Laboratorio Farmamedica Vital Fuerte H3 EF Review

This is the DSLD label page for Vital Fuerte H3 EF, a multivitamin and mineral dietary supplement from Laboratorio Farmamedica, listed under the Other Combinations product type with a Capsule supplement form. The label shows a net content of 100 capsules, a serving size of one capsule, and 100 servings per container. The suggested intake is one capsule one to two times daily for adults and children aged four or more years. The label lists vitamins A, C, D, E, B1, B2, niacin, B6, B12, pantothenic acid, and minerals including calcium, iron, magnesium, zinc, selenium, copper, manganese, molybdenum, potassium and cobalt, plus lecithin from soybean and rutin from Dimorphandra mollis pods. The label states it contains soy and carries an iron overdose warning for children under 6. Other content is described as Blister, Antioxidant, and Vital H3, and the product is made in Guatemala. It is produced by Laboratorio Farmamedica, S.A. in Guatemala and distributed by Pharmadel, LLC of Seaford, DE. The DSLD entry was added on 23 August 2019 and is marked On Market. The page shows no retail price, no customer ratings and no written reviews.

Product Focus: EnergyAlso covers:BrainMetabolismImmune systemRanked among:Multivitamins
Tier ⓘ
Tier 4
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
31 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
– no stars shown, 1 reviews
Biohacker Mentions
8 of 10

Study, Trial or Testing Result Summary

Members Only282 human studies · 126 improved

37 of these 282 human studies gave the ingredient by drip, injection or inhaler, not by mouth.

282 human studies126 improved121 no effect217,234 people studied

Only thiamine and riboflavin are present at a full studied dose. In 80 older women who were slightly low in thiamine, 10 mg a day for 6 weeks lowered fatigue and improved well-being [1]. Higher-dose thiamine helped fatigue in people with bowel disease [2] but not in people with a liver disease [3]. Riboflavin in fortified juice lowered fatigue in construction workers [4], but a nutrient mix with riboflavin did not help dialysis patients [5]. Selenium reaches a full dose only at three servings a day; it lifted mood and eased tiredness in people who ate little selenium [6], but a six-year trial saw no change in vitality [7]. Vitamins A, D and B6 and iron are below the doses that helped in studies, and they mainly helped people who were low or ill [8][9][10]. Vitamin C, vitamin E, calcium, magnesium, zinc and manganese are present only in trace amounts. Vitamin B12 did not boost energy in people who were not deficient [11]. Rutin has only been tested in animals [12]. Animal and cell studies are never counted.

See all 282 studies →Hide the studies

Review Totals and Summary

Members Only1 reviews
1 reviews · Facebook 1

Written feedback on this product is limited and mostly comes from marketplaces such as Amazon and eBay. Buyers, many of them Spanish-speaking and in the Latino diaspora, usually describe it as a familiar, trusted multivitamin they buy again. They like the capsule format and call it a good everyday option. The Amazon listing for the 30-capsule pack is rated about 4.4 stars from a small number of ratings, and eBay buyers use short phrases such as "excellent product" and "great product." Most eBay comments are about the seller. They praise careful packaging, fast delivery and accurate descriptions more than any effect of the supplement. Few reviewers describe specific results such as more energy, better sleep or relief from tingling. When they do, the comments are positive but general, and they do not report dramatic or fast effects. Retailer pages echo the marketing themes of fatigue, energy and nerve support, but that is promotional language, not customer experience. The most specific complaint I found concerns shelf life. One Spanish-language Amazon reviewer said the capsules are good but expire quickly. This matches a wider concern with imported supplements and third-party sellers, where buyers should check expiry dates. Price is another theme. The same product sells for about $12 to $17 for 30 to 100 capsules at some US sellers. Other retailers charge much more, including about $42 for 100 softgels on a specialty site, and shipping adds to the cost. Some buyers see this as a reason to compare sellers. Several listings also have inconsistent names and descriptions, such as "H3," "H3 EF," "Regular" and "Antioxidant," and different capsule counts. Some eBay listings even show an unrelated ingredient list. This can confuse buyers about which formula they are getting. I found no meaningful customer discussion of side effects, pill size or taste. That is too little evidence to say those are not problems. Taken together, the feedback suggests a dependable, inexpensive and familiar multivitamin whose main strengths are convenience and brand familiarity. Its main weaknesses are the quality of its sellers, expiry dates and unclear versions. It does not have much detailed, independently verified evidence of benefit.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

The main ingredient here is not clearly identified in the panel's statements, since every ingredient is a smaller ingredient in this product, so the panel's views are best read ingredient by ingredient. Vitamin D drew the most support: most of the panel recommend or use it, for general health, immune, brain and muscle support, with doses of 5,000 units a day from one panelist and 10,000 or more in winter from another, taken with dietary fat for better absorption and with blood levels tested. Magnesium is used by several for sleep, in forms like glycinate and threonate, with one panelist taking 400 mg before bed and another warning that labels can make the dose look larger than it is. Zinc gets support for prostate and wound healing, with a caution that too much can lead to low copper, and one panelist stopped iron after years of trying it without raising his levels. Vitamin C is paired with collagen for joints and connective tissue, and potassium is best taken from foods like bananas and potatoes rather than supplements, according to one panelist.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · warns
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 30 Oct 2026 · Magnesium · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 30 Oct 2026 · Iron · neutral · YouTube ↗
      Identifies iron as the Achilles' heel of cancer, as it is needed for its DNA to replicate.
    • 29 Oct 2026 · Potassium · recommends · Podcast ↗
      States that people need more potassium than any other mineral, yet most people aren’t getting enough.
    • 28 Oct 2026 · Magnesium · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 28 Oct 2026 · Potassium · recommends · YouTube ↗
      Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
  • Dave Asprey · Vitamin D · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 31 Oct 2026 · Magnesium · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 25 Oct 2026 · Magnesium · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Magnesium · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 9 Oct 2026 · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
    • 27 Sep 2026 · Magnesium · recommends · Podcast ↗
      Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
    • 7 Sep 2026 · Magnesium · uses · Instagram ↗
      Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
    • 5 Sep 2026 · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
  • Dr. Mark Hyman · Magnesium · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Iron · neutral · YouTube ↗
      Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 16 Oct 2026 · Potassium · warns · Facebook ↗
      Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
    • 14 Oct 2026 · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 8 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
    • 7 Oct 2026 · Vitamin D · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 25 Oct 2026 · Magnesium · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 14 Oct 2026 · Iron · neutral · Instagram ↗
      Mentions that iron is a mineral necessary for making collagen.
    • 14 Oct 2026 · Copper · neutral · Instagram ↗
      Mentions that copper is a mineral necessary for making collagen.
    • 12 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 7 Oct 2026 · Magnesium · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Magnesium · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 30 Sep 2026 · Magnesium · recommends · Instagram ↗
      States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
    • 30 Sep 2026 · Magnesium · neutral · X ↗
      Lists seafood and pumpkin seeds as sources of Magnesium.
  • Andrew Huberman · Zinc · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 22 Oct 2026 · Magnesium · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 19 Oct 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 14 Sep 2026 · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 17 Aug 2026 · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 7 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 7 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
  • Ben Greenfield · Copper · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
    • 29 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 29 Oct 2026 · Zinc · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · Magnesium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 22 Oct 2026 · Potassium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · Magnesium · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · Magnesium · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
  • Dr. Rhonda Patrick · Magnesium · neutral
    • 29 Oct 2026 · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 29 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 29 Sep 2026 · Zinc · recommends · YouTube ↗
      Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 28 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 28 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
    • 24 Sep 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 2 Sep 2026 · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 25 Aug 2026 · Vitamin D · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin E · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
  • Thomas DeLauer · Magnesium · uses
    • 28 Oct 2026 · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 28 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 24 Oct 2026 · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 24 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Zinc · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Zinc · recommends · Facebook ↗
      Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 22 Oct 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 8 Jul 2026 · Iron · stopped · YouTube ↗
      Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
    • 7 Jul 2026 · Iron · uses · X ↗
      Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 4 May 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 2 May 2026 · Magnesium · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
  • Peter Attia · Potassium · recommends
    • 6 Sep 2026 · recommends · YouTube ↗
      States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
    • 1 Jun 2026 · Magnesium · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · Magnesium · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 4 Jan 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 15 Sep 2025 · Magnesium · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 20 Jul 2025 · Vitamin A · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin A for male mice.
    • 10 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.

RAL Summary

Members OnlyTier 4 for Energy

Human studies support Zinc (2 of 16 human studies showed an improvement), but there are not yet enough reviews to confirm it (0). The final check notes: The rules based the tier on zinc, which this product has only in trace amounts (0.4 mg a day) and which mostly showed no effect on energy; the evidence still supports only a thin-evidence tier, based on thiamine and riboflavin at full dose.

Take 3 servings a day (3 capsules) to match the dose that worked in the studies.

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 121 of the 282 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Metabolic system, Blood, Immune system

Combine with: If the goal is mood support, pair a general vitality formula with ingredients that have clinical evidence for mood: omega-3 fish oil (EPA-dominant, 1-2 g/day), vitamin D3 if levels are low, magnesium glycinate, and a B-complex with methylfolate and B12. Saffron extract (about 30 mg/day), L-theanine, or ashwagandha may help emotional balance and stress-related low mood. Check the label for overlapping vitamins and minerals to avoid exceeding upper limits. Consult a healthcare professional before combining with meds, since St. John's wort, 5-HTP and SAMe can interact with them and cause serotonin syndrome. Persistent low mood needs medical evaluation.

Possible side effects: No major side effects reported. One reviewer noted that the capsules expire quickly.

Supplement Facts

Vitamin A 2500 IU · Vitamin C 2.3 mg · Vitamin D 165 IU
Supplement Facts
Serving Size 1 Capsule(s)
Servings Per Container 100
Amount Per Serving% Daily Value
Vitamin A2,500 IU
Vitamin C2.3 mg
Vitamin D165 IU
Vitamin E1.6 IU
Thiamine4.8 mg
Riboflavin2.2 mg
Niacin10.75 mg
Vitamin B64.2 mg
Vitamin B122.4 mcg
Pantothenic Acid4 mg
Calcium11 mg
Iron1.6 mg
Magnesium0.2 mg
Zinc0.2 mg
Selenium15 mcg
Copper0.04 mg
Manganese0.03 mg
Molybdenum20 mcg
Potassium0.04 mg
Cobalt10 mcg†
Lecithin14 mg†
Rutin5 mg†
† Daily Value not established.

Other ingredients: Soybean Oil, Gelatin, Dicalcium Phosphate, Beeswax, Soy Lecithin, Niacinamide, Calcium Pantothenate, Rutin, Ferrous Fumarate, Thiamine Mononitrate, Pyridoxine Hydrochloride, Ascorbic Acid, Riboflavin, DL-Alpha-Tocopherol Acetate, FD&C Yellow No. 5, Colecalciferol, FD&C Blue No. 1, Retinyl Palmitate, FD&C Red No. 40, Zinc Oxide, Copper Sulfate, Magnesium Sulfate, Manganese Sulfate, Potassium Sulfate, Sodium Molybdate, Sodium Sulfate, Cobalt Sulfate, Cyanocobalamin.

Directions: Suggested intake: Take one capsule one to two times daily.

Barcode (UPC) 675873001234 · Label source: NIH label database · Report a label change

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Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.