InfoWars Life The Real Red Pill Plus Review
The Real Red Pill Plus is a capsule dietary supplement sold by Infowars Life. It comes in a 120-capsule bottle, and the serving size is 2 capsules. The NIH Dietary Supplement Label Database lists it as an "Other Combinations" product for adults, with structure/function claims and no disease claims. Infowars presents it as an upgraded version of its original Real Red Pill. The company says it keeps the same pregnenolone formula and adds a new energy-boosting blend. The retailer page names these components: 1. **Pregnenolone (50 mg, per the Amazon title).** Pregnenolone is a med made from cholesterol in the adrenal glands, brain and gonads. The body converts it into DHEA, progesterone, and downstream estrogens, androgens and cortisol, which is why it is called a "mother hormone." It is also a neurosteroid. In the lab it modulates NMDA and GABA-A receptors and supports neuronal signaling. This is the basis for the brand's claims about cognitive function and healthy aging. Human evidence that oral supplementation improves memory or mood is limited and mixed. Because it feeds into hormone pathways, its effects vary from person to person. 2. **Energy blend of L-theanine, caffeine and theobromine.** The page describes these as naturally occurring. - Caffeine blocks adenosine receptors, which promotes alertness. - Theobromine is a milder, longer-acting methylxanthine that adds gentle stimulation and vasodilation. - L-theanine promotes alpha-wave activity and is widely reported to smooth the jitteriness of caffeine. Caffeine plus L-theanine is a well-studied pairing for attention. 3. **Essential trace minerals and B vitamins.** The listing says these are the same as in the original Real Red Pill and are meant to support cognitive function and heart health. The NIH label also lists vitamin K as menaquinone. B vitamins act as cofactors in energy metabolism and neurotransmitter synthesis. Trace minerals serve as enzyme cofactors. In practice, the product combines a hormone precursor with a mild stimulant stack and basic micronutrients. Its likely effects are mostly the energy and focus from the caffeine group, plus whatever hormonal effect the pregnenolone has in a given person. The statements are structure/function claims and are not FDA-evaluated. People who are pregnant, on hormone therapy, or managing hormone-sensitive conditions, and anyone sensitive to caffeine, should talk to a clinician first. Check the current label for exact doses of each ingredient.
Tier ⓘ
Tier 4 · Rank 4
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 4 within Tier 4 for Hormone Balance for Men; 7 of 10 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
33 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
9 of 10
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Study, Trial or Testing Result Summary
Members Only99 human studies · 24 improved
2 of these 99 human studies gave the ingredient by injection, not by mouth.
99 human studies24 improved57 no effect29,630 people studied
There is little good evidence that this product supports men's hormones. Magnesium is at a full dose. One small trial found it raised testosterone in men, more so in those who exercised [1], but a review of testosterone boosters did not find magnesium effective compared with placebo [2]. Selenium reaches a full dose at three servings a day. A large trial in infertile men raised testosterone at 200 micrograms [3], but trials in healthy or active men found no change [4][5]. Zinc is below the dose that raised testosterone in men on dialysis [6], and most zinc trials found no hormone change [7]. For folic acid, the best trials found no change in testosterone [7][8]. Vitamin K lowered male-type hormones, but only in women with a hormone disorder [9]. Beetroot showed mixed effects on testosterone balance in athletes [10][11]. Copper, manganese and molybdenum were only studied as body levels, and higher manganese was linked to lower testosterone [12]. Pregnenolone, chromium and the energy blend had no human studies here, and the energy blend's contents and amounts are hidden. Animal and cell studies are never counted.
See all 99 studies →Hide the studies
- In a pooled analysis of 44 studies of 3853 men with erectile dysfunction, adding folic acid to a PDE5 inhibitor improved erectile function scores by 3.46 points over the PDE5 inhibitor alone, though this was based on only one study.Assessment of Combination Therapies vs Monotherapy for Erectile Dysfunction: A Systematic Review and Meta-analysis.
- Across 31 trials with 1999 people with antipsychotic-induced high prolactin, adding high-dose vitamin B6 lowered prolactin significantly in those with levels above 50 ng/ml, but no treatment beat placebo when levels were below 50 ng/ml.Pharmacological treatment strategies for antipsychotic-induced hyperprolactinemia: a systematic review and network meta-…
- In a pooled review of 15 trials of men and women with chronic kidney disease, oral zinc raised testosterone in one small study of 20 patients, but zinc added to dialysis fluid did not, and luteinizing and follicle-stimulating hormones did not change.Interventions for treating sexual dysfunction in patients with chronic kidney disease.
- In a pooled analysis of seven trials in subfertile men, folate plus zinc did not change testosterone, inhibin B or FSH compared with placebo, but it raised sperm concentration and shape, and folate alone raised sperm concentration only.The Effect of Folate and Folate Plus Zinc Supplementation on Endocrine Parameters and Sperm Characteristics in Sub-Ferti…
- In a review of 14 trials in people with chronic kidney disease, oral zinc improved testosterone but zinc added to dialysis fluid did not, and luteinizing and follicle-stimulating hormones were unchanged.Treatment options for sexual dysfunction in patients with chronic kidney disease: a systematic review of randomized cont…
- A review of treatments for men with erectile dysfunction who did not respond to PDE5 inhibitors found the evidence for adding folic acid too limited to say whether it works.Systematic Review of Oral Combination Therapy for Erectile Dysfunction When Phosphodiesterase Type 5 Inhibitor Monothera…
- A review of 52 studies of supplements marketed to raise testosterone, including 5 on zinc and magnesium, found that most failed to raise total testosterone compared with placebo, and zinc and magnesium were not among the ones judged effective.Do "testosterone boosters" really increase serum total testosterone? A systematic review.
- A review of 105 trials on ingredients in male testosterone and erectile supplements, including zinc, found limited evidence overall, with many ingredients having contradicting or lacking evidence.A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction sup…
- A review of 6 placebo-controlled trials in physically active people found selenium at 180 to 240 micrograms a day lowered a marker of fat damage and raised an antioxidant enzyme, but had no significant effect on testosterone or athletic performance.The Role of Selenium Mineral Trace Element in Exercise: Antioxidant Defense System, Muscle Performance, Hormone Response…
- In 468 infertile men, 200 micrograms of selenium daily for 26 weeks (alone or with N-acetyl-cysteine) lowered follicle-stimulating hormone and raised testosterone and inhibin B compared with placebo, and improved semen quality.Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo c…
- In 148 men aged 70 and over with low testosterone and mobility problems, 20 weeks of calcium, vitamin D and protein plus strength training and testosterone injections improved chair stand performance, quality of life and tiredness compared with no intervention; calcium's own effect could not be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In a one-year follow-up of 148 older men with low testosterone, only the group given testosterone plus strength training (with calcium, vitamin D and protein supplements) improved chair stand performance and fatigue; calcium's own effect was not separated.Testosterone and resistance training improved physical performance and reduced fatigue in frail older men: 1 year follow…
- In 143 boys aged 16 to 18, 1000 mg of calcium carbonate daily for 13 months increased bone mineral and height compared with placebo, with no significant interaction with plasma testosterone.Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys.
- In 88 male heart transplant patients all given calcium and vitamin D, about 24% had low testosterone and lower bone density, and adding testosterone for 1 to 2 years did not significantly raise bone density.[Effect of immunosuppression-induced hypogonadism on bone metabolism after heart transplantation].
- In 87 fertile and subfertile men given folic acid and zinc or placebo for 26 weeks, sperm concentration rose in subfertile men but FSH, testosterone and inhibin B did not change.Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?
- In 84 women with polycystic ovary syndrome, 90 mcg of vitamin K2 (menaquinone-7) daily for 8 weeks lowered dihydrotestosterone and free androgen index and raised sex hormone binding globulin compared with placebo.Beneficial health effects of Menaquinone-7 on body composition, glycemic indices, lipid profile, and endocrine markers i…
- In 80 men with untreated prostate cancer, a supplement with selenium, vitamins E and C and coenzyme Q10 for 21 weeks did not change testosterone, other sex hormones or PSA compared with placebo.Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients w…
- In 60 vitamin D-deficient women with polycystic ovary syndrome, vitamin K (90 mcg) with vitamin D and calcium twice daily for 8 weeks lowered free testosterone and DHEAS and improved antioxidant markers compared with placebo, with no change in inflammation markers.The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vit…
- In 55 men with urinary symptoms and prostate enlargement, 240 micrograms of selenium plus silymarin daily for 6 months lowered PSA and improved urinary symptoms but had no effect on blood testosterone.Use of selenium-silymarin mix reduces lower urinary tract symptoms and prostate specific antigen in men.
- In infertile men taking zinc 10 mg combined with D-aspartic acid and ubiquinol daily for 3 months, total testosterone and progressive sperm motility rose significantly compared with before treatment.Evaluation of in vivo supplementation of 2660 mg D-aspartic acid and 200 mg ubiquinol and 10 mg zinc on different semen …
- In 42 men, 300 micrograms of selenium daily for 48 weeks had no effect on blood androgen levels or semen quality compared with placebo.Selenium supplementation does not affect testicular selenium status or semen quality in North American men.
- In 37 men with prostate cancer, a 6-week multi-ingredient supplement including selenium lowered testosterone and DHT compared with placebo, which was the intended effect in this cancer setting but a reduction in male hormones.Dietary intervention in prostate cancer patients: PSA response in a randomized double-blind placebo-controlled study.
- In 37 men after prostate surgery, 240 micrograms of selenium plus silymarin daily for 6 months had no influence on testosterone, though it lowered cholesterol and improved quality of life.The safety and efficacy of a silymarin and selenium combination in men after radical prostatectomy - a six month placebo…
- In 36 healthy men given 247 mcg of selenium-enriched yeast daily for 9 months, blood testosterone, dihydrotestosterone and their ratio did not change compared with placebo, though antioxidant glutathione levels rose and prostate-specific antigen dipped slightly.Influence of selenium-enriched yeast supplementation on biomarkers of oxidative damage and hormone status in healthy adu…
- In 32 trained male triathletes, 9 weeks of 2.1 g a day of beetroot extract plus 3 g citrulline prevented a rise in cortisol and improved the testosterone-to-cortisol ratio compared with placebo, but did not reduce muscle damage markers.Long-Term Combined Effects of Citrulline and Nitrate-Rich Beetroot Extract Supplementation on Recovery Status in Trained…
- In 21 men with idiopathic osteoporosis, 1000 mg daily calcium carbonate alone produced no change in bone density over 12 months. Adding weekly nandrolone raised bone density early, but it fell back to near baseline by 12 months, and testosterone levels dropped.Nandrolone decanoate for men with osteoporosis.
- In 20 men on hemodialysis, 50 mg of zinc daily for 6 months raised testosterone and sperm count and lowered luteinizing and follicle-stimulating hormones, with better libido and potency, unlike placebo.Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study.
- In 18 male dialysis patients with sexual dysfunction and normal prolactin, oral zinc acetate for 6 months raised blood zinc but did not change testosterone, sex hormone binding globulin, gonadotrophins, sperm counts or erections compared with placebo; 1 of 9 on zinc reported better sexual function.Zinc deficiency and hyperprolactinaemia are not reversible causes of sexual dysfunction in uraemia.
- In 14 obese young men, 100 mg a day of zinc sulfate for one month raised zinc and leptin levels but did not change androgens or insulin sensitivity compared with placebo.[Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males].
- In 14 men on kidney dialysis, 6 weeks of zinc chloride added to the dialysis fluid did not change testosterone, gonadotrophin levels or sexual function compared with placebo.Absence of a therapeutic effect of zinc in the sexual dysfunction of haemodialysed patients.
- In 12 trained men, a single 140 ml dose of beetroot juice before a CrossFit workout raised cortisol more than placebo (76% vs 36%) and did not change testosterone or the testosterone-to-cortisol ratio, though it increased repetitions in the first routine.Understanding the effects of beetroot juice intake on CrossFit performance by assessing hormonal, metabolic and mechanic…
- In 11 healthy men on a controlled diet for 120 days, high selenium intake of 297 mcg per day left serum androgen levels unchanged, although it lowered sperm motility.Effects of dietary selenium on sperm motility in healthy men.
- In 8 dialysis men with low zinc, zinc given during dialysis improved potency in all four treated men and brought low testosterone back to normal in the two who had low levels, while placebo did not help.Reversal of uraemic impotence by zinc.
- In men after varicocele surgery, taking folic acid with zinc sulphate daily for 6 months raised blood inhibin B and seminal antioxidant activity compared with placebo.Effect of folic acid and zinc sulphate on endocrine parameters and seminal antioxidant level after varicocelectomy.
- In 100 infertile men, half took a once-daily multi-ingredient antioxidant supplement (including vitamin B6) for 6 months; their FSH, LH and total testosterone rose significantly from baseline while the untreated control group showed no change, and sperm count did not significantly improve.Do antioxidants improve serum sex hormones and total motile sperm count in idiopathic infertile men?
- In 64 men with metabolic syndrome, adding an antioxidant complex containing folic acid to standard care for 3 months lowered oxidative stress, HbA1c and body mass index and improved erectile function compared with standard care alone.[The role of antioxidants in the therapy of metabolic syndrome in men].
- In 11 young men fed controlled diets, 35 days on very low zinc (1.4 mg a day) lowered testosterone (26.9 to 21.9 nmol/L) and semen volume compared with 10.4 mg a day, showing testosterone drops when zinc is depleted.Effects of dietary zinc depletion on seminal volume and zinc loss, serum testosterone concentrations, and sperm morpholo…
- In men who were sedentary or practiced tae kwon do, 4 weeks of magnesium at 10 mg per kilogram of body weight raised free and total testosterone, with larger increases in those who exercised.Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaust…
- In men with liver cirrhosis and impotence or low sex hormones, zinc sulfate taken for 6 to 8 months did not work better than placebo, and testosterone levels did not change.Effect of the administration of zinc sulfate on hypogonadism and impotence in patients with chronic stable hepatic cirrh…
- In adult men with sickle cell anemia, oral zinc supplementation raised serum testosterone compared with placebo and corrected their androgen deficiency.Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects.
- In 100 men on hemodialysis, 250 mg of zinc sulfate daily for 6 weeks raised testosterone and luteinizing hormone levels, though the authors judged the effect on sexual dysfunction unclear; there was no placebo group.Impact of oral zinc therapy on the level of sex hormones in male patients on hemodialysis.
- In 26 infertile men given 1,500 mcg of methylcobalamin daily for 4 to 24 weeks, sperm measures improved in about half, while serum LH, FSH and testosterone were unchanged; 42% were judged improved overall.[Clinical experience with methylcobalamin (CH3-B12) for male infertility].
- In 15 overweight men with low testosterone, a nutraceutical containing folic acid taken twice daily for 3 months raised testosterone, luteinizing hormone and erectile function scores and reduced body fat and insulin resistance.Positive effects of dietary supplementation with nutraceuticals on male subclinical hypogonadism: a pilot study.
- In 10 sedentary young men taking zinc sulfate at 3 mg per kg of body weight daily for 4 weeks, testosterone levels were higher after supplementation, and zinc appeared to prevent the drop in testosterone seen after exercise; there was no placebo group.Effect of fatiguing bicycle exercise on thyroid hormone and testosterone levels in sedentary males supplemented with ora…
- In a large US national health survey of men, higher manganese exposure was associated with about 15% higher odds of testosterone deficiency, especially in men aged 45 to 50 and in obese men.Toxic metals and trace elements, markers of inflammation, and hyperandrogenemia in women and testosterone deficiency in …
- In a follow-up analysis of 2118 men with heart disease who were in a niacin trial, men with low testosterone (30% of the group) had a higher risk of heart attack, stroke or heart death over about 3 years than men with normal testosterone, and the study did not test whether niacin changed testosterone.Testosterone concentrations and risk of cardiovascular events in androgen-deficient men with atherosclerotic cardiovascu…
- In about 1,940 US men, higher blood selenium was linked to a higher free androgen index but lower SHBG; this is an association from a population survey, not a supplement trial.Association of blood metals with serum sex hormones in adults: A cross-sectional study.
- In 1136 Chinese men, higher manganese in semen was linked to lower sperm concentration, while the study did not report a manganese link to male sex hormones.The association between metal exposure and semen quality in Chinese males: The mediating effect of androgens.
- In 1,060 children aged 6 to 19 from a national survey, a metal pattern high in blood manganese was linked with higher estradiol and lower testosterone-to-estradiol ratio in girls aged 12 to 19, while mixture links were not significant in boys.Exposure to metals and the disruption of sex hormones in 6-19 years old children: An exploration of mixture effects.
- In 1059 US children and adolescents aged 6 to 19, higher molybdenum exposure was one of several metals linked to lower total testosterone and estradiol.Read the study on PubMed (39739052) →
- In a retrospective study of 966 adults with depression, higher blood folate was linked to lower suicide risk, especially in men, but testosterone levels were not significantly associated with suicide risk.Serum folate and homocysteine as biomarkers for suicide risk in major depressive disorder: insights in males and younger…
- In a case-control study of 388 women with polycystic ovary syndrome and 465 controls, higher follicular fluid manganese was linked with lower polycystic ovary syndrome risk, partly through the luteinizing to follicle-stimulating hormone ratio.The association between metal exposure in follicular fluid and PCOS risk in reproductive-aged women: Mediating Roles of …
- In 815 pregnant women in Puerto Rico, blood manganese was associated with a small rise in sex hormone binding globulin, while arsenic and nickel were the metals linked with lower testosterone.Association of biomarkers of exposure to metals and metalloids with maternal hormones in pregnant women from Puerto Rico…
- In a national survey of 687 men, copper's association with testosterone weakened after adjustment for other factors, so no clear effect on male hormones was found.Serum Minerals and Male Age-related Hypogonadism: Multimodal Evidence Decoding Associations and Intervention Strategies.
- In 533 pregnant women in China, higher levels of manganese measured in the placenta were linked to lower testosterone levels in umbilical cord blood.Read the study on PubMed (38733803) →
- In 511 Chinese men from an infertility clinic, higher urinary molybdenum was linked to a lower ratio of total testosterone to luteinizing hormone.Associations of urinary metal levels with serum hormones, spermatozoa apoptosis and sperm DNA damage in a Chinese popula…
- In 484 US men in NHANES 2011 to 2012, higher urinary molybdenum was linked to lower serum testosterone, though a suggestive quartile trend was only significant at quintiles.Biomarkers of exposure to molybdenum and other metals in relation to testosterone among men from the United States Natio…
- In 399 men aged 65 and older, higher blood magnesium was independently linked to higher total testosterone and growth factor levels, though this observational association does not show that magnesium intake raises testosterone.Magnesium and anabolic hormones in older men.
- In a cross-sectional study of 251 welders and 100 office workers, occupational manganese exposure was linked with higher prolactin and, in a structural model, lower testosterone.Effect of manganese exposure on the neuroendocrine system in welders.
- In 336 healthy middle-aged Germans, plasma vitamin B12 was one of several factors linked to homocysteine levels, which were higher in men mainly due to differences in fat-free mass and estradiol; vitamin B12 was not given as a supplement.Factors explaining the difference of total homocysteine between men and women in the European Investigation Into Cancer …
- In a case-control study of 160 pregnant women with preeclampsia and 160 with normal deliveries, lower blood manganese was linked with preeclampsia, and manganese was linked with lower estradiol and cortisol; no testosterone link was reported for manganese.A study on the mediating role of serum hormones in the effects of heavy metals on preeclampsia.
- In 314 men aged 50 and older with testosterone deficiency, blood magnesium was not reported as linked to depressive symptoms; only manganese and chromium showed a significant correlation.The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Agi…
- In 313 men aged 50 to 75, higher blood magnesium was associated with normal total testosterone, while lower magnesium was seen alongside testosterone deficiency, metabolic syndrome, diabetes and high blood pressure, though this is an observational association.Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older men.
- In 313 men aged 50 to 75, those with low total testosterone had higher blood manganese levels, and total testosterone was inversely correlated with manganese; this is an observational association, not a supplement effect.Analysis of the relationship between the blood concentration of several metals, macro- and micronutrients and endocrine …
- In a cross-sectional study of 138 copper and cobalt miners and 139 bakers in the Democratic Republic of the Congo, miners had lower free testosterone and poorer sexual function, which the authors suggest may be linked to their high exposure to trace metals; this study does not test copper supplements.Erectile dysfunction in copper and cobalt miners: a cross-sectional study in the former Katanga province, Democratic Rep…
- In 274 men from Karachi, higher serum folic acid was associated with better sperm count, motility and morphology, and with higher testosterone levels.Estimation of folic acid/micro nutrients levels; Does it reflect sperm parameters.
- In 259 regularly menstruating women followed prospectively, dietary manganese intake below 1.8 mg was associated with about twice the risk of anovulation compared with higher intakes.Dietary minerals, reproductive hormone levels and sporadic anovulation: associations in healthy women with regular menst…
- In 225 children aged 7 to 12 living near a manganese alloy plant in Brazil, higher manganese levels in toenails were linked to higher prolactin, and manganese was not linked to testosterone or estradiol.Manganese exposure and association with hormone imbalance in children living near a ferro-manganese alloy plant.
- In 225 school-aged children near a manganese alloy plant, manganese exposure was not associated with the age of puberty onset in boys or girls, while blood lead was linked to some pubertal changes.Manganese and Lead Exposure and Early Puberty Onset in Children Living near a Ferromanganese Alloy Plant.
- In 225 young Japanese men seeking infertility consultation, higher serum molybdenum was among trace elements that negatively influenced testosterone levels.Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.
- In 219 men from Michigan infertility clinics, higher blood molybdenum was associated with lower testosterone, and high molybdenum was linked to about a 37% lower testosterone among men with low zinc.Environmental exposure to metals and male reproductive hormones: circulating testosterone is inversely associated with b…
- In 84 male workers exposed to manganese at work compared with 92 non-exposed men, higher manganese levels in urine were linked to higher gonadotropin-releasing hormone and luteinizing hormone, lower testosterone, and reduced sperm motility.Occupational manganese exposure, reproductive hormones, and semen quality in male workers: A cross-sectional study.
- Men aged about 22 with congenital hypogonadism had lower plasma copper than 80 healthy controls, along with lower zinc and selenium and higher insulin resistance.Trace Element Levels in Congenital Hypogonadotrophic Hypogonadism.
- In 120 men with erectile dysfunction and 40 healthy men, total testosterone did not differ between groups, while folic acid levels were lower in the moderate and severe erectile dysfunction groups.Association between serum folic acid level and erectile dysfunction.
- In a review of 151 patients at a cancer weight-loss clinic, most men had low testosterone (73%), while low vitamin B12 was uncommon (3%); this review did not test vitamin B12 treatment on hormone levels.Clinical outcomes and contributors to weight loss in a cancer cachexia clinic.
- In a cross-sectional study of 52 welders, 48 smelters and 43 office workers, smelters with high occupational manganese exposure had lower testosterone, prolactin and follicle-stimulating hormone than controls or welders.Effect of manganese on neural endocrine hormones in serum of welders and smelters.
- In 133 Spanish boys aged 15 to 17, the study reported hormone links for other metals such as mercury, arsenic, cadmium and chromium, but no association between urinary manganese and hormone levels was reported.Association of urinary metal concentrations with blood pressure and serum hormones in Spanish male adolescents.
- In 102 infertile men with workplace metal exposure compared with 30 fertile men, metal levels, including copper, were higher, and testosterone and follicle-stimulating hormone were lower in the infertile group, though copper was not specifically linked to hormone changes.Effects of lead, cadmium, copper and zinc levels on the male reproductive function.
- In 125 women with polycystic ovary syndrome, higher blood selenium was linked to lower ADMA and triglycerides, but not to total testosterone or SHBG.Correlations of selenium and selenoprotein P with asymmetric dimethylarginine and lipid profile in patients with polycys…
- In 118 men from an infertility clinic, urinary copper was not reported as linked to testosterone, while higher manganese and zinc were associated with lower testosterone.Associations of urinary metal concentrations and circulating testosterone in Chinese men.
- In 52 men with testis cancer and 61 healthy men, testosterone and estradiol were lower in the cancer group, while copper levels differed in distribution across tissues without a clear hormone link.Cadmium and lead implication in testis cancer; is there a connection?
- In 92 human semen samples, folic acid was negatively correlated with sperm concentration and was lower in hyperviscous semen, but the abstract reports no hormone outcome tied to folic acid.Associations between biochemical components of human semen with seminal conditions.
- In 40 copper smelter workers compared with 40 unexposed workers, higher serum copper was linked to lower testosterone, and copper exposure was also associated with higher follicle-stimulating hormone.Male reproductive hormone disorders among copper smelter workers.
- In 77 sexually active men, testosterone levels were comparable between men with erectile dysfunction and healthy men, while folic acid levels were lower in men with erectile dysfunction and fell as severity increased.Novel predictive risk factor for Erectile Dysfunction: Serum folic acid.
- In 73 men undergoing IVF or ICSI, higher vitamin B12 levels in seminal plasma were linked to higher sperm concentration; this study did not report any effect of vitamin B12 on male hormone levels.Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures.
- In 64 women, 50 with polycystic ovary syndrome and 14 controls, higher plasma niacin levels were linked to lower levels of a hormone-binding protein and lower good cholesterol; this was a correlation study and does not show niacin changes hormones.The implications of vitamin content in the plasma in reference to the parameters of carbohydrate metabolism and hormone …
- Copper levels did not differ between 41 boys with pubertal gynecomastia and 21 healthy boys, while low zinc was linked to the condition and to lower testosterone.Low zinc levels may contribute to gynecomastia in puberty.
- In 60 high-level male endurance runners, higher plasma selenium was correlated with lower plasma testosterone; this is a correlation, not a supplement trial.Correlations between Basal Trace Minerals and Hormones in Middle and Long-Distance High-Level Male Runners.
- In 28 people with facioscapulohumeral dystrophy and 28 controls, blood folic acid levels were measured and compared with DNA methylation and sex hormones, and the study did not show folic acid as a treatment effect.Progesterone may be a regulator and B12 could be an indicator of the proximal D4Z4 repeat methylation status on 4q35ter.
- In a retrospective review of 56 men with chronic testicular pain who received vitamin B12 and testosterone replacement for deficiency, 65% of those with follow-up reported significant symptom improvement; hormone levels were not separately tested against a control.Prevalence of Relative Deficiencies in Testosterone and Vitamin B12 Among Patients Referred for Chronic Orchialgia: Impl…
- In 47 women with polycystic ovary syndrome, red blood cell manganese was negatively correlated with thyroid-stimulating hormone in obese women only; no testosterone link was reported for manganese.Levels of Trace Elements in Erythrocytes as Endocrine Disruptors in Obese and Nonobese Women with Polycystic Ovary Syndr…
- In 32 long-term survivors of intensively treated myeloma, hypogonadism was common in men (65%), and folate was reduced in 25% of patients, but folic acid was not tested as a treatment.Endocrine, metabolic, nutritional and body composition abnormalities are common in advanced intensively-treated (transpl…
- In a study of 27 elderly men, total testosterone fell with age but did not correlate with bone density, while vitamin D and vitamin K levels did.Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men.
- In 20 obese men who had weight-loss surgery, testosterone and other reproductive hormones rose over two years, while blood copper and zinc fell; copper levels were only weakly linked to sperm movement, so copper did not clearly improve sperm quality.Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study…
- In a large US survey of children and adolescents, higher blood selenium was associated with higher testosterone in male adolescents; this is an association, not a supplement trial.Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011-2012.
- In 14 regularly exercising men, a high-dose zinc-containing supplement raised blood zinc but did not change serum testosterone or testosterone metabolites in urine.Read the study on PubMed (17882141) →
- In male rats given a med drug that damages the testes, niacin at 50 mg per kg per day for 7 days brought blood testosterone back to control levels, and higher doses improved sperm motility, testicular structure, and reduced testicular cell death.Effects of pharmacological doses of niacin on subacute glucocorticoid-induced testicular damage in rats.
- In male rats given alcohol, nicotinamide at 200 mg per kg of body weight did not change the alcohol-related drop in blood testosterone and did not alter testicular energy molecule levels.[Nicotinamide has no effect on the ethanol-induced decrease in testosterone biosynthesis].
- In animal experiments only (mice and rabbits, not people), lyophilized beetroot at two doses was reported to improve fertility, with no pup anomalies, and to raise reproductive hormone levels compared with baseline.Effect of different doses of lyophilized beetroot on fertility and reproductive hormones.
Review Totals and Summary
Members OnlyWhat buyers say
I wasn't able to read actual customer reviews for this product, so I can't honestly report real customer themes. My searches returned the Amazon product listing and the NIH label record, which contain manufacturer copy and supplement facts but no review text. Anything I wrote about "what customers say" would be fabricated. What I can say is that the manufacturer's own pitch centers on two selling points: the added energy blend (caffeine, theobromine and L-theanine) as a "pick-me-up," and the continuity of the original pregnenolone formula with its minerals and B vitamins. Those are the areas where reviewers would be expected to comment, such as noticeable energy or jitters, mood and focus, and any hormonal side effects. That is only a guess at what to look for and not a finding. To get real feedback, read the verified-purchase reviews on the Amazon listing (B07D7GD7Z2) and on the Infowars store page. Look for repeated comments on stimulant effects, sleep disruption, capsule size, price, and any hormone-related changes. Treat reviews on the brand's own store with some caution, since they may be curated. If you'd like, I can try again to pull review text in a new session.
Biohacker Summary
Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it
Selenium is the main ingredient, and eight of the ten panelists spoke about it: seven recommend it and one is neutral. They point to thyroid support, protection from oxidative stress through the body's glutathione recycling, immune regulation, hair loss, sperm health, and having enough of it before trying advanced longevity strategies. One panelist suggests getting it from food, two or three Brazil nuts a day, while another notes studies in Hashimoto's disease; no one gave a supplement dose, and no one said they stopped or warned against it. Magnesium is a smaller ingredient in this product, and panelists mostly take it for sleep, with threonate as the favored form, though one warns that labels can overstate the real magnesium dose.
See all 10 biohackers →Hide the biohackers
Ben Greenfield · Selenium · recommends
- Recommends taking sufficient selenium to ensure free T3 levels are right, which is important for the reverse calcium transport system.
- Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
- Uses magnesium during surgery because it is neuroprotective.
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Discusses vitamin K2, specifically the menaquinone forms, as crucial for arterial health and notes that it breaks down into MK-4 and MK-7.
- Explains that gut bacteria liberate K from the diet or make the K needed, and that poor absorption of vitamin K due to bacterial imbalances is linked to heart disease.
- Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
- Warns that folic acid is an inactive form of folate that the body cannot efficiently convert, meaning one won't get the full benefit.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Began supplementing with pregnenolone after noticing his levels were low, which he believes boosted his testosterone.
- Mentions that Dave Pascoe uses pregnenolone as part of his routine for aging.
Dr. Mark Hyman · Selenium · recommends
- Includes selenium in a formula he uses to support health during the winter season.
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
- Explains that pellagra, which killed 100,000 Americans, was a niacin deficiency, a B vitamin.
- Recommends correcting nutrient deficiencies with magnesium.
- Recommends correcting nutrient deficiencies with zinc.
- Recommends Magnesium Breakthrough Advance 10 from BiOptimizers, which has 10 bioavailable forms of magnesium and more elemental magnesium, as part of his evening routine for sleep, muscle recovery, and metabolic health.
- Recommends nutrient-dense foods rich in selenium, such as Brazil nuts and sardines, to reduce inflammation.
Thomas DeLauer · Selenium · recommends
- Recommends adding selenium to the diet, found in Brazil nuts (two or three a day), eggs, shellfish, and mushrooms, as the glutathione recycling process is very selenium dependent and it helps protect against feroptosis.
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Warns that synthetic folic acid supplements may not convert effectively in many people due to a gene variant, potentially blocking cellular folate uptake and masking B12 deficiencies.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Mentions that magnesium in pumpkin seeds relaxes bronchial smooth muscle.
- Compares magnesium content, stating bananas have 32mg and pumpkin seeds have 156mg per ounce, a 5x difference.
Dr. Eric Berg · Selenium · recommends
- Recommends selenium as one of the best things to do for alopecia.
- Discusses foods that contain Vitamin K2.
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Recommends taking 40 to 45 milligrams of vitamin K2 daily for osteoporosis, citing a study from Japan with great results.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- Mentions that easy bruising can result from a lack of vitamin K1.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
Dave Asprey · Selenium · recommends
- Emphasizes the importance of having enough selenium before trying advanced longevity strategies like peptides.
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- States that magnesium can affect how the body responds to a supplement.
- Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
- Recommends Vitamin K2, stating it supports healthy calcium metabolism.
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Recommends adding vitamin K2 to vitamin D supplementation.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
- Recommends pregnenolone for women, especially starting at age 35, to help balance stress hormones.
Siim Land · Selenium · recommends
- States that deficiencies in nutrients such as selenium can impair normal immune regulation.
- States that Magnesium can be a useful addition for some people for sleep.
- Mentions that copper is a mineral necessary for making collagen.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
- Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- Lists Vitamin K2 as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists leafy greens as a source of Vitamin K1.
- Lists dairy and sardines as sources of Calcium.
Andrew Huberman · Selenium · recommends
- Recommends selenium for sperm health.
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Discusses Magnesium Threonate as a tool for falling asleep.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 90 mcg of Vitamin K2 in the morning for longevity.
Peter Attia · Selenium · neutral
- Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Peter Attia's AVIA Skincare vitamin C serum also contains niacinamide, which is useful to apply to the skin right after washing.
- States that folic acid is important for anyone trying to get pregnant.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
- Notes that deficiencies in certain vitamins and minerals, such as B12, can be a cause of hair loss in women.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions magnesium as an important nutrient component for testosterone.
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- Recommends a combination of methyl folate and folic acid, as folic acid has been shown to reduce neural tube defects.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
- Mentions that kale delivers magnesium, a micronutrient many diets fall short on.
Bryan Johnson · Vitamin K · uses
- Takes 90 mcg of Vitamin K2 in the morning for general health.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 15 mg of Zinc in the morning for longevity.
- He takes 100 mcg of Vitamin K2 in the morning for general health.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 100 mcg of Vitamin K2 in the morning for longevity.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 90 mcg of Vitamin K2 in the morning.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 15 mg of Zinc in the morning.
RAL Summary
Members OnlyTier 4 for Hormone Balance for Men
Tier 4 because the human evidence for male hormones is thin and mixed. The best folic acid, zinc and selenium trials mostly found no hormone change [7][2], and there are no counted reviews.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 57 of the 99 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Reproductive system, Nervous system
Combine with: For fast relief of occasional heartburn, use a proper antacid such as calcium carbonate (Tums) or magnesium hydroxide for rapid neutralization, or an alginate such as sodium alginate (Gaviscon) to form a barrier against reflux. For longer-term support, consider DGL licorice, zinc-carnosine, or aloe vera juice (decolorized) to soothe the stomach and esophageal lining. If keeping Red Pill Plus for male hormone or vitality support, pair it with zinc, magnesium glycinate, vitamin D3 and ashwagandha, and take it with food. Avoid stimulant-heavy products on an empty stomach if you are prone to reflux. Persistent heartburn more than twice a week should be evaluated by a clinician.
Possible side effects: No major side effects reported in the studies given. The magnesium dose is above the daily recommended limit, so members can take less.
Supplement Facts
Vitamin K 80 mcg · Niacin 20 mg · Vitamin B6 20 mg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 60
Amount Per Serving% Daily Value
| Vitamin K | 80 mcg | |
| Niacin | 20 mg | |
| Vitamin B6 | 20 mg | |
| Folic Acid | 400 mcg | |
| Vitamin B12 | 30 mcg | |
| Calcium | 100 mg | |
| Magnesium | 400 mg | |
| Zinc | 15 mg | |
| Selenium | 70 mcg | |
| Copper | 2 mg | |
| Manganese | 1.5 mg | |
| Chromium | 90 mcg | |
| Molybdenum | 56 mcg | |
| Red Beet root juice | 200 mg | † |
| Energy Blend | 140 mg | † |
| Pregnenolone | 50 mg | † |
† Daily Value not established.
Other ingredients: Vegetable Capsule, Rice Bran concentrate.
Directions: Directions: Take two capsules daily in the morning.
Barcode (UPC) 810083030289 · Label source: NIH label database · Report a label change
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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