Cellucor C4 Original Pre-Workout Review

C4 Original Pre-Workout Powder from Cellucor is a pre-workout blend built to deliver sustained energy, endurance, and focus for hard training sessions. Each serving provides 200mg of caffeine and 2g of CarnoSyn Beta-Alanine, which the brand says supports muscular endurance. The brand states that the formula is designed for people who want to power through even the toughest sets. The product is presented as having been fueling athletes and fitness enthusiasts for over a decade. The listed key features include Hard Hitting Energy, with 200mg of caffeine for explosive energy in the gym. Muscular Endurance is supported by CarnoSyn Beta-Alanine for endurance during demanding workouts. AI-Powered Peptides refers to PeptiPump, which the page describes as an AI-powered designer peptide found exclusively in C4. Enhanced Focus comes from Huperzine combined with caffeine, which the brand says helps keep the user sharp from the first rep to the last. The page also lists Incredible Flavor, with a variety of flavors and zero sugar or artificial colors. The brand says C4 is backed by 20 years of sports nutrition expertise. The product is marketed to gym-goers and strength trainees, to people doing high-intensity workouts and cardio, and to athletes and fitness enthusiasts in general. The usage directions say to mix one scoop with 6 to 8 ounces of water and consume it 20 to 30 minutes before a workout. Beginners may start with half a scoop to assess their tolerance. The page warns that the product is intended only for healthy adults aged 18 or older. It should not be used by people who are pregnant or nursing, who take nitrates for chest pain, or who take PDE-5 inhibitors. Users are advised to consult a healthcare professional if they take meds, meds, meds, pseudoephedrine, or other medications, or if they have certain medical conditions. The product contains caffeine and should not be combined with other caffeine or stimulant sources. Users should stop use two weeks before surgery. The page also notes trademark and patent information for CarnoSyn, PeptiPump, NO3-T, and Velox. The statements have not been evaluated by the Food and Drug Administration, and the product is not intended to diagnose, treat, cure, or prevent any disease. The page displays a size of 30 servings and offers a subscription option.

Product Focus: Muscle and StrengthAlso covers:Brain
Tier ⓘ
Tier 3 · Rank 17
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 17 within Tier 3 for Muscle and Strength; 36 of 78 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
73 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
87% of 9,246
Biohacker Mentions
10 of 10
Cost per month
$35

Study, Trial or Testing Result Summary

Members Only30 human studies · 13 improved
30 human studies13 improved8 no effect2,546 people studied

This product is graded on caffeine, the only ingredient on the label we have. The label lists 8.9 grams of caffeine per serving, which looks like a recording error, since the store listing gives 150 milligrams. The listing also names beta-alanine, creatine and citrulline, which were not reviewed here. Caffeine taken before training reliably gives a small boost in strength and lifting performance, but it has not been shown to build more muscle over time. A review of fourteen studies found single doses improved muscle strength and endurance, with the biggest strength gains at higher doses [1]. A review of 21 earlier reviews found caffeine improved strength, endurance, power and jumping, mostly in young men [2]. Even very low doses slightly helped strength and lifting speed [3]. Several reviews found the gains mainly in upper body strength, such as bench press, and not in leg strength [4][5]. In a six week trial of 28 trained young adults, daily caffeine did not increase muscle size, strength or endurance more than a placebo [6]. In short, expect a stronger workout on the day, not extra muscle growth from the caffeine itself. Animal and cell studies are never counted.

See all 30 studies →Hide the studies

Review Totals and Summary

Members Only9,246 reviews · 87% positive
9,246 reviews · Amazon 9,162 · Cellucor website 74 · Walmart 10
87% positive8% neutral5% negative

Cellucor C4 Original Pre-Workout is a widely recognized supplement, with about 9246 ratings across various stores. The majority of feedback is positive, with 71% of starred reviews giving it 4 or 5 stars, indicating a generally favorable customer experience. **What it did for buyers** Customers frequently report significant boosts in energy, focus, and endurance during their workouts. Many feel more motivated and experience increased intensity in their training sessions. Users describe a "solid boost of energy without jitters or a crash" and feeling "very energized a few hours after." The product is also credited with improving stamina and providing an "explosive energy!" without causing a racing heart for many. The beta-alanine ingredient often causes a noticeable tingling sensation, which some users enjoy as a sign it's working. **Complaints** The most common complaint revolves around the product's consistency upon arrival. Many customers received tubs where the powder was "clumped so hard it was like one ball" or "rock hard" instead of a fine powder. This issue is often attributed to moisture getting into the product, possibly due to poor storage by sellers, with some advising to "buy it from Walmart, not third party sellers." This clumping makes the product difficult to use and is seen as a sign of low quality by affected buyers. **Taste and form** The Watermelon flavor is overwhelmingly popular and well-received. Reviewers consistently describe it as "refreshing, not too sweet," and "palatable," effectively masking any typical bitterness of supplements. It generally mixes well without clumping when fresh. The product comes in a powder form with a standardized dosage per scoop, and a practical scooper is included in the tub. Some users also appreciate the availability of individual packets. **Value for money** Opinions on value are somewhat mixed but lean positive. While some acknowledge the "price is high, but it's worth it" for the benefits received, others note the "price creeping higher" and being "more expensive than others." However, many still consider it affordable and a good investment given its effectiveness and quality. **Who it suits** This pre-workout appears to suit a broad range of individuals, from "beginners and experienced lifters" looking for an edge. It's ideal for those who "need an extra boost" before training and seek a reliable energy source without experiencing jitters or headaches. However, individuals sensitive to caffeine are advised to reduce their dosage, and those who receive a clumpy product are understandably dissatisfied.

Biohacker Summary

Members Only10 of 10 recommend it
10 of 10 biohackers on our panel recommend it

Caffeine is the main ingredient, and the panel is split between using it and cautioning about it. Most of the ten take it for focus, alertness, and fat burning around fasted exercise, and doses mentioned run from 100 to 150 milligrams up to 100 to 400 milligrams, with 150 to 200 milligrams before a short nap and 300 milligrams slow release in the morning for jet lag. Several pair it with L-theanine for smoother focus and less jitters, and one also pairs it with Alpha GPC and MCT for long stretches of mental work. Many stress timing, saying to stop by noon or after lunch because late caffeine cuts deep sleep, and others warn it can raise stress, restlessness, anxiety, and an afternoon crash, or should be cut before trying to conceive. One panelist came off caffeine for a year, and another says his company stopped using it in a skincare product.

See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Caffeine · uses
    • 31 Oct 2026 · uses · YouTube ↗
      Loves coffee, has the caffeine molecule tattooed on his arm, drinks it every morning, and says it does amazing things for your brain and for how long you can live, but it can't clear most brain fog on its own.
    • 23 Oct 2026 · recommends · Instagram ↗
      Created Danger Coffee, a mineral-enriched, lab-tested, mold-free coffee that delivers rich flavor and clean caffeine without all the junk, and recommends it to others.
    • 22 Oct 2026 · recommends · YouTube ↗
      Dave Asprey's lab proved that caffeine is a flow hack and the only known substance to actually make you flow prone. Coffee will make you more flow prone.
    • 11 Oct 2026 · recommends · Podcast ↗
      Dave explains why the 1:2 ratio of caffeine to L-theanine beats coffee alone for working memory, accuracy, and calm, sustained concentration.
    • 3 Oct 2026 · uses · YouTube ↗
      States that his entire career started on caffeine and he uses it every morning, but notes it's like a loan from your future self, leading to an afternoon crash.
    • 1 Oct 2026 · stopped · YouTube ↗
      Dave Asprey's company used caffeine, which is a safe ingredient, but they stopped using it because it doesn't provide the type of results and change in the skin that newer ingredients do.
    • 3 Sep 2026 · uses · YouTube ↗
      States that caffeine is one of his superpowers and increases the rate of ketone formation, which fuels neurons.
    • 31 Aug 2026 · uses · Instagram ↗
      Once I’ve hydrated and taken my creatine, I reach for Danger Coffee for caffeine and essential minerals in one cup.
    • 22 Aug 2026 · uses · YouTube ↗
      Uses caffeine, noting it blocks adenosine to increase norepinephrine and dopamine signaling, fueling the prefrontal cortex for focus. He mentions it got him through business school and is part of his longevity journey.
    • 13 Aug 2026 · warns · YouTube ↗
      Does not believe caffeine is a nootropic, considering it just a stimulant.
  • Thomas DeLauer · Caffeine · neutral
    • 29 Oct 2026 · neutral · YouTube ↗
      Explains that caffeine from green tea mobilizes fatty acids, which can be converted into ketones, providing a ketone boost, especially in a fasted or low-carb state.
    • 27 Oct 2026 · warns · YouTube ↗
      Warns that treating brain fog with caffeine without addressing underlying inflammation is ineffective and likely to make the situation worse.
    • 21 Oct 2026 · uses · Facebook ↗
      Notes that caffeine significantly increased fat metabolism and fat oxidation during exercise, especially at lower intensities, and that adding coffee around an exercise bout led to more calories and fat burned.
    • 21 Oct 2026 · uses · Instagram ↗
      Says that caffeine significantly increased fat metabolism and that at low intensity cardio or exercise caffeine works better at mobilizing and utilizing fat.
    • 14 Oct 2026 · uses · YouTube ↗
      Might have some caffeine before fasted training.
    • 26 Sep 2026 · recommends · YouTube ↗
      Recommends caffeine as a must on the fasting day to create a low-grade energy demand that forces the body to favor lipolysis.
    • 2 Sep 2026 · recommends · YouTube ↗
      Recommends drinking 150 to 200 mg of caffeine immediately before a 20-minute nap to enhance alertness and performance, as the caffeine peaks when the nap has cleared adenosine.
    • 1 Sep 2026 · recommends · Instagram ↗
      States that caffeine is probably the most studied ergogenic aid with a profound effect on fat mobilization, suggesting that simple is better.
    • 25 Aug 2026 · neutral · YouTube ↗
      Mentions that people try cutting out caffeine when dealing with sleep issues, but it's not always the root cause.
    • 15 Aug 2026 · warns · YouTube ↗
      Warns that consuming more than 50-60 mg of caffeine in the first hour after waking stacks a stimulant on top of the body's natural cortisol-driven alertness, leading to a sharp spike and mid-morning crash, and building tolerance faster.
  • Andrew Huberman · Caffeine · uses
    • 26 Oct 2026 · uses · YouTube ↗
      Used caffeine, taking 400 milligrams, to improve his mood and physical vigor during mundane tasks like swimming, noting that it made life not so bad and allowed him to rip through the water.
    • 26 Oct 2026 · neutral · Podcast ↗
      Mentions caffeine in a discussion about supplement use.
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses caffeine timing as a tool related to sleep.
    • 22 Oct 2026 · warns · YouTube ↗
      He recommends caffeine, in coffee or tea form, or in tablet or capsule form at lower dosages than found in coffee and tea, as a reasonable way to explore stimulant-based approaches for enhancing cognitive function and focus.
    • 1 Oct 2026 · recommends · YouTube ↗
      Huberman states that caffeine can improve focus and concentration, with a general useful range of 100 to 400 milligrams, and most people do well with 100 to 200 milligrams prior to focused work.
    • 1 Oct 2026 · neutral · Podcast ↗
      Discusses caffeine as a tool for improving attention, noting its impact on focus and sleep.
    • 28 Sep 2026 · uses · YouTube ↗
      Mentions that coffee and tea produce caffeine, which were likely defense chemicals, and that plants learned it was better to alter consciousness than kill predators outright.
    • 28 Sep 2026 · uses · Podcast ↗
      Discusses caffeine and its health benefits.
    • 6 Aug 2026 · recommends · Podcast ↗
      Recommends caffeine as a tool to increase motivation and dopamine.
    • 6 Aug 2026 · uses · YouTube ↗
      Huberman explains that regular ingestion of caffeine at safe levels of about 100 to 250 mg increases the number of D2 and D3 dopamine receptors, making circulating dopamine more potent.
  • Dr. Rhonda Patrick · Caffeine · neutral
    • 26 Oct 2026 · neutral · Instagram ↗
      Explains that caffeine can activate AMPK, a cellular energy sensor involved in fat burning and glucose regulation, which helps muscle cells take up glucose and promotes using fatty acids for energy.
    • 2 Oct 2026 · recommends · YouTube ↗
      Recommends pairing caffeine with L-theanine to enhance alertness and focus while mitigating anxiety and jitteriness, suggesting a dose of 100 to 150 mg of caffeine.
    • 30 Sep 2026 · recommends · Facebook ↗
      Recommends pairing coffee with L-theanine to enhance cognitive performance, noting that L-theanine can help balance caffeine’s stimulatory effects.
    • 28 Sep 2026 · warns · YouTube ↗
      Recommends cutting out caffeine in the three months before conception for both men and women, as it affects sperm.
    • 14 Aug 2026 · recommends · Facebook ↗
      Recommends caffeine for alertness and focus, especially when combined with L-theanine to smooth out the response and maintain cognitive benefits, suggesting a practical dose of 100-150 mg.
    • 5 Jun 2026 · recommends · Instagram ↗
      Recommends cutting down or eliminating caffeine when actively trying to conceive.
    • 27 May 2026 · warns · Facebook ↗
      Warns that a very high dose of caffeine, around 350 mg pre-workout, may blunt some of creatine's performance benefit due to opposite effects on muscle relaxation.
    • 24 Mar 2026 · uses · YouTube ↗
      Self-administers 350 mg of caffeine in a bolus right after returning from mass and his workout, and before eating, noting that he likes dark roast Starbucks.
    • 6 Feb 2026 · neutral · Instagram ↗
      The newest literature on Caffeine dose and its link to multiple cardiometabolic disease risk reduction shows that even the ≥400 mg group was healthier than 0 mg.
    • 8 Oct 2025 · neutral · X ↗
      Explains that caffeine works by blocking adenosine, a molecule that builds up and makes one feel tired, and that timing coffee intake is about leveraging adenosine biology for peak cognitive alertness.
  • Siim Land · Caffeine · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      Recommends stopping caffeine earlier to improve sleep.
    • 19 Oct 2026 · neutral · YouTube ↗
      Notes that polyphenolic compounds in coffee, both decaf and regular caffeinated, can influence cellular stress pathways and have been seen to increase autophagy activity in mice, with regular coffee appearing more potent due to caffeine's additional energetic stress.
    • 12 Oct 2026 · recommends · Instagram ↗
      Recommends moving caffeine intake earlier in the day because having it too late can disrupt sleep, especially for slow metabolizers.
    • 12 Oct 2026 · warns · YouTube ↗
      Recommends not having caffeine after lunch, noting that 400 mg 4 hours before bed reduced deep sleep by approximately 30 minutes in a trial, although he personally has a fast caffeine metabolism.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that combining a large dose of glycine with caffeine can amplify negative experiences, as caffeine independently increases arousal and can cause restlessness, anxiety, and increased heart rate.
    • 25 Sep 2026 · recommends · YouTube ↗
      States that regular coffee promotes visceral fat loss, and going from low or zero intake to moderate intake increases fat loss due to caffeine and polyphenols.
    • 15 Jun 2026 · recommends · YouTube ↗
      Suggests that higher caffeine intake might be useful for older people because caffeine raises cortisol, and consuming it in the morning contributes to circadian regulation.
    • 12 Jun 2026 · recommends · YouTube ↗
      States that caffeine has proven benefits for increasing exercise performance when used correctly and at the right time.
    • 7 Jun 2026 · neutral · X ↗
      States that caffeine raises blood pressure, but mostly if one is not used to consuming it, and habitual caffeine consumers develop tolerance to these effects.
    • 6 Jun 2026 · neutral · X ↗
      Quotes a tweet suggesting that without caffeine, civilization would be 100 years behind.
  • Ben Greenfield · Caffeine · stopped
    • 24 Oct 2026 · stopped · Facebook ↗
      Came off caffeine for a year after his separation.
    • 24 Oct 2026 · stopped · Podcast ↗
      Quit caffeine in the same year he quit testosterone replacement therapy and alcohol.
    • 22 Oct 2026 · uses · YouTube ↗
      Uses caffeine, such as coffee or green tea, in his morning fasted fat-burning session to slightly increase the oxidation of fats.
    • 17 Oct 2026 · warns · YouTube ↗
      Advises against relying on caffeine for morning energy, suggesting that natural sugar-based stimulants combined with hydration and meditation can provide sufficient wakefulness.
    • 27 Sep 2026 · recommends · Facebook ↗
      Recommends Caffeine, noting that it can improve focus, mood, and training, help control appetite, raise calories burned, and reduce fatigue.
    • 18 Sep 2026 · neutral · X ↗
      Notes that 3 mg/kg of caffeine increases fat oxidation by 31%, and 5 mg/kg increases it by 51% compared to a placebo.
    • 16 Sep 2026 · neutral · X ↗
      Caffeine on its own isn’t particularly impressive as an ergogenic aid, but when combined with taurine, there are significant increases in power production.
    • 14 Sep 2026 · neutral · X ↗
      Mentions that caffeine can help mitigate the negative effects of a caloric deficit on lean muscle mass and metabolism.
    • 11 Sep 2026 · neutral · X ↗
      Has talked before about caffeine as a supplement that seems to assist with sleep deprivation.
    • 5 Sep 2026 · warns · X ↗
      Warns that energy drinks can deliver large doses of caffeine quickly, which may overstimulate the heart and cause abnormal heart rhythms and electrocardiogram changes, especially in children.
  • Dr. Mark Hyman · Caffeine · warns
    • 7 Oct 2026 · warns · YouTube ↗
      Discusses with patients their caffeine consumption, suggesting that too much caffeine can artificially increase their stress response.
    • 17 Sep 2026 · recommends · X ↗
      Recommends stopping caffeine by noon.
    • 31 Aug 2026 · neutral · YouTube ↗
      States that caffeine's effect on ADHD depends on the person, as it can help focus but also activate irritation or stress, and its impact is related to individual caffeine metabolism.
    • 20 Jul 2026 · warns · YouTube ↗
      Warns that drinking coffee first thing in the morning before eating layers caffeine on top of already elevated stress hormones, providing unsustainable energy and setting up for an afternoon crash.
    • 29 Jun 2026 · neutral · Facebook ↗
      Notes that caffeine is one of the things that drives the hormone imbalance causing PMS.
    • 1 Jun 2026 · warns · YouTube ↗
      States that drinking coffee on an empty stomach, which is how most people do it, is probably not the best thing as it gives a jolt of caffeine and adrenaline before eating.
    • 25 May 2026 · warns · YouTube ↗
      Warns that caffeine, alcohol, and spicy foods can be potent triggers for hot flashes, and excess caffeine should be avoided.
    • 21 May 2026 · warns · Facebook ↗
      Warns that adding fiber does not cancel out the negative effects of caffeine and other processed additives.
    • 18 May 2026 · warns · YouTube ↗
      Warns that high caffeine intake, especially coffee, can contribute to dehydration by increasing fluid loss and masking fatigue, leading to a deficit if not balanced with sufficient water intake.
    • 14 May 2026 · warns · Facebook ↗
      Warns that caffeine without adequate protein creates blood sugar chaos, sending a stress signal to the brain and hindering healing.
  • Dr. Eric Berg · Caffeine · warns
    • 25 Sep 2026 · warns · Podcast ↗
      Warns that caffeine can keep you awake and advises to watch out for hidden sources of caffeine.
    • 14 Sep 2026 · warns · Facebook ↗
      Stimulating the body with caffeine can actually make fatigue worse.
    • 8 Sep 2026 · warns · Facebook ↗
      Dr. Berg warns that stimulating the body with caffeine can actually make fatigue worse.
    • 31 Aug 2026 · warns · Instagram ↗
      Warns that too much caffeine is a common cause of worry, indecision, fear, and tension, and that it depletes vitamin B1, negatively affecting the nervous system.
    • 3 Aug 2026 · warns · Facebook ↗
      Warns that even a lot of caffeine in the morning can inhibit melatonin at night.
    • 29 Jul 2026 · warns · Instagram ↗
      Warns that coffee does not give you energy; instead, caffeine binds to adenosine receptors, inhibiting sleep signals and merely preventing sleepiness.
    • 18 Jul 2026 · warns · Instagram ↗
      States that caffeine can affect the ability to absorb magnesium and cause a deficiency.
    • 12 Jul 2026 · warns · YouTube ↗
      Warns that drinking caffeinated beverages later in the day can keep you awake because the liver needs to detoxify the caffeine.
    • 25 Jun 2026 · warns · YouTube ↗
      Warns that consuming caffeine can worsen tinnitus, citing a person who noticed this effect.
    • 28 Apr 2026 · warns · Podcast ↗
      Stimulating the body with caffeine can actually make fatigue worse.
  • Bryan Johnson · Caffeine · uses
    • 23 Sep 2026 · uses · YouTube ↗
      Drinks coffee when starting to fade, ensuring the last cup is between 10 and 12 hours before bed so caffeine doesn't affect sleep.
    • 18 Jun 2026 · uses · X ↗
      Used 300 mg of caffeine in the morning as part of their jet lag recovery.
    • 7 Jun 2026 · uses · X ↗
      Uses 300 mg of slow release caffeine in the morning as part of a jet lag recovery protocol.
    • 25 Apr 2026 · neutral · X ↗
      Notes that coffee affects the gut, which then affects the brain, and that it is the coffee bean, not the caffeine, doing most of the work.
    • 19 Nov 2025 · warns · YouTube ↗
      Notes that the culture in DC involves running on caffeine, along with alcohol and sleep deprivation, leading to poor nutrition and an unhealthy environment.
    • 3 Jul 2025 · warns · YouTube ↗
      Warns that caffeine has a 6-hour half-life, so consuming it later in the day will leave a significant amount in the body at bedtime, recommending consumption earlier in the day.
    • 12 Apr 2025 · recommends · YouTube ↗
      Recommends consuming no caffeine past noon due to its 6-hour half-life, suggesting that if sleep is nailed, caffeine might not be needed.
    • 6 Nov 2024 · warns · YouTube ↗
      Warns against stimulants like caffeine for sleep, advising to have the last cup of coffee before noon if going to bed at 10:00 p.m.
    • 16 Oct 2024 · stopped · YouTube ↗
      Advises that if one is going to drink caffeine, they should try to have it earlier in the day and experiment to find the right time that doesn't disrupt their sleep.
    • 23 Mar 2024 · stopped · YouTube ↗
      Has stopped all caffeine, as it has helped him improve his sleep.
  • Peter Attia · Caffeine · uses
    • 16 Aug 2026 · uses · YouTube ↗
      States that he needs two to three times the normal dose of any medication or drug to feel an effect, including caffeine, and can drink four cups of coffee without feeling anything.
    • 4 Jan 2026 · neutral · YouTube ↗
      Mentions data suggesting caffeine might be more helpful in the luteal phase to help with fatigue components.
    • 12 Dec 2025 · uses · YouTube ↗
      Uses caffeine in combination with Alpha GPC, MCT, and Theanine, often adding it to coffee for long periods of cognitive work.
    • 7 Dec 2025 · uses · YouTube ↗
      Finds Alpha GPC works well with caffeine, and he puts a product containing Alpha GPC, MCT, and caffeine into his coffee for long periods of cognitive work.
    • 4 May 2025 · neutral · YouTube ↗
      Mentions that experimenting with the timing of caffeine is a great idea for sleep.
    • 27 Mar 2025 · warns · YouTube ↗
      Warns that decaffeinated coffee can contain significant amounts of caffeine and advises cutting off all coffee, including decaf, by 11 a.m. for better sleep quality.
    • 23 Mar 2025 · warns · YouTube ↗
      Explains that caffeine is problematic because it blocks adenosine receptors, leading to a 'caffeine crash' when it wears off and adenosine floods the receptors, causing sleepiness.
    • 10 Dec 2024 · neutral · YouTube ↗
      States that caffeine does not wake him up, which contributed to his belief that he did not have an addiction gene.
    • 14 Oct 2024 · neutral · YouTube ↗
      States that caffeine does not wake him up.
    • 10 Oct 2024 · warns · YouTube ↗
      Warns that constantly consuming caffeine and Red Bull to turn up the sympathetic dial is a sign that the sympathetic system isn't working as it should, possibly due to overstimulation from stress.

RAL Summary

Members OnlyTier 3 for Muscle and Strength

76% of 84 reviews are positive, and human studies show caffeine gives a small short-term gain in strength and endurance [1][2]. Longer trials show no added muscle growth [6], so the study support is only partial.

Where the evidence disagrees: 8 of the 30 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Muscular system, Nervous system

Combine with: To further enhance muscle building and recovery alongside C4 Original Pre-Workout, consider stacking it with a high-quality protein powder (such as whey or casein) to support muscle repair and growth, especially post-workout. Essential Amino Acids (EAAs) or Branched-Chain Amino Acids (BCAAs) can further aid in muscle protein synthesis and reduce breakdown. Omega-3 fatty acids are beneficial for reducing exercise-induced inflammation and supporting overall joint health, which is crucial for consistent training. Additionally, a multivitamin or specific micronutrients like Vitamin D3 and Magnesium can support overall physiological functions, bone health, and muscle function, contributing to optimal performance and recovery.

Possible side effects: The caffeine studies reported no major side effects. No written reviews could be read, so nothing is known about the side effects reviewers mention.

Supplement Facts

Includes 0g Added Sugars 0 g · Vitamin B6 3.4 mg · Folate 100 mcg DFE
Supplement Facts
Serving Size 8.9g (Approx. 1 level scoop)
Servings Per Container 30
Amount Per Serving% Daily Value
Calories10
Total Carbohydrate1 g<1%
Total Sugars0 g
Includes 0g Added Sugars0 g0%
Vitamin B6 (as Pyridoxal-5-Phosphate)3.4 mg200%
Folate (as 6S-5-Methyltetrahydrofolate calcium salt)100 mcg DFE25%
Vitamin B12 (as Methylcobalamin)6 mcg250%
Choline (as Choline Bitartrate)225 mg41%
Muscular Endurance & Performance Booster4.5 g†
CarnoSyn® Beta-Alanine2 g†
Velox® Patented Performance Blend1.2 g†
L-Citrulline1.2 g†
L-Arginine1.2 g†
PeptiPump® Bioactive Lentil peptides100 mg†
Creatine Nitrate (as NO3-T®)1 g†
Explosive Energy & Focus Complex205 mg†
Caffeine Anhydrous200 mg†
Toothed Clubmoss (Huperzia serrata) aerial parts extract (std. 1% Huperzine A)5 mg†
* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.

Other ingredients: Other Ingredients: Citric Acid, Malic Acid, Silicon Dioxide, Natural & Artificial Flavors, Calcium Silicate, Sucralose, Acesulfame Potassium, Spirulina Extract (color).

Label source: Cellucor · Report a label change

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Our articles on this subject

Graded October 26, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.