • 7 May 2026 · Vitamin B6 · recommends · YouTube ↗
      Recommends vitamin B6 to support GABA production and find balance for mental clarity.
  • Siim Land · Folate · neutral
    • 17 Jan 2026 · neutral · Instagram ↗
      States that Homocysteine levels can often be improved through adequate folate intake.
    • 19 Aug 2026 · Inositol · neutral · X ↗
      States that Inositol has been shown to improve blood sugar and insulin sensitivity.
    • 19 Aug 2026 · Inositol · neutral · X ↗
      States that Inositol has a key role in glucose metabolism and that grapefruit is one of the richest sources of it.
    • 20 Jul 2026 · Inositol · uses · X ↗
      He takes 900 mg of Inositol before bed for sleep.
    • 29 Jun 2026 · Inositol · uses · X ↗
      He takes 900 mg of inositol before bed for sleep.
    • 12 Jun 2026 · Inositol · neutral · YouTube ↗
      Describes Inositol as interesting, noting it is sweet-tasting like glycine and found in grapefruit, and that it lowers blood sugar and cholesterol, though the effects are not massive.
    • 24 Apr 2026 · Vitamin B12 · uses · YouTube ↗
      Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
    • 24 Mar 2026 · Vitamin B12 · recommends · YouTube ↗
      States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
    • 15 Feb 2026 · Niacin · recommends · TikTok ↗
      Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
    • 12 Feb 2026 · Niacin · recommends · Instagram ↗
      Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
    • 17 Jan 2026 · Niacin · neutral · Instagram ↗
      Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
    • 28 Dec 2025 · Inositol · recommends · YouTube ↗
      Likes inositol, stating it helps with neurotransmitters, mood, and blood sugar regulation, placing it in the 'good tier'.
    • 28 Dec 2025 · Niacin · neutral · YouTube ↗
      Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
    • 28 Dec 2025 · Vitamin B1 · uses · YouTube ↗
      Places Thiamine, Vitamin B1, in the 'good' tier for its benefits in blood sugar regulation and energy metabolism, noting that he personally takes bentothiamine occasionally, especially when consuming many carbohydrates.
  • Andrew Huberman · Folate · recommends
    • 31 Mar 2025 · recommends · YouTube ↗
      States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
    • 22 Oct 2026 · Inositol · neutral · Podcast ↗
      Discusses Myo-Inositol as a tool for middle-of-the-night waking.
    • 6 Aug 2026 · Inositol · neutral · Podcast ↗
      Discusses Myo-inositol as a supplement that can impact serotonin.
    • 6 Aug 2026 · Inositol · uses · YouTube ↗
      Has been taking 900 mg of myo-inositol every third night or so to test its ability to improve sleep, finding the depth and quality of sleep to be remarkable.
    • 6 Aug 2026 · Choline · recommends · Podcast ↗
      Recommends choline-rich foods to enhance focus and acetylcholine.
    • 20 Jul 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 20 Jul 2026 · Choline · recommends · YouTube ↗
      Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
    • 16 Jul 2026 · Inositol · neutral · Podcast ↗
      Mentions inositol as a nutraceutical that can be used for bipolar disorder.
    • 16 Jul 2026 · Inositol · uses · YouTube ↗
      Personally takes 900 mg of myo-inositol every third night or so to improve sleep and for its anti-anxiety effect during the day, but not for bipolar disorder.
    • 9 Jul 2026 · Inositol · neutral · Podcast ↗
      Mentions Inositol as a nutraceutical for OCD.
    • 9 Jul 2026 · Inositol · recommends · YouTube ↗
      Highlights myoinositol, stating that 900 milligrams or higher dosages can improve sleep and reduce anxiety, and suggests more systematic exploration of nutraceuticals like inositol for OCD treatment, especially in combination with behavioral therapies.
    • 6 Jul 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 13 Apr 2026 · Inositol · recommends · YouTube ↗
      Mentions inositol for PCOS, stating it decreases insulin resistance and offers a huge benefit.
    • 13 Apr 2026 · Biotin · neutral · Podcast ↗
      Mentions biotin.
  • Peter Attia · Folate · recommends
    • 19 Aug 2024 · recommends · YouTube ↗
      Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 11 May 2025 · Biotin · warns · YouTube ↗
      Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
    • 9 Sep 2024 · Vitamin B12 · neutral · YouTube ↗
      Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
    • 20 May 2024 · Choline · neutral · YouTube ↗
      States that for choline deficiencies, which are sometimes measurable and seen in people post-bariatric surgery, they are not terribly aware of any downsides to taking choline supplements, but cautions about quantifying what's in supplements.
    • 26 Feb 2024 · Biotin · warns · YouTube ↗
      Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
    • 24 Oct 2023 · uses · YouTube ↗
      Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
    • 23 Oct 2023 · uses · YouTube ↗
      Takes Jarrow methylfolate, a methylated version, once a day at the lower of two strengths, to keep homocysteine levels below nine.
    • 9 Oct 2023 · Biotin · warns · YouTube ↗
      Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
    • 28 Aug 2023 · neutral · YouTube ↗
      Mentions that in a mouse model for obesity, the amount of folate given to the mother mouse during pregnancy affects the epigenetics of her offspring, leading to changes in coat color and obesity.
    • 5 Jun 2023 · uses · YouTube ↗
      Personally takes methylfolate to help get homocysteine into the desired zone and prefers the Jarrow brand.
    • 30 Jan 2023 · Niacin · stopped · YouTube ↗
      Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
    • 7 Nov 2022 · Niacin · stopped · YouTube ↗
      Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
    • 1 Aug 2022 · Niacin · neutral · YouTube ↗
      Recalls that a flush from niacin typically occurred with doses of a few grams.
  • Bryan Johnson · Folate · recommends
    • Date not recorded · recommends · Source ↗
      Recommends supplementing with folate for brain health for both the mother and the baby during pregnancy.
    • 4 May 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 15 Apr 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 8 Apr 2026 · Inositol · uses · X ↗
      Takes 900 mg of inositol before bed for sleep.
    • 31 Mar 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 20 Mar 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 10 Mar 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 7 Mar 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 5 Jun 2025 · Vitamin B12 · uses · YouTube ↗
      States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
    • 5 Sep 2024 · Biotin · neutral · YouTube ↗
      Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
    • Date not recorded · Biotin · recommends · Website ↗
      Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
    • Date not recorded · Niacin · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • Date not recorded · Niacin · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.

RAL Summary

Members OnlyTier 4 for Occasional Heartburn: Fast Relief

The tier rests on a diet survey linking folate from food to lower reflux odds, which is only an association and did not test folate supplements, and the one trial tested a blend with melatonin, so no study shows a clear improvement from these vitamins for heartburn. So it is graded Tier 4, lower than the rules alone gave.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 7 of the 17 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system, Nervous system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: In one trial a drink containing vitamin B6 with other ingredients caused heartburn in 10 of 25 people. No other major side effects were reported in the studies, and no written reviews could be read.

Supplement Facts

Thiamine 100 mg · Riboflavin 100 mg · Niacin 100 mg
Supplement Facts
Serving Size 1 Tablet(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Thiamine100 mg
Riboflavin100 mg
Niacin100 mg
Vitamin B6100 mg
Folate667 mcg DFE
Vitamin B12100 mcg
Biotin100 mcg
Pantothenic Acid100 mg
Choline10 mg
Inositol10 mg†
PABA10 mg†
† Daily Value not established.

Other ingredients: Microcrystalline Cellulose, Stearic Acid, Dicalcium Phosphate, Contains less than 2% of.

Directions: Directions: For adults, take one (1) tablet daily, preferably with a meal.

Barcode (UPC) 307610225206 · Label source: NIH label database · Report a label change

Show entire label
The Basic Vitamins B-Complex 100 Time Released label, 60 Tablet(s)
B-Complex 100 Time Released, 60 Tablet(s)

More occasional heartburn: fast relief products

Members OnlyThe highest ranked for the same goal

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Our articles on this subject

Graded November 15, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.