Basic Vitamins B-Complex 100 Time Released Review
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Study, Trial or Testing Result Summary
Members Only17 human studies · 9 improved
3 of these 17 human studies gave the ingredient by drip or injection, not by mouth.
No study has tested this B-complex, or any single B vitamin in it, for fast relief of occasional heartburn. The strongest human evidence is indirect. A large diet survey linked more riboflavin, vitamin B6 and folic acid from food to lower odds of one type of reflux, but this shows only an association [1]. A smaller study linked more riboflavin and folate from food to less inflammation of the food pipe [2]. A trial in people with reflux found a blend of melatonin, vitamin B6, folic acid, vitamin B12 and other nutrients worked better than an acid-reducing drug over about 40 days, but this product has no melatonin and the vitamins' own share is unknown [3]. Other studies disagree: one linked more vitamin B6 to more reflux [4], and folic acid did worse than an herbal remedy for upper-stomach pain [5]. Thiamine helped indigestion only when injected into acupuncture points [6]. Vitamin B12 here is 100 micrograms, below the 1000 micrograms studied for indigestion [7]. Choline evidence is from animals only [8]. Animal and cell studies are never counted.
See all 17 studies →Hide the studies
- In 351 adults with acid reflux disease, a blend containing vitamin B6 plus melatonin and other nutrients led to complete symptom relief in all 176 people after 40 days, versus 65.7% of those taking a med, though the vitamin B6 effect cannot be separated from the other ingredients.Read the study on PubMed (16948779) →
- In 196 people with chronic atrophic gastritis, folic acid was used as the comparison treatment for 6 months and did worse than the herbal Moluodan at easing upper-stomach pain, belching and fullness, so it showed no clear benefit for heartburn-type symptoms.Randomized double-blind clinical trial of Moluodan () for the treatment of chronic atrophic gastritis with dysplasia.
- In 49 adults with constipation-type irritable bowel syndrome, a drink with 2 mg vitamin B6, inulin and menthol taken for 2 weeks improved bowel symptoms but caused noticeable heartburn in 10 of 25 people who drank it.[Using a multicomponent functional food in IBS patients with constipation a comparative controlled study].
- In 100 adults with functional dyspepsia, vitamin B1 injected into two acupuncture points every other day for one week lowered symptom scores and improved stomach emptying more than the standard drug mosapride, with benefits still seen two weeks later.[Clinical observation on treatment of functional dyspepsia by injection of vitamin B1 into Zusanli (ST36) and Hegu (LI4)…
- In a study of 11,690 people who had endoscopy and recorded their diet for 3 days, higher dietary vitamin B2 (riboflavin) intake was linked to lower odds of non-erosive reflux disease (odds ratio 0.68), but not to erosive esophagitis.Gender-specific Effect of Micronutrient on Non-erosive Reflux Disease and Erosive Esophagitis.
- In 1,991 children and teens with disabilities, a better Mediterranean diet was linked to fewer stomach symptoms such as reflux, but this study did not test thiamine supplements and found thiamine intake was often too low.Mediterranean diet is associated with better gastrointestinal health and quality of life, and less nutrient deficiency i…
- In a case-control study of 918 people, higher dietary riboflavin intake was linked to lower risk of reflux esophagitis, an inflammation of the esophagus caused by stomach acid backing up.Intakes of dietary folate and other B vitamins are associated with risks of esophageal adenocarcinoma, Barrett's esophag…
- In a case-control study of 150 women with reflux and 300 controls in Iran, higher dietary vitamin B6 intake was linked to higher odds of reflux disease.Dietary Vitamin B6 Intake and Gastroesophageal Reflux Disease: A Case-Control Study.
- In a cross-sectional study of 328 young adults, lower dietary vitamin B6 intake was linked to higher overall gastrointestinal symptom scores, but vitamin B6 intake was not directly linked to reflux status.Health cooking at home: can cooking skills reduce gastrointestinal symptoms, cross sectional study?
- This observational study used a PABA-based test to measure pancreas digestive function in people with indigestion. It did not give PABA as a treatment and did not test it for heartburn or acid indigestion.Postprandial Symptoms Felt at the Lower Part of the Epigastrium and a Possible Association of Pancreatic Exocrine Dysfun…
- In 200 arthritis patients taking a med with folic acid over about 41 months, heartburn was more common in those with raised red blood cell size, and folic acid did not change the overall side-effect rate.Read the study on PubMed (2068578) →
- In 34 people with Helicobacter pylori infection and low vitamin B12, 1000 mcg daily for 3 months shortened stomach emptying time and reduced dyspepsia scores, with no control group.The impact of B(12) treatment on gastric emptying time in patients with Helicobacter pylori infection.
- This lab and mouse study found that choline, a part of yarrow extract, made isolated mouse and human stomach muscle tissue contract, and yarrow extract sped stomach emptying in mice; no people were given choline for heartburn, so it does not show that choline relieves heartburn in people.Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: studies in the mo…
- In a study of 20 dogs, a single intravenous dose of 50 mg per kg of phosphatidylcholine given before bile exposure of the esophagus protected the esophageal lining from bile-related damage. This was an animal study and did not measure heartburn in people.Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux.
- In a study of 20 dogs, a single intravenous dose of 50 mg per kg of phosphatidylcholine given before bile exposure of the esophagus reversed bile-related energy loss and inflammatory changes in the esophageal lining. This was an animal study and did not measure heartburn in people.[Effects of phosphatidylcholine pretreatment during acute experimental biliary reflux].
- In a rat study of prenatal stress, folic acid reduced stomach hypersensitivity and nerve overactivity by increasing the DNMT1 enzyme and lowering the ASIC1 ion channel, but this was tested only in animals, not people.DNMT1 involved in the analgesic effect of folic acid on gastric hypersensitivity through downregulating ASIC1 in adult o…
- In a study of rats, oral phosphatidylcholine taken one hour before bacterial endotoxin injection reduced leakiness of the stomach and small intestine lining. It did not prevent the rise in blood inflammatory marker TNF-alpha, stomach volume or pH change, or bile reflux into the stomach. This was an animal study and did not measure heartburn in people.Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation.
Review Totals and Summary
Members Only9,100 reviews · 95% positive
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Biohacker Summary
Members Only0 of 10 recommend it
Folate is the main ingredient, and the panel leans positive: five of the ten recommend it and the other five are neutral, with no one warning against it or stopping it. The two who named a form both prefer methylfolate, described as an active form the body can use directly, and one links it to mitochondrial function. People mainly take it to lower homocysteine, to cover low intake from food, and to support brain health during pregnancy, with one noting it helped reduce spina bifida and another using it to correct a child's low folate levels. No one gave a folate dose, and the only pairing mentioned was a prenatal vitamin for women preparing for IVF. Among the smaller ingredients in this product, inositol drew the most attention, with several panelists taking 900 mg before bed for sleep.
See all 10 biohackers →Hide the biohackers
Dr. Rhonda Patrick · Folate · neutral
- Mentions folate as one of the micronutrients found in multivitamins that people often don't get enough of from their diets.
- Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
- States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
- Choline plays a critical role in fetal brain development, and the form and dose matter. Pregnant women who supplemented with twice the RDA for choline (900 mg/day) had children with higher intelligence scores than women taking 450 mg/day.
- Recommends that pregnant women supplement with choline, specifically phosphatidylcholine, to potentially have smarter babies, citing a randomized controlled trial where mothers who nearly doubled their choline intake had children who scored higher on IQ and cognitive tests.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
- Has found myo-inositol helps calm "mental chatter" before bed, although it is not strongly evidenced as a sleep aid.
- Notes that dark leafy greens are a great source of folate.
- Discusses which choline supplement won't raise TMAO.
- Discusses why and how much myo-inositol they took.
- Choline is vital for brain function and development, and even slight deficiencies can elevate homocysteine levels, which is linked to cardiovascular disease and cognitive decline.
- Rhonda's current supplement routine includes Myo-inositol.
- Recommends that pregnant women consume 900 mg of choline per day for greater outcomes in a child’s cognitive, attention, and possibly social development.
Dr. Mark Hyman · Folate · neutral
- Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
- Lists inositol as a supplement that helps balance neurotransmitters and can help lower anxiety or depression symptoms.
- Notes that some people may need a little bit extra folate with a supplement.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Optimized a child's nutrient status with folate, as the child had low folate levels and was not eating greens.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Notes that a med depletes folate.
- States that folate is a nutritional deficiency that impacts mental health.
- States that vitamin B12 is a nutritional deficiency that impacts mental health.
- Takes 900 mg of Inositol before bed for sleep.
- Recounts giving a patient with MCI high-dose methylfolate, along with B12 shots and B6, which completely cured her MCI.
- Recommends folate with vitamin B6 and B12 as supplements with strong evidence for PMS.
- Recommends vitamin B6 with folate and B12 as supplements with strong evidence for PMS.
- Recommends vitamin B12 with vitamin B6 and folate as supplements with strong evidence for PMS.
Dr. Eric Berg · Folate · neutral
- Notes that birth control pills deplete the body of folate, which is needed for the brain to make serotonin.
- Mentions that one can of sardines provides 348% of the daily Vitamin B12.
- Dr. Berg states that when nutrients like vitamin B12 are too low, fatigue and weakness can follow.
- Notes that irritability, overthinking, and nightmares can point to low vitamin B1, which is depleted by refined grains and sugar.
- Explains that vitamin B1 is needed to support the autonomic nervous system and metabolize glucose.
- States that cracked corners on the mouth are often a B2 vitamin issue, which is also behind cracked heels and chapped lips.
- Suggests that increasing vitamin B1 may help address the underlying problem of bruxism.
- Recommends ensuring adequate choline intake, as a deficiency can make one susceptible to liver fat, and it's important for preventing fat accumulation in the liver.
- States that vitamin B6 is needed to absorb magnesium.
- Recommends choline for brain health, noting that consuming two eggs provides 300 mg of choline, which is essential for brain communication.
- States that taking Vitamin B1 might help with swollen legs and ankles.
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Dr. Eric Berg states that vitamin B1 supports the nerve function and energy production involved in the brain's response to changes in hearing, which plays a major role in tinnitus.
- Mentions that egg yolks contain choline, which helps the brain and prevents a fatty liver.
Dave Asprey · Folate · neutral
- States that folate can affect how the body responds to a supplement.
- Mentions that most places put in extra biotin for hair growth, suggesting it's not always necessary or beneficial.
- Suggests trying inositol for PCOS before going on a med, to see if it helps with sex binding globulin and anorobes.
- Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
- Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
- Dave explains how to stack racetams with choline for smarter cognitive enhancement.
- Recommends taking choline donors, especially if over 35, to prevent headaches and muscle tension that can occur when taking racetams due to increased demand on the acetylcholine system.
- Recommends methylfolate as a better option than folic acid.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Dave Asprey notes that 80% of their clients have a problem absorbing certain forms of folate, and when the exact form of folate or folinic acid is dialed in, clients experience shifts, with the brain waking up as one of the first improvements.
- Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
- He takes 900 mg of Inositol before bed for sleep.
- Notes that niacin has been a standard longevity ingredient since the 1990s.
Ben Greenfield · Folate · recommends
- Recommends methylfolate as an active form of folate that the body can use directly without conversion.
- Notes that inositol has solid research behind it for fertility.
- Recommends Inositol at 1 to 5 grams per day for women, noting its involvement in FSH signaling and citing trials showing fewer immature oocytes and more high-quality embryos in women undergoing IVF.
- He discusses inositol for female fertility.
- Myo-inositol has the same insulin-sensitivity mechanism as in men and is tied to egg quality.
- Mentions Inositol with a dose of 1-5 grams/day.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
- Recommends bioavailable folate, not synthetic folic acid, as folate deficiencies seem to impact hearing health in older individuals.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Recommends introducing methylfolate into the diet to address high homocysteine levels.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Takes 900 mg of Inositol before bed for sleep.
Thomas DeLauer · Folate · recommends
- Recommends taking methylfolate as a methylated form of B vitamin for mitochondrial function.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
- Warns against conventional cereal, describing it as extruded, sugared, and then sprayed with vitamins that were destroyed during its making.
- Mentions that a single serving of sardines provides vitamin B12 at something like three to four times the daily needs.
- Recommends taking methylcobalamin as a methylated form of B vitamin for mitochondrial function.
- Discusses niacin as an essential vitamin involved in NAD production and known for its flushing effect as a vasodilator. He also mentions its role as an agonist for GPR109A receptors, which could potentially block fat mobilization.
- Thinks biotin is a little overhyped, suggesting that consuming adequate protein is probably more effective for hair, skin, and nails. He notes that some people might be deficient, especially if consuming a lot of eggs with avidin, but doesn't consider it the 'Mecca of perfect hair'.
- Recommends methylfolate as a runner-up for insulin resistance, especially for individuals with the MTHFR variant, as it directly enters the methylation cycle without conversion.
- Recommends ensuring adequate vitamin B6 intake, as it is a required cofactor for cells to use absorbed magnesium and improves central nervous system relaxation when combined with magnesium.
- Explains that choline is the direct precursor to acetylcholine, a neurotransmitter tied to memory, attention, and learning speed, and that most adults don't get enough of it.
- Recommends vitamin B6 to support GABA production and find balance for mental clarity.
Siim Land · Folate · neutral
- States that Homocysteine levels can often be improved through adequate folate intake.
- States that Inositol has been shown to improve blood sugar and insulin sensitivity.
- States that Inositol has a key role in glucose metabolism and that grapefruit is one of the richest sources of it.
- He takes 900 mg of Inositol before bed for sleep.
- He takes 900 mg of inositol before bed for sleep.
- Describes Inositol as interesting, noting it is sweet-tasting like glycine and found in grapefruit, and that it lowers blood sugar and cholesterol, though the effects are not massive.
- Created Microvitamin, a supplement that bundled all the supplements he was taking, to help fund his a med trial.
- States that vitamin B12 deficiency is the most common reason for premature graying of hair and recommends fixing B12 status if it is deficient, as it gives a greater likelihood of reversing gray hair.
- Suggests that in the mornings, NAD supplements like niacinamide can help kickstart the circadian rhythm.
- Recommends Niacinamide for skin protection, explaining it works partly through NAD metabolism that the body uses against DNA damage and is found in protein sources.
- Mentions that only specific therapies like niacin can meaningfully reduce Lp(a).
- Likes inositol, stating it helps with neurotransmitters, mood, and blood sugar regulation, placing it in the 'good tier'.
- Notes that Niacin notoriously raises HDL cholesterol, but this increase does not lower the risk of heart disease events, and while it can be good in many cases, very high doses can affect liver function.
- Places Thiamine, Vitamin B1, in the 'good' tier for its benefits in blood sugar regulation and energy metabolism, noting that he personally takes bentothiamine occasionally, especially when consuming many carbohydrates.
Andrew Huberman · Folate · recommends
- States that B12, folate, and iron are essential to mitochondrial function and if deficient, mitochondria will not function properly, which is consistent with the mitochondrial theory of neuropsychiatric disorders.
- Discusses Myo-Inositol as a tool for middle-of-the-night waking.
- Discusses Myo-inositol as a supplement that can impact serotonin.
- Has been taking 900 mg of myo-inositol every third night or so to test its ability to improve sleep, finding the depth and quality of sleep to be remarkable.
- Recommends choline-rich foods to enhance focus and acetylcholine.
- Takes 900 mg of Inositol before bed for sleep.
- Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
- Mentions inositol as a nutraceutical that can be used for bipolar disorder.
- Personally takes 900 mg of myo-inositol every third night or so to improve sleep and for its anti-anxiety effect during the day, but not for bipolar disorder.
- Mentions Inositol as a nutraceutical for OCD.
- Highlights myoinositol, stating that 900 milligrams or higher dosages can improve sleep and reduce anxiety, and suggests more systematic exploration of nutraceuticals like inositol for OCD treatment, especially in combination with behavioral therapies.
- Takes 900 mg of Inositol before bed for sleep.
- Mentions inositol for PCOS, stating it decreases insulin resistance and offers a huge benefit.
- Mentions biotin.
Peter Attia · Folate · recommends
- Highlights folate supplementation as a significant practical progress in nutrition science, which has radically reduced spinabifida.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that for choline deficiencies, which are sometimes measurable and seen in people post-bariatric surgery, they are not terribly aware of any downsides to taking choline supplements, but cautions about quantifying what's in supplements.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Takes Jarrow methylfolate to keep homocysteine levels below nine, taking the lower of two available strengths once a day.
- Takes Jarrow methylfolate, a methylated version, once a day at the lower of two strengths, to keep homocysteine levels below nine.
- Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
- Mentions that in a mouse model for obesity, the amount of folate given to the mother mouse during pregnancy affects the epigenetics of her offspring, leading to changes in coat color and obesity.
- Personally takes methylfolate to help get homocysteine into the desired zone and prefers the Jarrow brand.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
- Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
- Recalls that a flush from niacin typically occurred with doses of a few grams.
Bryan Johnson · Folate · recommends
- Recommends supplementing with folate for brain health for both the mother and the baby during pregnancy.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- Takes 900 mg of Inositol before bed for sleep.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
- Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
- He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.
RAL Summary
Members OnlyTier 4 for Occasional Heartburn: Fast Relief
The tier rests on a diet survey linking folate from food to lower reflux odds, which is only an association and did not test folate supplements, and the one trial tested a blend with melatonin, so no study shows a clear improvement from these vitamins for heartburn. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 7 of the 17 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Digestive system, Nervous system
Combine with: Combine with a healthy diet and lifestyle.
Possible side effects: In one trial a drink containing vitamin B6 with other ingredients caused heartburn in 10 of 25 people. No other major side effects were reported in the studies, and no written reviews could be read.
Supplement Facts
Thiamine 100 mg · Riboflavin 100 mg · Niacin 100 mg
| Thiamine | 100 mg | |
| Riboflavin | 100 mg | |
| Niacin | 100 mg | |
| Vitamin B6 | 100 mg | |
| Folate | 667 mcg DFE | |
| Vitamin B12 | 100 mcg | |
| Biotin | 100 mcg | |
| Pantothenic Acid | 100 mg | |
| Choline | 10 mg | |
| Inositol | 10 mg | † |
| PABA | 10 mg | † |
Other ingredients: Microcrystalline Cellulose, Stearic Acid, Dicalcium Phosphate, Contains less than 2% of.
Directions: Directions: For adults, take one (1) tablet daily, preferably with a meal.
Barcode (UPC) 307610225206 · Label source: NIH label database · Report a label change
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More occasional heartburn: fast relief products
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Our articles on this subject
- Folate vs Folic Acid: What the Studies Show About Each FormArticle · Oct 29, 2026
- Supplement Safe Upper Limits: How Much Is Too Much, Nutrient by Nutrient, and How to Check Your StackArticle · Oct 16, 2026
Graded November 15, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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