LivOn Laboratories Lypo–Spheric Liposomal Vitamin C 1000mg - No Sugar, Immune Support, Plant Based - Easy to Swallow, Absorbable - Non–GMO, Gluten Free (0.19 fl oz Individual 30 Packets) Review
Lypo-Spheric Vitamin C is sold by LivOn Laboratories as a liposomal vitamin C supplement, supplied as 30 packets per carton. The page describes the product as clinically shown to support the immune system and skin, and to deliver long-lasting antioxidant power to the blood and cells. It positions Lypo-Spheric Vitamin C as a daily product for anyone looking to support optimal health from the cells outward. The listed areas of support include the immune system, collagen production, antioxidant activity, exercise recovery, cholesterol levels already in normal range, exercise tolerance, healthy circulation, blood cell health, cell membrane fortification, and normal brain chemistry, along with elite absorption using liposomal encapsulation technology. The page cites a home-use study on ageing, non-firm skin and a laboratory paper on enhanced bioavailability and immune benefits of liposome-encapsulated vitamin C. The page explains the reasoning behind its delivery method. It states that the body can only absorb as much oral vitamin C as its limited nutrient transporters can carry from the digestive system to the cells, and that pills, powders and gummies overwhelm this system with more vitamin C than the transporters can carry. The page says the liposomes are designed to get around this restrictive transport system to deliver vitamin C into the cells. Directions say to take one packet 1 to 2 times per day or as directed by a healthcare practitioner. The steps are to tear the packet at the notches, squeeze the entire contents into 1 to 3 oz of a cool beverage, and swallow in one gulp like a shot. The product should not be blended, frozen, or exposed to heat. If a packet is opened and not fully used, the page advises placing it in an airtight bag or plastic wrap and refrigerating for up to 24 hours. The product should be stored at room temperature and not frozen or left in direct sunlight for extended periods. The ingredient list names vitamin C as sodium ascorbate, along with choline, phosphatidylcholine, sodium, essential phospholipids from soy lecithin, purified water, ethanol and citric acid. The page says the product uses 1000 mg vitamin C per packet, has a pH of 6.5, and causes less gastric distress because of superior absorption. It says the supplements are vegan and contain no sugar, gluten, artificial flavors or colors, or GMO ingredients, and that each is third-party tested after at least two years of research and development. The product is covered by a 100% Lifetime Satisfaction Guarantee for purchases made directly from LivOn Labs. Shipping is calculated at checkout, with free shipping on orders over $99 in the contiguous US.
Tier ⓘ
Tier 3 · Rank 15
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 15 within Tier 3 for Mood; 24 of 32 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
74 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
94% of 34,357
Biohacker Mentions
9 of 10
Cost per month
$43
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Study, Trial or Testing Result Summary
Members Only66 human studies · 31 improved
4 of these 66 human studies gave the ingredient by drip or inhaler, not by mouth.
66 human studies31 improved17 no effect123,693 people studied
Vitamin C is here at 1000 mg, above the 250 mg that worked in studies. A review pooling 10 trials found it did not improve mood overall, but it gave a small benefit in people with mild depression not taking meds [1]. In young adults with low vitamin C, 250 mg daily for 4 weeks improved well-being, and mood and tiredness in those who stayed low [2]. A similar trial found only a marginal mood gain, mainly in people who started low [3]. Smaller trials found less anxiety in high school students [4] and in adults with type 2 diabetes taking 1000 mg daily [5]. Essential phospholipids from soy are at a full dose. A soy phospholipid complex lowered distress after a stress test [6], and soy lecithin raised vigor in tired middle-aged women, though fatigue did not change [7]. Phosphatidylcholine reaches a studied dose only at two servings a day, and its mood evidence is mixed: lecithin did not change mood in young women [8]. Choline is only 60 mg, a dose not clearly studied, and its mood evidence is limited and mixed [9]. Animal and cell studies are never counted.
See all 66 studies →Hide the studies
- In 25 observational studies of 91,966 people, those with the highest vitamin C intake from food had about 28% lower risk of depression than those with the lowest intake.Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies.
- Across 10 trials with 836 adults, vitamin C did not improve mood overall, but in 5 trials of people with mild depression not taking meds it gave a small mood benefit.The effect of vitamin C supplementation on mood status in adults: a systematic review and meta-analysis of randomized co…
- People with depression had lower vitamin C intake and lower blood vitamin C than healthy people, but this compared levels and did not test supplements.The relationship between antioxidant vitamins and mental disorders: a meta-analysis.
- A scoping review found only two small human studies (7 people) on phosphatidylcholine in bipolar disorder, suggesting better manic symptoms and mood stability, but the evidence was too limited and varied to combine.Therapeutic Potential of Gotu Kola (Centella asiatica), Phosphatidylcholine, and Taurine in Mood Disorders: A Systematic…
- In a review of 37 mostly uncontrolled studies in cancer patients, intravenous vitamin C may have eased symptoms including depression, but the evidence was preliminary.Intravenous Vitamin C and Cancer: A Systematic Review.
- A review of add-on nutrient trials for depression found mixed results for vitamin C, while other nutrients like omega-3 and vitamin D had more positive results.Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.
- In a review of 14 studies in women, high-dose sustained-release vitamin C reduced anxiety and blood pressure responses to stress, though evidence was limited.The impact of essential fatty acid, B vitamins, vitamin C, magnesium and zinc supplementation on stress levels in women:…
- A review of nine studies linked vitamin C deficiency to depression and poorer thinking, but no studies tested whether replacing vitamin C helps.The neuropsychiatric effects of vitamin C deficiency: a systematic review.
- In 400 young women given lecithin (1.6 g a day), carnitine, both or placebo for 3 days, mood and attention were not changed by lecithin.The influence on cognition of the interactions between lecithin, carnitine and carbohydrate.
- In 263 older adults with memory complaints taking milk phospholipids for 16 weeks, memory and thinking scores did not improve, but alertness during testing was better with the high dose, and inflammation marker TNF-alpha fell while serotonin and GABA rose.The effect of milk fat globule membrane phospholipid supplementation on cognitive function in older adults with subjecti…
- In 215 working men aged 30 to 55, a high-dose B vitamin, vitamin C and mineral supplement taken for 33 days improved stress, general mental health and vigour ratings compared with placebo.Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males.
- In 213 sepsis survivors given intravenous vitamin C, thiamine and hydrocortisone for up to 4 days, there was no psychological benefit at 6 months and higher odds of posttraumatic stress disorder than with placebo.Read the study on PubMed (36853612) →
- In 198 working men aged 30 to 55, a B vitamin, vitamin C and mineral supplement taken for 4 weeks improved self-rated physical stamina, concentration, mental stamina and alertness compared with placebo.Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and m…
- In 171 young adults, two extra daily servings of fresh fruit and vegetables for 2 weeks improved vitality, flourishing and motivation but not depression, anxiety or mood, and the benefit was not explained by blood vitamin C.Let them eat fruit! The effect of fruit and vegetable consumption on psychological well-being in young adults: A randomi…
- In 167 young adults with low vitamin C, a 250 mg vitamin C tablet daily for 4 weeks improved well-being after two weeks, and also improved mood and fatigue in those with consistently low vitamin C, while placebo showed no change; kiwifruit had somewhat stronger effects.KiwiC for Vitality: Results of a Randomized Placebo-Controlled Trial Testing the Effects of Kiwifruit or Vitamin C Table…
- In older adults with memory problems, 300 mg phosphatidylserine plus 240 mg phosphatidic acid daily for 3 months improved memory and prevented winter low mood, and in Alzheimer's patients for 2 months it stabilized daily functioning, with 49% reporting better general condition versus 26% on placebo.Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioni…
- In 142 graduate students given a single 1000 mg dose of vitamin C, anxiety and mood scores did not change overall, but the most anxious women had a significant drop in anxiety two hours later.Effects of ascorbic acid on anxiety state and affect in a non-clinical sample.
- In 96 fatigued middle-aged women taking 1200 mg soy lecithin daily for 8 weeks, fatigue scores did not differ from placebo, but vigor on a mood scale improved more than with placebo.Effect of soy lecithin on fatigue and menopausal symptoms in middle-aged women: a randomized, double-blind, placebo-cont…
- In 84 patients with vascular depression on meds, vitamin C was used as an inactive comparator and did worse than nimodipine, with 25% reaching full remission versus 45% on nimodipine.Read the study on PubMed (11288158) →
- In 83 men and women recovering from heroin addiction, a combination of lecithin and three other nutrients reduced anxiety, depression, anger and fatigue and raised vigor more than placebo by day 6, though lecithin was not tested alone.Neurotransmitter-precursor-supplement intervention for detoxified heroin addicts.
- In an 81-person placebo-controlled trial, 3000 mg per day of sustained-release vitamin C for 2 weeks lowered depression questionnaire scores in the vitamin C group, while the placebo group showed no such drop.High-dose ascorbic acid increases intercourse frequency and improves mood: a randomized controlled clinical trial.
- In anemic new mothers, a placebo containing 25 mg vitamin C did not improve mood or cognition, while iron treatment did; vitamin C was not tested on its own.Maternal iron deficiency anemia affects postpartum emotions and cognition.
- In 80 healthy people taking 400 mg of a soy phospholipid complex daily for 3 weeks, stress hormone responses were blunted and distress after a stress test decreased versus placebo, but larger doses did not show this effect.Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological respon…
- In interviews with 73 healthy adults from a trial of milk phospholipids, more people taking the supplement than placebo reported better ability to cope with stress and better sleep.Milk fat globule membranes for psychological and physical health: qualitative results from the Employing Milk Phospholip…
- In 62 adults with alcohol use disorder, 2,000 mg a day of citicoline for 12 weeks did not change depressive symptoms, alcohol craving, drinking, or thinking test scores compared with placebo.A Randomized, Double-Blind, Placebo-Controlled Trial of Citicoline in Patients with Alcohol Use Disorder.
- In 62 hepatitis C patients on interferon and ribavirin, adding a silybin-vitamin E-phospholipid pill for 12 months reduced depression and anxiety and improved work ability compared with placebo.Silybin supplementation during HCV therapy with pegylated interferon-α plus ribavirin reduces depression and anxiety and…
- In 53 people with Alzheimer's disease given lecithin plus either tacrine or placebo for 36 weeks, tacrine added no meaningful benefit, including for mood, and lecithin alone was not tested.Efficacy of tacrine and lecithin in mild to moderate Alzheimer's disease: double blind trial.
- In 46 healthy young adults with low vitamin C, 500 mg twice daily for four weeks improved attention and work absorption compared with placebo but did not change mood.Vitamin C supplementation promotes mental vitality in healthy young adults: results from a cross-sectional analysis and …
- In 45 adults with type 2 diabetes, 1000 mg of vitamin C daily for six weeks significantly reduced anxiety compared with placebo, though it did not change stress or depression scores.Efficacy of supplementary vitamins C and E on anxiety, depression and stress in type 2 diabetic patients: a randomized, …
- In 43 adults with major depression, adding vitamin C to citalopram for eight weeks did not improve depression scores more than adding placebo.Vitamin C as an adjuvant for treating major depressive disorder and suicidal behavior, a randomized placebo-controlled c…
- In 42 high school students, 500 mg of vitamin C daily for 14 days reduced anxiety scores compared with placebo.Effects of Oral Vitamin C Supplementation on Anxiety in Students: A Double-Blind, Randomized, Placebo-Controlled Trial.
- In 41 healthy older adults taking 300 mg egg yolk choline daily for 12 weeks, verbal memory improved versus placebo, but processing speed and physical quality of life scores were lower at 6 weeks; mood and well-being results were not reported as improved.Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Jap…
- In 39 healthy volunteers taking alpha-glycerylphosphorylcholine for two weeks, motivation at night was significantly higher than with placebo and showed a general upward tendency, but anxiety did not change.Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controll…
- In a 30-woman pilot trial, a date bar with 300 mg vitamin C plus other nutrients eaten daily for 4 weeks lowered perceived stress within the group, but the difference from the placebo bar was not statistically significant.The Effect of a Fortified Date Bar on Perceived Stress and Morning Salivary Cortisol in Female Students: A Pilot Randomi…
- In 28 healthy young adults, a single 120 mg dose of ginkgo extract bound to phosphatidylserine improved memory and memory speed, and all three ginkgo products (including plain ginkgo) increased calmness compared with placebo.Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine.
- In 26 adults with mild to moderate mood disturbance, eating two SunGold kiwifruit daily for four weeks significantly reduced mood disturbance compared with their usual diet, in a non-blinded crossover trial.SunGold Kiwifruit and Psychological Health (GoKiPH): A Randomised Controlled Crossover Trial.
- In 25 elderly people with mild memory impairment, 12 weeks of a DHA-phospholipid emulsion with melatonin and tryptophan improved overall cognition scores, smell sensitivity and nutrition scores versus placebo; the abstract does not report a mood (depression scale) result.Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly …
- In 24 children with major depression, adding 1000 mg of vitamin C daily to a med for six months reduced depressive symptoms more than a med plus placebo.Read the study on PubMed (23510529) →
- In 20 obese adults on a calorie-restricted diet, 500 mg of vitamin C daily for 4 weeks lowered self-reported fatigue and reduced heart rate and perceived exertion during moderate walking, compared with placebo.Vitamin C status and perception of effort during exercise in obese adults adhering to a calorie-reduced diet.
- In frail nursing home residents, 8 weeks of selenium, vitamin C and folate combined reduced depression scores in a subgroup with higher scores, but depression tracked selenium rather than vitamin C levels, so vitamin C's own effect is unclear.Effect of micronutrient supplementation on mood in nursing home residents.
- In a double-blind trial of acutely hospitalized patients with low vitamin C, 500 mg taken twice daily reduced mood disturbance by 34% compared with the vitamin D comparison group, which showed no mood change.Vitamin C provision improves mood in acutely hospitalized patients.
- In acutely hospitalized patients with low vitamin C, 500 mg twice daily for about 8 days reduced mood disturbance and psychological distress more than high-dose vitamin D did.Effects of vitamin C and vitamin D administration on mood and distress in acutely hospitalized patients.
- In a multicentre trial of older people with Alzheimer's disease, ascorbic acid was used as an inactive comparator for three months of injections; posatirelin improved memory, mood and daily function more than the comparator, so vitamin C showed no benefit.Posatirelin for the treatment of late-onset Alzheimer's disease: a double-blind multicentre study vs citicoline and asco…
- An inhaled vitamin C aerosol helped some people stop smoking over 5 weeks, and among those who quit, the fine-particle version lowered cravings and negative mood more than the coarse-particle version.Clinical trials using ascorbic acid aerosol to aid smoking cessation.
- In 155 young adults with low vitamin C, 250 mg vitamin C daily for 4 weeks marginally improved mood until day 12 and effects were weaker than kiwifruit, but mood improved in those with low starting vitamin C.Smartphone survey data reveal the timecourse of changes in mood outcomes following vitamin C or kiwifruit intervention i…
- In 94 elderly long-term inpatients with low vitamin C levels, taking vitamin C for 2 months raised vitamin C levels and gave slight gains in weight and blood proteins, but mood and mobility did not change compared with placebo.The effect of vitamin C supplements on body weight, serum proteins, and general health of an elderly population.
- In 48 people with major depression, adding hypothalamic phospholipids to trazodone sped up a med effect, improved symptoms and reduced some side effects compared with trazodone alone, in an open trial.A combination of hypothalamic phospholipid liposomes with trazodone for treatment of depression. An open controlled stud…
- In 20 young men, raising plasma vitamin C through supplementation did not change alertness, memory, or self-rated mood compared with low vitamin C periods.Lack of effect on mental efficiency of extra vitamin C.
- In nine people with schizophrenia, up to 20 grams per day of choline chloride did not change symptom ratings but appeared to increase symptoms of depression.Choline chloride in schizophrenia.
- Large double-blind trials of daily vitamin C with extra doses during illness reduced the days of winter illness, but produced little change in infection frequency, sense of well-being, or cholesterol.Large scale studies with vitamin C.
- In a double-blind, placebo-controlled crossover trial, a single 3 gram dose of vitamin C made both manic and depressed patients significantly better than placebo.Vanadium: a possible aetiological factor in manic depressive illness.
- In an open trial of 4 people with Friedreich's ataxia, 50 to 100 grams per day of lecithin granules for 16 weeks gave no improvement, and side effects included depression, nausea, diarrhoea and weakness.Effect of lecithin on disability and plasma free-choline levels in Friedreich's ataxia.
- In acutely hospitalized patients with low vitamin C, one week of vitamin C raised blood levels to normal and improved mood disturbance scores by 33%.Metabolic origin of hypovitaminosis C in acutely hospitalized patients.
- In a large Korean survey of young adults, food insecurity was linked to more anxiety and depression and to diets often below the vitamin C requirement, but vitamin C intake itself was not tested against mood.How does young adults' dietary and health-related quality of life vary by food security and household income?
- In a large US survey of 9306 adults, a machine learning model ranked dietary vitamin C among the strongest predictors of depression with suicidal thoughts, but the study does not show whether vitamin C improves mood.Machine learning and SHAP-based interpretation of dietary antioxidants' impact on comorbid MDD and suicidal ideation.
- In 3,643 adults, eating red meat within a high-quality diet raised intake of brain-supporting nutrients including choline but did not change mental health outcomes.Red meat consumption in higher healthy eating index diets is associated with brain health critical nutritional adequacy,…
- In Australian adults, a plant-based dietary pattern rich in vitamin C, fiber, and carotenoids was linked to fewer depressive symptoms, but vitamin C was not studied on its own.Nutrient patterns and depressive symptoms among Australian adults.
- In 988 Iranian adolescent girls, those with the highest vitamin C intake had lower odds of depressive symptoms (odds ratio 0.61) compared with those with the lowest intake, though this was not statistically significant.Dietary antioxidants and fibre intake and depressive symptoms in Iranian adolescent girls.
- In 612 patients after ischemic stroke, higher blood levels of choline and betaine were linked to a lower risk of depression three months later.Circulating choline pathway nutrients and depression after ischemic stroke.
- Among 322 hospitalized older adults, those with low blood vitamin C had more depression symptoms at baseline and at 6 weeks than those with normal levels.Poor vitamin C status is associated with increased depression symptoms following acute illness in older people.
- Homeless adults in Reading, UK, ate less vitamin C (79 vs 109 mg) than matched housed adults and had higher depression and anxiety symptom scores.Dietary intake, nutritional status and mental wellbeing of homeless adults in Reading, UK.
- In a retrospective German cohort of 125 breast cancer patients, those given intravenous vitamin C (7.5 g, at least 4 weeks) alongside standard treatment reported less depression and other symptoms than untreated controls.Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and a…
- In 100 people living with HIV in Iran, higher daily dietary vitamin C intake was linked to lower depression, anxiety, and stress scores, but this food-based correlation does not show that vitamin C itself caused the change.Correlation Between Daily Dietary Micronutrients Intake and Mental Health Outcomes in Iranians Living With HIV Infection…
- In a prospective observational study of pregnant women with iron deficiency anemia taking a liposomal iron and vitamin C product, anxiety and depression scores improved over the course of pregnancy.Liposomal ferric pyrophosphate and ascorbic acid supplementation in pregnant women with iron deficiency anaemia: haemato…
- In 38 patients taking high doses of deanol, eight had mood changes: five became depressed and three became hypomanic.Mood alterations during deanol therapy.
- In a 10-week study of people with Alzheimer's disease taking tetrahydroaminoacridine and lecithin, depression scores did not change significantly over the treatment period.Canadian collaborative study of tetrahydroaminoacridine (THA) and lecithin treatment of Alzheimer's disease: effect on m…
Review Totals and Summary
Members Only34,357 reviews · 94% positive
34,357 reviews · Amazon 33,334 · LivOn Labs website 696 · Walmart 205 · Target 109 · Desertcart.com.sa 13
94% positive3% neutral3% negative
This liquid Vitamin C product has garnered about 34235 ratings across various stores, with a strong majority of 87% giving it 4 or 5 stars, indicating high overall satisfaction. This summary focuses exclusively on feedback for the liquid packet form, excluding reviews of other product types like gummies or capsules. **What it did for buyers** Many customers report significant benefits from taking this liquid Vitamin C. It is frequently praised for immune support, with users stating it "has kept my family healthy" and is "great for your immune system." Some describe it as a crucial aid during illness, saying it "always got me up & going again" when feeling very ill, and one user calls it "a very strong medication." Beyond immune health, customers also note increased energy, with one saying it "gives the extra energy you need to start your day," and another mentioning it "give's more energy." Skin health is also cited as a benefit. One reviewer was recommended it by a dentist for post-surgery recovery, reporting that "so far it seems to be working." **Complaints** While most feedback is positive, some users express specific complaints. The most prominent issue is the product's texture, described as "thick and slippery" and "like swallowing snails," making it "very difficult for me to swallow." Another concern raised was receiving a product with a "very short date," expiring soon after delivery, and with contents that were "no longer orange color but almost dark red." Difficulty mixing into liquids is also mentioned. **Taste, Smell, and Form** The product comes in individual liquid packets, which many find convenient and appreciate as "not another pill to swallow." It's often described as "so easy to get down" when mixed with a little cold water or juice, or even taken straight. However, the texture is a significant point of contention for some, who struggle with its "thick and slippery" consistency. While "Flavor" is a frequent topic in store filters, specific taste opinions are not widely visible in the provided reviews, though some mention taking it with juice to make it easier. **Value for Money** Many customers consider this Vitamin C product to be worth its cost, despite acknowledging that it can be "pricey" or "hefty." Users often state it's "worth the money" and that they "definitely can tell the difference when not taking it." The perceived effectiveness and benefits seem to justify the expense for loyal users. **Who it suits and who it does not** This product appears to be well-suited for individuals seeking a highly absorbable form of Vitamin C for daily immune support, energy, and overall well-being. It's popular among those who prefer a liquid supplement over pills and are looking for a "super effective product." Many integrate it into their daily routine, calling it a "staple" they "try never to run out of." However, it may not be suitable for those with a strong aversion to unusual textures, as the "thick and slippery" consistency can be a significant barrier for some.
Biohacker Summary
Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it
The panel leans toward recommending vitamin C, the main ingredient, though the product's panel data is mixed with sodium talk that does not apply to a vitamin C packet. Four of the ten recommend it outright, mainly for collagen in skin, gums and joints, immune support, and help with inflammation, and a few others take it or mention it as part of a basic routine. Doses came up from two of them: about 500 mg at the first sign of a cold, and 2 to 4 grams for inflammation and immune support, while one panelist cautioned that the best dose is unclear and high doses might blunt some of the benefits of exercise. Pairings include taking it with collagen, and one panelist takes a liquid liposomal form for its taste and ease of mixing into water or juice; another noted that skin creams deliver far more vitamin C to skin than swallowing it, and that panelist stopped using a vitamin C serum over its smell. Choline and lecithin are smaller ingredients in this product, and the panel mostly favors choline for focus and cell health while one warns against soy lecithin.
See all 10 biohackers →Hide the biohackers
Dr. Eric Berg · Vitamin C · warns
- Warns against generic multivitamins, stating they are often full of fillers and synthetics.
- Mentions that bleeding or swollen gums point to vitamin C deficiency, and sugar competes with it directly, reducing absorption.
- Recommends ensuring adequate choline intake, as a deficiency can make one susceptible to liver fat, and it's important for preventing fat accumulation in the liver.
- Recommends choline for brain health, noting that consuming two eggs provides 300 mg of choline, which is essential for brain communication.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Recommends Vitamin C as a cofactor, especially for collagen.
- States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
- Dr. Eric Berg discusses sodium in relation to blood pressure, noting that the ratio between sodium and potassium matters.
- States that hydration is water plus electrolytes like sodium, implying its importance for proper hydration.
- Highly recommends taking natural food vitamin C, about 500 mg, at the first sign of a cold.
- Mentions that egg yolks contain choline, which helps the brain and prevents a fatty liver.
- Notes that choline is a key nutrient many people are deficient in, helping repair membranes, reduce breakouts, improve skin texture, and lift brain fog by being a building block for acetylcholine, which aids memory, focus, and concentration.
- Recommends around 3000 to 4000 mg of sodium each day to maintain healthy hydration levels, which is equal to about 1½ to 2 teaspoons of salt per day.
Thomas DeLauer · Vitamin C · recommends
- Recommends whole food vitamin C, found in kiwi fruit, citrus, and bell peppers, to help clear uric acid by competing at kidney transporters, preventing reabsorption.
- Recommends Element electrolytes, mentioning new flavors and sparkling cans with half the sodium, and suggests a lemonade iced tea flavor with caffeine is perfect in the morning.
- Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
- Uses Element's 500 mg sodium cans first thing in the morning to prime his day and enhance workout performance, noting that the pump is often driven by sodium.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 500 mg sodium cans first thing in the morning to prime his day and help with workout performance and pump.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Has been starting his day with 500 to 1,000 milligrams of sodium before coffee, noticing a significant difference in mental acuity before going to the gym.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
- Suggests that the amount of sodium in restaurant food makes a difference in how one feels, implying a negative impact.
- Notes that lecithin is also considered a detergent and could potentially cause similar gut disruption to polysorbate, although it might be less potent.
- Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
- Compares the Vitamin C content of oranges (53mg) to guava (228mg), noting guava has 4x more.
Dave Asprey · Sodium · recommends
- Suggests adding sodium to help keep potassium in the system longer, as they work hand in hand.
- Recounts a doctor telling him in his 20s that vitamin C would kill him.
- Recommends taking vitamin C for better skin health.
- States that currently, he is only taking vitamin C and vitamin D.
- Warns against using soy lecithin as a source of choline because it is usually GMO and full of xenoestrogens.
- Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
- Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
- Recommends that people who feel bad try more sodium, as it often works, especially for those with low blood pressure and anxiety.
- Dave Asprey reflects on how new research clarifies the mechanism behind IV vitamin C's anti-cancer effect, vindicating a decades-old idea that was dismissed for the wrong reasons.
- Dave explains how to stack racetams with choline for smarter cognitive enhancement.
- Recommends taking choline donors, especially if over 35, to prevent headaches and muscle tension that can occur when taking racetams due to increased demand on the acetylcholine system.
- Notes that plain Vitamin C isn't enough and that most people never think to check for a specific ingredient that makes it work.
- Dave Asprey recommends taking maybe a gram of vitamin C a day in divided doses, noting that plasma levels peak around 250 milligrams twice a day.
- Recommends Qualia Vitamin C Plus, highlighting its combination of seven forms of vitamin C with 250 mg of citrus bioflavonoids, which helps with absorption and use for building collagen and a strong immune system.
Ben Greenfield · Vitamin C · recommends
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions vitamin C as part of a bare-minimum protocol.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Notes that IV vitamin C has been used for decades for cancer patients with almost no standardization and that he receives many questions about its effectiveness and combination with chemo.
- Addresses her MTHFR gene by taking choline rather than high doses of methylolate.
- Notes that while sodium is known to affect blood pressure, the balance between sodium and magnesium is also important, and isolated sodium chloride in ultra-processed foods is more problematic than sodium from other sources.
- Recommends Vitamin C for skin repair post-tattoo.
- Warns that sodium nitrate hurts endurance exercise adaptations in women.
- Recommends sodium as it is relied upon by the creatine transporter for better creatine efficacy.
- Opens a sparkling electrolyte drink from LMNT, noting it contains 500 mg of sodium, and says he just needs something to wet his whistle.
- Adds a pinch of Celtic Sea Salt® to his post-workout smoothie to replace sodium and trace minerals lost during training, noting it retains minerals like magnesium, potassium, and calcium.
- Uses Celtic Sea Salt in everything from smoothies to roast chicken, not just for taste, but because its mineral content influences hydration, electrolyte balance, and how the body handles sodium.
- Warns that free-flowing white table salt has been stripped, bleached, and reduced to little more than straight sodium chloride.
Siim Land · Vitamin C · recommends
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Mentions that sodium is a mineral necessary for making collagen.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Notes that Vitamin C is one of several supplements with human evidence.
- Notes that researchers found vitamin C alleviates ferro-aging, a process of iron overload and lipid peroxidation that drives aging, and that it directly inhibited ACSL4, a protein driving ferro-aging.
- States that Vitamin C has a central role in aging and longevity, and that in monkeys, oral vitamin C slowed ovarian aging during a 3.3-year study.
- States that vitamin C is one of the most important vitamins for staying healthy and aging well, and that intakes of 200 to 400 mg a day from food or supplements largely saturates plasma and neutrophils in most healthy adults. He also recommends spreading out the vitamin C across the day to avoid oversaturation.
- Mentions vitamin C in comparison to topical melatonin for oxidative defense, stating that melatonin would compete but is not as broadly validated clinically.
- Was found to be vitamin C deficient by True Health and Mayo Clinic tests, and now addresses this by eating one extra kiwi fruit daily.
- States that the biggest evidence for multivitamin is that it improves cognition and enhances episodic memory in elderly people, who tend to have worse diets and are more likely to be deficient.
- Mentions sodium as one of the factors related to blood sugar covered in his book.
- States he does not quantify his sodium intake and doesn't regularly salt his food or drink electrolytes, estimating his intake to be around 2,500 milligrams a day, which is on the lower end.
- States that he consumes around 5-6 grams of sodium per day, emphasizing its importance for overall health.
Dr. Rhonda Patrick · Sodium · recommends
- Notes that lowering sodium intake can help individuals improve their vascular system and blood flow, which is beneficial if hypertension contributes to cognitive problems.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Advises limiting sodium, ideally closer to 1,500 mg/day and not above 2,300 mg/day, for a diet linked to longer life.
- Warns that most people get too much sodium.
- States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
- Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
- Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
- Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
- Notes that ~35% of Americans are low in vitamin C.
- Choline plays a critical role in fetal brain development, and the form and dose matter. Pregnant women who supplemented with twice the RDA for choline (900 mg/day) had children with higher intelligence scores than women taking 450 mg/day.
- Recommends increasing vitamin C intake if concerned about skin aging, noting it is an essential cofactor for collagen synthesis.
- Recommends that pregnant women supplement with choline, specifically phosphatidylcholine, to potentially have smarter babies, citing a randomized controlled trial where mothers who nearly doubled their choline intake had children who scored higher on IQ and cognitive tests.
- Suggests avoiding a multivitamin if it contains biotin before a testosterone blood test to prevent confounding results.
- Multiple randomized controlled trials show older adults taking a standard multivitamin (like Centrum Silver) had measurable improvements in processing speed, cognition, and episodic memory.
Dr. Mark Hyman · Vitamin C · recommends
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
- Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
- Used intravenous vitamin C cocktails to help him detoxify and recover from chronic fatigue.
- States that sodium is essential for fluid balance, nerve signaling, and muscle function, and that low levels can cause weakness, confusion, and dizziness, while high levels may indicate dehydration or too much salt.
- Recommends vitamin C for immune system support and modulation.
- Relies on Big Bold Health's HTB Immune Energy Chews, which deliver 1000mg of sprouted Himalayan tardy buckwheat, along with vitamin C, D, magnesium, and zinc, to support immune balance, resilience, energy, and focus.
- States that with sodium, water can fully cross the cell membrane and get inside where it's needed for intracellular hydration.
- Recommends that pregnant women consume enough choline, ideally from four eggs a day, to support their baby's brain development and prevent irreparable brain damage, as 90% of pregnant mothers are below the minimum recommended amount.
- Dr. Hyman discusses choline as one of the nutrients that matter most during pregnancy.
Peter Attia · Sodium · neutral
- Peter discusses lifestyle factors impacting blood pressure, including sodium.
- Mentions that dietary sodium guidelines are around 5 grams per day, but some newer information suggests 8 to 10 grams might be acceptable before concern.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
- Warns that for individuals with gene polymorphisms making them sensitive to salt, a higher sodium intake can significantly increase blood pressure.
- States that for choline deficiencies, which are sometimes measurable and seen in people post-bariatric surgery, they are not terribly aware of any downsides to taking choline supplements, but cautions about quantifying what's in supplements.
- Peter discusses lifestyle factors impacting blood pressure, including sodium.
- Warns that for individuals with gene polymorphisms making them sensitive to salt, a higher sodium intake can significantly increase blood pressure.
- States that 0.9 sodium chloride is the baseline for an isotonic solution given intravenously, which can be adjusted up or down.
- Notes that while vitamin C deficiency is associated with an elevated risk of cataract, supplementation to supranormal levels has been conclusively shown not to protect against cataract formation.
- Discusses the role that sodium plays on hypertension through the lens of uric acid, vasopressin, and fluid retention.
- Mentions that a survey of doctors showed they recommend Vitamin C for COVID-19, but notes there is no real evidence behind it.
Andrew Huberman · Sodium · uses
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Recommends choline-rich foods to enhance focus and acetylcholine.
- Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
- Takes a multivitamin every day for longevity.
- Uses Element, which contains sodium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
- Explains how salt (sodium) affects mental and physical performance, as well as cellular health, and how the brain monitors sodium levels to regulate thirst and fluid balance.
- Notes that choline can be converted into TMAO, similar to L-carnitine, and suggests measuring TMAO levels if supplementing with it.
- Recommends AG1, a vitamin, mineral, and probiotic drink, and notes that for a limited time, a subscription comes with additional supplements.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, drinking it first thing in the morning and during physical exercise.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure he is hydrated and has sufficient electrolytes. He drinks it first thing in the morning and during physical exercise, especially on hot days.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium but no sugar, to ensure adequate hydration and electrolytes, especially when waking up and during exercise.
- Uses LMNT, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes for brain and body function, especially when starting his day fast or during physical exercise.
- He highlights specific nutrients, including choline, and discusses their recommended doses and dietary sources for focus.
- Uses Element, which contains sodium, for proper hydration and electrolyte balance.
Bryan Johnson · Sodium · warns
- Warns that Taco Bell's beefy five-layer burrito contains 1,290 mg of sodium, almost maxing out the daily reasonable consumption recommended by the American Heart Association, and that sodium increases blood volume, putting pressure on blood vessels.
- Uses sunflower lecithin as an ingredient in Nutty Pudding.
- Warns against excess sodium, stating it can negatively affect the ability to absorb and hold onto calcium intake.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
- Applies vitamin C after showering.
- Uses 1 teaspoon of sunflower lecithin in his Nutty Pudding for phospholipids and as a safe choline source.
- Takes 250 milligrams of Vitamin C.
- Includes sunflower lecithin in his Nutty Pudding, which he consumes an hour after his Super Veggie.
- Recommends sodium at 200 to 400 mg daily for women during the luteal phase.
- Recommends Vitamin C for skin health, noting it's good to pair with collagen peptides and is included in the Blueprint stack.
- Bryan Johnson takes Vitamin C daily as part of his Longevity Mix, which is an antioxidant-rich essential vitamin that supports immune function and metabolic energy.
- He uses Vitamin C, typically in a serum, in the morning for skin health.
- Bryan Johnson uses 1 tsp of sunflower lecithin in his Nutty Pudding.
RAL Summary
Members OnlyTier 3 for Mood
The tier cites two meta-analyses with 91,966 people, but the only pooled review given covers 836 adults and found no overall mood benefit, so a clear improvement for mood is not shown. So it is graded Tier 3, lower than the rules alone gave.
Where the evidence disagrees: 17 of the 66 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Nervous system, Immune system
Combine with: To enhance the benefits of Vitamin C, especially for immune support and antioxidant protection, consider combining it with Vitamin D3 and Zinc. Vitamin D3 is crucial for immune cell function, while Zinc plays a vital role in immune system development and function. For broader antioxidant support, Alpha-Lipoic Acid or CoQ10 can be synergistic. If the goal is truly mood support, consider adding Magnesium or B-complex vitamins, which are more directly involved in neurotransmitter function and stress response.
Possible side effects: The studies given report no major side effects at these doses. Some buyers find the thick, slippery texture hard to swallow.
Supplement Facts
Vitamin C 1000 mg · Choline 60 mg · Essential Phospholipids 1000 mg
Supplement Facts
Serving Size 1 Packet (5.7 mL)
Servings Per Container 30
Amount Per Serving% Daily Value
| Calories | 15 | |
| Total Fat | 1 g | 1% |
| Total Carbohydrate | 1 g | <1% |
| Vitamin C (as sodium ascorbate) | 1,000 mg | 1,111% |
| Choline (from phosphatidylcholine) | 60 mg | 11% |
| Sodium (as sodium ascorbate) | 160 mg | 7% |
| Essential Phospholipids (from soy lecithin) | 1,000 mg | † |
| Total Phosphatidylcholine (PC) | 500 mg | † |
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.
Other ingredients: Purified Water, Ethanol (0.684 g), Citric Acid.
Label source: Livonlabs · Report a label change
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Graded October 28, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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