Cymbiotika Metabolic Health Review

Metabolic Health from Cymbiotika is presented on this page as a capsule formula that helps curb appetite. The product is sold as one size, in a jar of 84 capsules, at a price of $66.00. The page explains that the formula contains Dihydroberberine, sold under the name GlucoVantage, which the brand describes as a highly bioavailable form of berberine that supports blood sugar balance and helps the body burn fat for fuel. The brand says the newest version adds this ingredient together with Moringa Leaf Powder and Theobromine, which it describes as providing natural energy, cellular health support and improved detoxification. The page also states that Huperzine-A and Fountain Bush Extract were removed to ensure digestive ease. Two key ingredients are described in detail. EGCG, or epigallocatechin gallate, is described as a type of polyphenol flavonoid called a catechin that acts as an antioxidant to protect against cellular damage caused by oxidative stress. The page says studies have linked EGCG to support for weight loss through increased metabolism and improved blood circulation, and notes that studies also indicate it may reduce inflammation. OEA, or oleoylethanolamide, is described as a naturally occurring compound produced in the human gut. The page states that OEA is responsible for the feeling of satiety, or fullness, after a meal, and that research suggests it may contribute to the body's ability to burn fat. The directions say to take 3 capsules daily, about 30 minutes before the largest meal of the day. The FAQ section explains that the formula contains green tea extract, theobromine and coffee bean extract, which provide a modest amount of naturally occurring caffeine, so people sensitive to caffeine should take it earlier in the day. The page also says the formula is designed to support metabolic function as part of a balanced diet and lifestyle and is not meant to replace them. The page lists certifications including GMP Certified, Non-GMO, No Artificial Flavors, No Preservatives, Plant Based, Gluten Free, Soy Free, Keto, Third Party Tested and Made In USA. A certificate of analysis from a third-party lab is provided. The page notes that the statements have not been evaluated by the Food and Drug Administration and that the product is not intended to diagnose, treat, cure or prevent any disease. A 60-day money back guarantee is offered, and the page shows a SuppCo TrustScore of 10.0.

Product Focus: Blood SugarAlso covers:HormonesMetabolismHeartDigestion
Tier ⓘ
Tier 2 · Rank 5
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 5 within Tier 2 for Blood Sugar; 5 of 46 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
84 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
95% of 2,507
Biohacker Mentions
8 of 10
Cost per month
$212 at 3 servings

Study, Trial or Testing Result Summary

Members Only474 human studies · 264 improved

6 of these 474 human studies gave the ingredient by drip, not by mouth.

474 human studies264 improved104 no effect1,204,763 people studied

Several ingredients here are at doses used in studies. Chromium, at a full dose, lowered fasting and long-term blood sugar in people with type 2 diabetes in pooled trials [1][2], though it showed no effect in people without diabetes. Oleoylethanolamide, at a full dose, lowered blood sugar and insulin resistance in people with prediabetes [3], but one trial in obese people found no change [4]. Cinnamon, near a studied dose, lowered fasting and long-term blood sugar [5][6]. Alpha-lipoic acid, at the full three-capsule daily dose, helped in some trials [7], but a two-year trial found long-term blood sugar unchanged [8]. Green tea extract lowered blood sugar in pooled trials [9]. Ginseng studies used root or berry, not this leaf and stem extract [10]. Gymnema and moringa are below studied doses, and ginger, fenugreek and coffee bean are at trace amounts [11][12]. Thiamine did not lower blood sugar in pooled trials [13], theobromine did not either [14], and dihydroberberine has no human studies here. Animal and cell studies are never counted.

See all 474 studies →Hide the studies

Review Totals and Summary

Members Only2,507 reviews · 95% positive
2,507 reviews · Cymbiotika.ca 623 · Skinbeautifulrx 5 · Vitacost 4
95% positive0% neutral5% negative

Cymbiotika Metabolic Health capsules are well liked, with about 2,507 ratings across the stores that sell them and a mostly positive tone. Buyers praise appetite control, energy and blood sugar, while weight loss is the least consistent result. **What buyers say it did for them:** The most common praise is for quieter appetite, which buyers call "food noise." One says it "takes care of food noise and my energy level." Another takes one or two capsules in the morning and says it "gives me extra energy and helps me feel eat less." Blood sugar comes up often too. One buyer reports "less bloating" and blood sugar "slowly coming down" in month two. Another says "I saw the effects on my glucose in just a couple days." One reviewer started it for sleep and says they "definitely notice a difference." One store's reviewers also mention fewer cravings, a calm energy lift with no jitters and a more balanced mood, and a couple report early weight loss of a few pounds. **What they complain about:** Weight loss is the main complaint. A three-star reviewer says it "has more energy but didn't loose weight." At one store, a critical reviewer says it did not reduce their appetite or help them lose weight, and calls it a waste of money. They also say another product from the brand did not work for them. Another buyer there says the capsules really work, so results are mixed. Several buyers admit they were inconsistent with use, which may affect how much they noticed. **Taste, smell, pill size or form:** The reviews say little about taste or smell. One store's reviewer calls the size and dosage acceptable at three capsules. Another buyer takes two before a meal and one during it, and recommends not spreading doses across the day. Others take one or two in the morning. Side effects are hardly discussed, apart from one reviewer noting no jitters. Reviews of other forms of the product were left out, as this summary covers the capsules only. **Value for money:** Price is rarely discussed. One buyer says "Worth it in my opinion." The one clear value complaint is the "waste of money" verdict from the reviewer who saw no effect. Beyond that, store pages say little about cost. **Who it seems to suit and who it did not:** It seems to suit people who want help with appetite, cravings, steady energy and blood sugar, especially as a start to a diet or daily routine. One buyer called it "a great start for a dieting journey." Some buyers say they love the brand and its quality. It suited people hoping for weight loss less reliably, and those who saw no change in appetite did not rate it well. Many positive reviews are short, such as "I absolutely love this," and some buyers are still early in use, so these results are early impressions rather than long trials.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Cinnamon is the main ingredient, and six of the ten panelists spoke about it: four recommend it, two use it in food, and one warns about it. Those who recommend it point to cutting blood sugar cravings, easing the load on the pancreas, and adding flavor to coffee without sugar, while the users stir it into puddings, drinks, popcorn and a keto mousse. Ceylon cinnamon is the form named by two of them, one of whom uses half a teaspoon in a pudding, and the one caution is that cinnamon is high in oxalate. Chromium and alpha-lipoic acid were also covered by the panel, with one recommending chromium for body composition and one recommending alpha-lipoic acid with a partner nutrient in four doses a day for nerve complaints. Green tea, ginger and niacin are smaller ingredients in this product, and the panel mostly likes ginger and green tea, though one person stopped taking niacin.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Cinnamon · recommends
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends adding cinnamon to coffee as a way to enjoy fall flavors without the high sugar content.
    • 5 Oct 2026 · Ginger · uses · YouTube ↗
      Uses ginger in his chicken soup and a special drink because it is anti-inflammatory and helps with symptoms when feeling sick.
    • 30 Sep 2026 · Green Tea · neutral · YouTube ↗
      Mentions that EGCG from green tea activates thermogenesis, contributing to calorie burning.
    • 30 Sep 2026 · Niacin · neutral · YouTube ↗
      Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
    • 14 Sep 2026 · Ginger · recommends · Facebook ↗
      Recommends ginger as an anti-inflammatory powerhouse.
    • 29 Jul 2026 · Green Tea · uses · YouTube ↗
      States he was using green tea to stimulate the NRF2 pathway and open up detox.
    • 21 Jul 2026 · uses · Instagram ↗
      Dr. Mark Hyman designed 'The World's Smartest Smoothie' using organic ingredients, including Organic Cinnamon.
    • 21 Jul 2026 · Ginger · uses · Instagram ↗
      Dr. Mark Hyman designed 'The World's Smartest Smoothie' using organic ingredients, including Organic Ginger juice.
    • 5 Jun 2026 · uses · YouTube ↗
      Adds a little bit of cinnamon to his overnight oats, noting that it helps blood sugar.
    • 27 May 2026 · Ginger · neutral · YouTube ↗
      Mentions that Paleovalley's turmeric complex includes organic ginger.
    • 29 Apr 2026 · Green Tea · neutral · YouTube ↗
      Mentions that green tea has super beneficial effects on Akkermansia muciniphila, a keystone species that protects the gut lining, prevents leaky gut, reduces inflammation, and helps metabolic health.
    • 11 Apr 2026 · uses · Facebook ↗
      Includes cinnamon in their smoothie to help with blood sugar balance.
    • 11 Apr 2026 · Ginger · uses · Facebook ↗
      Includes ginger in their smoothie for anti-inflammatory support.
    • 3 Apr 2026 · Ginger · uses · Facebook ↗
      Included ginger in their chicken dish as part of an anti-inflammatory power couple with turmeric.
  • Ben Greenfield · Chromium · neutral
    • 15 Oct 2026 · neutral · YouTube ↗
      Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
    • 29 Oct 2026 · Ginger · warns · YouTube ↗
      Advises patients to stop ginger before surgery because it can act as a med or antiplatelet agent.
    • 29 Aug 2026 · Niacin · neutral · YouTube ↗
      States that Nrf2 activators, when combined with something like niacin, may have a good effect on plaque progression.
    • 20 Aug 2026 · Green Tea · uses · YouTube ↗
      Drinks green tea in the morning as part of her quiet time.
    • 20 Aug 2026 · Moringa · stopped · YouTube ↗
      Was doing a lot of moringa, a whole tablespoon a day, but stopped because she thought it might be messing with her thyroid.
    • 23 May 2026 · Cinnamon · recommends · YouTube ↗
      Recommends cinnamon, noting it is a bark and not a seed, for use on the AIP diet.
    • 23 May 2026 · Ginger · recommends · YouTube ↗
      Recommends root spices like ginger for use on the AIP diet.
    • 25 Apr 2026 · Niacin · neutral · YouTube ↗
      Mentions nicotinamide as an ingredient found in many NAD products and notes that niacinamide and nicotinamide are structurally the same.
    • 25 Apr 2026 · Green Tea · uses · YouTube ↗
      States that Nuchido Time Plus includes green tea extract for its high level of EGCG, which inhibits the methylating enzyme NNMT, ensuring nicotinamide is recycled rather than excreted.
    • 18 Apr 2026 · Niacin · recommends · X ↗
      Believes the niacinamide approach, along with the NAMPT/salvage pathway angle, is underrated and deserves more attention.
    • 26 Mar 2026 · Green Tea · recommends · YouTube ↗
      Suggests that one could do a carnivore diet and still have a cup of green tea in the morning to introduce hormetic stressors.
    • 14 Mar 2026 · Cinnamon · uses · TikTok ↗
      Now uses Ceylon cinnamon as a natural strategy instead of a med and as a natural insulin-sensitizer.
    • 14 Mar 2026 · Cinnamon · recommends · Podcast ↗
      Offers cinnamon as a natural alternative for better blood sugar control.
    • 14 Mar 2026 · Cinnamon · recommends · YouTube ↗
      Recommends Ceylon cinnamon at around 2g a day for modest fasting glucose improvements, suggesting its use in a morning smoothie, yogurt, or trail mix.
  • Dr. Eric Berg · Alpha-Lipoic Acid · recommends
    • 2 Oct 2026 · recommends · YouTube ↗
      Recommends alpha-lipoic acid, usually taken with benfotiamine, to help with peripheral neuropathy, suggesting four doses through the day.
    • 1 Nov 2026 · Ginger · recommends · X ↗
      Suggests that ginger is an easy addition to a daily routine that may support digestion, inflammation, and healthy blood sugar levels.
    • 19 Oct 2026 · Niacin · recommends · Podcast ↗
      States that expensive NAD+ supplements only turn into $5 niacin in the body and that research has shown niacin can actually raise NAD levels in the blood 5 to 8 times their baseline levels.
    • 17 Oct 2026 · Green Tea · neutral · Instagram ↗
      Suggests pairing green tea with lemon for better absorption.
    • 14 Oct 2026 · Ginger · recommends · YouTube ↗
      Recommends consuming ginger every single day for its benefits on digestion, inflammation, skin, blood sugar stability, and potential fat loss.
    • 11 Oct 2026 · Niacin · recommends · YouTube ↗
      Recommends cheap flush niacin, stating that it outperforms expensive NAD supplements and even IV drips in raising NAD levels in the blood.
    • 2 Oct 2026 · Ginger · neutral · YouTube ↗
      Mentions ginger as a food that black cumin seed oil outperforms in reducing inflammation.
    • 2 Oct 2026 · Niacin · recommends · YouTube ↗
      States that cheap niacin, which creates a flush, ends up more in the blood than expensive NAD versions, suggesting it is more effective for unhealthy individuals.
    • 27 Sep 2026 · Niacin · neutral · X ↗
      Niacin is linked to several areas of physical and mental health. Studies have looked at its effects on cholesterol, the heart, liver health, schizophrenia, depression, and bipolar disorder.
    • 20 Sep 2026 · recommends · Facebook ↗
      Recommends taking alpha-lipoic acid to block the effects of grains.
    • 20 Sep 2026 · Cinnamon · recommends · YouTube ↗
      Recommends adding a pinch of cinnamon to water daily, stating that it mimics insulin and activates insulin receptors, making cells more sensitive to insulin to help regulate blood sugar.
    • 20 Sep 2026 · Cinnamon · recommends · Facebook ↗
      Recommends consuming cinnamon to block the effects of grains.
    • 18 Sep 2026 · Green Tea · recommends · Instagram ↗
      Suggests incorporating anti-cancer foods like green tea to help prevent pancreatic cancer.
    • 10 Sep 2026 · Cinnamon · recommends · YouTube ↗
      Recommends taking a pinch of cinnamon with apple cider vinegar in a glass of water three times a day to stabilize blood sugar and reduce carbohydrate cravings.
  • Dr. Rhonda Patrick · Alpha-Lipoic Acid · neutral
    • 7 Sep 2026 · neutral · YouTube ↗
      Describes alpha-lipoic acid as a short-chain fatty acid produced in mitochondria and found in various foods. They highlight its role as a cofactor in mitochondrial energy production and biogenesis, its strong antioxidant capabilities, and its ability to regenerate vitamins C and E and glutathione. They also mention its anti-inflammatory effects, its role in chelating metal ions like iron and copper, and its ability to reduce advanced glycation end products, which is beneficial for people with diabetes.
    • 9 Jul 2026 · Ginger · uses · Instagram ↗
      Likes adding ginger to bone broth for flavor, warmth, and its anti-inflammatory compounds.
    • 29 Dec 2025 · Theobromine · neutral · Instagram ↗
      Notes that people with higher blood levels of theobromine, a cocoa-derived alkaloid, showed signs of slower biological aging and longer telomeres according to a study.
    • 9 Sep 2025 · Fenugreek · warns · YouTube ↗
      States that Fenugreek, along with tribulus and D-aspartic acid, has been disproven for its effects on testosterone.
    • 5 Aug 2025 · neutral · Podcast ↗
      Discusses ideal dosing for alpha-lipoic acid.
    • 5 Aug 2025 · Moringa · warns · Podcast ↗
      Discusses whether moringa, as a greens powder, is high in heavy metals.
    • 26 Jun 2025 · uses · Facebook ↗
      Rhonda's current supplement routine includes Alpha-lipoic acid.
    • 12 Jun 2024 · Ginger · uses · YouTube ↗
      Takes a ginger capsule, which seems to improve his digestion.
    • 15 Jan 2024 · Moringa · uses · Instagram ↗
      Includes 1 tbsp of moringa powder in her smoothie recipe, which she describes as packed with micronutrients.
    • 28 Jan 2020 · Niacin · neutral · YouTube ↗
      States that NAD can be synthesized from the three forms of niacin, also known as vitamin B3, found in foods like lean meats, legumes, and veggies.
    • 6 Jan 2017 · Moringa · neutral · YouTube ↗
      Mentions moringa as a tropical tree that grows everywhere and is full of an isothiocyanate that may be as effective as sulforaphane in many situations. He has been involved in promoting moringa for nutritional reasons and is fascinated by its pharmaceutical potential.
    • 4 Sep 2013 · Green Tea · neutral · YouTube ↗
      Dr. Patrick mentions that catechins and polyphenols are found in things like green tea, dark chocolate, turmeric, blueberries, and other purple pigmented fruits and vegetables, as well as red wine.
    • Date not recorded · uses · Website ↗
      Dr. Patrick takes alpha-lipoic acid by Pure Encapsulations.
    • Date not recorded · uses · Website ↗
      And then with breakfast, I take about 1 gram of fish oil, alpha-lipoic acid.
  • Thomas DeLauer · Cinnamon · recommends
    • 20 Aug 2026 · recommends · Instagram ↗
      Recommends Ceylon cinnamon for pancreas health, describing it as an insulin mimetic that eases beta cell load.
    • 30 Oct 2026 · Green Tea · uses · YouTube ↗
      Now rotates green tea with coffee, having green tea for two days, then coffee for two days, to maintain energy and benefit from different antioxidant profiles. He previously focused too much on green tea and neglected coffee.
    • 29 Oct 2026 · Green Tea · uses · YouTube ↗
      Combines MCT oil with matcha green tea in a cognitive cocktail, finding that green tea provides more mental benefits than coffee for focus and calm energy.
    • 16 Oct 2026 · Green Tea · recommends · Facebook ↗
      Explains that green tea's catechin benefits often diminish in the intestines, with less than 20% surviving digestion, but adding citrus can reclaim these benefits by about 5x.
    • 16 Oct 2026 · Green Tea · recommends · Facebook ↗
      Recommends adding citrus, specifically lemon, to green tea to reclaim the benefits of catechins, as it can leave 80% of them intact.
    • 16 Oct 2026 · Ginger · neutral · YouTube ↗
      Mentions that Dose Daily contains organic ginger root powder.
    • 4 Oct 2026 · Ginger · uses · YouTube ↗
      Uses ginger oil, an ingredient in Curcumin Gold, stating it helps modulate inflammation within the gut.
    • 3 Oct 2026 · Fenugreek · neutral · YouTube ↗
      Mentions that more fenugreek could be beneficial for testosterone, but it's not working on the axis that most people need help with.
    • 11 Sep 2026 · Green Tea · recommends · YouTube ↗
      Recommends sipping green tea while walking fasted in the morning to help extend the fat oxidation window.
    • 5 Sep 2026 · Niacin · uses · YouTube ↗
      Uses niacin as part of their detoxification protocol, taking enough to flush about half an hour before a sauna session.
    • 31 Aug 2026 · Green Tea · recommends · YouTube ↗
      Recommends one to three small cups of green tea, ideally in the morning, as consistent consumption over two to three weeks increases BDNF due to EGCG.
    • 15 Aug 2026 · recommends · YouTube ↗
      Recommends adding cinnamon to morning coffee to improve insulin sensitivity and stop insulin resistance from progressing.
    • 15 Aug 2026 · Green Tea · recommends · YouTube ↗
      Recommends switching to a good quality green tea first thing in the morning because it is lower in caffeine and contains theanine, which has a cortisol-blunting effect, balancing out the stimulation.
    • 11 Aug 2026 · Green Tea · recommends · Instagram ↗
      Recommends green tea, mentioning its EGCG content.
  • Siim Land · Chromium · recommends
    • 26 Jul 2026 · recommends · X ↗
      Recommends chromium as a mineral that can lead to better body composition.
    • 31 Oct 2026 · Green Tea · recommends · Instagram ↗
      States that green tea is very effective for visceral fat loss due to its polyphenol content.
    • 27 Oct 2026 · Green Tea · uses · Instagram ↗
      Personally drinks 2 cups of green tea a day and made it one of the small changes while reducing his visceral fat.
    • 19 Oct 2026 · Green Tea · neutral · YouTube ↗
      Mentions that green tea's EGCG has stimulated autophagy in cultured liver cells and mouse experiments by increasing AMPK.
    • 11 Oct 2026 · Green Tea · uses · YouTube ↗
      Consumed more polyphenol-rich foods, including green tea, to reduce visceral fat.
    • 30 Sep 2026 · Green Tea · uses · YouTube ↗
      Mentions that he drank green tea, which targets visceral fat, as one of the things he did to reduce visceral fat.
    • 26 Sep 2026 · Green Tea · uses · X ↗
      Drinks 1-3 cups of green tea a day, noting that there are multiple lines of evidence suggesting it improves various health markers and may have longevity benefits.
    • 26 Sep 2026 · Green Tea · recommends · X ↗
      States that green tea is one of the healthiest beverages in the world, improving cardiovascular disease risk factors, heart health, metabolic health markers, targeting all hallmarks of aging, reducing visceral fat, and being associated with lower mortality.
    • 25 Sep 2026 · Green Tea · uses · YouTube ↗
      When dropping his visceral fat, Siim Land drank around one to three cups of green tea per day, usually in the morning and before exercise, and believes it contributed to visceral fat loss.
    • 7 Aug 2026 · Ginger · neutral · YouTube ↗
      Mentions ginger as a compound that can increase autophagy, but notes it doesn't come close to exercise in effectiveness.
    • 30 Jul 2026 · Green Tea · uses · Instagram ↗
      Drank 2–3 cups of green tea per day to reduce visceral fat.
    • 28 Jul 2026 · Green Tea · uses · X ↗
      Reduced visceral fat by adding 2 cups of green tea per day.
    • 4 Jul 2026 · Cinnamon · uses · YouTube ↗
      Includes cinnamon powder in their supplement stack.
    • 27 Jun 2026 · uses · YouTube ↗
      Would take chromium for pre-diabetes.
  • Andrew Huberman · Cinnamon · recommends
    • 30 Apr 2026 · recommends · Podcast ↗
      Recommends cinnamon as a tool to reduce blood sugar cravings.
    • 28 Sep 2026 · Green Tea · uses · YouTube ↗
      Drinks green tea and believes it has very positive cognitive benefits in terms of focus.
    • 28 Sep 2026 · Ginger · neutral · YouTube ↗
      Discusses a study where people who had taken powdered ginger were less judgmental because their stomachs were calmed, noting that ginger calms the stomach.
    • 13 Jul 2026 · Green Tea · uses · X ↗
      Uses Athletic Greens AG1 in the morning for gut health.
    • 10 Jun 2026 · Ginger · neutral · Facebook ↗
      Asks if ginger can increase metabolism and states that apparently, it can.
    • 8 Jun 2026 · Ginger · neutral · YouTube ↗
      Conducted a study on ginger powder dissolved in warm water, which significantly elevated the thermic effect of food over a 6-hour period, suggesting it could boost energy expenditure.
    • 30 Apr 2026 · warns · YouTube ↗
      Warns that cinnamon contains a med, which can be toxic at high levels, so one should not ingest more than about a teaspoon to a teaspoon and a half per day to avoid exceeding the problematic threshold.
    • 23 Mar 2026 · Alpha-Lipoic Acid · neutral · YouTube ↗
      Mentions that their mentor's lab studied the combination of L-carnitine and alpha-lipoic acid for improving mitochondrial health, leading to a supplement called Juvenon.
    • 1 Jan 2026 · Moringa · uses · YouTube ↗
      Has shifted to supplementing with moringa powder, which is a cousin to sulfurophane and activates the NRF2 pathway similarly, adding Koolie Moringa powder to smoothies.
    • 5 Jun 2025 · Ginger · recommends · YouTube ↗
      States that there are good, unbiased peer-reviewed studies showing that 1 to 3 grams of ginger can cause a notable reduction in nausea.
    • 29 Jul 2024 · Green Tea · uses · YouTube ↗
      Takes a couple of green tea capsules in the morning.
    • 1 Jul 2024 · Niacin · neutral · Instagram ↗
      Reviews data on ingesting or topically applying niacinamide to improve skin's youthfulness and appearance, including reducing wrinkles, sagging, and pore size.
    • 1 Jul 2024 · Niacin · recommends · YouTube ↗
      Recommends niacinamide supplementation, a form of Vitamin B3, at 500 milligrams twice per day for a total of 1 gram daily, to increase ceramide production, improve skin moisture, reduce inflammation, balance oil production, and reduce the appearance of clogged pores and hyperpigmented spots.
    • 6 May 2024 · Green Tea · uses · YouTube ↗
      Includes green tea in his diet because its EGCG compound has been shown to stimulate GLP-1.
  • Dave Asprey · Cinnamon · warns
    • 9 Apr 2026 · warns · YouTube ↗
      Warns that cinnamon is high in oxalate.
    • 9 Sep 2026 · Green Tea · warns · YouTube ↗
      Warns that very high doses of EGCG or green tea extract could cause harm to the liver.
    • 25 Jul 2026 · Niacin · recommends · YouTube ↗
      Recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish, or from supplements.
    • 6 Jul 2026 · Ginger · recommends · Instagram ↗
      Recommends ginger as a midwife remedy to help with nausea during pregnancy.
    • 30 May 2026 · Niacin · recommends · YouTube ↗
      Dave Asprey recommends niacin, a form of vitamin B3, as one of the two most important raw materials for NAD+ production, found in foods like beef liver, chicken, turkey, and fish.
    • 15 May 2026 · Niacin · neutral · X ↗
      Notes that niacin has been a standard longevity ingredient since the 1990s.
    • 5 May 2026 · Green Tea · neutral · YouTube ↗
      Mentions green tea as a source of EGCG but notes it also contains oxalates.
    • 13 Mar 2026 · Fenugreek · recommends · Podcast ↗
      Recommends soaking fenugreek seeds overnight and consuming them before meals to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent, citing multiple small human trials.
    • 17 Feb 2026 · Green Tea · warns · YouTube ↗
      Warns that green tea depletes folic acid and may not be advisable during pregnancy, or at least should be taken with folic acid.
    • 17 Feb 2026 · Niacin · neutral · Podcast ↗
      Dave discusses how niacinamide compares as an NAD precursor.
    • 17 Feb 2026 · Niacin · neutral · YouTube ↗
      Dave explains that niacinamide is an old-school way to mildly elevate NAD levels, and it was the only way to raise NAD in the very early days.
    • 10 Feb 2026 · Niacin · stopped · YouTube ↗
      Used niacin for a while to address plaque in his arteries and high LP(a), but stopped because it caused high liver values and made him feel unwell, despite dropping his LP(a).
    • 30 Dec 2025 · Green Tea · warns · YouTube ↗
      Mentions that green tea contains oxalate, though it is lower than black tea and matcha.
    • 26 Dec 2025 · Theobromine · neutral · Podcast ↗
      Dave breaks down new research suggesting that theobromine, found in cocoa, is associated with epigenetic markers of slower biological aging, and how this adds credibility to cocoa’s cardiometabolic benefits.
  • Peter Attia · Cinnamon · uses
    • 7 Dec 2025 · uses · YouTube ↗
      Uses cinnamon in his keto mousse in the evening.
    • 29 Jun 2025 · Niacin · uses · YouTube ↗
      Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
    • 6 Jun 2024 · uses · YouTube ↗
      Puts a little bit of cinnamon on air-popped popcorn.
    • 30 Jan 2023 · Niacin · stopped · YouTube ↗
      Used to prescribe niacin to many patients, primarily to raise HDL, lower APO B, triglycerides, LDL, and LP(a), but stopped after clinical trials showed minimal or disappointing effects on reducing cardiovascular events.
    • 7 Nov 2022 · Niacin · stopped · YouTube ↗
      Notes that niacin lowers LP little a but was not shown to have clinical benefit in outcome studies, and they are not currently using it.
    • 1 Aug 2022 · Niacin · neutral · YouTube ↗
      Recalls that a flush from niacin typically occurred with doses of a few grams.
    • 13 Jun 2022 · Niacin · warns · YouTube ↗
      Explains that niacin does reduce Lp(a) levels, increase HDL, and lower triglycerides, but two large cardiovascular outcome trials have shown no cardiovascular benefits and many side effects, such as flushing. He concludes that the cost-to-benefit ratio does not support its use.
    • 13 Jun 2022 · Niacin · neutral · Podcast ↗
      He dives into data on the possible treatments for lowering Lp(a) such niacin, meds, and PCSK9 inhibitors.
    • 8 Feb 2021 · Green Tea · neutral · YouTube ↗
      Explains that green tea extract was tested due to popular reputation and traditional medicine claims, but it did not extend the lifespan of animals in their studies.
    • 21 Sep 2020 · Niacin · warns · YouTube ↗
      States that niacin is a dead drug and is not recommended by any guidelines, though some still selectively use it for Lp(a).
    • 13 Jan 2020 · Niacin · warns · YouTube ↗
      Warns against taking high doses of nicotinamide (a form of niacin/vitamin B3) because it is an effective inhibitor of sirtuins, which are enzymes one wants to keep active for the purpose of raising NAD.
    • 1 Jan 2020 · Niacin · warns · YouTube ↗
      Peter Atia notes that some people still argue niacin makes sense because it lowers LP little-a, but he advises against it, stating that it has a weak lowering effect of about 20% and that he knows many lipidologists who would not use it.
    • 1 Jan 2020 · Niacin · stopped · YouTube ↗
      Warns against niacin, stating that it causes acanthosis nigricans, worsens insulin resistance, and has numerous other side effects, despite lowering apoB. He recounts a patient who experienced a severe pruritic reaction, thinking he was going to die.
    • Date not recorded · Alpha-Lipoic Acid · stopped · Website ↗
      Used to take Alpha-lipoic acid for longevity but stopped because he didn't see enough evidence.
  • Bryan Johnson · Cinnamon · uses
    • 23 Dec 2023 · uses · YouTube ↗
      Uses half a teaspoon of Ceylon cinnamon in his Nutty Pudding for blood sugar, liver, and pancreas health.
    • 7 Mar 2026 · Green Tea · uses · X ↗
      Takes Athletic Greens AG1 in the morning for gut health.
    • 2 Jul 2024 · Ginger · uses · YouTube ↗
      Includes three capsules of Ginger in his Blueprint stack.
    • 9 Dec 2023 · Ginger · uses · YouTube ↗
      Includes 3g of ginger in his Super Veggie for a variety of benefits including liver, pancreas, artery health, and digestion.
    • 27 Jul 2023 · uses · YouTube ↗
      Includes cinnamon in his Green Giant drink, which he consumes first thing in the morning.
    • 27 Jul 2023 · Ginger · uses · YouTube ↗
      Includes ginger in his Super Veggie meal, which he eats at 7 AM.
    • 25 Jan 2023 · Ginger · uses · YouTube ↗
      Includes ginger in his daily 'Super Veggie' breakfast for its nutrient density.
    • Date not recorded · uses · Website ↗
      Bryan Johnson uses ½ tsp of ceylon cinnamon in his Nutty Pudding.
    • Date not recorded · Ginger · uses · Source ↗
      Uses ginger in his Super Veggies.
    • Date not recorded · Niacin · recommends · Website ↗
      Recommends Niacinamide as a supplement for skin health, noting it is in the Blueprint stack.
    • Date not recorded · Niacin · uses · Website ↗
      He uses Niacinamide, found in serums or moisturizers, morning and night, and takes 15 mg in Blueprint Essential Capsules.

RAL Summary

Members OnlyTier 2 for Blood Sugar

Tier 2 is supported because full-dose chromium, oleoylethanolamide and cinnamon each improved blood sugar in human trials [1][3][5], and 95% of 2515 reviews are positive.

Take 3 servings a day to match the dose that worked in the studies.

Where the evidence disagrees: 104 of the 474 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Endocrine system, Metabolic system, Cardiovascular system, Digestive system

Combine with: For blood sugar and metabolic support, berberine and alpha-lipoic acid pair well with chromium picolinate, magnesium glycinate, cinnamon extract, and omega-3 fish oil. Taking them with meals improves tolerance and effectiveness. If the user's real goal is regularity, they should use a separate, purpose-built approach: magnesium citrate or oxide (osmotic effect), psyllium husk or partially hydrolyzed guar gum (fiber), adequate water, and probiotics such as Bifidobacterium lactis BB-12 or Lactobacillus reuteri. Other options are prunes or kiwifruit extract and, for long-term relief, consistent fiber and hydration. Anyone with persistent constipation should consult a clinician, especially when taking berberine, which can interact with medications and may aggravate constipation.

Possible side effects: Fenugreek caused mild stomach upset in studies, and theobromine at higher doses raised blood sugar after meals in one trial. High-dose niacin worsened blood sugar, far above the amount in this product.

Supplement Facts

Thiamine 40 mg · Niacin 15 mg NE · Chromium 250 mcg
Supplement Facts
Serving Size 3 Vegetarian Capsule(s)
Servings Per Container 28
Amount Per Serving% Daily Value
Thiamine40 mg
Niacin15 mg NE
Chromium250 mcg
Oleoylethanolamide300 mg†
Horseradish tree (Moringa oleifera) leaf powder250 mg†
GlucoVantage150 mg†
Green Tea Leaf Extract150 mg†
Theobromine100 mg†
Cinnamon bark powder100 mg†
Alpha-Lipoic Acid100 mg†
Gymnema Leaf Extract75 mg†
Asian Ginseng Leaf, Stem Extract20 mg†
Ginger Root Extract20 mg†
Fenugreek Seed Extract20 mg†
Dandelion Root Extract20 mg†
Coffee Bean Extract20 mg†
† Daily Value not established.

Other ingredients: Hypromellose, L-Leucine, Bamboo Leaf Extract.

Label source: NIH label database · Report a label change

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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.