Celsius Sparkling Cola Review
CELSIUS Sparkling Cola, Sugar Free Energy Drink, 12 Fl Oz (Pack of 12) is listed on this Amazon page as a carbonated energy drink in the cola flavor. The product is sold as a pack of twelve 12 fluid ounce cans, with a unit count of 144 fluid ounces. The page lists the item form as liquid and the package type as can. The listing is sold and shipped by Amazon.com, with the brand listed as CELSIUS and the manufacturer as Celsius, Inc. The page shows a current one-time price of $19.98, or $0.14 per fluid ounce, and a Subscribe and Save option at $18.98, or $16.98 with 15 percent savings, depending on the selected delivery frequency. According to the About this item section, the drink is marketed as functional, essential energy with 200mg of caffeine, intended to help customers live fit. The page states that it is made with premium, proven ingredients and seven essential vitamins. It is labeled as having no sugar, no high fructose corn syrup, no aspartame, and no artificial flavors or colors. The listed diet types are gluten free, kosher, and vegan, and the page also describes the product as non-GMO and certified vegan. The item details list specialty features including low calorie, no artificial colors, no artificial flavors, and sugar free. The recommended uses are pre-workout and general fitness or wellness, and the specific uses listed are workout and energy boost. The product is listed with a flavored drink type of carbonated flavored drink and a liquid contents description of carbonated energy drink. The item details also list the UPC as 889392000566, the global trade identification number as 00889392000566, and the model number as FGSS1207. The best sellers rank shows the product at number one in Grocery and Gourmet Food and number one in Energy Drinks. The ingredients listed include carbonated filtered water, taurine, citric acid, caramel color, guarana seed extract, green tea extract, caffeine, calcium carbonate, phosphoric acid, ascorbic acid, sucralose, glucuronolactone, natural flavor, ginger root extract, calcium pantothenate, niacinamide, pyridoxine hydrochloride, riboflavin, chromium chelate, biotin, and cyanocobalamin. The page also lists the item as non-returnable due to food safety reasons, although damaged or defective items may be refunded or replaced through Your Orders. The product is shown with 4.6 out of 5 stars from 4,592 ratings on the page. Other CELSIUS flavors appear as separate listings on the page, including Cherry Cola, Assorted Flavor Variety, and several Fizz Free options, and the flavor selector shows Cola as the selected option.
Study, Trial or Testing Result Summary
Members Only117 human studies · 44 improved
13 of these 117 human studies gave the ingredient by drip or injection, not by mouth.
The main energy ingredients are in a 1.81 gram proprietary blend, and no human studies of that blend were provided, so its amounts and effects are unknown. Riboflavin is at a full dose. One trial in construction workers found less fatigue [1], but a larger trial of a nutrient mix with riboflavin found no fatigue benefit [2]. Vitamin C here is below the studied dose. It helped mainly people with low vitamin C [3], while a large trial in people who were not low found no benefit [4]. Vitamin B6 and calcium are at trace amounts compared with the doses studied [5][6]. Niacin and related vitamin B3 forms did not ease tiredness across 27 studies [7]. Vitamin B12 did not boost energy in people who were not deficient [8]. Pantothenic acid did not improve exercise performance [9], and chromium showed no stamina benefit [10]. Biotin's only human support is an uncontrolled study of a mixed product in people with fatigue after a coronavirus infection [11]. Animal and cell studies are never counted.
See all 117 studies →Hide the studies
- A review of 32 studies of phone apps for osteoporosis self-management found no clear effect on fatigue or on calcium intake; this was not a test of calcium supplements.Digital Health Technologies for Long-term Self-management of Osteoporosis: Systematic Review and Meta-analysis.
- Across 16 trials with 6276 people, B12 with or without folic acid and B6 did not improve thinking or depression, and only one trial looked at fatigue so it could not be analyzed.Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Met…
- Across 27 studies of 1,599 adults, NAD+ precursors did not improve perceived fatigue or sleep, but nicotinamide mononucleotide improved endurance and NADH improved cognitive performance.Domain-specific effects of NAD+ precursors on fatigue and functional performance: a systematic review and network meta-a…
- In two placebo-controlled trials of 404 adults with Charcot-Marie-Tooth disease type 1A, ascorbic acid at two doses over 12 to 24 months had little meaningful effect on fatigue.Interventions for fatigue in peripheral neuropathy.
- Across nine studies of 720 people, three of four controlled trials found intravenous vitamin C lowered fatigue scores more than control, and four of five uncontrolled studies saw fatigue fall.Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review o…
- In 10 trials of 489 people, NADH was well tolerated and linked to better quality of life, less anxiety and lower heart rate after stress, but fatigue results were not clearly shown.Evaluation of safety and effectiveness of NAD in different clinical conditions: a systematic review.
- In a review of 13 small trials with 85 people with McArdle disease, vitamin B6 gave no benefit for exercise performance.Pharmacological and nutritional treatment for McArdle disease (Glycogen Storage Disease type V).
- A review of 37 studies in cancer patients found intravenous vitamin C may ease fatigue and other symptoms, but the evidence is preliminary and mostly uncontrolled.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of supplements for football players said vitamin C may improve performance by lowering oxidative stress, but gave no numbers and called for more research.The efficacy of dietary supplements on health status and performance of football players: a systematic review.
- A review of 14 reviews found oral niacin and nicotinamide can cause side effects including fatigue, stomach upset, flushing and liver problems, more often at higher doses and with niacin than nicotinamide.The adverse effects of oral niacin/nicotinamide - an overview of reviews.
- In 8112 healthy French adults, a daily antioxidant capsule containing 120 mg vitamin C for about 6 years did not change quality of life scores, including vitality, compared with placebo.Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, pla…
- In 2501 heart disease or stroke survivors given low-dose B vitamins including 3 mg B6 for about 3 years, quality of life was not improved, and activity limits due to emotional problems were slightly worse.B vitamin and/or n-3 fatty acid supplementation and health-related quality of life: ancillary findings from the SU.FOL.O…
- In 275 adults with early COVID-19 given a 10-day combination that included vitamin C, less fatigue at day 14 was seen only when famotidine was added, not with the vitamin C combination alone.Read the study on PubMed (41693032) →
- In 271 adults with Charcot-Marie-Tooth disease type 1A, 1.5 g of ascorbic acid daily for 2 years did not differ from placebo on neuropathy or on secondary outcomes including fatigue.Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial.
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement for 33 days improved vigour, stress and mental health ratings and made them feel less mentally tired than placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 202 hemodialysis patients, a multinutrient supplement containing vitamin C for 12 weeks did not reduce fatigue compared with placebo, though some heart rate variability measures improved.Effects of nutritional supplementation on fatigue, and autonomic and immune dysfunction in patients with end-stage renal…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 14 days improved vitality and motivation, but blood vitamin C did not explain these benefits.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 171 adults with mild insomnia, a blend including vitamin B6 for 2 weeks did not differ from placebo on sleep or physical fatigue, as both groups improved similarly.Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Tr…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit gave somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In 160 heart bypass surgery patients, vitamin C plus omega-3 fatty acids given from the day before surgery through the first 5 days after reduced post-operative fatigue more than placebo.The combined effect of vitamin C and omega-3 polyunsaturated fatty acids on fatigue following coronary artery bypass gra…
- In 160 heart disease patients over about 38 months, niacin plus a med caused fatigue, nausea or muscle aches in 9% versus 5% on placebo, not a significant difference.Read the study on PubMed (14759379) →
- In 148 men aged 70 and older, 20 weeks of calcium, vitamin D and protein with strength training and testosterone reduced tiredness and improved chair-stand performance compared with no intervention, but calcium's own effect cannot be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In 141 healthy office workers, a single 10 gram intravenous vitamin C dose lowered fatigue scores for up to one day compared with saline placebo, especially in those with low starting vitamin C, and also lowered oxidative stress.Intravenous vitamin C administration reduces fatigue in office workers: a double-blind randomized controlled trial.
- In a 3-month double-blind trial of 99 people with severe kidney failure taking 250 mg vitamin C three times weekly, symptoms including fatigue were similar to placebo, and nausea trended worse with vitamin C.Vitamin C supplementation in kidney failure: effect on uraemic symptoms.
- In 94 adults, a 4-week high-calcium diet was compared with a DASH-type diet and the abstract reports mood benefits only for the low-sodium, high-potassium diet, not for the high-calcium diet.Dietary electrolytes are related to mood.
- In 65 people with chronic fatigue syndrome, a daily combination with 1.05 mg B6, beta-glucan, vitamin D3 and zinc for 36 weeks improved cognitive fatigue compared with their own baseline.Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Enceph…
- In 63 women with premenstrual symptoms (32 completed), 50 mg of vitamin B6 daily for 3 months in a crossover design improved emotional symptoms including depression, irritability and tiredness compared with placebo.Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial.
- In 58 healthy adults with mild prolonged tiredness, a supplement combining pomegranate extract with B vitamins and vitamin C reduced fatigue scores over 8 weeks compared with placebo, though vitamin C was not tested alone and biochemical markers did not change.Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monoce…
- In 58 people with long-COVID, 2000 mg of nicotinamide riboside daily raised blood NAD+ about 3-fold but did not significantly improve fatigue, cognition, or sleep versus placebo.Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled …
- In 54 cancer patients with hand-foot skin reactions from chemotherapy, topical pyridoxine for 6 weeks did not improve the skin reaction grade, but patients reported lower fatigue, better physical function and better quality of life than the placebo group.A pilot randomized double-blind, placebo-controlled study on the effects of the topical application of pyridoxine on pal…
- In 50 people recovering from COVID-19, one month of 1-methylnicotinamide improved 6-minute walk distance in 92% versus 60% without it, and severe fatigue was 20% versus 56%.Use of 1-MNA to Improve Exercise Tolerance and Fatigue in Patients after COVID-19.
- In healthy young adults with low vitamin C levels, 500 mg twice a day for 4 weeks improved attention and work absorption compared with placebo, with a trend toward less fatigue.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In a 28-day placebo-controlled trial of 46 adults with long COVID, twice-daily liposomal vitamin C (500 mg) with l-arginine reduced persistent fatigue (2 of 23 still fatigued vs 21 of 23 on placebo) and improved walking distance and handgrip strength.Effects of l-Arginine Plus Vitamin C Supplementation on Physical Performance, Endothelial Function, and Persistent Fatig…
- In 43 adults with sleep complaints, a blend containing a small amount of vitamin B3 taken with the evening meal for 14 days shortened sleep onset time and improved next-morning mood and vigor, but had no effect on cognitive performance.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 healthy adults aged 40-76, a glycine, glutamine and niacin mixture taken for 3 weeks raised growth hormone by about 70% compared with placebo, but did not change IGF-I, mood or memory.Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and…
- In 41 trained cyclists, 4 weeks of a combination supplement including 2.5 mcg B12 did not improve aerobic or anaerobic performance or fatigue measures compared with placebo, though blood lactate was lower after hard exercise.l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduct…
- In 40 young adults with low vitamin C, 1000 mg daily for 4 weeks improved mental vitality and reduced inflammation compared with placebo, with gut bacteria changes linked to the gains.Gut microbiota links vitamin C supplementation to enhanced mental vitality in healthy young adults with suboptimal vitam…
- In 36 volunteers, 1 g of vitamin C daily for 30 days improved maximal oxygen uptake and lowered oxidative stress only in those with the lowest vitamin C levels, and it did not reduce fatigue index.Antioxidant supplementation, redox deficiencies and exercise performance: A falsification design.
- In 32 Gulf War veterans with illness, a 4-6 week program of exercise, sauna and nicotinic acid plus other supplements improved physical quality of life by 6.9 points versus waitlist, and 11 of 16 quality of life, pain and fatigue measures improved.A Detoxification Intervention for Gulf War Illness: A Pilot Randomized Controlled Trial.
- In 30 young women with premenstrual syndrome, both groups took vitamin B6 and calcium for 3 months; the group that also did treadmill exercise improved fatigue and other symptoms, so the effect is from exercise rather than vitamin B6.Effect of aerobic exercise on premenstrual symptoms, haematological and hormonal parameters in young women.
- In 28 men with marginal vitamin C status, 1000 mg daily for 8 weeks produced a physical activity rise that was not statistically significant compared with placebo, though cold episodes were fewer.Vitamin C supplementation slightly improves physical activity levels and reduces cold incidence in men with marginal vit…
- In 26 overweight middle-aged women doing aerobic training for 3 months, drinking 500 mL of orange juice daily was linked with lower blood lactate, suggesting less muscle fatigue than training alone.Orange juice improved lipid profile and blood lactate of overweight middle-aged women subjected to aerobic training.
- Eating two SunGold kiwifruit daily for 4 weeks improved mood disturbance, wellbeing and vitality compared with usual diet in 26 adults with mild to moderate mood disturbance.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 25 healthy young adults, a single dose of a pre-workout drink containing 500 mg vitamin C along with other ingredients raised self-rated energy and vigour compared with placebo, though adding synephrine gave no extra benefit.Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditu…
- In 25 breast cancer survivors, 500 mg vitamin C plus vitamin E daily for 10 weeks alongside strength training did not reduce fatigue more than placebo.Effect of strength training and antioxidant supplementation on perceived and performance fatigability in breast cancer s…
- In a double-blind crossover trial of 25 resistance-trained adults, 7 days of a pre-workout drink containing 65 mg niacin (plus caffeine and other ingredients) improved some lower-body strength and endurance measures compared with placebo, but not cycling time-trial performance, with no differences in side effects.Short-Term Effects of a Ready-to-Drink Pre-Workout Beverage on Exercise Performance and Recovery.
- In 25 untrained men, a single 1000 mg dose of niacin before cycling raised the respiratory exchange ratio and shortened time to exhaustion compared with caffeine, suggesting impaired exercise performance.Niacin supplementation impairs exercise performance.
- In 24 adults with low parathyroid function, one month each of calcium citrate and calcium carbonate showed no difference in quality of life scores; the abstract does not report a fatigue difference.Calcium Citrate Versus Calcium Carbonate in the Management of Chronic Hypoparathyroidism: A Randomized, Double-Blind, Cr…
- In 21 untrained men, a caffeine supplement containing 40 mg of niacin taken once did not improve bench press strength, leg extension strength, or time to exhaustion on a bike compared with placebo.Acute effects of a caffeine-containing supplement on bench press and leg extension strength and time to exhaustion durin…
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during exercise compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In 20 singers with mild vocal symptoms, a single 1000 mcg B12 injection did not improve voice fatigue or singing measures more than a placebo injection.Effect of Vitamin B12 Injection on the Vocal Performance of Professional Singers: A Randomized, Double-blind, Placebo-Co…
- In 18 healthy volunteers, 1000 mg a day of ascorbic acid for 8 days did not reduce physical fatigue during a long cycling task, while a different product did.Effects of Applephenon and ascorbic acid on physical fatigue.
- In 18 trained adults, three days of hydrogen-rich calcium powder lowered breathing rate and blood pH during exercise but did not change oxygen uptake compared with placebo.Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Increme…
- In 17 people doing hard cycling at high altitude, a 3-week broad antioxidant capsule that included vitamin C did not improve performance; a different supplement combination did better than both this capsule and placebo.Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.
- In 17 amateur cyclists who took a herbal formula containing 200 mcg of chromium for 2 weeks, there was no improvement over placebo in oxygen use, time to exhaustion or peak power.Effects of a commercial herbal-based formula on exercise performance in cyclists.
- In 15 people with chronic fatigue syndrome, injections of liver extract with folic acid and B12 worked no better than placebo, which had a strong response.Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome.
- In 14 healthy volunteers, 3000 mg a day of ascorbic acid for 8 days did not change physical fatigue during a long cycling task compared with placebo.Daily oral administration of crocetin attenuates physical fatigue in human subjects.
- In 12 middle-aged triathletes during a 90-minute cycling session, taking vitamin C with glutathione improved energy-related metabolic and heart measures and lowered an oxidative stress marker compared with placebo, though vitamin C was not tested alone and this was a single acute session.Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Perf…
- In 8 healthy young men, one week of 1.5 grams each of pantothenic acid and cysteine daily did not change muscle coenzyme A, fuel use during exercise, or work output compared with placebo.Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exerci…
- In eight men doing calf contractions to exhaustion, calcium carbonate used as the control had no effect on time to fatigue, which was similar to the acid and alkaline trials, showing that changing muscle pH did not alter fatigue.The effect of pH on fatigue during submaximal isometric contractions of the human calf muscle.
- In 8 active men doing high-intensity shuttle running, adding 400 mg of chromium picolinate to a carbohydrate drink did not extend running time beyond what the carbohydrate drink alone achieved.Effects of carbohydrate and chromium ingestion during intermittent high-intensity exercise to fatigue.
- In 7 well-trained male cyclists, a multinutrient supplement containing pyridoxine-alpha-ketoglutarate for 3 weeks did not extend time to exhaustion during cycling or speed recovery compared with placebo.Tricarboxylic-acid-cycle intermediates and cycle endurance capacity.
- In a placebo-controlled crossover pilot in healthy middle-aged adults, 7 days of RiaGev (1520 mg twice daily) raised blood NAD+ metabolites and reduced fatigue and improved concentration and motivation compared with baseline, with no clinically relevant side effects.A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD+ Metabolome in Healthy Middle-…
- In young women with premenstrual syndrome, 500 mg of calcium carbonate twice daily for 3 months reduced early tiredness compared with placebo.Effects of calcium supplement therapy in women with premenstrual syndrome.
- In 155 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks only marginally improved mood until day 12, with effects weaker than kiwifruit, though mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 134 patients after cerebral aneurysm embolization, adding glycerol fructose to routine vitamin B6 gave better neurological fatigue scores than B6 alone, so the benefit is from glycerol fructose rather than B6.Glycerol fructose combined with vitamin B6 is beneficial to postoperative recovery of patients with cerebral aneurysm.
- In 70 diabetic fatty liver patients, 1000 mg of nicotinamide daily for 12 weeks improved quality of life including the activity and fatigue scores versus no supplement, in an open-label trial.Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial.
- In 61 hemodialysis patients, 100 mg of intravenous vitamin C after each session for 6 months did not improve energy-related quality of life or red blood cell production compared with no vitamin C.Effects of intravenous ascorbic acid on erythropoiesis and quality of life in unselected hemodialysis patients.
- In 14 trained male cyclists, 6 grams of pantothenic acid daily for 16 weeks did not change muscle coenzyme A levels or cycling performance compared with the control group.Chronic pantothenic acid supplementation does not affect muscle coenzyme A content or cycling performance.
- In 11 male runners, 4 days of calcium phosphate loading did not improve maximal aerobic capacity or time to exhaustion compared with placebo.Phosphate supplementation, cardiovascular function, and exercise performance in humans.
- In 8 people with COPD, a single 2 g IV vitamin C dose compared with saline reduced quadriceps neuromuscular fatigue and lowered inflammatory C-reactive protein during exercise, but did not improve breathlessness or exercise tolerance.Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise…
- In 7 male triathletes, 6 weeks of a daily antioxidant capsule containing 600 mg ascorbic acid did not change maximal oxygen uptake or muscle fatigue compared with placebo.No effect of antioxidant supplementation in triathletes on maximal oxygen uptake, 31P-NMRS detected muscle energy metabo…
- Construction workers who drank riboflavin-fortified apple juice daily for 28 days reported less fatigue on fatigue questionnaires, along with improved antioxidant markers.Physicochemical properties of and volatile compounds in riboflavin fortified cloudy apple juice; study of its effect on …
- In 214 outpatients with COVID-19, 8000 mg ascorbic acid for 10 days did not shorten symptoms, including fatigue, compared with usual care.Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulator…
- In an open-label trial of 40 head and neck cancer survivors, 100 mg vitamin C tablets daily for 8 weeks gave less fatigue relief than Tualang honey.Effects of Tualang Honey on Cancer Related Fatigue: A Multicenter Open-label Trial of H&N Cancer Patients.
- In 39 advanced cancer patients with cachexia, a 4-month combined treatment including 500 mg daily vitamin C improved fatigue scores and lowered inflammatory markers, but the study had no placebo group.A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and ant…
- In a small uncontrolled pilot of 23 iron-deficient women, a daily food-derived supplement that also contained vitamin C was taken for 8 weeks, and self-reported energy improved, though vitamin C alone was not tested and there was no placebo group.A Food-Derived Dietary Supplement Containing a Low Dose of Iron Improved Markers of Iron Status Among Nonanemic Iron-Def…
- In a survey of complementary medicine practitioners giving IV vitamin C (average 28 g every 4 days), 59 of 9,328 patients with data had lethargy or fatigue as a side effect, and most side effects were minor.Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects.
- In a chart review of 2142 people with fibromyalgia, 42.4% had vitamin B12 deficiency, and deficiency was linked to higher odds of fatigue (odds ratio 1.39) after adjusting for vitamin D.Association of Vitamin B12, Vitamin D, and Thyroid-Stimulating Hormone With Fatigue and Neurologic Symptoms in Patients …
- In 1676 people with colorectal cancer, higher blood levels of active vitamin B6 were linked with less fatigue and better quality of life six months after diagnosis, though this was not a supplement trial.Circulating B-vitamin biomarkers and B-vitamin supplement use in relation to quality of life in patients with colorectal…
- In 1,643 Spanish adults aged 65 and over followed for about 3.5 years, low dietary vitamin C intake was linked to a higher risk of frailty, which includes exhaustion, but this link was not statistically significant on its own.Low vitamin intake is associated with risk of frailty in older adults.
- In a 90-day follow-up of 923 Indonesian COVID-19 survivors, vitamin C combined with other micronutrients and favipiravir did not significantly change post-COVID symptoms, including fatigue, which was the most common symptom.Vaccination status, favipiravir, and micronutrient supplementation roles in post-COVID symptoms: A longitudinal study.
- In a retrospective study of 689 children without complaints, 23.2% had vitamin B12 deficiency and it was linked to vitamin D deficiency, but no supplement was tested for energy.Is There An Association Between Vitamin B12 Level and Vitamin D Status in Children?
- In a survey of 576 people in Syria who had COVID-19, 76.4% reported using vitamin C, but the survey did not measure whether vitamin C improved energy or fatigue, and fatigue was the most reported symptom.COVID-19 infected patients' experiences in Syria, and the role of the pharmacists during their infection.
- In 411 dentists and their wives, people who took little vitamin C reported about double the number of fatigue symptoms compared with those who took more.Daily vitamin C consumption and fatigability.
- In 335 older adults, vitamin B12 levels were not associated with frailty, and no supplement was tested.Association between serum vitamin B12 level and frailty in older adults.
- In a prospective study of 146 people with fatigue after COVID-19 who took Astenor Energy, a product containing arginine aspartate, vitamin B6, biotin and magnesium, fatigue scores fell over three months of treatment, but there was no placebo group and biotin's effect could not be separated from the other ingredients.The Effects of Arginine-Based Supplements on Fatigue Levels following COVID-19 Infection: A Prospective Study in Romania…
- In a retrospective German cohort of 125 breast cancer patients, adding intravenous vitamin C of 7.5 g for at least 4 weeks was associated with fewer treatment side effects, including fatigue, than no added vitamin C.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- Women with fibromyalgia had lower vitamin B12 levels than 58 healthy women, and lower levels were linked to more tender points, though this study did not test supplements.Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?
- In people with irritable bowel syndrome, lower vitamin B6 intake was linked with more fatigue, but this was an observational association within a diet study and not a test of vitamin B6 supplements.Poor intake of vitamins and minerals is associated with symptoms among patients with irritable bowel syndrome.
- In a retrospective chart review of 86 cancer patients given high-dose IV vitamin C (50 to 150 g per infusion), patients overall reported improved fatigue, pain, and mood, with temporary nausea and injection-site discomfort as the most common side effects.Retrospective Evaluation of Clinical Experience With Intravenous Ascorbic Acid in Patients With Cancer.
- In 67 adults with shingles, about 2 weeks of intravenous vitamin C alongside standard treatment was followed by reduced pain and less general fatigue, but the study had no placebo group.Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study.
- In COVID-19 survivors with lingering fatigue, a multi-ingredient supplement containing vitamin B6 improved strength and walking performance over 8 weeks compared with a control group, but vitamin B6 was not tested alone.Effects of a New Multicomponent Nutritional Supplement on Muscle Mass and Physical Performance in Adult and Old Patients…
- In 65 adults with self-reported gluten sensitivity on a gluten-free diet, average calcium intake from food was 695 mg a day, below recommendations, and energy was not studied.Dietary and symptom assessment in adults with self-reported non-coeliac gluten sensitivity.
- Vitamin B12 levels were normal in 55 people with primary fibromyalgia, who reported muscle fatigue as one of their most disabling symptoms.Primary fibromyalgia. A clinical and laboratory study of 55 patients.
- In a Swedish registry of 40 adults with a med-associated multiple acyl-CoA dehydrogenase deficiency, 38 of 39 treated with riboflavin clinically improved, including reduced fatigue and muscle symptoms.Read the study on PubMed (41808636) →
- In a 7-day diary study of 20 adults with hypophosphatasia and 20 matched controls, vitamin B6 intake did not differ significantly between groups, and the study did not measure energy levels directly.Mineral Intake and Clinical Symptoms in Adult Patients with Hypophosphatasia.
- In a survey of 38 people with chronic fatigue syndrome or fibromyalgia who had weekly or more frequent B12 injections for six months or more, 15 were good responders who rated themselves much or very much improved, and higher doses and longer use were linked to better response.Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
- In a retrospective review of 38 children with neurological symptoms of vitamin B12 deficiency, all recovered within one month of B12 supplementation; fatigue was among the symptoms but was not reported separately.Neurological symptoms of vitamin B12 deficiency: analysis of pediatric patients.
- In a study of 37 adults with pulmonary arterial hypertension, 29% had a functional vitamin B12 deficiency, but no supplement was tested, so the study does not show whether B12 improves energy.Nutritional status in pulmonary arterial hypertension.
- In 25 patients with multiple acyl-CoA dehydrogenase deficiency, those whose condition responded to riboflavin had favorable outcomes, while non-responders had more severe early illness.Determinants of Riboflavin Responsiveness in Multiple Acyl-CoA Dehydrogenase Deficiency.
- In a small case series of 20 infants with vitamin B12 deficiency, who were treated with cyanocobalamin, clinical and lab findings improved overall, though energy was not separately reported and the dose and duration were not stated.Vitamin B12 Deficiency in Infants.
- In 19 people with multiple sclerosis, those on a less inflammatory diet, which had higher vitamin B6 intake, reported more energy and fewer symptoms than those on a more inflammatory diet.Assessment of Functional Status in Patients with Multiple Sclerosis Based on the Inflammatory Potential of Their Diet.
- In 10 patients with late-onset multiple acyl-CoA dehydrogenase deficiency, high-dose riboflavin at 400 mg daily produced rapid muscle strength improvement, though neuropathic symptoms did not improve.Diagnostic Challenges in Late Onset Multiple Acyl-CoA Dehydrogenase Deficiency: Clinical, Morphological, and Genetic Asp…
- All 5 people with ALS who received methylcobalamin injections reported more energy and less fatigue, based on interviews; the dose was not stated.Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.
- In a case series of 19 adults with a rare bone disorder, four patients given empirical pyridoxine (vitamin B6) did not get symptom relief, including fatigue.Hypophosphatasia in Adults: Clinical Spectrum and Its Association With Genetics and Metabolic Substrates.
- In lymphoma survivors, a higher vitamin B6 breakdown marker was associated with a greater risk of chronic cancer-related fatigue, pointing to low-grade inflammation as a possible cause.Metabolic analysis of amino acids and vitamin B6 pathways in lymphoma survivors with cancer related chronic fatigue.
- A survey of U.S. adults found that drinkers had higher energy intake than non-drinkers, but their diets were less nutrient dense, including for calcium; the survey did not test calcium for energy.Alcohol consumption and nutrient density of diets in the Nationwide Food Consumption Survey.
- This survey of hypothetical scenarios found people kept taking B12 for fatigue after a small symptom improvement, showing post hoc bias rather than any real effect of B12 on energy.Post Hoc Bias in Treatment Decisions.
- In a large family with an inherited mitochondrial muscle mutation, riboflavin given to two affected members did not improve their exercise intolerance or fatigue.Benign mitochondrial myopathy with exercise intolerance in a large multigeneration family due to a homoplasmic m.3250T>C…
- In hypertensive patients, a nicotinamide mononucleotide supplement lowered blood pressure and improved vascular function, but energy was not measured.NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension.
- In this mostly lab and animal study, nicotinamide with pyridoxine helped muscle stem cells regenerate muscle and improved strength in animals, but energy was not measured.Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
- In a rat study lasting 6 weeks, chromium picolinate added to the diet lowered blood sugar, total cholesterol, and triglycerides and reduced oxidative stress, with a stronger effect in rats that exercised regularly. This was an animal study, not a human trial.The effects of chromium picolinate on glucose and lipid metabolism in running rats.
- In mice, biotin deficiency shortened swimming time in a forced-swim test, suggesting fatigue or low mood, and a single biotin injection quickly restored swimming time; this was an animal study with no human data.Experimental study of fatigue provoked by biotin deficiency in mice.
- In exhausted rats, a daily mix of ten nutrients including a small biotin dose (0.1 mg per kg) let them run longer, reduced oxidative damage, and increased mitochondrial proteins in muscle compared with rats given no supplement; this was an animal study and biotin's effect alone was not isolated.Mitochondrial nutrients stimulate performance and mitochondrial biogenesis in exhaustively exercised rats.
- In mice, pantothenate deficiency lowered tissue levels of coenzyme A and glycogen stores and shortened running time to exhaustion compared with supplemented mice.The effect of pantothenate deficiency in mice on their metabolic response to fast and exercise.
- In rats given a multi-ingredient energy formula containing niacin-bound chromium (0.45% of the formula) for 90 days, heart energy levels and heart function after an induced blood-flow interruption improved. The chromium was not tested alone, and this was an animal study.Enhanced cardiovascular function and energy level by a novel chromium (III)-supplement.
Review Totals and Summary
Members Only37,275 reviews · 90% positive
With about 37092 ratings across various stores, Celsius Sparkling Cola generally receives a positive reception, with 80% of reviewed experiences earning 4 or 5 stars. This indicates a strong preference for the product among a large number of consumers. **What it did for them** Many customers report that Celsius Sparkling Cola provides an effective energy boost. They appreciate that this energy is often described as smooth, without the jitters or subsequent crash associated with other energy drinks. Reviewers mention it "gets me going for the afternoon with the energy" and is "Perfect for workouts." Some users also noted benefits related to metabolism and weight management, with comments like "burns fat" and "jump starts your metabolism." The drink is frequently praised as a healthier alternative to traditional sodas and energy drinks, highlighting its "better ingredients," "low calories and no sugar," and "natural energy instead of feeling the jittery energy." **Complaints** While the product itself receives high marks, a recurring theme of dissatisfaction centers on shipping and product quality upon arrival. Customers reported issues such as "arrived with 3 cans empty," "Expired product received," and "Arrived super flat. No carbonation at all." These logistical problems led to frustration and a feeling that the purchase was "Not worth the cost if some cans are empty." The price is also a point of contention for some, who find it "a bit pricey" or "Too expensive." **Taste and Form** The taste of Celsius Sparkling Cola is a major highlight for many, often compared favorably to traditional sodas. Reviewers describe it as having a "Great taste" and an "awesome" cola flavor, with one exclaiming, "taste like I am drinking soda." It's frequently noted for being "similar to original coke but low calorie" and "tastes like cola but not too sweet." However, a few reviews mentioned issues with carbonation, with some cans arriving "super flat" or having "zero carbonation," leading to a taste described by one as "does taste like flat soda." The product is consistently sold as a sparkling liquid in cans. Reviews of other forms, such as gummies or capsules, were not included in this summary. **Value for Money** Opinions on value are mixed. While some customers find the product "a bit pricey" or "Too expensive," others implicitly accept the cost for its benefits, stating they "try to get it as often as I can!" One review even suggested it's "more affordable than most other drinks" when comparing it to other energy drink options. The perceived value often ties into the effectiveness and healthier profile of the drink. **Who it suits and who it did not** Celsius Sparkling Cola appears to be well-suited for individuals seeking a functional beverage that delivers a clean energy boost for daily activities or workouts, without the negative side effects of jitters or crashes. It appeals to those looking for a "healthy cola" alternative with "low calories and no sugar." It also seems to suit people who want a metabolism boost. Conversely, it may not suit those who are highly sensitive to price or who have experienced issues with product delivery and quality, such as flat cans or damaged packaging.
Biohacker Summary
Members Only10 of 10 recommend it
On biotin, the main ingredient, the panel is split and lukewarm: two of ten recommend it for hair strength and hair follicle growth, four are neutral with only passing mentions, and three warn. One of the warners calls it overhyped and says enough protein is probably more useful for hair, skin and nails, while two others caution that biotin supplements can throw off blood tests for testosterone and estrogen, so they advise avoiding it before such a test. The two who recommend it point to keratin production and name eggs, almonds and salmon as food sources, and nobody gave a dose or a preferred form. Nobody said they take biotin themselves or stopped taking it, and no one paired it with anything. Vitamin C, calcium, vitamin B12 and chromium are smaller ingredients in this product, and the panel talked about them far more than about biotin, mostly praising vitamin C for collagen and immunity.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Biotin · neutral
- States that thinning hair often indicates low biotin, which is required to produce keratin for hair, skin, and nails.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Dr. Berg lists pyridoxine hydrochloride as a synthetic vitamin to avoid.
- Recommends taking the active form of vitamin B6, pyridoxal-5-phosphate (P5P), for its benefits to the nervous system, including building the myelin sheath and protecting sensory nerve integrity.
- Notes that Vitamin B6 is intimately involved in the nervous system and may be behind sciatica and carpal tunnel syndrome.
- Recommends taking the natural form of vitamin B12, methylcobalamin, to support nerve regeneration, myelin production, and nerve growth factors.
Thomas DeLauer · Biotin · warns
- Thinks biotin is a little overhyped, suggesting that consuming adequate protein is probably more effective for hair, skin, and nails. He notes that some people might be deficient, especially if consuming a lot of eggs with avidin, but doesn't consider it the 'Mecca of perfect hair'.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
- States that collagen synthesis is vitamin C dependent, in the context of glowing skin.
- Recommends Vitamin C for sleep, noting that intake in the range of 125 to 200 mg per day is associated with a lower risk of sleep disorders and sleep apnea, with the benefit plateauing beyond this range.
- Recommends consuming a little bit of vitamin C, such as a couple of berries or kiwi, along with flavanol-rich cocoa to help the delicate flavanols hold up and prevent oxidation in the gut.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that vitamin C improves the ability of neutrophils to engulf bacterial infections, and that they have a greater ability to engulf larger infections.
Dave Asprey · Biotin · neutral
- States that biotin clears out oxalates.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
- Warns that taking too much vitamin C can raise oxalate levels, emphasizing that everything has risk and reward.
- States that Vitamin B12 is extremely important for every kind of brain function and recommends ensuring B12 levels are optimal, around 500, not just barely above normal.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Recommends Vitamin C as the real biological fix for deep focus issues, explaining how the brain hoards it at levels 100 times higher than blood and how to bypass the blood-brain barrier.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
Andrew Huberman · Biotin · neutral
- Mentions biotin.
- Takes a multivitamin every day for longevity.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- States that a deficiency in vitamin B12 can be terrible and lead to chronic fatigue-like syndromes, as many parts of mitochondria require B vitamins.
- Takes an extra gram of vitamin C a day for its effects on immunity and potential synergy with collagen.
- Found the Met RX Big 100 Bar to be 'magic' on the trail because it's a hunk of calories with protein and fortified with vitamins and minerals, despite being something they would never eat in normal life.
- Started taking AG1 in 2012 and still takes it every single day to ensure he meets his quota for daily vitamins and minerals and to support gut health, which is critical for proper brain function, immune system, and neurotransmitter production.
- Has been taking AG1 daily since 2012 because it is the highest quality and most complete foundational nutritional supplement, ensuring he gets all necessary vitamins, minerals, and micronutrients for daily health.
- Has been drinking AG1 since 2012, finding it difficult to get enough vitamins, minerals, micronutrients, and adaptogens from diet alone. He finds that taking AG1 daily improves all aspects of his health, including physical and mental health, performance, recovery from exercise, and immune system strength, and also notices more mental clarity and energy.
- Recommends AG1 as the highest quality and most complete foundational nutritional supplement, containing vitamins, minerals, probiotics, prebiotics, and adaptogens to cover dietary gaps and support a demanding life.
- Recommends taking methyl B12 as part of methylated B vitamins to lower homocysteine levels and reduce cardiovascular risk.
- Mentions that Riboflavin (Vitamin B2) hits cytochrome 2 in the mitochondrial electron transport chain, contributing to energy production.
- States that AG1 is the highest quality and most complete foundational nutritional supplement available, containing vitamins, minerals, probiotics, prebiotics, and adaptogens, and that he has been taking it daily since 2012, often twice a day, to bolster his energy, immune system, and gut microbiome.
- Huberman mentions that vitamin C seems to help with the absorption or utilization of collagen protein.
Siim Land · Biotin · neutral
- Siim Land's company has published papers and filed patents for improvement in mitochondria in the skin using their core mitochondrial approach and other things like biotin.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Lists dairy and sardines as sources of Calcium.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that Boron reduces calcium/magnesium loss.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Recommends chromium as a mineral that can lead to better body composition.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- Would take chromium for pre-diabetes.
Dr. Rhonda Patrick · Biotin · warns
- Advises avoiding biotin-containing supplements before a testosterone blood test as they can cross-detect with estrogens and confound results.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Notes additional gaps in calcium.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Warns that Vitamin B12 enhances light's melatonin-suppressing effects and should be avoided too close to bedtime.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
- Currently takes the Pure Encapsulations O.N.E Multivitamin.
- Rhonda's current supplement routine includes Vitamin C.
Peter Attia · Biotin · warns
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Advises that if taking a biotin supplement, one should discontinue it for at least a few days, if not a week, before a blood test, as it can dramatically skew thyroid values.
- Warns that certain things, like biotin, should not be taken before a blood test because they can mess up readings.
- Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
Ben Greenfield · Biotin · recommends
- Recommends biotin (Vitamin B7) for supporting keratin production and strengthening hair, noting it can be found in eggs, almonds, and salmon.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Mentions vitamin C as part of a bare-minimum protocol.
- Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Recommends Vitamin C for skin repair post-tattoo.
- Recommends getting vitamin B12 tested and supplementing if deficient, as B12 deficiency can cause damage to the myelin coating around nerves, including cochlear nerves, and improve tinnitus severity scores.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
- Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
- Recommends adequate intake of calcium for bone strength.
Dr. Mark Hyman · Biotin · recommends
- Recommends supplementing with biotin for hair follicle health and growth.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- Optimized a child's nutrient status with vitamin B6, as the child had low B6 levels.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- Recommends vitamin C for immune system support and modulation.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
Bryan Johnson · Biotin · neutral
- Mentions biotin as an example of an ingredient that AG1 lists with a specific dose, but then contrasts it with other ingredients in proprietary blends where doses are not disclosed.
- States that Blueprint essential capsules and soft gels are packed with key vitamins and minerals needed for strong bone health.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Takes 250 milligrams of Vitamin C.
- Recommends adequate Biotin (Vitamin B7) for hair health, noting it is in the Blueprint stack.
- Recommends prioritizing calcium intake for postmenopausal women to help maintain bone density and reduce the risk of osteoporosis.
- Bryan Johnson takes Calcium daily as part of his Longevity Mix, which supports healthy bones and teeth.
- Recommends continuing with calcium to support bone health during the follicular phase.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
RAL Summary
Members OnlyTier 4 for Energy
The tier 3 grade leans on animal studies and one uncontrolled blend study of biotin, a trace vitamin, while the main energy ingredients sit in the MetaPlus blend with no studies given, and the vitamins at their label doses show no clear human benefit for energy. So it is graded Tier 4, lower than the rules alone gave.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 58 of the 117 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Metabolic system
Combine with: To enhance the energy-boosting effects of Celsius Sparkling Cola and support overall vitality, consider combining it with L-Theanine to promote focused energy without jitters, or CoQ10 for cellular energy production. Magnesium can also be beneficial as it plays a crucial role in ATP synthesis, while adaptogens like Rhodiola Rosea or Ashwagandha could help manage stress and provide sustained energy throughout the day.
Possible side effects: No major side effects reported in the studies at these doses; high-dose niacin can cause fatigue, stomach upset and flushing, which does not apply to the 20 mg here.
Supplement Facts
Vitamin C 60 mg · Riboflavin 1.7 mg · Niacin 20 mg
| Calories | 10 | |
| Total Carbohydrate | 2 g | |
| Vitamin C | 60 mg | |
| Riboflavin | 1.7 mg | |
| Niacin | 20 mg | |
| Vitamin B6 | 2 mg | |
| Vitamin B12 | 6 mcg | |
| Biotin | 300 mcg | |
| Pantothenic Acid | 10 mg | |
| Calcium | 50 mg | |
| Chromium | 50 mcg | |
| Sodium | 0 mg | |
| MetaPlus Proprietary Blend | 1.81 g | † |
Other ingredients: Carbonated filtered Water, Natural Flavors, Sucralose, Citric Acid, Caramel color.
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Graded November 3, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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