dr.bo 15 Day Colon Detox Review

Tier ⓘ
Tier 4 · Rank 11
Tier 4 · Emerging. A promising mechanism or animal data, with thin human evidence so far. Rank 11 within Tier 4 for Digestion and Bloating; 44 of 53 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
15 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Biohacker Mentions
0 of 10

Study, Trial or Testing Result Summary

Members Only150 human studies · 79 improved
150 human studies79 improved40 no effect64,435 people studied

This colon cleanse mainly combines two stimulant laxative herbs, senna and cascara sagrada, with smaller amounts of fiber, aloe, a probiotic, licorice and oil. Reviews of 41 trials found good evidence that senna works as a first-line laxative for long-term constipation, but bloating, cramping and belly pain were common [1][2]. In 82 people with constipation after chemotherapy, senna relieved constipation in about 93 percent [3]. It is unclear whether this product's senna dose matches the studied amounts. Cascara sagrada has only been tested inside a fiber blend, which improved bowel movements but could cause stomach pain [4]. The probiotic Lactobacillus acidophilus is roughly at a studied amount, and one strain eased pain and bloating in people with irritable bowel syndrome [5]. The strain here is not named, and another strain showed no benefit [6]. Psyllium is present only in a trace amount, far below the 7.5 to 10 grams that helped constipation in studies [7]. Flaxseed, aloe and licorice have weak or mixed evidence [8][9][10]. Medium chain fats often cause belly pain or diarrhea, though the amount here is very small [11]. Animal and cell studies are never counted.

See all 150 studies →Hide the studies

Review Totals and Summary

Members OnlyWhat buyers say

Extensive customer reviews and qualitative feedback are currently being aggregated for this product. Check back soon for a detailed sentiment analysis.

Biohacker Summary

Members Only0 of 10 recommend it
0 of 10 biohackers on our panel recommend it

Only four of the ten panelists spoke about Lactobacillus acidophilus, the main ingredient, and they split: two recommend it, one is neutral, and one warns against it. The two who recommend it point to foods like yogurt, kefir, sauerkraut and buttermilk, and cite its ability to degrade microplastics and its support of vaginal and urinary health. The neutral comment only noted it as a probiotic in a meal replacement, while the one who warns says it grows fast, crowds out other good bacteria, can make weight loss and digestion harder, and is pro-inflammatory. Nobody gave a dose or a preferred form beyond food sources, and no one said they stopped taking it. Psyllium, flaxseed, licorice and aloe vera are smaller ingredients in this product, and licorice drew the most caution because it can raise cortisol and blood pressure and should be used carefully with meds.

See all 10 biohackers →Hide the biohackers
  • Siim Land · Lactobacillus acidophilus · recommends
    • 20 Aug 2025 · recommends · YouTube ↗
      Lists Lactobacillus acidophilus as a researched probiotic strain that can degrade microplastics, found in yogurt, kefir, sauerkraut, and kombucha.
    • 4 Nov 2026 · Psyllium · recommends · YouTube ↗
      Suggests trying psyllium husk to improve lipids and blood sugar.
    • 7 Oct 2026 · Psyllium · recommends · Instagram ↗
      Recommends Psyllium husk for LDL, blood sugar and gut health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · Psyllium · neutral · X ↗
      Lists Psyllium husk as one of 15 supplements backed by human studies.
    • 21 Aug 2026 · Psyllium · neutral · X ↗
      Notes that kiwis were as effective as psyllium matched for fiber in improving constipation symptoms.
    • 1 Jul 2026 · Psyllium · uses · YouTube ↗
      Takes 10 grams of psyllium husk mixed with yogurt.
    • 28 Dec 2025 · Psyllium · recommends · YouTube ↗
      Considers psyllium husk 'god tier' as a high source of fiber that helps with cholesterol and digestion, calling it one of the easiest ways to lower cholesterol.
    • 28 Dec 2025 · Aloe Vera · neutral · YouTube ↗
      Mentions aloe vera as a natural agent with an SPF of 7, which can be used as a complementary ingredient in sunscreens but is insufficient as a primary sunscreen.
    • 23 Aug 2025 · Psyllium · uses · Instagram ↗
      Includes 1 tbsp of psyllium husk in their first meal of the day.
    • 16 Aug 2025 · Psyllium · recommends · YouTube ↗
      Recommends Psyllium Husk as a food powder that is a high source of fiber, helps with cholesterol, and aids digestion.
    • 4 Apr 2025 · Flaxseed · recommends · YouTube ↗
      Suggests consuming ground flaxseed as it contains lignans and polyphenols, which are beneficial for liver health, and are a better alternative than milk thistle.
    • 15 Feb 2025 · Licorice · warns · YouTube ↗
      Warns that licorice root, often found in thyroid supplements, can raise adrenaline levels, leading to overstimulation and anxiety.
    • 24 Sep 2024 · Psyllium · uses · YouTube ↗
      Gives Apollo psyllium husk mixed with his food to support daily bowel movements.
    • 20 Aug 2024 · Psyllium · uses · YouTube ↗
      Adds psyllium husk to his protein shake to make it thicker.
  • Thomas DeLauer · Lactobacillus acidophilus · warns
    • 11 Jul 2018 · warns · YouTube ↗
      Warns against Lactobacillus acidophilus, stating that its rapid growth crowds out other good bacteria, creates a monopoly, and can make it harder to lose weight, digest food, and go to the bathroom, while also being pro-inflammatory.
    • 12 Oct 2026 · Psyllium · recommends · YouTube ↗
      Recommends psyllium husk as a powerful source of soluble fiber to aid in detoxification by binding to bile acids and speeding up gut transit time.
    • 28 Sep 2026 · Psyllium · recommends · YouTube ↗
      Recommends psyllium fiber as one of the things that support the gut.
    • 5 Sep 2026 · Psyllium · recommends · YouTube ↗
      Suggests using psyllium as an alternative to oatmeal for lowering cholesterol, implying it works through the same mechanism of binding to bile salts.
    • 4 Sep 2026 · Psyllium · uses · Instagram ↗
      Uses 5g of psyllium husk pre meals because the viscous gel it forms slows gastric emptying.
    • 1 Sep 2026 · Psyllium · recommends · Instagram ↗
      Recommends Psyllium, stating that it can help move ingested microplastics through the gut, as studies show microplastics in feces.
    • 26 Aug 2026 · Psyllium · recommends · YouTube ↗
      Recommends adding psyllium husk to carbs to slow down how fast they hit the bloodstream, thereby preventing visceral fat accumulation.
    • 3 Aug 2026 · Psyllium · recommends · YouTube ↗
      Recommends psyllium as a good fiber supplement choice, noting it has a strong research track record, forms a gel to slow glucose, curbs appetite, and shifts gut bacteria to increase butyrate producers.
    • 3 Aug 2026 · Psyllium · recommends · YouTube ↗
      Recommends taking 5 to 10 grams of psyllium husk mixed with water, allowing it to form a gel, 5 to 10 minutes before a carb-heavy meal to create a physical barrier in the gut that slows glucose absorption.
    • 30 Jul 2026 · Psyllium · recommends · YouTube ↗
      Suggests using psyllium husk as a prebiotic fiber to pair with collagen.
    • 7 Jul 2026 · Psyllium · recommends · YouTube ↗
      If someone needs to bring on fiber, Thomas DeLauer recommends starting with a small amount of psyllium and gradually increasing it.
    • 30 Nov 2024 · Aloe Vera · recommends · YouTube ↗
      Recommends drinking organic aloe vera juice without added sugars or preservatives to coat the esophagus and provide relief from heartburn.
    • 30 Nov 2024 · Licorice · recommends · YouTube ↗
      Recommends DGL (deglycyrrhizinated licorice), especially when combined with aloe vera gel and slippery elm, to be taken any time for symptoms of acid reflux.
    • 4 Sep 2024 · Aloe Vera · uses · YouTube ↗
      Has been taking aloe vera juice for the first time ever as of this morning, hoping it starts working for digestion.
  • Ben Greenfield · Lactobacillus acidophilus · neutral
    • 27 May 2017 · neutral · YouTube ↗
      Ben Greenfield mentions lactobacillus acidophilus as a probiotic included in Ample meal replacement.
    • 14 Mar 2026 · Psyllium · warns · YouTube ↗
      Notes that psyllium husk has been shown to slow glucose absorption and improve hemoglobin A1c at 10g a day, but he doesn't like it because it can irritate the digestive tract and cause gastric inflammation at those doses.
    • 22 Feb 2025 · Aloe Vera · recommends · YouTube ↗
      Recommends topical aloe vera for hair growth, noting that dermarolling can enhance its absorption.
    • 31 Jan 2025 · Aloe Vera · recommends · YouTube ↗
      Recommends using aloe vera after sun exposure to maintain overall skin health.
    • 19 Dec 2024 · Psyllium · neutral · YouTube ↗
      Mentions that his teachers never taught him what to do if constipated beyond just taking a bunch of psyllium husk.
    • 5 Oct 2024 · Psyllium · neutral · YouTube ↗
      Ben Greenfield mentions psyllium husk extract as a potential solution for constipation.
    • 6 Jun 2024 · Psyllium · warns · YouTube ↗
      Warns that taking psyllium powder or fiber without water could result in an intestinal obstruction and constipation.
    • 23 May 2024 · Licorice · recommends · Podcast ↗
      Mentions that a report for a client with high gut inflammation suggested using DGL, a form of licorice acid.
    • 18 Apr 2024 · Aloe Vera · recommends · YouTube ↗
      Recommends aloe vera for H. pylori issues in the gut.
    • 18 Apr 2024 · Licorice · recommends · YouTube ↗
      Recommends some forms of DGL licorice for H. pylori issues in the gut.
    • 6 Apr 2024 · Licorice · recommends · YouTube ↗
      Recommends licorice root to delay the conversion of cortisol to cortisone, but warns against high doses found in many supplements, suggesting a very low dose of about 20 milligrams.
    • 4 Jan 2024 · Psyllium · neutral · YouTube ↗
      Notes that psyllium fiber showed decent certainty of evidence for weight loss in a meta-analysis, attributing its effect to being fiber-based and promoting fullness.
    • 16 Dec 2023 · Licorice · neutral · YouTube ↗
      Mentions YumEarth licorice as a healthier alternative to Twizzlers.
    • 10 Aug 2023 · Flaxseed · recommends · YouTube ↗
      Recommends flaxseeds for wound healing by stimulating collagen synthesis and for their anti-inflammatory properties, noting their effect on epithelial tissues and potential for cancer inhibition.
  • Dr. Eric Berg · Lactobacillus acidophilus · recommends
    • Date not recorded · recommends · Website ↗
      Dr. Berg states that Lactobacillus acidophilus, found in yogurt, sauerkraut, aged cheeses, and buttermilk, supports vaginal health by maintaining a balanced microbiome within the urinary tract and may help reduce the risk of infections.
    • 18 Sep 2026 · Psyllium · recommends · Instagram ↗
      Recommends using psyllium husk powder as an ingredient for making healthy bread.
    • 3 Sep 2026 · Licorice · recommends · Facebook ↗
      Recommends Licorice root, noting it has traditionally been used to soothe the throat and respiratory tract.
    • 24 Aug 2026 · Licorice · recommends · Podcast ↗
      Recommends Licorice root, noting its traditional use to soothe the throat and respiratory tract during chest infections.
    • 22 Aug 2026 · Licorice · recommends · YouTube ↗
      Recommends licorice root as an ancient remedy that is great for sore throats, viral-related issues, lung infections, coughing, and asthma attacks, suggesting it be taken orally as a supplement.
    • 15 Aug 2026 · Flaxseed · warns · Facebook ↗
      Advises avoiding flaxseed due to its estrogenic effects.
    • 14 Aug 2026 · Psyllium · recommends · YouTube ↗
      Suggests psyllium husk as a fiber that can bind to bile salt to help with excess bile and prevent diarrhea.
    • 12 May 2026 · Psyllium · uses · TikTok ↗
      Uses ¼ cup of psyllium husk powder in their healthy bread recipe.
    • 23 Apr 2026 · Psyllium · uses · Podcast ↗
      Dr. Berg uses ¼ cup of psyllium husk powder as an ingredient in his healthy bread recipe.
    • 22 Apr 2026 · Psyllium · uses · YouTube ↗
      Includes psyllium husk powder as an ingredient in their recommended healthy bread recipe.
    • 8 Mar 2026 · Flaxseed · neutral · YouTube ↗
      Lists flaxseed as a type of fiber that can help increase short-chain fatty acids and activate GLP-1, suggesting it can be put in a shake with kefir.
    • 2 Feb 2026 · Licorice · warns · Podcast ↗
      Dr. Berg warns that consuming too much licorice, even chronic low doses like 100 mg of licorice candy daily for 2 weeks or two cups of licorice tea per day, can cause sodium retention, potassium flushing, muscle cramps, and heart arrhythmias, especially for older individuals, those with high blood pressure, or those on certain medications.
    • 28 Nov 2025 · Flaxseed · stopped · YouTube ↗
      Dr. Berg used to recommend flaxseed as superfoods for the heart, but now he advises against them because they don't provide essential nutrients like protein and can lead to bloating and low energy. He also notes that flaxseed has ALA, a precursor to DHA and EPA, but the conversion is not great.
    • 17 Apr 2025 · Aloe Vera · recommends · Podcast ↗
      Recommends aloe vera juice because it potently affects the cells that make insulin.
  • Dr. Mark Hyman · Flaxseed · recommends
    • 19 Oct 2026 · recommends · YouTube ↗
      Recommends ground flaxseed as a wonderful fiber that helps with binding toxins and is rich in omega-3 fats.
    • 7 Sep 2026 · recommends · YouTube ↗
      Recommends flaxseeds as particularly good for binding excess estrogen in the gut to help with estrogen dominance.
    • 7 Sep 2026 · Psyllium · neutral · YouTube ↗
      States that psyllium is good if used strategically and if it's tolerated.
    • 22 Jun 2026 · Licorice · recommends · YouTube ↗
      Recommends licorice to help repair the gut lining.
    • 9 May 2026 · uses · TikTok ↗
      Includes 1/4 cup ground golden flaxseeds in a bread recipe.
    • 29 Nov 2024 · Licorice · recommends · YouTube ↗
      Recommends licorice root, marshmallow root, and slippery elm bark as herbs that can help soothe the gut lining, reduce inflammation, and promote healing, especially when taken in powdered form or as a tea before or after meals or before bed.
    • 13 Sep 2024 · Licorice · uses · YouTube ↗
      Includes licorice in herbal antimicrobial regimens.
    • 6 Sep 2024 · Psyllium · recommends · YouTube ↗
      Mentions psyllium as helpful for gut health.
    • 6 Sep 2024 · Licorice · recommends · YouTube ↗
      Recommends licorice root as a gut-healing nutrient.
    • 16 Jun 2024 · recommends · TikTok ↗
      Recommends flaxseed as a great source of healthy fats.
    • 3 Apr 2024 · Aloe Vera · uses · YouTube ↗
      Uses aloe vera for increased intestinal permeability, which they commonly observe in patients, including professional athletes.
    • 18 Oct 2023 · uses · TikTok ↗
      Uses 1 tablespoon of whole flaxseed or chia seed in their cold brew shake.
    • 11 Nov 2022 · Licorice · recommends · YouTube ↗
      Recommends DGL (deglycerized licorice) as a supplement for reflux, suggesting chewing two or three tablets before eating and before bed.
    • 15 Jun 2022 · recommends · YouTube ↗
      Recommends adding ground flaxseed to the diet as it is a great source of fiber and omega-3 fats that can improve cholesterol profile.
  • Andrew Huberman · Psyllium · uses
    • 21 Sep 2026 · uses · YouTube ↗
      Mentions that he recently started supplementing with powdered psyllium husk and found that it made post-meal sensations feel good, which he did not expect.
    • 27 Jul 2026 · neutral · YouTube ↗
      Mentions that some family members take a small amount of psyllium husk to increase fiber, which is inexpensive and can benefit colon health and reduce inflammation for most people.
    • 8 Jun 2026 · neutral · YouTube ↗
      Mentions that doctors are now telling many people to take a little bit of psyllium husk for supplemental fiber, noting it's ground into a powder.
    • 1 Oct 2025 · Licorice · warns · Instagram ↗
      Mentions that a component of licorice root can significantly increase cortisol but warns that it can be contraindicated with many medications.
    • 9 Aug 2025 · Licorice · warns · Instagram ↗
      Warns that licorice root potently increases cortisol and should be avoided at night and approached with caution, as it can raise blood pressure and is contraindicated with some medications.
    • 5 Aug 2025 · Licorice · uses · Instagram ↗
      States that licorice root is a potent elevator of cortisol and can be used early in the day, but advises caution due to potential medication interactions, and mentions personally using it in the morning.
    • 4 Aug 2025 · Licorice · recommends · Podcast ↗
      Recommends black licorice as a nutritional strategy to increase morning cortisol.
    • 1 Jul 2024 · Licorice · recommends · YouTube ↗
      Mentions evidence that licorice root can be of benefit for rosacea, typically found in a topical ointment.
    • 2 May 2022 · Flaxseed · neutral · YouTube ↗
      States that flaxseeds are a high plant source of ALA.
    • 3 May 2021 · Licorice · warns · Podcast ↗
      Warns that licorice increases cortisol and blood pressure, and reduces testosterone due to glycyrrhizin.
    • Date not recorded · Licorice · warns · Website ↗
      Licorice, specifically black licorice, contains glycyrrhizin, which increases cortisol and can decrease estrogen and testosterone, and also increases blood pressure, making it a bad idea if you're trying to optimize testosterone and estrogen or during periods of chronic stress.
  • Dr. Rhonda Patrick · Psyllium · uses
    • 10 Sep 2026 · uses · Facebook ↗
      If Dr. Rhonda Patrick needs fuel before training, they will have a homemade muffin made with psyllium husk.
    • 8 Sep 2026 · uses · Facebook ↗
      Rhonda's current diet includes a homemade blueberry, whey protein, and psyllium husk muffin as a pre-workout.
    • 7 Aug 2026 · recommends · Facebook ↗
      Recommends soluble fibers like psyllium husk, stating they form a viscous gel that can limit microplastic absorption.
    • 8 Jun 2021 · neutral · YouTube ↗
      States that arabinoxylan, which is found in psyllium husk, will actually drop cholesterol.
    • 6 Jan 2015 · Flaxseed · uses · YouTube ↗
      Dr. Patrick adds about one tall shot glass full of flaxseed to her smoothie, noting it's a great source of soluble fiber and alpha-linoleic acid, a plant omega-3 fatty acid.
    • Date not recorded · neutral · Website ↗
      Dr. Rhonda Patrick discusses beta-glucan versus psyllium for lowering LDL.
  • Dave Asprey · Psyllium · warns
    • 9 Sep 2026 · warns · YouTube ↗
      States that psyllium husk does not have a prebiotic effect and can cause rapid fermentation and bloating, which is counterintuitive to gut health. He also mentions that in high doses, it can be abrasive and not nourishing to the microbiome.
    • 1 Jan 2026 · Licorice · recommends · YouTube ↗
      Recommends licorice root extract (not DGL) as an effective way to increase cortisol, especially for those with chronic fatigue syndrome, but advises caution for individuals with high blood pressure.
    • 27 Nov 2025 · Flaxseed · warns · YouTube ↗
      States that a lot of natural foods, such as flaxseed, are not good for you.
    • 1 Apr 2025 · Aloe Vera · recommends · YouTube ↗
      Recommends aloe vera juice or liquids to strengthen the entire digestive tract.
    • 23 Apr 2024 · Licorice · uses · YouTube ↗
      Says he takes herbs like licorice root to support his body's ability to have a healthy stress response during global public speaking trips.
    • 7 Nov 2023 · Licorice · uses · YouTube ↗
      Started using licorice root to support adrenal function and recovery from adrenal fatigue.
    • 10 Oct 2023 · Flaxseed · neutral · YouTube ↗
      Mentions that flaxseed feeds the beta line, which is the good estrogen you want in your breast.
    • 4 Aug 2023 · Licorice · recommends · YouTube ↗
      Mentions licorice root as a way to keep blood pressure up if needed.
    • 18 Apr 2023 · Licorice · neutral · YouTube ↗
      Mentions taking licorice root extract as part of a protocol for adrenal fatigue.
    • 8 Nov 2022 · Aloe Vera · uses · YouTube ↗
      Uses aloe vera as a beautiful ingredient in their products.
    • 24 Aug 2022 · recommends · Podcast ↗
      Dave Asprey highlights activated psyllium as the star ingredient in Uprising Food, detailing its benefits as a prebiotic fiber and bio-active polysaccharide.
    • 12 Jan 2022 · Licorice · recommends · YouTube ↗
      Recommends deglycerated licorice (DGL) to help protect the gut, emphasizing that it must be deglycerinated to avoid raising blood pressure.
    • Date not recorded · Licorice · recommends · Website ↗
      Mentions licorice root as a way to keep blood pressure up if needed.
  • Bryan Johnson · Flaxseed · uses
    • 1 Jul 2026 · uses · X ↗
      Uses ground flaxseed as an ingredient in Nutty Pudding.
    • 27 Jul 2023 · uses · YouTube ↗
      Includes flaxseed in his Nutty Pudding, which he consumes an hour after his Super Veggie.
    • Date not recorded · uses · Website ↗
      Bryan Johnson uses 1 tsp of ground flaxseeds in his Nutty Pudding.
  • Peter Attia · Psyllium · neutral
    • 9 Nov 2025 · neutral · YouTube ↗
      Identifies psyllium husk as a common soluble fiber supplement.
    • 6 Apr 2025 · Aloe Vera · recommends · YouTube ↗
      Says that patients can use an aloe vera plant if they have it for skin reactions from radiation.
    • 28 May 2023 · Licorice · recommends · YouTube ↗
      Recommends licorice root as a potent ingredient in adrenal support supplements to help increase cortisol levels in patients with low free cortisol, citing an anecdote about its strong effect.
    • 22 Dec 2019 · warns · YouTube ↗
      States that psyllium husk is soluble fiber, and while the food industry adds it to products like Fiber One bars, it doesn't make a difference because both soluble and insoluble fiber are needed for functional fiber.
    • Date not recorded · uses · Website ↗
      Takes 30 grams of psyllium fiber twice a day for cholesterol.

RAL Summary

Members OnlyTier 4 for Digestion and Bloating

Senna and a probiotic have human support for regularity and bowel symptoms, but there are no counted reviews, and the stimulant laxatives often cause cramping and bloating, so the evidence stays emerging [1][5].

  • Emerging: not enough evidence to rank higher yet.

Where the evidence disagrees: 40 of the 150 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system

Combine with: Combine with a healthy diet and lifestyle.

Possible side effects: Studies of senna and cascara sagrada report cramping, belly pain and bloating, and flaxseed and medium chain fats were linked to bloating, diarrhea and nausea at higher doses.

Supplement Facts

Senna Leaf Extract 285 mg · Cascara Sagrada bark extract 300 mg · Psyllium, Powder 300 mg
Supplement Facts
Serving Size 1-2 Capsule(s)
Servings Per Container 15
Amount Per Serving% Daily Value
Senna Leaf Extract285 mg†
Cascara Sagrada bark extract300 mg†
Psyllium, Powder300 mg†
Flaxseed, Powder100 mg†
Aloe vera Leaf Gel Concentrate80 mg†
Lactobacillus acidophilus50 mg†
Licorice Root Extract50 mg†
Medium Chain Triglycerides Oil14 mg†
† Daily Value not established.

Other ingredients: Bovine Gelatin, Magnesium Stearate, Silicon Dioxide, Rice Flour.

Directions: Suggested use: For occasional use only: 1 to 2 capsules taken at bedtime with 10 ounces of water or as directed by your healthcare professional.

Label source: NIH label database · Report a label change

Show entire label
The dr.bo 15 Day Colon Detox label, 30 Capsule(s)
15 Day Colon Detox, 30 Capsule(s)

More digestion and bloating products

Members OnlyThe highest ranked for the same goal

Read more

Our articles on this subject

Graded November 14, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.