Thorne Whey Protein Isolate - Vanilla Review
Thorne Whey Protein Isolate in Vanilla is a powder that supplies 21 grams of bioavailable protein per scoop, with flavors and sweeteners derived from natural sources. The product is presented as a great tasting, high-quality whey protein designed for athletes, aging individuals, and anyone who needs additional support for maintaining healthy muscle mass. It is NSF Certified for Sport. Many trainers and dieticians recommend consuming protein with every meal, and this is particularly important for people who need support for a workout routine or who want to maintain a healthy weight. Protein is essential for muscle repair and maintenance, and whey protein provides a complete amino acid profile, optimized for absorption and assimilation. Supplementing the diet with a high-quality whey protein can make reaching macro goals easier. The page lists these benefits: it helps maintain healthy muscle mass, supports muscle repair after exercise, benefits a healthy weight, aids in the digestion and assimilation of protein with added bromelain and papain, and offers a balanced amino acid profile including branched-chain amino acids. Features listed include 21 grams of protein per serving, 2.2 grams of leucine per serving, 100 calories, 3 g sugar and 0.5 g fat per serving, a whey protein isolate form for optimal absorption, easy digestion, and a taste the brand describes as great. The product is available in bulk powder or as individual single-serving packets. The page suggests it for teens with growing bodies, aging individuals, athletes and exercise enthusiasts, and anyone supporting healthy weight management. Suggested uses include shaking with water or a preferred beverage, blending into smoothies with fruit or coffee, stirring into oatmeal, and adding to pancakes, muffins, or chia pudding. The Why Thorne section says the formula reflects scientific rigor, with each ingredient carefully selected, clinically studied, and tested through multiple rounds of quality control for purity, potency, and consistency. NSF Certified for Sport batches are tested for compliance with label claims and for the absence of nearly 300 substances banned by many major athletic organizations. The FAQ notes that isolate has higher protein and lower fat and lactose than concentrate, and that the added bromelain and papain are natural enzymes derived from pineapple and papaya. The page states the product provides all nine essential amino acids and is a complete protein. The label lists per serving calcium 94 mg, bromelain and papain blend 30 mg, sodium 75 mg, and whey protein isolate 25 g, with a serving size of one scoop and 30 servings per container. The page also carries a California Proposition 65 lead warning and an allergy warning that it contains milk-derived whey protein isolate.
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Study, Trial or Testing Result Summary
Members Only94 human studies · 32 improved
1 of these 94 human studies gave the ingredient by drip, not by mouth.
Each scoop gives 25 grams of whey protein isolate, close to the 30 grams that worked in studies. The best evidence shows whey helps build muscle when combined with strength training. A review of 116 trials in 4,711 adults doing strength training found that protein, including milk proteins such as whey, increased muscle mass and strength compared with placebo [1]. A review of 36 trials found whey added about 1.24 kilograms of lean mass, with benefits leveling off around 30 to 35 grams a day [2]. In older adults with muscle loss, whey increased limb muscle mass, and increased grip strength mostly when paired with exercise [3][4]. Without training the picture is weaker. A review of 30 trials in adults aged 60 and older found little overall benefit [5], and a one-year trial in 208 older adults found whey alone did not build muscle while adding strength training did [6]. The 94 milligrams of calcium is not expected to help build muscle. Trials and reviews found no muscle benefit from calcium on its own [7][8]. The small enzyme blend of bromelain and papain was not studied here. Animal and cell studies are never counted.
See all 94 studies →Hide the studies
- Across 116 trials of 4,711 adults doing resistance training, protein taken after exercise or at night increased muscle mass and strength versus placebo, and milk proteins including whey were among the types that helped both, but no timing or type improved physical performance tests.Effects of Timing and Types of Protein Supplementation on Improving Muscle Mass, Strength, and Physical Performance in A…
- In 30 trials of 2,105 adults aged 60 and older, whey protein did not improve handgrip strength, walking tests, lean mass or fat mass overall, but with resistance training it modestly improved lower body strength.Effectiveness of whey protein supplementation on muscle strength and physical performance of older adults: A systematic …
- In 36 trials of 1,552 people doing resistance training for at least 6 weeks, whey protein added about 1.24 kg of lean mass compared with placebo, the largest gain of any protein type, with benefits leveling off around 30 to 35 g per day and a smaller advantage in older adults.Dose-structure-population interactions of protein supplementation combined with resistance training on body composition:…
- In 18 trials of 1,341 older adults with or at risk of sarcopenia, adding supplements such as whey protein to exercise improved grip strength and limb muscle mass but not walking mobility, though the certainty of evidence was very low.Comparative effectiveness of protein or protein-related supplementation combined with resistance or functional exercise …
- In 10 trials of 1,154 older adults with sarcopenia, whey protein increased limb muscle mass and gait speed, increased handgrip strength when combined with resistance training, and lowered interleukin-6.Improving sarcopenia in older adults: a systematic review and meta-analysis of randomized controlled trials of whey prot…
- In three trials of 637 patients with sarcopenia, whey protein with leucine and vitamin D increased limb muscle mass, and improved grip strength and physical function only when combined with an exercise program.Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Met…
- In seven trials of 591 older people with sarcopenia doing resistance training, adding whey protein gave small gains in muscle mass and about 2.3 kg more handgrip strength, though the effects were small and the evidence quality was low.Effectiveness of Whey Protein Supplementation during Resistance Exercise Training on Skeletal Muscle Mass and Strength i…
- In seven trials of 472 older people with sarcopenia, strength training with whey protein or HMB increased fat-free mass and some physical performance measures, and whey with training improved handgrip strength, though the evidence should be viewed cautiously.Combined effects of strength training, whey protein, and HMB on sarcopenia in older people: A systematic review and meta…
- Across seven trials of 349 older people with weak bones and low muscle, strength training raised muscle mass, grip strength and protein intake, but calcium intake did not change significantly.Effects of Strength Training on Body Composition, Physical Performance, and Protein or Calcium Intake in Older People wi…
- In seven trials with 270 people doing exercise training, whey protein and beef protein gave similar lean mass, fat mass and protein intake results, so whey showed no advantage over beef protein.Does Beef Protein Supplementation Improve Body Composition and Exercise Performance? A Systematic Review and Meta-Analys…
- In nine trials with 266 people doing resistance training for at least 6 weeks, whey and soy protein both raised strength and gave no difference in lean mass or strength between them.No Difference Between the Effects of Supplementing With Soy Protein Versus Animal Protein on Gains in Muscle Mass and St…
- In 12 trials with 261 young adults doing resistance training, whey protein improved bench press and squat strength but did not significantly change lean body mass.The Impact of Whey and Soy Protein Supplementation on Resistance Training in Young Adults: A Systematic Review and Meta-…
- In eight trials with 246 healthy athletes training for about 9 weeks, whey protein reduced fat mass more than placebo but did not significantly change fat-free mass.Comparative Meta-Analysis of the Effect of Concentrated, Hydrolyzed, and Isolated Whey Protein Supplementation on Body C…
- Across 9 trials in resistance-trained adults, whey protein alone or in a multi-ingredient product gave small extra gains in fat-free mass and upper and lower body strength compared with calorie-matched carbohydrate or other protein supplements, with the larger effect seen when creatine was included.Effects of Whey Protein Alone or as Part of a Multi-ingredient Formulation on Strength, Fat-Free Mass, or Lean Body Mass…
- In 13 trials of women, whey protein modestly increased lean mass by about 0.37 kg compared with non-whey controls without changing fat mass, with larger gains when combined with energy restriction.Effect of whey protein supplementation on body composition changes in women: a systematic review and meta-analysis.
- In adults aged 60 and older doing resistance training, whey protein at 10 to 15 grams daily gave less lean mass gain than control supplements in four of five studies, and milk protein overall was superior to whey for lean mass.Effects of Milk Protein in Resistance Training-Induced Lean Mass Gains for Older Adults Aged ≥ 60 y: A Systematic Review…
- In postmenopausal women, whey protein improved biceps strength and lower-limb lean mass only when combined with resistance training, and showed no benefit on strength or lean mass without training.Effect of Whey Protein Supplementation in Postmenopausal Women: A Systematic Review and Meta-Analysis.
- Whey protein alone did not change lean mass or strength overall but improved physical function in older adults, and improved lean mass in sarcopenic or frail older adults; adding vitamin D gave larger gains in lean mass, strength, and function.Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Anal…
- Across 30 randomized trials, animal protein (including whey) gave modestly greater muscle mass gains than non-soy plant protein and plant-based diets, but muscle strength and physical performance did not differ between plant and animal protein.Effect of Plant Versus Animal Protein on Muscle Mass, Strength, Physical Performance, and Sarcopenia: A Systematic Revie…
- In a network meta-analysis of 51 trials, whey protein taken after resistance training was the only protein source that significantly raised short-term muscle protein synthesis, though the evidence was of low to moderate certainty.Impact of different protein sources on acute muscle protein synthesis following resistance training: a systematic review…
- In a review of nine reviews covering 128 studies, calcium supplements had only modest effects on bone mineral content and no muscle benefit was reported for calcium itself, though cheese and yogurt were linked to better grip strength.Nutrients and food supplements for the prevention of musculoskeletal diseases: an umbrella review.
- In a review of six randomized trials in 186 people after knee ligament surgery, one small study of whey protein plus electrical muscle stimulation found no significant difference between groups in strength of the operated leg.[Effect of dietary supplements and whey protein on muscle mass and strength of the operated limb after anterior cruciate…
- In a review of 45 mostly cross-sectional studies in older adults, no link was found between calcium and muscle mass, strength, physical performance or sarcopenia.Minerals and Sarcopenia in Older Adults: An Updated Systematic Review.
- In 16 studies of older adults with sarcopenia, resistance exercise combined with whey protein or essential amino acids and vitamin D improved muscle mass and lean mass.Exercise Programs Combined with Diet Supplementation Improve Body Composition and Physical Function in Older Adults with…
- In 1434 children aged 6 to 9, two years of an after-school program with 380 mg daily calcium-rich snacks and exercise raised bone stiffness in one group but did not change muscle strength or vertical jump.Beat osteoporosis - nourish and exercise skeletons (BONES): a group randomized controlled trial in children.
- Over 13 weeks, sarcopenic older adults who drank a vitamin D and leucine-enriched whey protein supplement twice daily gained more leg muscle mass and improved chair-stand time compared with an iso-caloric control drink, though handgrip strength and physical performance scores did not differ between groups.Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adult…
- In 241 older adults with sarcopenia over 12 weeks, nutrition supplementation with whey protein, fish oil and vitamin D improved muscle mass and grip strength compared with routine care.Effects of nutrition supplementation and physical exercise on muscle mass, muscle strength and fat mass among sarcopenic…
- In 208 healthy adults over 65 followed for one year, taking 20 grams of whey protein twice daily without exercise did not increase muscle size or strength compared with a carbohydrate drink, while adding heavy resistance training did.The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, a…
- In 156 older women with low muscle mass, 1500 mg daily of calcium-HMB for 12 weeks did not add to the effects of resistance training on muscle quality compared with placebo.β-Hydroxy-β-Methylbutyrate Supplementation May Not Enhance Additional Effects of Exercise on Muscle Quality in Older Wom…
- In 150 patients with Parkinson disease or parkinsonism doing a 30-day intensive rehabilitation program, twice-daily whey protein formula with leucine and vitamin D improved walking distance more than standard diet alone and helped preserve muscle mass.Muscle-targeted nutritional support for rehabilitation in patients with parkinsonian syndrome.
- In 150 people with cirrhosis, 30 grams daily of branched-chain amino acids for 12 months did not improve muscle strength or muscle mass better than an equal amount of whey protein.Branched-chain amino acid supplementation does not improve measures of sarcopenia in cirrhosis: results of a randomised …
- In 148 men aged 70 and over with low testosterone, 20 weeks of calcium, vitamin D and protein with resistance training and testosterone improved chair stand performance versus no intervention, but calcium's own effect could not be separated.Beneficial effects of exercise, testosterone, vitamin D, calcium and protein in older men-A randomized clinical trial.
- In hospitalized older adults with sarcopenia doing physical rehabilitation, a whey protein formula enriched with leucine and vitamin D improved walking speed, physical performance, function and muscle mass more than a control formula, over a stay of about 4 to 8 weeks.Improving rehabilitation in sarcopenia: a randomized-controlled trial utilizing a muscle-targeted food for special medic…
- In 130 sarcopenic elderly people over 12 weeks with exercise, 22 g of whey protein with amino acids and vitamin D increased lean mass and handgrip strength and lowered C-reactive protein compared with placebo.Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, fu…
- In 116 physically active older adults, 31 g a day of milk protein for 12 weeks increased lean body mass more than placebo, though strength did not change more than placebo.Protein supplementation improves lean body mass in physically active older adults: a randomized placebo-controlled trial…
- In 105 older outpatients at risk of malnutrition, a nutrient-rich drink for 12 weeks raised calcium intake and increased muscle mass in women, but muscle strength and physical performance did not differ from standard care.The effect of 12-weeks Nutritional supplementation on Nutritional Intake and Status among Indonesian Older Outpatients w…
- In 101 adults aged 55 and older, 12 weeks of resistance exercise and walking improved strength and mobility, but adding whey protein did not improve results beyond exercise alone.Changes in Strength, Mobility, and Body Composition Following Self-Selected Exercise in Older Adults.
- In older adults with sarcopenia, combining leucine-enriched whey protein (11 g protein per dose) with resistance training for 24 weeks did not differ from training alone at the end, but after 24 weeks without training, muscle mass and grip strength were higher in the combined group.De-Training Effects Following Leucine-Enriched Whey Protein Supplementation and Resistance Training in Older Adults with…
- In 80 mobility-limited adults aged 70 to 85, 40 g daily of whey protein concentrate for six months added no benefit beyond resistance training for lean mass, thigh muscle size or strength compared with an isocaloric control.Efficacy of whey protein supplementation on resistance exercise-induced changes in lean mass, muscle strength, and physi…
- In women after gastric bypass surgery, whey protein alone did not improve strength, but whey protein combined with 18 weeks of strength training increased lower-limb strength; lean body mass did not differ between groups.Resistance Training and Protein Supplementation Increase Strength After Bariatric Surgery: A Randomized Controlled Trial…
- In 73 functionally limited adults aged 70 to 85, six months of resistance exercise with whey protein or placebo was used to link blood metabolites to physical function, but the abstract does not report a clear whey-versus-placebo effect on muscle strength.Metabolites related to gut bacterial metabolism, peroxisome proliferator-activated receptor-alpha activation, and insuli…
- In 70 childhood cancer survivors over 24 weeks of resistance training, 21 g of daily whey protein did not increase lean mass or strength more than placebo.Protein Supplementation and Resistance Training in Childhood Cancer Survivors.
- In 70 older adults doing a 6-month exercise program, 40 g a day of whey protein did not improve walking speed, grip strength or physical performance compared with rice protein, though whey caused twice as many stomach symptoms.A Randomized Controlled Pilot Exercise and Protein Effectiveness Supplementation Study (EXPRESS) on Reducing Frailty Ris…
- In 70 men with prostate cancer on hormone therapy, 12 months of exercise with daily whey protein, calcium and vitamin D did not change thinking or memory compared with usual care.Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cog…
- Adding creatine and conjugated linoleic acid to 36 g daily of whey protein during 5 weeks of strength training gave larger gains in strength and lean body mass than whey protein with strength training alone.Conjugated linoleic acid combined with creatine monohydrate and whey protein supplementation during strength training.
- In 68 previously untrained men doing 12 weeks of resistance training, 30 g of whey protein after exercise did not increase muscle size or strength more than carbohydrate, but it did lower abdominal fat and increase lean mass relative to body weight.The effects of whey protein with or without carbohydrates on resistance training adaptations.
- In 60 older adults with muscle loss, a whey protein drink with vitamin D and vitamin E over six months improved muscle mass and grip strength compared with a control drink.A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older…
- In prostate cancer patients on androgen deprivation therapy, adding 31 g of whey protein to 20 weeks of resistance training did not produce greater gains in muscle mass or strength than placebo with training.Resistance Exercise Training Increases Muscle Mass and Strength in Prostate Cancer Patients on Androgen Deprivation Ther…
- In young adults taking 4.5 g daily of whey protein for 3 months, maximum knee strength rose, but muscle thickness and muscle mass did not change, and nerve activation fell less than with Alaska pollack protein.Effects of Alaska Pollack Protein Ingestion on Neuromuscular Adaptation in Young Healthy Adults: A Randomized, Placebo-C…
- In 54 healthy young men doing resistance training for 12 weeks, 22 g daily of whey protein isolate did not increase muscle fiber size, satellite cell content or myonuclei compared with a maltodextrin placebo.Protein Supplementation Does Not Affect Myogenic Adaptations to Resistance Training.
- In untrained young adults doing resistance training for 12 weeks, 19 g of whey protein isolate and 26 g of soy protein, matched for leucine, produced similar gains in lean mass and leg strength.No Significant Differences in Muscle Growth and Strength Development When Consuming Soy and Whey Protein Supplements Mat…
- In adults with fatty liver disease on a 30% calorie restriction for 4 weeks, whey protein with resistance training improved some muscle strength measures, but body composition changes did not differ between groups and muscle mass was preserved in all groups.Independent and Combined Effects of Resistance Training and Whey Protein on Skeletal Muscle Mass and Function in Individ…
- In young untrained men doing resistance training for 12 weeks, 45 g per day of whey protein drink and a plant protein blend produced similar gains in lean mass, muscle size and leg strength.Similar effects between animal-based and plant-based protein blend as complementary dietary protein on muscle adaptation…
- In 43 malnourished people with liver cirrhosis, 3 g a day of calcium HMB for 12 weeks did not change fat-free mass compared with the supplement without it, though handgrip strength trended upward.Randomized Clinical Trial: Effects of β-Hydroxy-β-Methylbutyrate (HMB)-Enriched vs. HMB-Free Oral Nutritional Supplement…
- In 43 older men with low bone density and muscle loss, both groups received whey protein, vitamin D and calcium; over 12 months, the high-intensity resistance training group gained muscle mass and strength while the control group lost muscle, so this study does not isolate whey's own effect.Effects of High-Intensity Resistance Training on Osteopenia and Sarcopenia Parameters in Older Men with Osteosarcopenia-…
- In 40 young men doing 8 weeks of resistance training, calcium HMB did not improve muscle thickness, strength or power more than placebo.Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness.
- In 40 resistance-trained young men over 8 weeks of training, calcium HMB did not reduce training-related inflammation or change muscle thickness or strength compared with placebo.Leucine metabolites do not attenuate training-induced inflammation in young resistance trained men.
- In 40 resistance-trained women over eight weeks, all groups took supplemental whey protein and gained similar lean mass and strength whether or not they used time-restricted eating, and whey dose was not separately tested.Time-restricted feeding plus resistance training in active females: a randomized trial.
- In 40 resistance-trained men over 8 weeks, 30 grams of whey protein daily with training increased muscle mass and strength more than a placebo drink.The combined effects of whey protein and collagen supplementation on bone mineral density and muscle mass in resistance-…
- In older adults with limited mobility doing electrical muscle stimulation for 12 weeks, whey protein isolate alone did not beat a carbohydrate drink for knee strength, while whey plus omega-3, rutin and curcumin raised knee strength by 13% more than the carbohydrate drink.Supplementation with Whey Protein, Omega-3 Fatty Acids and Polyphenols Combined with Electrical Muscle Stimulation Incre…
- In 36 healthy older men over 12 weeks, 25 grams of whey protein twice daily increased walking speed compared with a placebo, but did not add to the gains in strength or muscle mass from resistance exercise.Effects of resistance exercise and whey protein supplementation on skeletal muscle strength, mass, physical function, an…
- In 33 young men doing 12 weeks of elbow arm training, whey protein taken around workouts did not increase arm muscle size or strength compared with placebo.Whey protein does not enhance the adaptations to elbow flexor resistance training.
- In 32 men doing four weeks of supervised resistance exercise, those given whey protein isolate gained more muscle mass and strength and endurance in the knees and shoulders than those given placebo, under controlled meals.Effects of Whey Protein Supplement on 4-Week Resistance Exercise-Induced Improvements in Muscle Mass and Isokinetic Musc…
- In older adults on a calorie-restricted, low-activity diet, 60 g daily of whey protein did not prevent leg lean mass loss overall, but leg lean mass increased during the final recovery week only in the whey group.A randomized controlled trial of the impact of protein supplementation on leg lean mass and integrated muscle protein sy…
- In 31 older adults doing resistance training for 12 weeks, adding 20 grams of whey protein at breakfast and at dinner did not improve muscle strength, muscle size or daily function more than a placebo drink.Can supplemental protein to low-protein containing meals superimpose on resistance-training muscle adaptations in older …
- In 30 older men, a single session of very light resistance exercise raised muscle protein building, and whey protein taken in either pattern did not change this effect compared with a placebo drink.Light-load resistance exercise increases muscle protein synthesis and hypertrophy signaling in elderly men.
- In 30 healthy adults across three age groups, adding a saponin extract to whey protein for 4 weeks along with resistance training raised amino acid absorption and produced slightly greater gains in grip strength and muscle mass than placebo.Effects of Astragalus membranaceus and Panax notoginseng Saponins Extract on the Pharmacokinetics of Whey Protein Absorp…
- In 30 adults with fatty liver disease on a calorie-restricted diet for 4 weeks, adding resistance exercise plus whey protein at 0.7 g per kg daily increased muscle mass, while exercise alone did not.Effects of Resistance Exercise and Whey Protein Supplementation on Irisin Levels in Patients with MASLD Under a Calorie-…
- In 27 adults aged 50 to 70, a 10-day diet with whey protein did not build muscle differently than a plant protein diet, though resistance training increased muscle building in both groups.Resistance training increases myofibrillar protein synthesis in middle-to-older aged adults consuming a typical diet wit…
- In 26 healthy young adults doing 10 weeks of resistance training, a supplement with whey protein, leucine, creatine, calcium citrate and vitamin D twice daily increased lean body mass more than placebo (+4.1 vs +2.8 kg), but calcium's own effect cannot be separated.The Effect of a Multi-ingredient Supplement on Resistance Training-induced Adaptations.
- Over 10 weeks of resistance training, a multi-ingredient supplement containing calcium citrate increased the size of fast muscle fibers more than a collagen control, though calcium's effect could not be separated from the other ingredients.The Effect of Multi-Ingredient Protein versus Collagen Supplementation on Satellite Cell Properties in Males and Females…
- In 26 resistance-trained men over 12 weeks, whey protein with HMB or with leucine (both groups 50 g whey daily) produced equal muscle and strength gains, so HMB added nothing beyond leucine.Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men.
- In young men doing four weeks of alternate-day fasting, adding 25 g whey protein on fasting days did not prevent the muscle loss seen with fasting.Effects of Four Weeks of Alternate-Day Fasting with or Without Protein Supplementation-A Randomized Controlled Trial.
- In 25 people with cancer, a single 40 gram meal of a leucine-enriched casein and whey medical food increased muscle protein building over 5 hours, while a conventional 24 gram casein medical food did not.Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food.
- In 24 older adults, a single dose of 3 g calcium beta-hydroxy-beta-methylbutyrate added to 40 g whey boosted muscle protein synthesis in older women and reduced muscle protein breakdown, but the effect was not seen in men.The Effect of β-Hydroxy-β-Methyl Butyrate (HMB) upon Acute Fed-State Muscle Protein Turnover in Older Men and Women: A R…
- In 24 trained men who ate 80 g of whey protein over 12 hours after resistance exercise, 20 g every 3 hours produced more muscle protein synthesis than 10 g every 1.5 hours or 40 g every 6 hours, though all schedules raised synthesis above rest.Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar prot…
- In 24 master-age male triathletes over 10 weeks, 20 g a day of whey protein did not preserve thigh muscle thickness better than carbohydrate, and thickness fell in both groups; beef protein performed better.Effects of Supplementation with Beef or Whey Protein Versus Carbohydrate in Master Triathletes.
- In 22 adults doing 12 weeks of knee strength training, adding a high-leucine whey protein drink with carbohydrate increased thigh muscle size by 7.3% versus 3.4% with carbohydrate alone.Whey protein hydrolysate augments tendon and muscle hypertrophy independent of resistance exercise contraction mode.
- In 12 postmenopausal women over 10 weeks of resistance training, whey protein taken during sessions did not add to gains in strength or muscle thickness compared with maltodextrin placebo.Whey protein and high-volume resistance training in postmenopausal women.
- In nine older women on a low-protein diet for about two weeks, whey protein supplements were followed by weight loss and higher nitrogen loss, while a collagen supplement preserved lean body mass.Effects of whey and fortified collagen hydrolysate protein supplements on nitrogen balance and body composition in older…
- In 9 well-trained adults, a whey protein drink taken before a low-carbohydrate endurance ride did not raise muscle protein synthesis or protein balance compared with a flavored water drink.Effects of protein intake prior to carbohydrate-restricted endurance exercise: a randomized crossover trial.
- In eight men with overweight or obesity, taking a fat drink four hours before a milk protein and sugar drink reduced how much amino acids entered leg muscle early after the meal, compared with water, in a single-visit crossover test.Acute effects of prior dietary fat ingestion on postprandial metabolic responses to protein and carbohydrate co-ingestio…
- In resistance-trained men over 11 weeks of supervised training, whey protein isolate produced greater strength gains and muscle fiber growth than carbohydrate alone, though the size of muscle changes varied across measures.Effects of whey isolate, creatine, and resistance training on muscle hypertrophy.
- In older adults with frailty doing resistance training for 14 weeks, adding creatine to whey protein did not improve muscle or body composition beyond whey protein alone, though both groups improved strength and mobility.Resistance Training and Co-supplementation with Creatine and Protein in Older Subjects with Frailty.
- During a low-calorie diet, post-workout whey protein did not prevent a blunted growth-factor response to a single leg-strength workout, so muscle-building signals stayed suppressed.Caloric restriction induces anabolic resistance to resistance exercise.
- In resistance-trained young men over 60 days, 20 grams of whey protein with a probiotic raised blood amino acid levels and improved leg press strength and jump power more than whey protein with a placebo.The effect of Bacillus coagulans Unique IS-2 supplementation on plasma amino acid levels and muscle strength in resistan…
- Over 12 weeks, a postbiotic drink made with whey protein at 6 g per day improved grip strength in the dominant hand compared with placebo, but did not change lean mass or grip strength in the other hand.Bioconversion-Based Postbiotics Enhance Muscle Strength and Modulate Gut Microbiota in Healthy Individuals: A Randomized…
- In 66 adolescent girls, about 1300 mg daily calcium from milk for 12 weeks did not change body composition or muscle performance, though resistance training did improve them and milk with training improved bone density.Resistance Training and Milk-Substitution Enhance Body Composition and Bone Health in Adolescent Girls.
- Over about nine months of resistance training, men and women taking whey protein gained more lean body mass than those taking soy protein or a carbohydrate control.Whey protein supplementation during resistance training augments lean body mass.
- In 38 young men doing twice-weekly resistance training for 12 weeks, whey protein from supplements to reach 1.6 grams of protein per kilogram of body weight daily gave muscle and strength gains that were no different from a plant-based soy protein diet.High-Protein Plant-Based Diet Versus a Protein-Matched Omnivorous Diet to Support Resistance Training Adaptations: A Com…
- In 11 people with chronic tetraplegia doing circuit resistance training for 6 months, whey protein of about 36 to 37 grams taken around workouts was linked to bigger gains in arm aerobic capacity than delayed protein, though strength gains were similar in both groups.Circuit training and protein supplementation in persons with chronic tetraplegia.
- In sarcopenic older adults eating adequate protein, a whey, leucine and vitamin D supplement for 12 weeks did not change muscle mass or grip strength more than diet counseling alone, but it improved walking speed, especially in those under 75.Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adu…
- In 53 Chinese men and women aged 18 to 35, calcium intake was similar across age and sex groups, and the study found only correlations between bone, body composition, and muscle strength, with no intervention tested.Muscle-Bone Interactions in Chinese Men and Women Aged 18-35 Years.
- In 49 resistance-trained men, those who used whey protein had less body fat, but whey use was not linked to better muscle strength.Association between whey protein, regional fat mass, and strength in resistance-trained men: a cross-sectional study.
Review Totals and Summary
Members Only3,700 reviews · 88% positive
Across the stores that sell it, Thorne Whey Protein Isolate in vanilla carries about 1,259 ratings, and buyers are largely happy. The praise centers on taste, quality and easy mixing. The recurring reservations are the half-empty container and, for some, the sweetness. **What buyers say it did for them:** Many use it for workouts and recovery. One 76-year-old gym-goer reported "energy and strength levels have increased significantly" after four weeks, and another found it "excellent when used with resistance & plyo workouts." Others use it to reach protein goals. A med user calls it "a perfect 'lunch'" when not hungry, and a morning-shake drinker says it "fills me up." One reviewer's wife used it during chemotherapy on a healthcare professional's recommendation, for its digestibility and taste. One buyer reported "no side effects." **What they complain about:** The most common complaint is the container, which several reviewers say arrives about half full. One wrote, "your jugs are only half filled," and another called it "an enormous waste of plastic and space." Two asked for a bag instead of a heavy plastic tub. One reviewer found the container smaller than expected, while another said the size was perfect. A single two-star reviewer found the flavor so bad "I couldn't drink it." That is the only outright rejection of the taste here. **Taste, texture and form:** Most reviewers like the flavor, and several mention a smooth texture and easy mixing. Comments include "tastes great with a smooth consistency" and "tasty and dissolves easily." One reviewer said it is better mixed with milk. One user who normally dislikes stevia found it "ok" and finished a container. Another said they couldn't mix it fully at work but didn't mind, because the taste beat other powders. A couple of reviewers found vanilla "slightly sweeter than I like" or "a little too sweet," and the store summaries note mixed opinions on vanilla and container size. **Value for money:** Few reviewers discuss price. One says "the price is right and I trust Thorne!" The store summaries mention value in the large size for regular use. The half-empty tubs undercut that for the reviewers who noticed. One of them still called the product "excellent for all the right reasons." **Who it suits and who it didn't:** It seems to suit regular gym-goers, older active adults, people with low appetite who struggle to get enough protein, and those who value a trusted brand with clean ingredients. Repeat purchases come up often, with reviewers on their second bottle or planning to reorder. It suits less well anyone who dislikes sweet flavors, anyone bothered by excess plastic packaging, and the one buyer who found the flavor undrinkable. The chemotherapy reviewer said they would use it only while needed and would not continue because of the packaging. Reviews of other forms of this product, such as gummies or capsules, were left out; this summary covers the vanilla powder only.
Biohacker Summary
Members Only10 of 10 recommend it
Most of the panel recommends or uses whey protein, mainly to build and keep muscle, support recovery, and manage weight and blood sugar, with several stressing protein at breakfast or at every meal. Doses vary: targets run from about 1.2 grams per kilogram of body weight up to 1.6 to 2.4 grams, and one panelist aims for 130 grams a day. Panelists use it in shakes, smoothies, and homemade muffins, and pair it with collagen, olive oil, or fiber, while a few prefer a grass-fed, low lactose isolate. One panelist warns that many whey brands have been found to contain lead and other contaminants, so choosing a clean source matters. Two panelists stopped or cut back, one because he rarely drinks whey shakes now and gets protein from food, and another who reversed high cholesterol and fatty liver by limiting excess animal protein. Calcium is a smaller ingredient in this product and drew only passing comments.
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Dr. Mark Hyman · Whey Protein · recommends
- Recommends eating protein at every meal as part of a longevity starter pack.
- Recommends pairing coffee with protein, like eggs, to keep energy steady.
- Recommends having protein as part of improving meal composition for insulin resistance.
- Has her protein shot on the counter in the morning, ready to take, so she doesn't have a choice.
- Recommends ensuring adequate protein intake to address insulin resistance.
- Recommends filling meals with protein as part of their 10-Day Detox to help people feel satisfied.
- Encourages people to start with a simple foundation of quality protein for health.
- Highlights the importance of protein for nervous system regulation, explaining that it is packed with amino acids which are building blocks for neurotransmitters critical for balancing mood and stress.
- Recommends including a good source of protein at every meal to help balance blood sugar.
- Includes goat whey in a berry smoothie for breakfast.
- Notes that calcium is in bones but is also essential for nerves, muscles, and the heart, and low levels can affect muscle function and heart rhythm.
- States that green leafy vegetables are great sources of calcium.
- Notes that calcium needs are lower than advertised and that stress, soda, and excess sugar can drive calcium loss.
- Does not prescribe calcium supplements at all, teaching people to get it from whole foods instead, because calcium supplements don't work for building bones or preventing fractures, and it's bone quality, not density, that matters.
Thomas DeLauer · Whey Protein · neutral
- States that protein spikes insulin, which is a good thing and different from how carbs spike insulin, making it one of the most anabolic foods.
- States that the gut lining's constant renewal requires an enormous amount of protein, amino acids, phospholipids, vitamins, and minerals.
- Recommends prioritizing protein, noting that 20-30% of calories from protein are used up as heat.
- Recommends consuming a bunch of protein as part of a massive breakfast to help manage hyperphagia.
- Warns against buying just any whey protein because many brands have been found to contain ridiculous amounts of lead and other contaminants, making the market 'sketchy'.
- Recommends a sugar-free protein bar over a candy bar, stating that it has a decent metabolic profile.
- Recommends Purity Protein as the cleanest protein on the market, noting its public third-party testing for over 200 contaminants and its simple five-ingredient profile.
- Consumes 18-20 grams of pure whey protein before lifting 30-50% of the time to boost resting metabolic rate and provide fuel without sugar or carbs.
- Recommends whey protein, specifically whey protein isolate, for increasing the body's master detoxification molecule, glutathione, which directly affects fatty liver and insulin resistance.
- Recommends Four Sigmatic's new protein coffee, highlighting its third-party testing, protein, creatine, lion's mane, collagen, and yacon root fiber for satiety, gut support, and brain function.
- Notes that milk contains 120mg of calcium, while sardines contain 351mg, highlighting a 3x difference.
- Recommends getting calcium, along with vitamin D, zinc, and magnesium, from foods like sardines, as they are important for inflammatory pathways in the gut.
- Explains that eating sardines with their soft bones provides a serious hit of calcium, which is a perfect combination for bones and may contribute to satiety.
- Mentions that magnesium and calcium should not be taken together as they cancel each other out.
Andrew Huberman · Whey Protein · uses
- Eats one or two David Bronze Bars per day as a snack to easily hit his protein goal without consuming excess calories.
- Discusses protein and food-based supplements.
- He mentions Dr. Layne Norton pointed to interesting data on potato protein as a potential great plant-based substitute for those avoiding whey-based protein.
- States that enough protein is critical for health.
- Confesses to loving the Mateina protein smoothie, which contains whey protein, collagen, pineapple, veggies, and Mateina, and suggests it's perfect for before or after workouts, as a healthy snack or meal replacement.
- Says he eats David protein bars, specifically the new bronze bar, and finds them to be the best tasting protein bars he's ever had.
- Personally eats one or two David Bronze Bars per day as a snack to easily hit his protein goal without consuming excess calories.
- Eats one or two David Bronze Bars per day as a snack to easily hit his protein goal of 1 gram of protein per pound of body weight without consuming excess calories.
- Takes 20 grams of whey protein in the morning for muscle.
- States that protein is a significant lever for muscle building, with benefits plateauing around 1.6 grams per kilogram of body weight, though some evidence suggests slightly higher amounts may offer a little more benefit.
- Discusses "hard water" and the role of magnesium and calcium in cardiovascular health.
Dr. Eric Berg · Whey Protein · neutral
- Dr. Eric Berg mentions that sardines are packed with protein, which supports brain health and metabolism.
- Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
- The amino acid leucine is important for muscle growth, but getting sufficient protein is just as essential for maintaining muscle mass.
- Recommends consuming high-quality animal protein in conjunction with other weight loss methods.
- Dr. Eric Berg recommends getting enough high-quality protein to maintain muscle, especially after menopause.
- Dr. Berg includes calcium carbonate among the synthetic supplements to avoid.
- Recommends high-quality protein as a way to lower blood sugar for better sleep.
- Warns against calcium carbonate, also known as limestone, stating that while it lowered hip fractures in a study, it also increased kidney stones and is not good for arteries, requiring the body to work hard to use it.
- Notes that leucine comes from whey protein powder.
- Ideally recommends eating protein from meat, but if using a protein powder, to find one made from meat, or even dehydrated/freeze-dried meat slices.
- Notes that tannins in tea bind calcium, blocking its absorption.
- Recommends consuming high-quality animal protein as a source of leucine for muscle growth.
- Warns that most protein bars contain very low-quality protein and tons of sugar.
- Dr. Berg recommends consuming the right amount of protein to satisfy hunger and stop overeating, as it gives the body what it needs without converting to sugar or fat.
Ben Greenfield · Whey Protein · recommends
- Notes that a recent review found that protein stops muscle loss and starts muscle gains and muscle protein synthesis around 1.9 to 3.2 g per kg of body weight a day, and frequency is as important as getting that total amount daily.
- Recommends aiming for 0.8-1.2 g of protein per pound of body weight to help fill the space fat used to occupy under loose skin.
- Recommends Protein powder for optimizing muscle protein synthesis, recovery, and muscle maintenance.
- Recommends starting with protein for body remodeling.
- States that introducing high protein, around 1g/lb, can mitigate the negative effects of a caloric deficit on lean muscle mass and metabolism.
- Is considering adding a protein shake right after her workout to easily add 20-30 grams of protein to her daily intake.
- States that if he had cancer, he would limit protein based on the idea of an anabolic scenario potentially causing a tumor to grow.
- While animal protein sources and essential amino acids are still my #1 protein priority, it’s good to know that collagen still produces impactful results for multiple aspects of your biology.
- Personally consumes a whey protein shake post-workout.
- Recommends switching to a high-protein version of favorite foods like ramen as an effective short-term strategy to reduce subsequent energy intake, noting that eating more protein at breakfast reduces calorie intake at lunch.
- Is considering whether he needs a calcium supplement because lead can displace calcium in bones, affecting bone strength.
- Mentions calcium as a common deficiency.
- Recommends adequate intake of calcium for bone strength.
- Is using calcium chloride mixed with PRP before injecting for the P-shot.
Dave Asprey · Whey Protein · recommends
- Discovered that to meditate with high focus for hours a day, one absolutely needs enough fat and some carbohydrate, and protein helps one last longer.
- Notes that protein burns 20-30% of its own calories just to digest, making it the most powerful diet lever for cutting visceral fat.
- Reversed his high cholesterol and fatty liver disease by limiting his excessive animal protein intake.
- Recommends eating protein first as part of a reset for insulin resistance.
- Recommends prioritizing animal protein because the body burns 20% to 30% of those calories just digesting them, which helps with cutting visceral fat.
- Recommends eating animal protein and animal fats because they help build muscle and hormones and provide satiety.
- Recommends consuming one gram of animal protein per pound of body weight, noting it can be challenging to achieve while traveling.
- Dave Asprey recommends eating good quality animal protein, aiming for about 1 gram per pound of body weight every day, to help burn calories during digestion and release satiety hormones.
- Notes that protein delivers amino acids and that low protein can contribute to a gap in essential amino acids.
- Advises how to stack glutathione with protein.
- Notes that when energy intake is too low for training demand, nutrient intake often falls short, especially for calcium, which is associated with reduced bone health.
- Explains that calcium provides the raw material for bones, but it isn't a standalone input and needs a whole system to be effective.
- Notes that people take calcium for their bones.
- Warns that taking calcium without vitamin D, A, and K2 can lead to calcium going into tissues, causing bone spurs and other issues, and recommends a two-to-one ratio of calcium to magnesium.
Siim Land · Whey Protein · uses
- Reduced his protein intake from around 2 g/kg to 1.4–1.6 g/kg.
- Recommends Protein powder for muscle growth and recovery, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Protein powder as one of 15 supplements backed by human studies.
- Lists dairy and sardines as sources of Calcium.
- Recommends eating approximately 1.6 grams of protein per kilogram of body weight daily.
- Recommends eating around 0.4 grams of protein per kilogram per meal, divided into three or four meals, to ensure net positive muscle protein synthesis.
- Notes that 30 g of isolated potato protein stimulated muscle protein synthesis similarly to 30 g of milk protein at rest and after resistance exercise in a 2022 randomized controlled trial.
- Notes that Boron reduces calcium/magnesium loss.
- Recommends getting enough protein to help maintain muscle, especially in a calorie deficit, and as part of the best way to lose fat while maintaining muscle.
- Recommends eating enough protein for declining muscle mass and strength.
- Aims to increase protein intake in meals because Asian food in Singapore tends to be very carbohydrate-heavy and imbalanced.
- Consumes 1.4 to 1.6 grams of protein per kilogram of body weight, which for him is 120 to 135 grams, from sources like protein powder, yogurt, collagen, beef, and fish.
- Recommends a high calcium intake for bone health.
- Places calcium supplementation in the 'bad tier' due to its association with increased cardiovascular events, recommending dairy or bones as easier ways to get calcium, though it can be useful for postmenopausal women with low bone density.
Dr. Rhonda Patrick · Whey Protein · recommends
- Recommends supplementing with protein powders, especially those higher in leucine, to help achieve the recommended 1.2 grams of protein per kilogram body weight.
- If Dr. Rhonda Patrick needs fuel before training, they will have a homemade muffin made with whey protein.
- Focuses on protein, aiming for at least 1.2 g/kg daily and usually getting 1.3-1.4 g/kg.
- Rhonda's current diet includes a homemade blueberry, whey protein, and psyllium husk muffin as a pre-workout.
- Personally likes and recommends Nutra Cost grass-fed unflavored whey protein isolate for its high protein content, low lactose and fat, fewer calories, grass-fed source, organic nature, and lack of heavy metal contaminants.
- Recommends focusing on high-quality protein sources and aiming for 1.2 to 2.2 grams of protein per kilogram body weight, depending on training schedule, and timing some protein around workouts.
- Discusses the school of thought that eating too much protein accelerates aging and increases cancer risk, but also notes that maintaining muscle and strength is important for aging well, suggesting protein is not always protective or always harmful.
- States that adaptations from training require enough protein for recovery and rebuilding.
- Mentions that kale delivers calcium, a micronutrient many diets fall short on.
- Includes 1 scoop of protein powder in their daily smoothie.
- Emphasizes the importance of protein for muscle, bone, connective tissue, and brain health, stating that once you meet your protein needs, everything else becomes easier.
- Notes additional gaps in calcium.
- Reports that alcohol use disorder is associated with a 20-50% greater prevalence of Calcium deficiency.
- Around 38% doesn't meet the requirement for calcium.
Bryan Johnson · Whey Protein · uses
- Includes protein in their breakfast.
- Went off protocol and ate animal protein for the first time in six years while traveling in Australia, which changed his gut microbiome, causing good bacteria to drop 61%.
- Consumes protein at 4:55 am.
- Includes 'protein' as part of their daily morning routine.
- For breakfast, Bryan Johnson blends protein, collagen, and extra virgin olive oil, targeting 130g of protein daily for skin, joints, and muscle maintenance and building.
- Recommends getting enough protein, specifically collagen, which acts as the framework for bone structure, suggesting a range between 1.2 g and 2.2 g per kilogram of body weight depending on activity levels.
- Recommends calcium as a mineral that, along with phosphorus, magnesium, and boron, is deposited to fortify the bone structure after the collagen scaffold is in place.
- Agrees that consuming protein with carbohydrates post-workout is beneficial, as good data shows it's needed to prevent protein from being used for energy production instead of muscle protein synthesis.
- Consumes Blueprint Metabolic Protein daily, providing 27 grams of protein, as part of his plant-based approach to ensure a complete amino acid profile.
- Agrees that a little extra calcium is probably okay, especially for women, to really hit home for bone mineral density.
- Recommends having enough protein as part of a balanced diet to improve heart rate recovery.
- Is eating Blueprint's protein as part of their travel food.
Peter Attia · Whey Protein · stopped
- Used to worry about protein timing but now thinks about it less, especially since he doesn't consume whey protein shakes much, if at all, and tends to eat more of his protein.
- Recommends consuming 1.6 to 2.4 grams of protein per kilogram per day, or roughly a gram per pound of body weight, for muscle growth and preservation, especially for older or less active individuals, and aims for 40 to 50 grams of protein four times a day through meals or snacks.
- Notes that the full episode discusses the importance of protein.
- Recommends consuming enough protein, particularly around 130 to 150 grams per day, evenly spaced throughout the day, to maintain lean mass and improve muscle quality, especially when using GLP1 agonists.
- Learned that protein is really important and that if protein intake goes from 250 grams a day to 70-80 grams a day, a lot of muscle will be lost. He recommends a high protein intake, double the RDA, especially for athletes or those trying to gain muscle, to prevent sarcopenia and maintain lean body mass.
- Emphasizes the importance of getting enough protein, especially for an aging population, to combat sarcopenia. He recommends aiming for about one gram per pound of body weight daily and suggests using a food tracking app to monitor intake.
- Will look at interventions that can help improve muscle mass, including protein.
- Recommends that older adults might need a higher daily and per-meal protein dose of 30–40 grams to maximize muscle protein synthesis and increase or maintain muscle mass.
- Recommends around 1.6 g/kg/day of protein to maximize gains in muscle strength and fat-free mass, with potential benefits up to 2.2 g/kg/day for those aiming to fully optimize muscle growth and recovery.
- Peter recommends targeting 2g of protein per kg of body weight for muscle preservation and overall health, especially when trying to lose fat while preserving or gaining muscle.
- Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
- Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
- Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
- Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
RAL Summary
Members OnlyTier 2 for Muscle and Strength
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Musculoskeletal system
Combine with: For muscle building and recovery, pair this whey isolate with creatine monohydrate (3-5 g daily) to support strength and lean mass, and consider added leucine or EAAs around workouts. Vitamin D3 with K2 and magnesium support muscle function, bone health, and recovery, while omega-3 fish oil helps with inflammation and cardiovascular health. If blood sugar support is also a goal, add separate targeted ingredients such as berberine, chromium picolinate, alpha-lipoic acid, or Ceylon cinnamon, and use the whey before or with meals to help moderate post-meal glucose. Anyone on meds should consult a healthcare provider before combining these.
Possible side effects: No major side effects reported. Some buyers found the vanilla flavor too sweet.
Supplement Facts
Includes 1g Added Sugars 0 · Calcium 94 mg · Whey Protein Isolate 25 g
| Calories | 100 | |
| Total Fat | 0.5 g | |
| Cholesterol | 10 mg | |
| Total Carbohydrate | 3 g | |
| Dietary Fiber | 1 g | |
| Total Sugars | 3 g | |
| Includes 1g Added Sugars | ||
| Protein | 21 g | |
| Calcium | 94 mg | |
| Sodium | 75 mg | |
| Whey Protein Isolate | 25 g | † |
| Proprietary Blend | 30 mg | † |
Other ingredients: Vanilla Flavor, Evaporated Cane Juice Sugar, Carboxymethylcellulose Gum, Xanthan Gum, Rebaudioside A (from stevia).
Directions: Mix 1 scoop with at least 8 ounces of water, juice, or preferred beverage daily or as recommended by your health-care practitioner.
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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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