GNC Mega Men 50 Plus Multivitamin Review

GNC Mega Men 50 Plus Multivitamin for Men, Heart & Prostate, 120 Count is a men's multivitamin sold by GNC and listed on Amazon with an Item Form of Caplet, a Dosage Form of Capsule, and a Container Type of Bottle. The page highlights a clinically studied antioxidant formula that supports heart health, prostate health, and protection against free radicals. According to the bullets, the formula offers more antioxidant power than ever and over 30 clinically studied ingredients in every formula, in smaller and easier-to-swallow pills. The product is positioned for men's health and is described as containing a clinically studied men's multivitamin shown to work better than a basic multivitamin, with support for colon health. Antioxidants are included to help protect against harmful free radicals that can destroy healthy cells and promote cell aging. For heart health, the page notes that the formula includes vitamin B-6 and folic acid, which provide dietary support for the cardiovascular system. For prostate and circulatory support, the page says it features lycopene and saw palmetto to support prostate function, along with L-arginine, which helps maintain blood vessel tone and plays a key role in sexual health. The product details list the product benefit as a men's 50+ multivitamin with saw palmetto and lycopene to support heart health and prostate health, and the specific use as supporting overall health and wellness. The listed age range is All, the number of items is 1, and the unit count is 120 count. The flavor is listed as unflavored, the diet type as gluten free, and the allergen information as gluten free. The primary supplement type is multivitamin, and the item color is listed as natural. The item highlight repeats the clinically studied antioxidant claim. The page shows a Best Sellers Rank of 4,657 in Health & Household and 108 in Multivitamins. The ingredient panel includes vitamins A, C, D, E, K and the B vitamins, along with minerals such as calcium, iron, magnesium, zinc, selenium, copper and manganese, plus botanical and antioxidant components such as saw palmetto berry extract, alpha-lipoic acid, grape seed extract, ginkgo leaf powder, blueberry fruit powder, lycopene, astaxanthin and lutein. The page lists the dimensions as 5 x 4 x 4 inches. The price shown is $47.99 with a per count price of $0.40, and a Subscribe and Save option at $43.19 is also shown. This summary is drawn only from the scraped page text.

Product Focus: EnergyAlso covers:BrainMuscles and jointsImmune systemHeartEyesRanked among:MultivitaminsMultivitamins for over 50
Tier ⓘ
Tier 3 · Rank 18
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 18 within Tier 3 for Energy; 43 of 90 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
73 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
94% of 2,988
Biohacker Mentions
9 of 10

Study, Trial or Testing Result Summary

Members Only347 human studies · 155 improved

18 of these 347 human studies gave the ingredient by drip, injection or inhaler, not by mouth.

347 human studies155 improved148 no effect214,517 people studied

Several ingredients here are at or above the doses used in studies, but their energy evidence is mixed and mostly in people who were low in a nutrient or ill. Vitamin D eased fatigue in people low in it, though a huge trial in older women found no change in energy [1][2]. Oral magnesium reduced fatigue in small trials of adults with metabolic conditions and women with polycystic ovary syndrome, while a fibromyalgia trial found no change [3][4][5]. Selenium raised vigor in some groups but not in a large trial of healthy adults [6][7]. Vitamin C helped mainly people low in it [8]. Thiamine lowered fatigue in older women mildly low in it [9]. Vitamin B6 at this dose eased tiredness in women with premenstrual symptoms, but larger blend trials found no benefit [10][11]. Sage reached a studied dose only at two servings and reduced exhaustion in menopausal women [12]. Arginine, ginkgo, astaxanthin, vitamin A, phosphatidylserine and lutein are far below the doses that helped in studies [13][14][15]. Animal and cell studies are never counted.

See all 347 studies →Hide the studies

Review Totals and Summary

Members Only2,988 reviews · 94% positive
2,988 reviews · Amazon 2,062 · Gnc 472 · Walmart 454
94% positive3% neutral3% negative

Shoppers rate the GNC Mega Men 50 Plus Multivitamin warmly. It carries about 2,516 ratings across the stores that sell it, and most reviewers are long-term users who keep rebuying it. Complaints are mostly about cost and availability, and one reviewer reports an order mix-up. The reviews do not name a form, so this summary treats them as being about the capsules and leaves out any other forms of the product that may appear on store pages. **What buyers say it did for them:** Most of the praise comes from wives talking about their husbands. One says it "really helps keep my 87 year old husband going," and describes a noticeable difference in strength and overall well-being compared with other vitamins. Another says her husband "feels better then he takes them." One reviewer takes it for brain support. The store summaries add that a 76-year-old user says it works well for them. **What they complain about:** The sharpest complaint is about an order. One buyer ordered the "Men's 50 Essentials" with the brain booster for about $20 but was twice sent a cheaper package without it, and calls this a "SCAM." This is a single report about fulfilment, not about the vitamin itself. Availability is a more common frustration. One reviewer is disappointed about not finding it "on a consistent basis" at a local Walmart supercenter, and another notes it is "no longer instore, shipping only." The page also shows the item as out of stock. One reviewer dislikes the age-based name, saying she resents that it is for people 50 or older. **Taste, smell, pill size or form:** None of the reviews or store summaries say anything about taste, smell, pill size or how easy the capsules are to swallow. **Value for money:** Opinions are split. One long-term buyer says the price is "excellent compared to the local vitamin supplier," and another titles the review "Value is great!" A third calls it a "good product" but "a bit expensive." **Who it seems to suit and who it did not:** It seems to suit older men, and the people buying for them, who want a daily multivitamin they can stay on for years. Reviewers say they have used it "for many years" and call it a "repeat purchase and daily vitamin." One reviewer mentions a hope of pregnancy alongside brain support, but that is one person's remark and not something the product claims. The people it left unhappy were not unhappy with the vitamin. They were the buyer who got the wrong product, shoppers who could not find it in stores, and one reader who disliked the 50-plus label. Some reviewers would still choose a more expensive product, so price-sensitive shoppers may want to compare. **Overall:** Reviews are mostly four and five stars and short, with repeat buyers vouching for it. Check that you are ordering the exact version you want, and expect to buy it online if your local store no longer stocks it.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it

Magnesium, the main ingredient, drew comments from all ten panelists, and most of them use it or recommend it, mainly for sleep. Four of them say they take it themselves: one takes magnesium glycinate every night, another takes 400 mg of the threonate form before bed, and one uses a 30 milligram electrolyte drink in the morning for workout performance. Others tie it to muscle function, recovery, stress resilience, calming hunger when breaking a fast, and testosterone, and one notes that a standard blood test can miss a shortfall because most magnesium sits inside cells. Cautions were few: one panelist warned that supplement labels can make the dose look larger than it is, and another said magnesium does not fix waking in the night. Vitamin D, vitamin C and zinc were each mentioned by several panelists, but they are smaller ingredients in this product.

See all 10 biohackers →Hide the biohackers
  • Dr. Mark Hyman · Magnesium · uses
    • 1 Nov 2026 · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 23 Oct 2026 · Inositol · recommends · Facebook ↗
      Lists inositol as a supplement that helps balance neurotransmitters and can help lower anxiety or depression symptoms.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 14 Oct 2026 · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 9 Oct 2026 · Astaxanthin · recommends · YouTube ↗
      Mentions astaxanthin as a carotenoid that helps reduce oxidative stress.
    • 8 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends checking vitamin D levels and states that if they had to pick one single intervention for immune health, vitamin D would be it.
  • Dave Asprey · Magnesium · neutral
    • 31 Oct 2026 · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 25 Oct 2026 · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 17 Oct 2026 · Folate · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking vitamin K2 with vitamin D to keep calcium in the bones, and suggests kids also take it for stronger bones.
    • 7 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends Vitamin K2, stating it supports healthy calcium metabolism.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
  • Dr. Eric Berg · Magnesium · neutral
    • 30 Oct 2026 · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 2 Nov 2026 · Vitamin D · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Vitamin K · recommends · Podcast ↗
      Discusses foods that contain Vitamin K2.
    • 31 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 28 Oct 2026 · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
    • 25 Oct 2026 · recommends · X ↗
      Recommends increasing magnesium to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · Vitamin D · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
    • 25 Oct 2026 · Vitamin K · recommends · YouTube ↗
      Recommends taking 40 to 45 milligrams of vitamin K2 daily for osteoporosis, citing a study from Japan with great results.
  • Ben Greenfield · Magnesium · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 29 Oct 2026 · Copper · neutral · YouTube ↗
      Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
    • 29 Oct 2026 · Zinc · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 21 Oct 2026 · Saw Palmetto · neutral · Instagram ↗
      States Saw Palmetto Extract is traditionally used to support healthy hair growth by working against the hormone that drives thinning.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises getting vitamin D levels between 60 and 100 nanograms per milliliter as a minimum step for overall health and to slow down heart disease.
  • Dr. Rhonda Patrick · Magnesium · neutral
    • 29 Oct 2026 · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 16 Oct 2026 · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 29 Sep 2026 · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 29 Sep 2026 · Zinc · recommends · YouTube ↗
      Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
    • 28 Sep 2026 · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 28 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 28 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
    • 28 Sep 2026 · Folate · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 24 Sep 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
    • 7 Sep 2026 · Alpha-Lipoic Acid · neutral · YouTube ↗
      Describes alpha-lipoic acid as a short-chain fatty acid produced in mitochondria and found in various foods. They highlight its role as a cofactor in mitochondrial energy production and biogenesis, its strong antioxidant capabilities, and its ability to regenerate vitamins C and E and glutathione. They also mention its anti-inflammatory effects, its role in chelating metal ions like iron and copper, and its ability to reduce advanced glycation end products, which is beneficial for people with diabetes.
    • 2 Sep 2026 · neutral · Facebook ↗
      States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
    • 25 Aug 2026 · Vitamin D · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
  • Thomas DeLauer · Magnesium · uses
    • 28 Oct 2026 · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 24 Oct 2026 · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Zinc · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 20 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking a massive amount of vitamin D simultaneously with an early morning massive breakfast to help reset circadian rhythms and address hyperphagia.
    • 18 Oct 2026 · Vitamin B12 · recommends · YouTube ↗
      Recommends Vitamin B12 for mental health and mood, explaining its role in myelination and neurotransmitter production. They specifically recommend a liposomal and micellar form of methylcobalamin B12 for better absorption and to avoid toxicity.
    • 8 Oct 2026 · recommends · Facebook ↗
      Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Zinc · recommends · Facebook ↗
      Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 8 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D, stating that it has receptors throughout the brain and deficiency can quickly impact brain and mood.
    • 6 Oct 2026 · neutral · YouTube ↗
      Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
    • 6 Oct 2026 · Vitamin D · uses · YouTube ↗
      Takes supplemental vitamin D because he is skin sensitive and from northern latitudes, limiting his UV exposure.
  • Siim Land · Magnesium · recommends
    • 25 Oct 2026 · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 24 Oct 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 14 Oct 2026 · Copper · neutral · Instagram ↗
      Mentions that copper is a mineral necessary for making collagen.
    • 12 Oct 2026 · recommends · YouTube ↗
      Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
    • 9 Oct 2026 · Vitamin K · neutral · Instagram ↗
      Notes that Vitamin K2 helps activate proteins involved in bone mineralization and calcium regulation.
    • 8 Oct 2026 · Vitamin K · neutral · YouTube ↗
      Mentions that prunes contain vitamin K, which is a factor in their ability to help with bone density.
    • 8 Oct 2026 · Boron · neutral · Instagram ↗
      Boron is a mineral that helps with bone density and vitamin D utilization, and also helps to increase free testosterone by reducing SHBG.
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 7 Oct 2026 · Vitamin K · recommends · Instagram ↗
      Recommends Vitamin K2 for bone health and calcium metabolism, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Magnesium as one of 15 supplements backed by human studies.
  • Andrew Huberman · Magnesium · neutral
    • 22 Oct 2026 · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 29 Oct 2026 · Zinc · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · Zinc · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 22 Oct 2026 · Inositol · neutral · Podcast ↗
      Discusses Myo-Inositol as a tool for middle-of-the-night waking.
    • 19 Oct 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 14 Sep 2026 · Zinc · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · Zinc · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 17 Aug 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 7 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
  • Bryan Johnson · Magnesium · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 22 Oct 2026 · Vitamin K · uses · X ↗
      Takes 90 mcg of Vitamin K2 in the morning for general health.
    • 22 Oct 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 15 Aug 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 3 Jul 2026 · Vitamin D · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 4 May 2026 · Vitamin K · uses · X ↗
      Takes 100 mcg of Vitamin K2 in the morning for longevity.
    • 4 May 2026 · Vitamin D · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Boron · uses · X ↗
      Takes 2 mg of Boron in the morning for longevity.
    • 4 May 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 4 May 2026 · Inositol · uses · X ↗
      Takes 900 mg of Inositol before bed for sleep.
    • 2 May 2026 · uses · X ↗
      He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
    • 2 May 2026 · Vitamin K · uses · X ↗
      He takes 100 mcg of Vitamin K2 in the morning for general health.
  • Peter Attia · Magnesium · neutral
    • 1 Jun 2026 · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 1 Jun 2026 · Phosphatidylserine · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 4 Jan 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 17 Nov 2025 · Iodine · warns · Podcast ↗
      Discusses the dangers of supplementing with high levels of iodine.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 16 Nov 2025 · Iodine · warns · YouTube ↗
      Warns that high-dose iodine supplementation carries a risk of autoimmune thyroid disease, citing increased incidence in Japan due to higher dietary iodine intake.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 15 Sep 2025 · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.

RAL Summary

Members OnlyTier 3 for Energy

The 80 percent improvement figure behind the magnesium grade comes from a small trial of weekly magnesium injections in chronic fatigue syndrome, not oral magnesium like this tablet, and the oral magnesium trials are mixed. So it is graded Tier 3, lower than the rules alone gave.

Take 2 servings a day (4 caplets) to match the dose that worked in the studies.

Where the evidence disagrees: 148 of the 347 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Nervous system, Musculoskeletal system, Immune system, Cardiovascular system, Eyes

Combine with: For general support, pair this multivitamin with omega-3 fish oil for cardiovascular and anti-inflammatory benefits, and a CoQ10 supplement for cellular energy and heart health in men over 50. Extra vitamin D3 with K2 may help bone density if blood levels are low. If thyroid support is the actual goal, discuss with a clinician first and consider testing TSH, free T4/T3, and TPO antibodies. A dedicated selenium (about 100-200 mcg as selenomethionine) and, only if deficient, L-tyrosine or ashwagandha may be considered. Separate iron- and calcium-containing products from meds by at least 4 hours, and avoid extra iodine or kelp unless advised.

Possible side effects: No major side effects reported in reviews; studies note high-dose niacin can cause flushing, stomach upset and fatigue, and arginine may cause stomach upset.

Supplement Facts

Vitamin A 1500 mcg RAE · Vitamin C 300 mg · Vitamin D 50 mcg
Supplement Facts
Serving Size 2 Caplet(s)
Servings Per Container 60
Amount Per Serving% Daily Value
Vitamin A1,500 mcg RAE
Vitamin C300 mg
Vitamin D50 mcg
Vitamin E20.1 mg
Vitamin K80 mcg
Thiamine50 mg
Riboflavin50 mg
Niacin50 mg
Vitamin B650 mg
Folate680 mcg DFE
Vitamin B1250 mcg
Biotin300 mcg
Pantothenic Acid50 mg
Choline10 mg
Calcium210 mg
Iodine150 mcg
Magnesium120 mg
Zinc25 mg
Selenium200 mcg
Copper2 mg
Manganese2 mg
Chromium120 mcg
Molybdenum75 mcg
Saw Palmetto Berry Extract100 mg†
Arginine100 mg†
Sage, Powder50 mg†
Alpha-Lipoic Acid25 mg†
Ginkgo, Powder25 mg†
Inositol10 mg†
Phosphatidylserine10 mg†
Silica4 mg†
Boron2 mg†
Lutein2 mg†
Lycopene2 mg†
Zeaxanthin400 mcg†
Astaxanthin50 mcg†
Vanadium10 mcg†
† Daily Value not established.

Other ingredients: Cellulose, Corn Starch, Stearic Acid, Magnesium Stearate, Polyvinyl Alcohol, Titanium Dioxide, Polyethylene Glycol, Talc, Soy Lecithin, Caramel, Vanilla Mint Flavor, Natural, Steviol Glycosides.

Directions: Directions: As a dietary supplement, take two caplets daily with food.

Barcode (UPC) 048107248918 · Label source: NIH label database · Report a label change

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Graded November 7, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.