ProMix Nutrition Unflavored Casein Protein Powder Review

Product Focus: Blood PressureAlso covers:Heart
Tier ⓘ
Tier 4 · Rank 12
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 12 within Tier 4 for Blood Pressure; 45 of 60 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
28 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
100% of 3
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only167 human studies · 43 improved

14 of these 167 human studies gave the ingredient by drip or injection, not by mouth.

167 human studies43 improved94 no effect414,105 people studied

This product is mostly casein protein, and no studies on casein and blood pressure were provided, so the evidence below covers only small nutrients on the label, with no amounts stated. Calcium has modest support. In people with normal blood pressure, it lowered blood pressure by about 1 to 1.5 points [1][2]. In pregnant women, it lowered the risk of pregnancy high blood pressure [3][4], although one large trial found no benefit [5]. Potassium, mainly as potassium-enriched salt, lowered blood pressure by a few points, most in people with high blood pressure [6][7]. The benefit weakened at higher doses [8]. Vitamin D did not lower blood pressure in large trials of older adults and people with prediabetes [9][10][11], and results in pregnancy were mixed [4][12]. Iron did not change blood pressure [13][14]. The amounts of these nutrients in a protein powder are not given and are unlikely to match the studied doses. Animal and cell studies are never counted.

See all 167 studies →Hide the studies

Review Totals and Summary

Members Only3 reviews · 100% positive
3 reviews · Amazon 3
100% positive0% neutral0% negative

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Vitamin D is the main ingredient, and nearly the whole panel speaks well of it: most of them recommend it or take it themselves, and the rest are neutral. They take it for general health, brain and muscle function, bone health, and to fix low blood levels. Several favor the D3 form, three take 5000 IU in the morning, and one has taken D3 with K2 for over a decade. Two of them say to take it with dietary fat for better absorption, one suggests the morning, and one says it is not worth taking unless you are low. Blood level targets vary, from 40 to 50 up to 60 to 100 nanograms per milliliter, and nobody on the panel said they stopped taking it.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Facebook ↗
      Lists Vitamin D as an ingredient found in sardines.
    • 8 Nov 2026 · Calcium · neutral · Facebook ↗
      States that one can of sardines contains 382 mg of calcium.
    • 7 Nov 2026 · recommends · Facebook ↗
      Recommends Vitamin D3 because it's nearly impossible to get enough from food and most people don't get enough sun, advising to aim for blood levels of at least 50 to 80 ng/mL.
    • 7 Nov 2026 · neutral · Instagram ↗
      Dr. Berg states that when nutrients like vitamin D are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Calcium · warns · Facebook ↗
      Warns against calcium supplements, citing studies that link them to a higher risk of heart attack, especially in postmenopausal women, and suggests getting calcium from dairy instead.
    • 7 Nov 2026 · Iron · warns · Facebook ↗
      Warns against iron supplements, suggesting instead to get iron from red meat or liver.
    • 7 Nov 2026 · Iron · neutral · Instagram ↗
      Dr. Berg states that when nutrients like iron are too low, fatigue and weakness can follow.
    • 7 Nov 2026 · Potassium · recommends · Facebook ↗
      Recommends potassium as an important electrolyte, noting that most people get less than half of the 4700 mg RDA.
    • 6 Nov 2026 · recommends · Podcast ↗
      Recommends focusing on vitamin D3 to support stronger bones if a neck hump is associated with osteoporosis.
    • 6 Nov 2026 · recommends · YouTube ↗
      Recommends a minimum of 10,000 IU of vitamin D per day to support natural killer cells.
    • 6 Nov 2026 · Calcium · recommends · Podcast ↗
      Recommends focusing on calcium to support stronger bones if a neck hump is associated with osteoporosis.
    • 5 Nov 2026 · recommends · Podcast ↗
      Suggests that increasing vitamin D3 may help address the underlying problem of bruxism.
    • 4 Nov 2026 · Iron · warns · YouTube ↗
      Does not recommend taking iron supplements or cooking in iron skillets because the body has no mechanism of getting rid of iron unless one donates blood or is a menstruating female.
    • 2 Nov 2026 · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
  • Dr. Rhonda Patrick · Vitamin D · neutral
    • 8 Nov 2026 · neutral · Instagram ↗
      Notes that vitamin D from sunlight, food, or supplements needs to undergo conversions in the liver and kidneys to become its active hormone form, calcitriol.
    • 4 Nov 2026 · neutral · Instagram ↗
      States that Vitamin D supplementation has been associated with a 40% lower dementia risk, and low levels are linked to a 50 to 80% higher risk.
    • 28 Oct 2026 · recommends · YouTube ↗
      Recommends getting adequate vitamin D, noting that people taking vitamin D supplements have a 40% lower risk of dementia, while those with lower vitamin D have a 50-80% higher risk.
    • 5 Oct 2026 · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 28 Sep 2026 · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 24 Sep 2026 · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 25 Aug 2026 · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 28 Jul 2026 · recommends · Facebook ↗
      Recommends Vitamin D, noting it regulates over 5% of the genome, including genes involved in immune defense, neurotransmitter synthesis, and longevity, and correcting deficiency may slow epigenetic aging.
    • 22 Jul 2026 · neutral · YouTube ↗
      Uses Vitamin D3 as an example of a supplement that an AI model could track to see its impact on other metrics like glucose levels.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 23 Jun 2026 · Potassium · recommends · Facebook ↗
      Recommends getting enough potassium, noting that most people get too much sodium and not enough potassium.
    • 4 May 2026 · Iron · uses · YouTube ↗
      Recently found out he needed to get on an iron supplement and noticed he gets less sore in his training after taking it.
    • 22 Jan 2026 · Iron · recommends · YouTube ↗
      Advises that menstruating women should ensure they are getting enough iron.
  • Thomas DeLauer · Vitamin D · recommends
    • 5 Nov 2026 · recommends · YouTube ↗
      Recommends taking Vitamin D3 in the morning, between 6:00 and 10:00 a.m., to align with the body's natural metabolic activation phase and sunlight-triggered vitamin D production.
    • 2 Nov 2026 · Potassium · recommends · YouTube ↗
      Recommends Element electrolytes, noting they are focused on sodium first, then potassium, then magnesium, helping with sending signals and hydrating tissue.
    • 2 Nov 2026 · Iron · recommends · YouTube ↗
      Recommends giving any iron intervention a couple of months before deciding if it works, and suggests increasing heme iron through red meat or liver intake.
    • 28 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
    • 24 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
    • 5 Oct 2026 · recommends · YouTube ↗
      Recommends taking vitamin D on non-liver days to ensure both nutrients get proper receptor access.
    • 29 Sep 2026 · uses · YouTube ↗
      Takes Purity's liquid vitamin D3 with K2 because she is constantly inside during the day; D3 is for overall wellness and K2 helps the body absorb calcium properly.
    • 18 Sep 2026 · Iron · neutral · Facebook ↗
      Compares iron content in spinach (2.7mg) and beef (2.6mg), but emphasizes that beef's heme iron absorbs at about 25%, while spinach's non-heme iron absorbs at 2-8%.
    • 18 Sep 2026 · Calcium · neutral · Facebook ↗
      Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
    • 11 Sep 2026 · recommends · YouTube ↗
      Recommends getting vitamin D, suggesting it can be obtained while walking.
  • Dr. Mark Hyman · Vitamin D · uses
    • 4 Nov 2026 · uses · YouTube ↗
      Consumes Zetopia's Atlantic salmon to get Vitamin D, particularly in the winter months, as it is one of the few foods that provides both Omega-3s and Vitamin D.
    • 29 Oct 2026 · neutral · YouTube ↗
      Mentions that the body makes vitamin D from sunlight exposure, and a deficiency can hinder calcium absorption, which is crucial for strong bones.
    • 29 Oct 2026 · Iron · neutral · YouTube ↗
      States that iron helps red blood cells carry oxygen, and a deficiency can make one feel like they are running on low power mode.
    • 26 Oct 2026 · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Iron · neutral · YouTube ↗
      Mentions iron as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 16 Oct 2026 · Potassium · warns · Facebook ↗
      Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
    • 8 Oct 2026 · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman discusses vitamin D in relation to sun exposure patterns.
    • 7 Oct 2026 · recommends · YouTube ↗
      States that vitamin D supplementation can help with oxidative stress.
    • 5 Oct 2026 · neutral · Podcast ↗
      Mentions vitamin D as a key nutrient for supporting immune function.
    • 5 Oct 2026 · recommends · YouTube ↗
      States that vitamin D is probably the single most important intervention for immune health, recommending levels of 45 to 70 and emphasizing testing to determine the right dose.
    • 31 Aug 2026 · Iron · neutral · YouTube ↗
      Notes that a woman patient had very low iron.
  • Dave Asprey · Potassium · recommends
    • 3 Nov 2026 · recommends · YouTube ↗
      Explains that potassium helps open a gate, allowing creatine to slip through and cross the blood-brain barrier more effectively.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 5 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D, noting it's actually a hormone and that most people are deficient, even those who take it, because they don't take enough.
    • 3 Sep 2026 · Vitamin D · recommends · YouTube ↗
      States that most people on the spectrum are low in vitamin D and need more of it, mentioning his own product, Vitam DAKNE, which contains real vitamin A.
    • 29 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Dave Asprey recommends Vitamin D3 with K2, explaining D3 is a hormone made from sunlight and K2 directs calcium into bones, not arteries, highlighting its low cost, widespread deficiency, and the ability to test its effectiveness.
    • 18 Aug 2026 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D as one of the most important supplements for overall health.
    • 12 Aug 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs because D3, A, K2, and E work together.
    • 28 Jul 2026 · Vitamin D · uses · YouTube ↗
      Mentions taking vitamin D in the morning, comparing it to the daily dosing of testosterone.
    • 24 Jun 2026 · Iron · warns · X ↗
      Warns that if a doctor diagnoses anemia, one should not assume they just need more iron, as low hemoglobin doesn't always mean low iron and the issue can sometimes be how well the body is using iron.
    • 16 Jun 2026 · Iron · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for iron, which is associated with impaired recovery.
    • 16 Jun 2026 · Calcium · neutral · Facebook ↗
      Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
  • Siim Land · Vitamin D · recommends
    • 31 Oct 2026 · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 24 Oct 2026 · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Iron · neutral · Instagram ↗
      Mentions that iron is a mineral necessary for making collagen.
    • 30 Sep 2026 · Potassium · neutral · X ↗
      Lists potatoes and fruit as sources of Potassium.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 6 Sep 2026 · recommends · Instagram ↗
      Thinks vitamin D has some of the strongest evidence and is worth considering.
    • 6 Sep 2026 · neutral · X ↗
      Notes that Vitamin K2 pairs well with vitamin D by regulating calcium and bone mineralization.
    • 3 Sep 2026 · Iron · warns · YouTube ↗
      States that excess iron promotes oxidative stress and inflammation, which increases heart disease risk.
    • 26 Aug 2026 · recommends · Instagram ↗
      Recommends taking vitamin D supplements with some fat to maximize its absorption, suggesting with food or a teaspoon of olive oil.
    • 23 Aug 2026 · neutral · X ↗
      Notes that taking vitamin D3 with a fat-containing meal resulted in 32% higher peak blood vitamin D levels.
    • 17 Aug 2026 · recommends · X ↗
      Recommends taking Vitamin D in the morning or at lunch with fat.
    • 14 Aug 2026 · neutral · X ↗
      Notes that Boron improves vitamin D.
    • 14 Aug 2026 · Calcium · neutral · X ↗
      Notes that Boron reduces calcium/magnesium loss.
  • Ben Greenfield · Vitamin D · recommends
    • 29 Oct 2026 · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · Potassium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
    • 20 Aug 2026 · uses · YouTube ↗
      Has been taking Vitamin D3 K2 for over a decade.
    • 17 Aug 2026 · Potassium · recommends · Instagram ↗
      Recommends Celtic Sea Salt's new electrolyte drink 'Hydrate' for replenishing electrolytes and trace minerals lost through sweat, noting it contains 70 naturally occurring trace minerals, magnesium, taurine, and potassium, with no added sugar, artificial colors, or synthetic ingredients.
    • 8 Aug 2026 · neutral · Instagram ↗
      Notes that sunlight influences more than just vitamin D production.
    • 8 Aug 2026 · recommends · YouTube ↗
      Recommends keeping vitamin D levels high, suggesting that a supplement is probably not a bad idea, especially given that many people are deficient due to spending most of their time indoors.
    • 18 Jul 2026 · recommends · YouTube ↗
      Recommends getting enough vitamin D for blood pressure management.
    • 9 Jul 2026 · recommends · YouTube ↗
      Recommends optimizing vitamin D levels to a serum score of around 50 to 80 nanograms per milliliter, as deficiency is linked to tinnitus volume and can assist with it.
    • 9 Jul 2026 · Iron · recommends · YouTube ↗
      Recommends testing for and replenishing iron if levels are low, as it can affect the ability to maintain or preserve muscle, especially for those on GLP-1s.
    • 7 Jun 2026 · recommends · Facebook ↗
      Recommends using hormone building blocks like vitamin D for hormone optimization.
    • 29 May 2026 · Iron · neutral · Facebook ↗
      Notes that one can eat iron-rich foods or supplement with iron, but still feel exhausted if iron is not the missing piece, emphasizing that focusing on a single mineral in isolation can support a number on a lab test rather than the system itself.
    • 9 May 2026 · Calcium · neutral · YouTube ↗
      Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 8 Jul 2026 · Iron · stopped · YouTube ↗
      Has had low iron for 11 years and despite eating meat and trying all forms of iron supplementation at different times and sequences, none of it worked to raise his iron or ferritin levels.
    • 7 Jul 2026 · Iron · uses · X ↗
      Had low iron for 11 years, with ferritin averaging 38 ng/mL, and has finally boosted it back to healthy levels.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 21 Apr 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 14 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 7 Apr 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 5 Jun 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
    • 12 May 2025 · Calcium · recommends · YouTube ↗
      Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
  • Andrew Huberman · Vitamin D · neutral
    • 21 Sep 2026 · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 7 Aug 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for longevity.
    • 27 Jul 2026 · Potassium · uses · YouTube ↗
      Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
    • 20 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 20 Jul 2026 · recommends · YouTube ↗
      States that Vitamin D is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 20 Jul 2026 · Iron · recommends · YouTube ↗
      States that Iron is one of the critical nutrients with the best evidence for cognitive function and reducing the risk of dementia.
    • 13 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 12 Jul 2026 · uses · X ↗
      He takes 5,000 IU of Vitamin D3 in the morning for overall health.
    • 6 Jul 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning.
    • 22 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning for general health.
    • 17 Jun 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 every day for longevity.
    • 6 Jun 2026 · uses · X ↗
      Takes 5,000 IU of Vitamin D3 in the morning.
    • 18 May 2026 · Potassium · uses · YouTube ↗
      Uses Element, which contains potassium in the correct ratios, to ensure proper hydration and electrolyte intake for brain and body function.
    • 26 Mar 2026 · Potassium · neutral · Podcast ↗
      Mentions potassium as an electrolyte.
  • Peter Attia · Potassium · recommends
    • 6 Sep 2026 · recommends · YouTube ↗
      States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.
    • 10 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might help overcome the negative effects of phenytoin on bone health by improving calcium absorption, though he is unaware of studies on this.
    • 9 Jul 2025 · Vitamin D · recommends · YouTube ↗
      Recommends Vitamin D3 as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 800 to 1,000 IU, which can be obtained through sunlight or supplementation.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · Vitamin D · neutral · YouTube ↗
      Suggests that supplementing with lots of vitamin D might overcome the negative effects of phenytoin on bone health by counteracting increased catabolism of vitamin D and subsequent decreased calcium absorption.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 8 Jun 2025 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D for people who tend to be vitamin D deficient, such as those living in Portland, Oregon.
    • 8 Jun 2025 · Iron · recommends · YouTube ↗
      Recommends iron supplements for women of reproductive age who are iron deficient.
    • 17 Mar 2025 · Vitamin D · neutral · Instagram ↗
      Discusses evaluating vitamin D, understanding deficiency, and optimal levels.

RAL Summary

Members OnlyTier 4 for Blood Pressure

Its studied ingredients are not at the doses that worked in studies, and reviews are not strong enough on their own. The final check notes: The grade rests on vitamin D, iron, calcium and potassium, which are trace nutrients from the nutrition facts panel, while the main ingredient, casein protein, has no blood pressure studies given.

  • Emerging: not enough evidence to rank higher yet.
  • Calcium: amount hidden in a blend
  • Potassium: amount hidden in a blend

Where the evidence disagrees: 94 of the 167 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Cardiovascular system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: In one study of people with kidney disease, high-dose iron infusions caused more temporary episodes of high blood pressure. Very high potassium intakes raised blood pressure in one review. The reviews report no side effects.

Supplement Facts

Total Carbohydrates 0 g · Includes 0g Added Sugars 0 g · Vitamin D 0
Supplement Facts
Serving Size 2 scoops (29g)
Servings Per Container 39 servings per container
Amount Per Serving% Daily Value
Total Fat0 g
Saturated Fat0 g
Trans Fat0 g
Cholesterol18 mg
Sodium45 mg
Total Carbohydrates0 g
Dietary Fiber0 g
Total Sugars0 g
Includes 0g Added Sugars0 g
Protein25 g
Vitamin D0
Iron0
Calcium0
Potassium0

Other ingredients: Ingredients: Micellar Casein, Sunflower Lecithin.

Barcode (UPC) 728120571452 · Label source: Reverseagelab · Report a label change

Show entire label
The ProMix Nutrition Unflavored Casein Protein Powder label, 2.5 lbs (1.13 kg)
Unflavored Casein Protein Powder, 2.5 lbs (1.13 kg)

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Our articles on this subject

Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.