Just Ripe Nutrition Glucopure Blood Sugar Support for Weight Loss & Heart Health 8 Bottles Review
Glucopure Blood Sugar Support for Weight Loss & Heart Health 8 Bottles is a dietary supplement from Just Ripe Nutrition, listed on the Reverse Age Lab Dietary Supplement Label Database under DSLD ID 349282. The product is sold as 60 capsules and its supplement form is listed as Capsule. Its product type is listed as Other Combinations, its dietary claim is listed as Structure/Function, and its market status is On Market. The label's date entered into DSLD is 29 October 2026. The target group is adults and children 4 or more years of age. The suggested serving size is 1 capsule, and the label lists 60 servings per container. Suggested use reads: as a dietary supplement, take one veggie capsule once a day. If desired, take two capsules daily. For best results, take 20-30 minutes before a meal with an 8 fl oz glass of water or as directed by your healthcare professional. The supplement facts list vitamins and minerals including Vitamin C, Vitamin E, Biotin, Magnesium, Zinc, Manganese and Chromium, along with botanical and other extracts including Banaba Extract, Guggul, Bitter Melon Extract, Licorice Extract, Cinnamon Powder, Gymnema Extract, Yarrow Powder, Cayenne Pepper Powder, Juniper Extract, White Mulberry Extract, Vanadium, Alpha Lipoic Acid and L-Taurine. The other ingredients are hypromellose vegetable capsule and rice flour. The label statements include a caution to not exceed the recommended dose, that pregnant or nursing mothers, children under 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement, to keep out of reach of children, not to use if the safety seal is damaged or missing, and to store in a cool, dry place. The FDA disclaimer states these statements have not been evaluated by the Food and Drug Administration and the product is not intended to diagnose, treat, cure or prevent any disease. Lot number and expiration date are printed on the bottom of the bottle. The SKU is listed as 46144-803 V2.1R0. The product is distributed by Just Ripe Nutrition at 253 Main Street ste. 132 Matawan, NJ 07747. The source is listed as Reverse Age Lab, October 2026. The page also lists other Just Ripe Nutrition labels, including a Glucopure 3 Bottles label, and other labels sharing an ingredient. The page shows a comparison to Kaya Naturals Blood Sugar Support as having nearly the same formula, with all 20 main ingredients and amounts alike. The page states that labels are shown as printed on the bottle with no grades, rankings or advice.
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Study, Trial or Testing Result Summary
Members Only493 human studies · 267 improved
14 of these 493 human studies gave the ingredient by drip or injection, not by mouth.
Five ingredients reach the doses used in studies when taken as directed. Chromium is at a full dose. Pooled trials in people with type 2 diabetes found it lowered fasting and long-term blood sugar, though certainty was low [1][2][3]. Magnesium, at two servings a day, lowered fasting blood sugar more than placebo in pooled trials [4], though some trials found no change [5]. Zinc, at two servings a day, lowered fasting blood sugar in people with prediabetes [6], but another trial found no change [7]. Cinnamon, at two servings a day, lowered fasting and long-term blood sugar in pooled trials [8], and as little as 120 milligrams of extract helped [9]. Alpha lipoic acid, at three servings a day, lowered fasting blood sugar in smaller trials [10], but the two largest and longest trials found no change [11][12]. Most other ingredients are far below the doses studied. These include banaba [13], bitter melon [14], gymnema [15], white mulberry [16], taurine [17], vanadium [18], vitamin C [19] and biotin [20]. Cayenne showed no blood sugar benefit in pooled trials [21]. Juniper has only animal studies [22]. Animal and cell studies are never counted.
See all 493 studies →Hide the studies
- In a large review of 884 trials of micronutrients, vitamin C showed no effect on heart disease or type 2 diabetes risk.Micronutrient Supplementation to Reduce Cardiovascular Risk.
- In a UK cohort of about 165,000 adults, higher dietary manganese was not clearly linked to lower diabetes or heart disease risk, but pooling six studies of over 270,000 people showed 4% lower diabetes risk per extra mg per day.Dietary manganese, type 2 diabetes, and cardiovascular disease: A UK Biobank cohort study and meta-analysis of over 270,…
- Across five observational studies of 91,249 pregnant women, those with the highest blood manganese had 31% higher odds of gestational diabetes than those with the lowest.Blood manganese level and gestational diabetes mellitus: a systematic review and meta-analysis.
- In 24 observational studies, people with higher blood magnesium had lower risk of high blood sugar and type 2 diabetes, while the link with prediabetes was weak and uncertain.Serum magnesium and risk of hyperglycemia, type 2 diabetes, and prediabetes: a systematic review and dose-response meta-…
- This review compared diets of women with and without polycystic ovary syndrome and found only a tendency toward lower zinc intake in affected women; it did not test zinc supplements on blood sugar or heart health.Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic …
- Across 199 trials of 98 Ayurvedic medicines in 21,191 adults with type 2 diabetes, bitter melon lowered long-term blood sugar (HbA1c) by about 0.3 percentage points compared with control.Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Ana…
- In 170 trials of 14,223 people with type 2 diabetes, vitamin E ranked best for lowering LDL cholesterol but with very low certainty, and it was not top-ranked for blood sugar.Comparative effects of vitamin and mineral supplements in the management of type 2 diabetes in primary care: A systemati…
- In a pooled comparison of 79 trials with 5,501 women with polycystic ovary syndrome, chromium improved blood fat levels, antioxidant capacity and a reproductive hormone, but it was not singled out for blood sugar and several other markers did not differ from placebo.The effectiveness of nutritional supplements in improving polycystic ovary syndrome in women: a systematic review and ne…
- Across 28 trials of 3054 adults with type 2 diabetes taking cinnamon for about 4 to 17 weeks, fasting blood sugar, after-meal blood sugar, long-term blood sugar (HbA1c) and insulin resistance all dropped more than with placebo or control, especially with capsules at 2 grams a day or less.Effects of cinnamon supplementation on metabolic biomarkers in individuals with type 2 diabetes: a systematic review and…
- In a pooled comparison of 41 trials with 2,362 women with polycystic ovary syndrome, chromium lowered fasting insulin and insulin resistance versus placebo, and also lowered triglycerides and total cholesterol.Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary synd…
- Across 22 randomized trials with 1447 people with type 2 diabetes, vitamin C lowered long-term blood sugar (HbA1c), fasting insulin and fasting blood sugar compared with no vitamin C, with the best results at 1000 mg or more per day for 12 weeks or longer.The effects of vitamin C supplementation on glycemic control in patients with type 2 diabetes: A systematic review and m…
- Across 15 randomized trials with 1202 adults with metabolic disorders, mulberry extract lowered fasting blood glucose, HbA1c, insulin resistance, cholesterol, triglycerides and inflammation markers compared with placebo or standard care.Integrative Evidence on Mulberry Extract for Modulating Metabolic Risk Factors Associated with Vascular Dementia.
- In ten trials of 1,045 people with type 2 diabetes followed for 4 to 16 weeks, bitter melon lowered fasting glucose, after-meal glucose and long-term blood sugar (HbA1c, by 0.26 points) more than placebo, though the evidence was low quality.Momordica charantia L. lowers elevated glycaemia in type 2 diabetes mellitus patients: Systematic review and meta-analys…
- Pooling 27 trials with 1,030 people, taurine supplements lowered long-term blood sugar, fasting glucose, insulin, cholesterol, blood pressure and inflammation markers, with about 3,000 mg a day suggested as the best balance.Taurine supplementation as a therapeutic strategy for cellular senescence and chronic inflammation in long COVID: a syst…
- Pooling 25 trials with 1,024 people taking 0.5 to 6 g of taurine daily for 5 to 365 days, taurine lowered fasting blood sugar by about 5.9 mg/dL, blood pressure and triglycerides compared with controls, with no significant side effects.Taurine reduces the risk for metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
- Across 13 trials with 821 adults, red pepper or capsaicin did not change blood sugar, insulin, insulin resistance, long-term blood sugar, LDL, HDL, triglycerides or systolic blood pressure; small drops in total cholesterol and diastolic pressure depended on a single study.The effect of red pepper/capsaicin on cardiovascular risk factors: a systematic review, meta-analysis, and GRADE assessm…
- In 10 trials with 683 women with polycystic ovary syndrome, chromium lowered fasting insulin, cholesterol, triglycerides, inflammation and oxidative stress and raised insulin sensitivity versus placebo, and lowered insulin resistance more than a med.Therapeutic effects of chromium supplementation on women with polycystic ovarian syndrome: A systematic review and meta-…
- In 15 trials with 618 people, chromium did not change blood sugar or insulin in people without diabetes, and results in people with diabetes were inconclusive, with only one Chinese study showing benefit.Glucose and insulin responses to dietary chromium supplements: a meta-analysis.
- Across 12 trials with 615 adults, mulberry leaf or leaf extract lowered fasting blood glucose, HbA1c and fasting insulin, with larger effects when taken for 8 weeks or longer.Effect of mulberry leaf or mulberry leaf extract on glycemic traits: a systematic review and meta-analysis.
- Across 11 trials with 609 people, Capsicum annuum lowered LDL cholesterol compared with placebo and had a borderline effect on body weight, with larger trials still needed.Effects of Capsicum annuum supplementation on the components of metabolic syndrome: a systematic review and meta-analysi…
- Across 10 trials of 577 people with type 1 or type 2 diabetes taking about 2 grams of cinnamon daily for 4 to 16 weeks, fasting blood sugar results were inconclusive and there was no significant difference in HbA1c, insulin or after-meal blood sugar.Cinnamon for diabetes mellitus.
- Across 10 trials of 543 people with type 2 diabetes taking 120 mg to 6 g of cinnamon daily for 4 to 18 weeks, fasting blood sugar fell by about 25 mg/dL, but long-term blood sugar (HbA1c) did not change significantly.Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis.
- In 10 trials with 509 people with type 2 diabetes, chromium modestly lowered long-term blood sugar (HbA1c) but did not significantly change fasting blood sugar or blood fats versus placebo.Effect of Chromium Supplementation on Blood Glucose and Lipid Levels in Patients with Type 2 Diabetes Mellitus: a System…
- Pooling five trials of 445 people with type 2 diabetes who took biotin for 28 to 90 days, total cholesterol fell, but the changes in fasting blood sugar and triglycerides were not statistically clear, and insulin did not change.Influence of biotin intervention on glycemic control and lipid profile in patients with type 2 diabetes mellitus: A syst…
- Across 6 trials of 435 people with type 2 diabetes taking 1 to 6 grams of cinnamon daily for 40 days to 4 months, long-term blood sugar (HbA1c) and fasting blood sugar were significantly lower.Cinnamon in glycaemic control: Systematic review and meta analysis.
- Pooling 10 studies of 419 people with type 2 diabetes, Gymnema lowered fasting blood sugar, after-meal blood sugar, long-term blood sugar (HbA1c), triglycerides and total cholesterol compared with their own baseline.The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and…
- In nine trials of 414 people followed for 4 to 16 weeks, bitter melon did not significantly change fasting blood glucose, long-term blood sugar (HbA1c) or blood pressure compared with placebo.The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence: a systematic …
- In 6 trials with 351 women with polycystic ovary syndrome, chromium lowered insulin resistance but did not change fasting blood sugar or fasting insulin, and testosterone levels rose.Chromium supplementation in women with polycystic ovary syndrome: Systematic review and meta-analysis.
- Across 5 placebo-controlled trials of 282 people with type 1 or type 2 diabetes, cinnamon did not significantly change HbA1c, fasting blood sugar or blood fat levels.Effect of cinnamon on glucose control and lipid parameters.
- Across five trials of 266 women with gestational diabetes, magnesium lowered fasting blood sugar and insulin resistance but did not clearly change insulin levels, preterm birth, large babies or BMI.The efficacy of magnesium supplementation for gestational diabetes: A meta-analysis of randomized controlled trials.
- Pooling three trials of 265 people with prediabetes taking 20-30 mg of zinc daily for 6-12 months, fasting blood glucose fell by about 11 mg/dL and 2-hour glucose fell by about 21 mg/dL.Zinc supplementation in prediabetes mellitus.
- In a pooled analysis of randomized trials in people with type 2 diabetes taking meds, adding vitamin C significantly improved long-term blood sugar (HbA1c) and fasting blood sugar.Could nutrient supplements provide additional glycemic control in diabetes management? A systematic review and meta-anal…
- This review compared nutrient levels in people with diabetic foot ulcers and found differences mainly in vitamin D, magnesium and selenium, and did not test vitamin C supplements for blood sugar.The association between micronutrient levels and diabetic foot ulcer: A systematic review with meta-analysis.
- In a pooled comparison of vitamin, exercise and probiotic treatments in people with type 2 diabetes, vitamin C had the strongest effects on fasting blood sugar and insulin measures, though vitamin supplementation alone did not significantly improve long-term blood sugar (HbA1c).Network meta-analysis of the effects of combined exercise and vitamin intervention on insulin resistance and related ind…
- In children with fatty liver, vitamin E lowered LDL and total cholesterol but raised fasting blood glucose when given for 12 months or less, with no change in fasting insulin or insulin resistance.Vitamin E in paediatric non-alcoholic fatty liver disease: a meta-analysis.
- In 12 trials in women with polycystic ovary syndrome, vitamin E lowered insulin resistance, triglycerides, LDL cholesterol and waist size.Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal fun…
- In 178 trials in adults with type 2 diabetes, vitamin E lowered HbA1c with low certainty, but not after poor-quality studies were excluded, and it did not improve fasting blood sugar or insulin resistance.Comparison of nutritional supplements for glycemic control in type 2 diabetes: A systematic review and network meta-anal…
- In 5 trials in people with diabetic kidney disease, vitamin E lowered HbA1c and serum creatinine compared with placebo, with no change in kidney filtration rate, urea or blood pressure.Effect of Vitamin E on Diabetic Nephropathy: A Meta-Analysis.
- In double-blind trials, oral magnesium beat placebo at lowering fasting blood sugar in people with diabetes and improved blood sugar and insulin sensitivity in people at high risk of diabetes.Oral Magnesium Supplementation for Treating Glucose Metabolism Parameters in People with or at Risk of Diabetes: A Syste…
- Pooling 13 trials in people with type 2 diabetes using 42 to 1,000 micrograms daily for 30 to 120 days, chromium lowered fasting glucose by about 29 mg/dL and total cholesterol by about 6.7 mg/dL.[Chromium supplementation in patients with type 2 diabetes and high risk of type 2 diabetes: a meta-analysis of randomiz…
- Pooling 7 trials in women with polycystic ovary syndrome, chromium lowered body mass index, free testosterone and fasting insulin (in larger studies), but did not change total testosterone, hormone levels or hair growth score.Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.
- Pooling 28 trials in people with type 2 diabetes, chromium supplements lowered fasting blood glucose by 19 mg/dl, long-term blood sugar (HbA1c) by 0.71%, insulin and insulin resistance compared with controls.Effects of chromium supplementation on glycemic control in patients with type 2 diabetes: a systematic review and meta-a…
- In 15 trials of people with type 2 diabetes taking 200 to 1000 micrograms of chromium daily, diastolic blood pressure and an oxidative stress marker fell, but body weight index, systolic blood pressure and liver enzymes did not change.Effects of chromium supplementation on blood pressure, body mass index, liver function enzymes and malondialdehyde in pa…
- Across 8 placebo-controlled trials in people with type 2 diabetes or prediabetes, cinnamon or cinnamon extract lowered fasting blood glucose by about 0.49 mmol/L.Cinnamon intake lowers fasting blood glucose: meta-analysis.
- A pooled analysis of randomized trials in people with type 2 diabetes found cinnamon lowered triglycerides and LDL cholesterol and raised HDL cholesterol, but had no significant effect on fasting blood glucose or long-term blood sugar (HbA1c); doses of 1200 mg or less showed a blood sugar lowering effect in subgroup analysis.The Effect of Cinnamon on Glycolipid Metabolism: A Dose-Response Meta-Analysis of Randomized Controlled Trials.
- Across 24 trials in people with type 2 diabetes, cinnamon lowered fasting blood sugar, insulin resistance and long-term blood sugar (HbA1c) compared with control, but did not significantly change insulin levels.The effect of cinnamon supplementation on glycemic control in patients with type 2 diabetes mellitus: An updated systema…
- In a review of trials of herbs and spices in people with type 2 diabetes, cinnamon significantly lowered fasting glucose (by roughly 17 to 27 mg/dL for the top spices) and insulin, but not long-term blood sugar (HbA1c).Effect of Aromatic Herbs and Spices Present in the Mediterranean Diet on the Glycemic Profile in Type 2 Diabetes Subject…
- Pooling 6 randomized trials in adults, Gymnema lowered fasting blood sugar, triglycerides, total and LDL cholesterol and diastolic blood pressure, though study quality was low and results varied widely.The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric …
- Across 14 controlled trials, capsaicin had no significant short-term or long-term effect on blood sugar or insulin.Short- and long-term effects of capsaicin supplementation on glycemic control: a systematic review and meta-analysis of …
- Across 13 randomized trials, Morus alba lowered blood sugar after meals at 30, 60 and 90 minutes but did not change fasting glucose, HbA1c, insulin resistance or blood fats.A meta-analysis of efficacy of Morus alba Linn. to improve blood glucose and lipid profile.
- Pooling 12 trials using 0.5 to 6 g of taurine daily for 15 days to 6 months, taurine lowered blood pressure, total cholesterol and triglycerides but had no effect on fasting blood glucose.The effects of taurine supplementation on obesity, blood pressure and lipid profile: A meta-analysis of randomized contr…
- Pooling 9 trials in adults with overweight or obesity, long-term taurine lowered fasting insulin and triglycerides, and 3 g a day lowered long-term blood sugar (HbA1c) by about 0.37 percentage points and fasting glucose by about 7 mg/dL.Effect of Long-Term Taurine Supplementation on the Lipid and Glycaemic Profile in Adults with Overweight or Obesity: A S…
- Pooling 34 randomized trials, oral taurine lowered fasting glucose by about 5.9 mg/dL, long-term blood sugar (HbA1c) by 0.21 points, blood pressure and cholesterol, with 1.5 to 3.0 g daily working best.Effects of Oral Taurine Supplementation on Cardiometabolic Risk Factors: A Meta-analysis and Systematic Review of Random…
- A review of 108 trials of herbs and supplements in 4,565 people with diabetes found insufficient evidence for firm conclusions, with bitter melon among those showing positive preliminary results for blood sugar.Systematic review of herbs and dietary supplements for glycemic control in diabetes.
- Four trials of 479 people with type 2 diabetes lasting up to three months found no significant difference in blood sugar control with bitter melon versus placebo, and no meaningful change versus a med or glibenclamide.Momordica charantia for type 2 diabetes mellitus.
- In nine trials of 363 women with polycystic ovary syndrome, magnesium alone did not improve blood sugar, but magnesium combined with vitamin E or other supplements improved insulin, insulin resistance, blood fats and a marker of inflammation.The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolis…
- Three trials of 350 people with type 2 diabetes lasting up to three months found no significant blood sugar difference between bitter melon and placebo, and leaf preparation was comparable to glibenclamide.Momordica charantia for type 2 diabetes mellitus.
- A review of six studies in people with gum disease and diabetes found lower vitamin C levels in those with both conditions, but evidence on whether vitamin C supplements help was inconclusive.Possible Involvement of Vitamin C in Periodontal Disease-Diabetes Mellitus Association.
- This review of diet and diabetic eye disease found no link between vitamin C intake and diabetic retinopathy, and it did not measure blood sugar.Dietary Intake and Diabetic Retinopathy: A Systematic Review of the Literature.
- A broad review of edible oils found the evidence supports possible benefits of high alpha-tocopherol (vitamin E) content for long-term diseases, but gave no specific blood sugar results for vitamin E.How should we judge edible oils and fats? An umbrella review of the health effects of nutrient and bioactive components …
- A review of trials in women with polycystic ovary syndrome found vitamin E combined with other nutrients helped male hormone levels and inflammation, while inositol was best for blood sugar control.Nutraceuticals and polycystic ovary syndrome: a systematic review of the literature.
- A review found low blood magnesium was linked to post-transplant diabetes and heart risk in kidney transplant recipients, but no studies yet tested whether correcting it helps.Serum Magnesium after Kidney Transplantation: A Systematic Review.
- A review of 60 meta-analyses found that high dietary magnesium intake was linked to a significantly lower risk of type 2 diabetes.Preventive Role of Diet Interventions and Dietary Factors in Type 2 Diabetes Mellitus: An Umbrella Review.
- In 12 studies of kidney and liver transplant recipients, eight linked low blood magnesium to higher risk of post-transplant diabetes, three found no link and one found a positive association with HbA1c.Hypomagnesaemia, an independent risk factor for the development of post-transplant diabetes mellitus in liver and renal …
- A review of 20 studies on manganese exposure in pregnancy found no significant link between maternal manganese levels and gestational diabetes risk.Manganese exposure and perinatal health: a systematic review of literature.
- In a review of 14 studies, chromium reduced inflammatory markers in 12, but only three were human studies and their results were conflicting, so evidence in people with diabetes remains unclear.Potential roles of chromium on inflammatory biomarkers in diabetes: A Systematic.
- A review of randomized trials in people with type 2 diabetes using 50 to 1000 micrograms of chromium daily for 2 to 6 months found lower fasting glucose, insulin, long-term blood sugar and insulin resistance, mainly in longer studies.Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review.
- A review of Ayurvedic herbs for diabetes found evidence of a glucose-lowering effect for several herbs, but only less extensive evidence for bitter melon.Are Ayurvedic herbs for diabetes effective?
- A review of 51 clinical trials of plants in diabetes listed bitter melon among those with the most trials, with plants like it linked to lower fasting blood glucose and long-term blood sugar.Clinical trials with plants in diabetes mellitus therapy: a systematic review.
- A review of mostly lab and animal studies of Mexican plants reported bitter melon extracts lowered blood sugar and raised insulin secretion; no human trial data were given.Mexican Plants Involved in Glucose Homeostasis and Body Weight Control: Systematic Review.
- A broad review of herbal remedies for polycystic ovary syndrome reported that cinnamon, among other herbs, lowered lipid and blood glucose levels, but gave no cinnamon-specific numbers.Polycystic ovaries and herbal remedies: A systematic review.
- A review found conflicting evidence on whether cinnamon improves blood sugar, with possibly modest effects in some adults and very few side effects.Sweetly Improving Sugars? Reviewing Cinnamon's Effects on Blood Glucose.
- A review of 45 studies found about 62% showed a significant benefit on at least one blood sugar measure (about 50% after quality ranking), suggesting a modest positive effect with very few side effects.A Systematic Review Evaluating Cinnamon's Effects on Glucose Utilizing a Ranking System to Assess Bias and Study Quality…
- A systematic review of Gymnema sylvestre for diabetes; the abstract gives no results or numbers.Gymnema sylvestre for diabetes mellitus: a systematic review.
- A review of animal and human studies of Gymnema extracts in obesity and diabetes; the abstract reports no specific human results.A systematic review of Gymnema sylvestre in obesity and diabetes management.
- A review found no trials of vanadium that met the quality criteria, and the five lower-quality trials of 30 to 150 mg daily showed benefits but were too weak to recommend vanadium for blood sugar control in type 2 diabetes.A systematic review of vanadium oral supplements for glycaemic control in type 2 diabetes mellitus.
- A review of 50 double-masked trials of supplements in type 2 diabetes, including alpha-lipoic acid, found positive effects on insulin resistance and heart risk factors, but gave no alpha-lipoic acid specific results.Nutritional supplementation for type 2 diabetes: a systematic review.
- A review of 25 publications, including five randomized trials and three open-label studies, found 600 mg a day for at least 3 weeks helped diabetic nerve damage, with some benefit on weight and insulin sensitivity.A Case for Alpha-Lipoic Acid as an Alternative Treatment for Diabetic Polyneuropathy.
- A review of 17 randomized trials in adults taking alpha-lipoic acid for at least one month found little consistent benefit on blood cholesterol and triglycerides.Evaluating the Lipid-Lowering Effects of α-lipoic Acid Supplementation: A Systematic Review.
- A review of lab, animal and some human studies concluded there is enough evidence to justify further clinical trials of taurine for preventing and treating diabetes and its complications.Taurine and glucose metabolism: a review.
- A review of mostly experimental studies and a few clinical ones suggested taurine may help prevent and manage diabetes and its complications through antioxidant effects, though human data are limited.Protective and therapeutic effectiveness of taurine in diabetes mellitus: a rationale for antioxidant supplementation.
- In 29,133 male smokers given 50 mg of alpha-tocopherol daily for a median of about 6 years, vitamin E did not significantly change the chance of developing type 2 diabetes compared with those not receiving it.Effect of alpha-tocopherol and beta-carotene supplementation on the incidence of type 2 diabetes.
- In 9,541 people aged 55 or older at high risk of heart problems, 400 IU of vitamin E daily for an average of 4.5 years did not reduce heart attacks, strokes or cardiovascular deaths compared with placebo.Vitamin E supplementation and cardiovascular events in high-risk patients.
- In 1,729 women planning pregnancy, an enhanced supplement that included zinc raised blood vitamin levels and reduced vitamin insufficiency, but this report did not state results for blood sugar.Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconc…
- In 467 people with type 2 diabetes, 600 mg a day of alpha-lipoic acid for 2 years did not prevent diabetic macular edema compared with placebo, and blood sugar (HbA1c) stayed constant.Alpha-lipoic acid for the prevention of diabetic macular edema.
- In 447 adults with poorly controlled type 2 diabetes, 90 days of chromium picolinate plus 2 mg biotin lowered long-term blood sugar (HbA1c) by 0.54% and fasting glucose more than placebo.Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese pati…
- In 430 adults with heart risk factors, 12 weeks of a magnesium-rich diet (about 1,142 mg a day) cut total cholesterol by 10.7%, LDL cholesterol by 10.5% and triglycerides by 10.1%, with no such changes on the usual diet.Can dietary magnesium modulate lipoprotein metabolism?
- In 400 high-risk adults followed for 10 years, a magnesium-rich diet (about 1,142 mg a day) was linked to fewer heart complications (28.6% vs 60.3%) and lower death rates (10.7% vs 18.0%) than the usual diet.Effect of dietary magnesium supplementation in the prevention of coronary heart disease and sudden cardiac death.
- In 359 patients at heart and metabolic risk, a supplement with Monacolin K plus Morus alba lowered blood sugar more than one with Monacolin K alone over 3 months, while both lowered LDL cholesterol.Dual modulation of lipid and glucose metabolism by a nutraceutical combination in patients at cardiometabolic risk: resu…
- In 348 adults with type 2 diabetes, 90 days of chromium plus 2 mg biotin lowered HbA1c and glucose versus placebo, and improved cholesterol in those with high cholesterol or taking meds.Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a pl…
- In 297 retired teachers, 2 to 4 months of a combined antioxidant supplement including 500 mg of vitamin C daily had no significant effect on fasting blood sugar, blood pressure or cholesterol compared with placebo.The effect of antioxidant vitamin supplementation on traditional cardiovascular risk factors.
- In 236 people with diabetic nerve damage, 1800 mg a day of alpha-lipoic acid for 12 weeks improved symptoms in 73% versus 18% on placebo, and blood sugar (HbA1c) fell further.[Efficacy and safety of high-dose α-lipoic acid in the treatment of diabetic polyneuropathy].
- In 210 adults with type 2 diabetes, Ceylon cinnamon extract taken for about 4 months lowered fasting blood sugar and HbA1c compared with placebo and improved insulin resistance and insulin-producing cell function.Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placeb…
- In 204 adults with type 2 diabetes, 3 grams of cinnamon a day taken with tea for 8 weeks did not lower blood pressure more than tea alone, and cinnamon did not show a meaningful effect on the endothelial marker measured.Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in p…
- In 200 adults with prediabetes, 20 mg of zinc daily for 12 months lowered fasting glucose, insulin resistance and cholesterol, and fewer developed type 2 diabetes than with placebo (11% vs 25%).Zinc supplementation in prediabetes: A randomized double-blind placebo-controlled clinical trial.
- In two crossover studies of 182 healthy people, a blend with white mulberry, white bean and green coffee extracts taken before high-sugar meals gave lower glucose and insulin peaks than placebo.A Synergistic Formulation of Plant Extracts Decreases Postprandial Glucose and Insulin Peaks: Results from Two Randomize…
- In 180 adults with type 2 diabetes, taking 1000 mcg of chromium picolinate daily for 4 months lowered average blood sugar (HbA1c) and fasting and two-hour glucose compared with placebo, while also lowering insulin and total cholesterol.Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.
- In 166 sedentary adults with risk factors for metabolic syndrome taking 400 or 800 mcg of chromium with plant extracts for 12 weeks alongside exercise and diet, some measures such as blood vessel function, insulin sensitivity and blood fats improved more than placebo, though evidence was modest and mostly seen at 6 weeks.Effects of 12 Weeks of Chromium, Phyllanthus emblica Fruit Extract, and Shilajit Supplementation on Markers of Cardiomet…
- In 160 Saudi adults with prediabetes, a six-month lifestyle program improved fasting glucose and insulin resistance and raised vitamin C intake compliance, but vitamin C was not given as a supplement.Improvements in Glycemic, Micronutrient, and Mineral Indices in Arab Adults with Pre-Diabetes Post-Lifestyle Modificatio…
- In 160 adults with type 2 diabetes taking their usual medicines, 3 grams a day of cinnamon capsules for 90 days lowered HbA1c by 0.2 percent and fasting blood sugar by 0.55 mmol/L compared with placebo.Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Rand…
- In 155 postmenopausal women with metabolic syndrome, six months of inositol plus alpha-lipoic acid cut insulin resistance by over 20% in 66.7% of the treated group and lowered triglycerides and waist size versus placebo.Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled tria…
- In 152 older adults with prediabetes, eating 200 g of sardines weekly for 12 months lowered insulin resistance, triglycerides and blood pressure and raised HDL cholesterol compared with the control diet, though the effect cannot be attributed to taurine alone.Type 2 diabetes preventive effects with a 12-months sardine-enriched diet in elderly population with prediabetes: An int…
- In 151 people with metabolic syndrome, 600 mg a day of alpha-lipoic acid for one year modestly lowered blood fatty acids but did not change blood sugar, insulin, or inflammation markers.The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.
- In 150 adults taking 1000 mg a day of Ceylon cinnamon extract for 12 weeks, fasting blood sugar fell more than with placebo, especially in people with type 2 diabetes, but LDL cholesterol did not drop significantly.Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A …
- In 148 people with chronic kidney disease, 12 months of magnesium hydroxide 15 mmol twice daily raised blood magnesium but did not slow artery calcification versus placebo, and caused more stomach side effects and serious adverse events.The Effect of Magnesium Supplementation on Vascular Calcification in CKD: A Randomized Clinical Trial (MAGiCAL-CKD).
- In 148 people with high fasting blood sugar, a once-daily combination tablet containing banaba lowered fasting and after-meal blood sugar, HbA1c and insulin resistance more than placebo over 3 months.An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fas…
- In a 3-month placebo-controlled trial of 140 adults with type 2 diabetes, 1,000 mg of cinnamon bark powder daily improved fasting glucose, insulin resistance and most lipid measures, with larger benefits in those with higher body mass index.Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial.
- In a 90-day trial of 140 adults with type 2 diabetes, 3 g of cinnamon daily lowered LDL cholesterol and raised HDL cholesterol, but changes in total cholesterol and triglycerides were not significant.Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial.
- In 124 women with polycystic ovary syndrome and insulin resistance, 100 mg daily of a cinnamon and banaba fraction for 6 months improved insulin resistance about as much as a med, though non-inferiority was not confirmed.The Efficacy and Safety of DLBS3233, A Combined Bioactive Fraction of Cinnamomum burmanii and Lagerstroemia speciosa Pla…
- In 123 men with type 2 diabetes and erectile dysfunction, 3 months of a combination of alpha lipoic acid, grape and ginkgo lowered fasting blood glucose and insulin resistance, alone or with avanafil.Evaluation of the Effect on Sexual Performance of a Nutraceutical Combination Containing Alpha Lipoic Acid, Vitis vinife…
- In 122 overweight women with polycystic ovary syndrome, a herbal blend containing licorice plus lifestyle advice for 3 months lowered insulin and blood pressure more than lifestyle advice alone.Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlle…
- In 120 obese women with type 2 diabetes on a low-calorie diet for 3 weeks, adding a multivitamin-mineral complex with biotin lowered blood glucose by 1.8 mmol/l versus 1.2 with diet alone.[Assessment of efficiency of dietotherapy with addition of a vitamin-mineral complex in patients with diabetes mellitus …
- In hypercholesterolemic children, low-dose chromium polynicotinate or policosanol lowered cholesterol only when combined with glucomannan fiber over eight weeks, while chromium with starch alone had no lipid-lowering effect.Low dose chromium-polynicotinate or policosanol is effective in hypercholesterolemic children only in combination with g…
- In 120 adults with or at risk of metabolic syndrome, 3 grams a day of cinnamon powder, among other spices, for 12 weeks improved blood sugar, HbA1c and total cholesterol compared with placebo.The Effect of Therapeutic Doses of Culinary Spices in Metabolic Syndrome: A Randomized Controlled Trial.
- In 120 people with type 2 diabetic nerve disease on short-term intensive insulin, 2 weeks of alpha lipoic acid lowered fasting glucose like the comparison treatment but gave better inflammation and adiponectin results than the comparison.[Effect of alpha-lipoic acid combined with transient intensive insulin therapy on adipokine level in patients with type …
- Asian Indian adults with metabolic syndrome who took 3 g of cinnamon daily for 16 weeks had lower fasting blood sugar, average blood sugar over three months, waist size and body mass index than those on placebo.Effect of oral cinnamon intervention on metabolic profile and body composition of Asian Indians with metabolic syndrome:…
- In 110 adults with pre-diabetes, six months of a lysine, zinc and vitamin C combination lowered blood sugar and HbA1c and fewer developed diabetes (7.3% vs 25.4% on placebo).Effects of the Lysulin™ supplementation on pre-diabetes: A randomized double-blind, placebo-controlled clinical trial.
- In 109 adults with type 2 diabetes, 1 gram of cinnamon capsules daily for 90 days added to usual care lowered HbA1c by about 0.83% versus 0.37% with usual care alone.Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial.
- In 107 people after hip replacement surgery, vitamin C lowered pain, morphine use and inflammation and, unlike dexamethasone, was not linked to higher blood sugar; blood sugar was not improved compared with control.Efficacy of Vitamin C as Glucocorticoid Substitute for Reducing Pain and Inflammation After Total Hip Arthroplasty: A Ra…
- In 105 adults with type 2 diabetes, 1 gram of cinnamon daily for 90 days did not change blood sugar, insulin sensitivity or cholesterol compared with placebo.Controlling type 2 diabetes mellitus with herbal medicines: A triple-blind randomized clinical trial of efficacy and saf…
- In 103 prediabetic adults, water-soluble cinnamon extract for 6 months did not change heart electrical tracings (ECG) compared with placebo, showing no heart rhythm side effects.Effect of water-soluble cinnamon extract on electrocardiographic parameters: An analysis of the CiNNaMON trial.
- In 100 people with fatty liver disease, 268 mg of alpha-tocopherol twice daily for 48 weeks lowered blood levels of several microRNAs linked to fat buildup in the liver, insulin resistance, oxidative stress and inflammation; delta-tocotrienol was more effective for two of them.Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: …
- In 98 adults with prediabetes, 30 mg of zinc gluconate daily for up to 12 months did not change long-term blood sugar or fasting glucose compared with placebo.The effect of zinc supplementation on glucose homeostasis: a randomised double-blind placebo-controlled trial.
- In 98 people with type 2 diabetes who had a heart attack, 12 weeks of taurine plus meldonium improved heart rate variability measures compared with the comparison group.Normalization of heart rate variability with taurine and meldonium complex in post-infarction patients with type 2 diabe…
- In 97 overweight or obese women on a calorie-restricted diet for 10 weeks, 300 mg daily of alpha lipoic acid increased weight loss, but glucose improvements did not differ between groups.Effects of α-lipoic acid and eicosapentaenoic acid in overweight and obese women during weight loss.
- In 95 people with type 2 diabetes, 2 or 4 grams of bitter melon daily for 10 weeks lowered long-term blood sugar (HbA1c) and fasting glucose from baseline, though less than the meds glibenclamide, and blood fats and blood pressure improved.Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients.
- In 94 people with impaired glucose tolerance or mild type 2 diabetes, 6 g daily of a ginseng, mulberry and banaba mix for 24 weeks did not change blood sugar control but lowered inflammation markers.A six-month supplementation of mulberry, korean red ginseng, and banaba decreases biomarkers of systemic low-grade infla…
- In 93 adults with obesity, 12 weeks of a combination of berberine, white mulberry leaf extract and chromium improved insulin sensitivity by 28% more than placebo and reduced body fat.Effects of Berberine, White Mulberry Leaf Extract and Chromium Picolinate on Body Composition and Insulin Resistance in …
- In 92 adults with type 2 diabetes, 500 mcg of chromium picolinate daily for 4 months kept insulin resistance from rising and lowered the inflammation marker TNF-alpha, but fasting blood sugar, average blood sugar, and cholesterol did not change significantly.The effects of chromium and vitamin D3 co-supplementation on insulin resistance and tumor necrosis factor-alpha in type …
- In 90 people with fatty liver inflammation, vitamin E at 400 IU twice daily for 6 months modestly reduced liver fat and a marker of oxidative stress, but was less effective than the N-acetyl cysteine and a med combination and did not significantly change most other blood markers.New Approach Combination-Dosed Therapy for Nonalcoholic Steatohepatitis Versus Vitamin E: A Randomized Controlled Trial.
- In 90 people with type 2 diabetes, 12 weeks of bitter melon extract lowered average fasting glucose compared with placebo, but long-term blood sugar (HbA1c) did not change.Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus.
- In 90 older adults with type 2 diabetes and acute stroke, alpha-lipoic acid given for 3 weeks alongside usual care lowered blood sugar, blood lipids and insulin resistance and reduced oxidative stress more than vitamin C alone.α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
- In 89 adults with type 2 diabetes, 1000 mg per day of a polyherbal formula containing Gymnema sylvestre for 8 weeks lowered fasting and after-meal blood sugar and HbA1c, and improved cholesterol and triglycerides.Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in p…
- In 87 malnourished children with long-lasting diarrhea, zinc sulfate at 3 mg per kg of body weight daily for 14 days did not improve weight gain or diarrhea recovery compared with placebo, and it lowered plasma copper; blood sugar and heart outcomes were not measured.Zinc supplementation in malnourished children with persistent diarrhea in Pakistan.
- In 86 women with polycystic ovary syndrome, 8 weeks of vitamin E alone did not significantly lower fasting blood sugar, though it did lower testosterone; blood sugar gains came from coenzyme Q10 alone or combined with vitamin E.Hormonal and Metabolic Effects of Coenzyme Q10 and/or Vitamin E in Patients With Polycystic Ovary Syndrome.
- In women with polycystic ovary syndrome, 1000 mcg of chromium picolinate daily for six months reduced insulin resistance and BMI and increased the chance of ovulation and regular periods compared with placebo.Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.
- In 85 healthy adults, a mulberry leaf and apple peel extract tablet taken before a carb-rich meal or sugar drink cut the rise in blood glucose and insulin over 2 hours compared with placebo.A Novel Nutraceutical Supplement Lowers Postprandial Glucose and Insulin Levels upon a Carbohydrate-Rich Meal or Sucrose…
- In 84 overweight or obese women with polycystic ovary syndrome, taking 1,500 mg of cinnamon daily for 8 weeks lowered fasting blood glucose, fasting insulin and insulin resistance compared with placebo.Cinnamon improves metabolic factors without detectable effects on adiponectin in women with polycystic ovary syndrome.
- In 84 healthy adults, mulberry fruit extract added to a rice meal lowered blood sugar and insulin after the meal compared with placebo, and worked at least as well as its main compound alone.Bioequivalence of Mulberry Fruit Extract and 1-Deoxynojirimycin for Postprandial Blood Glucose Lowering: A Randomized Tr…
- In 83 people with early diabetes, fermented licorice extract taken for 6 months improved nerve function but long-term blood sugar (HbA1c) stayed near baseline with no difference from placebo.Randomized Double-blind Placebo-controlled study to evaluate the efficacy of fermented deglycyrrhizinated licorice for t…
- In 82 adults with type 2 diabetes and nerve damage affecting the heart, adding alpha-lipoic acid to standard treatment improved the heart's diastolic (filling) function and electrical properties more effectively.[Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with di…
- In 81 adults with slightly high fasting blood sugar, 3 months of a Gymnema, corn, zinc and chromium supplement lowered fasting blood sugar and HbA1c compared with placebo in the one-tablet group, with no signs of kidney or liver harm.Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chro…
- In 80 adults with impaired glucose tolerance, 50-100 mg daily of a cinnamon and banaba fraction for 12 weeks reduced insulin resistance more than placebo (27% vs 5% drop).Read the study on PubMed (27099473) →
- In a placebo-controlled trial of 80 critically ill patients, 900 mg of alpha-lipoic acid daily for 10 days lowered blood sugar and prevented the rise in insulin resistance seen with placebo.The Beneficial Effects of α-Lipoic Acid in Critically Ill Patients: A Prospective, Randomized, Double-Blind, Placebo-Con…
- In 79 adults with type 2 diabetes, an extract equal to 3 g of cinnamon powder daily for 4 months lowered fasting blood glucose more than placebo, though average blood sugar control measured over months did not change significantly.Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.
- In 78 overweight or obese adults, 12 weeks of 360 mg magnesium glycinate plus vitamin D did not change blood sugar, insulin or insulin resistance compared with placebo.Combined vitamin D and magnesium supplementation does not influence markers of bone turnover or glycemic control: A rand…
- In 78 people with a heart attack, a 48-hour magnesium infusion was followed by 22% less heart failure, 28% fewer irregular heartbeats and 22% lower hospital death than placebo.[Treatment of acute myocardial infarct with magnesium].
- In 77 people with prediabetes, 300 mg of delta-tocotrienol daily for 12 weeks lowered fasting blood sugar, long-term blood sugar, insulin and insulin resistance more than placebo.Effects of delta-tocotrienol supplementation on glycaemic control in individuals with prediabetes: A randomized controll…
- In a randomized trial of adults with metabolic syndrome, eating 2 oz of almonds daily for 12 weeks lowered total and LDL cholesterol compared with crackers and increased magnesium intake from the diet.Beneficial changes in total cholesterol, LDL-C, biomarkers of intestinal inflammation, and vitamin E status in adults wi…
- In 76 obese children with fatty liver, 100 mg of vitamin E daily for one month improved insulin resistance and other measures compared with no treatment, though lifestyle changes worked better.Effect of lifestyle intervention on non-alcoholic fatty liver disease in Chinese obese children.
- In 76 men with type 2 diabetes and erectile dysfunction, 600 mg of alpha-lipoic acid with alprostadil given daily for 2 weeks improved blood vessel function and had fewer side effects than oral a med.Study on the clinical value of alprostadil combined with α-lipoic acid in treatment of type 2 diabetes mellitus patients…
- In 75 people with type 2 diabetes, 4 months of a multivitamin with 200 mcg biotin did not change blood sugar control compared with placebo.Improving neuropathy scores in type 2 diabetic patients using micronutrients supplementation.
- In a 3-month trial of adults with knee osteoarthritis, 1,500 mg taken three times daily of bitter melon capsules significantly lowered fasting blood sugar within the bitter melon group, though the placebo group was not reported to show this change.The effects of Momordica charantia (bitter melon) supplementation in patients with primary knee osteoarthritis: A single…
- In a 12-week placebo-controlled trial of 75 adults with prediabetes, 600 mg daily of bitter melon extract led to smaller rises in blood glucose than placebo, and 300 mg daily did too.Investigation of the Influence of a Bitter Melon Product on Indicators of Cardiometabolic Health in Adults with Prediabe…
- In 75 adults with type 2 diabetes taking a combination containing Gymnema for up to 6 months, blood sugar measures did not differ from placebo, but total cholesterol and LDL cholesterol were lower.Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type …
- In 74 patients after surgery receiving intravenous nutrition for 5 to 30 days, taurine did not change liver function more than the control solution, though LDL cholesterol fell more in the taurine group after 7 days.Phase IV prospective clinical study to evaluate the effect of taurine on liver function in postsurgical adult patients r…
- In 73 adults with type 2 diabetes taking 1000 mcg of chromium picolinate daily for 6 months, 63% responded with better insulin sensitivity compared with 30% on placebo; baseline insulin sensitivity was the main predictor of response.Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation.
- In 73 women with polycystic ovary syndrome, a four-herb blend including licorice taken for 12 weeks lowered insulin levels, while a med did not.Analysis of Unani coded formulation on the hormonal parameters of patients with polycystic ovarian syndrome.
- In 73 overweight women on a weight loss diet for 10 weeks, adding 0.3 g daily of alpha-lipoic acid did not change irisin levels beyond the effect of weight loss alone.Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid.
- In 72 teenagers with type 1 diabetes, 1 gram of cinnamon daily for 90 days did not improve blood sugar control compared with placebo.The effect of cinnamon on A1C among adolescents with type 1 diabetes.
- In 70 overweight people with type 2 diabetes, 50 mg of zinc gluconate daily for 8 weeks lowered fasting blood sugar, HbA1c, insulin resistance, triglycerides and total cholesterol, and raised antioxidant enzyme activity compared with placebo.Effects of zinc supplementation on superoxide dismutase activity and gene expression, and metabolic parameters in overwe…
- In 69 adults with type 2 diabetes, 200 mg vitamin C plus 150 mg vitamin E daily for 3 months did not change cholesterol or triglyceride levels, while the group taking minerals plus vitamins showed a rise in good cholesterol.The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes.
- In 69 adults with obesity, eating 57 g of almonds daily for six weeks lowered inflammation markers but did not change fasting blood sugar, insulin, cholesterol or blood pressure; manganese was not tested alone.Almond Consumption Improves Inflammatory Profiles Independent of Weight Change: A 6-Week Randomized Controlled Trial in …
- In 68 people at high risk of magnesium deficiency, magnesium treatment lowered blood levels of imidazole propionate, a compound linked to insulin resistance, by 39.9% while placebo raised it by 6.0%.Magnesium and imidazole propionate.
- In two trials of 68 adults with prediabetes, 12 weeks of 3.6 grams per day of freeze-dried whole bitter gourd lowered fasting blood sugar and insulin compared with a control, while a shorter 4-week trial with a lower dose showed no significant difference from control.Bitter gourd (Momordica charantia L.) supplementation for twelve weeks improves biomarkers of glucose homeostasis in a p…
- In 66 overweight women with polycystic ovary syndrome on a low-calorie diet, 1.5 g a day of licorice extract for 8 weeks improved fasting blood sugar, insulin and insulin resistance more than placebo.Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profi…
- In 66 Chinese adults with type 2 diabetes taking gliclazide, cinnamon extract at 120 or 360 mg daily for 3 months lowered HbA1c and fasting blood glucose, while placebo did not change them.Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabet…
- In 66 women with polycystic ovary syndrome, 1,500 mg of cinnamon powder daily for 12 weeks lowered fasting insulin and insulin resistance compared with placebo, with a drop in bad cholesterol compared with baseline.Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo contro…
- In obese adults with metabolic syndrome, 1000 mcg of chromium picolinate daily for 16 weeks did not improve insulin sensitivity, blood lipids or inflammation compared with placebo.Chromium picolinate does not improve key features of metabolic syndrome in obese nondiabetic adults.
- Adults who were overweight or obese with prediabetes and took a supplement containing cinnamon, chromium and carnosine for 4 months had a lower fasting blood sugar than those on placebo.A Dietary Supplement Containing Cinnamon, Chromium and Carnosine Decreases Fasting Plasma Glucose and Increases Lean Mas…
- In 61 adults with HIV-related fat loss, 48 weeks of lipoic acid with n-acetylcysteine improved a breath-test measure of mitochondrial function, but fat distribution and lipid levels did not change significantly.Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study.
- In a placebo-controlled trial of 60 women with polycystic ovary syndrome, taking 100 mg magnesium twice daily along with zinc, calcium and vitamin D for 12 weeks lowered insulin levels, improved insulin resistance and reduced triglycerides and total cholesterol compared with placebo.A Trial on The Effects of Magnesium-Zinc-Calcium-Vitamin D Co-Supplementation on Glycemic Control and Markers of Cardio-…
- In a placebo-controlled trial of 60 pregnant women with gestational diabetes, 6 weeks of a magnesium, zinc, calcium and vitamin D combination lowered inflammation and oxidative stress markers compared with placebo.The effects of magnesium-zinc-calcium-vitamin D co-supplementation on biomarkers of inflammation, oxidative stress and p…
- In adults with type 2 diabetes, 1000 mcg of chromium picolinate daily for three months shortened the QTc heart rhythm measure compared with placebo.Chromium supplementation shortens QTc interval duration in patients with type 2 diabetes mellitus.
- In 60 overweight adults without diabetes, a drink with 250 mcg of chromium picolinate and amino acids taken with a carbohydrate meal lowered the rise in blood sugar compared with placebo.A novel nutritional supplement containing amino acids and chromium decreases postprandial glucose response in a randomiz…
- In 60 women with polycystic ovary syndrome, 100 mg daily of a cinnamon and banaba fraction for 6 months, alone or with a med, showed no significant improvement in insulin resistance or fasting glucose.Read the study on PubMed (37424700) →
- In 60 women with fatty liver disease, 1,000 mg a day of licorice root extract for 12 weeks lowered insulin, insulin resistance and an oxidative stress marker more than placebo.Effects of licorice root supplementation on liver enzymes, hepatic steatosis, metabolic and oxidative stress parameters …
- In a 40-day placebo-controlled trial of 60 adults with type 2 diabetes, daily cinnamon at 1, 3 or 6 g lowered fasting blood glucose, triglycerides, LDL cholesterol and total cholesterol, while placebo showed no significant change.Cinnamon improves glucose and lipids of people with type 2 diabetes.
- In 60 adults with type 2 diabetes taking their usual medicine, 1.5 g per day of cinnamon cassia powder for 12 weeks did not lower fasting blood sugar or the 3-month sugar measure more than placebo.The effect of cinnamon cassia powder in type 2 diabetes mellitus.
- In 60 moderately obese adults over 8 weeks, a combination including 400 mg Gymnema extract reduced body weight, cholesterol and triglycerides compared with placebo; blood sugar was not reported.Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium a…
- In 60 adults with type 2 diabetes, taking 500 mg a day of yarrow (Achillea millefolium) capsules for 3 months lowered liver enzymes, triglycerides, LDL cholesterol and total cholesterol compared with placebo; blood sugar was not reported in the abstract.Achillea millefolium capsule improved liver enzymes and lipid profile compared to placebo in patients with type 2 diabet…
- In 60 adults with type 2 diabetes, 600 mg a day of white mulberry leaf extract for 12 weeks lowered insulin and an oxidative stress marker and raised HDL cholesterol versus placebo, but did not change other metabolic measures.Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2…
- In 60 adults with impaired fasting glucose, a daily 600 mg alpha-lipoic acid infusion for 3 weeks improved blood vessel dilation and lowered a blood marker of oxidative stress, while the untreated group showed no change.α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose.
- In 60 pregnant women with gestational diabetes, 100 mg of alpha-lipoic acid daily for 8 weeks lowered fasting blood sugar and insulin resistance in the treated group, along with lower oxidative stress markers.Elevation of the adiponectin/leptin ratio in women with gestational diabetes mellitus after supplementation with alpha-l…
- In a placebo-controlled trial of 60 pregnant women with gestational diabetes, 300 mg of alpha-lipoic acid daily for 8 weeks lowered fasting blood sugar and improved several antioxidant measures.Alpha-lipoic acid supplementation effects on serum values of some oxidative stress biomarkers in women with gestational …
- In 60 people with diabetes on dialysis, 600 mg a day of lipoic acid for six months lowered inflammation, a marker of oxidative damage, and HbA1c and improved blood counts compared with the control group.Alpha-lipoic acid improved anemia, erythropoietin resistance, maintained glycemic control, and reduced cardiovascular ri…
- In 59 adults, 400 mg of magnesium oxide daily did not change blood sugar or blood pressure compared with placebo, although it raised magnesium levels.A Pilot Randomized Trial of Oral Magnesium Supplementation on Supraventricular Arrhythmias.
- In 59 adults with type 2 diabetes, 1,200 mg per day of cinnamon for 12 weeks did not lower systolic blood pressure beyond placebo once starting values were accounted for.Dietary cinnamon supplementation and changes in systolic blood pressure in subjects with type 2 diabetes.
- Adults with poorly controlled type 2 diabetes who took 2 g of cinnamon daily for 12 weeks had a lower average blood sugar measure than those on placebo, along with lower blood pressure, though fasting blood sugar changes were not significant versus placebo.Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: …
- In a placebo-controlled trial of 57 adults with type 2 diabetes, 300 mg of alpha-lipoic acid daily for 8 weeks significantly lowered fasting blood sugar and insulin resistance compared with placebo.Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.
- In 56 outpatients with diabetes, 2 grams a day of vitamin C for 90 days lowered fasting blood sugar and HbA1c, cholesterol and triglycerides in those with non-insulin-dependent diabetes.Magnesium and ascorbic acid supplementation in diabetes mellitus.
- In 56 teens with obesity and insulin resistance, three months of myo-inositol with 5 mg zinc gluconate did not significantly improve the main insulin resistance score compared with placebo, though a post hoc analysis found lower insulin and insulin resistance in the most obese subgroup.Efficacy of myo-inositol and zinc on insulin resistance in a paediatric population with obesity.
- In 56 non-obese adults, a daily mix of 10 supplements including 1.7 g of cinnamon bark extract for 24 weeks did not change artery stiffness, blood vessel function, blood sugar, or cardiovascular risk markers compared with controls.Multiple dietary supplements do not affect metabolic and cardio-vascular health.
- In 54 people on dialysis given magnesium oxide 440 mg three times a week for 6 months, carotid artery wall thickness fell while it rose in the placebo group, but blood vessel function and CRP showed no benefit.Effect of magnesium supplementation on carotid intima-media thickness and flow-mediated dilatation among hemodialysis pa…
- In 27 adults with metabolic syndrome, 400 mg of magnesium daily for 12 weeks significantly lowered systolic and diastolic blood pressure and reduced the inflammation marker interleukin-6, compared with 27 controls who took no magnesium.Positive effects of magnesium supplementation in metabolic syndrome.
- In 54 overweight women with polycystic ovary syndrome, 200 mcg of chromium picolinate plus 1000 mg of carnitine daily for 12 weeks lowered weight, fasting blood sugar, insulin, insulin resistance, and triglycerides and LDL cholesterol more than placebo.Effects of Chromium and Carnitine Co-supplementation on Body Weight and Metabolic Profiles in Overweight and Obese Women…
- In 51 people with type 1 diabetes, 600 mg a day of lipoic acid for five weeks reduced platelet reactivity, a clotting measure, compared with placebo.Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients.
- In 50 people with diabetes, 500 mg vitamin C daily for 4 months did not change blood sugar, glycated hemoglobin, or blood fats compared with placebo.The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study.
- In 50 infants and neonates having heart surgery, a single intravenous magnesium dose did not significantly reduce postoperative heart rhythm problems compared with saline, though there was a trend toward fewer arrhythmias.Role of magnesium in the prevention of postoperative arrhythmias in neonates and infants undergoing arterial switch oper…
- In 50 critically ill ventilated ICU patients, adding intravenous magnesium to midazolam sedation shortened time on the ventilator and time to spontaneous breathing trials, and the group receiving magnesium needed less insulin over 48 hours.Can we use magnesium for sedation in the intensive care unit for critically ill patients: Is it as effective as other se…
- In a double-blind trial of 50 patients having heart bypass surgery, magnesium sulphate given for 5 days after surgery reduced atrial fibrillation, occurring in 1 of 25 patients versus 5 of 25 on placebo.Atrial fibrillation after coronary artery bypass surgery: predictors and the role of MgSO4 replacement.
- In 50 burn patients, a multi-nutrient tube feed that contained zinc, among other ingredients, was associated with improved glucose tolerance and fewer wound infections compared with two standard feeds, so the zinc effect cannot be isolated.Differential effects of three enteral dietary regimens on selected outcome variables in burn patients.
- In a placebo-controlled trial of 50 pregnant women with gestational diabetes, 30 mg of elemental zinc daily for 6 weeks lowered high-sensitivity C-reactive protein and raised total antioxidant capacity, but did not change pregnancy outcomes.Zinc Supplementation and the Effects on Pregnancy Outcomes in Gestational Diabetes: a Randomized, Double-blind, Placebo-…
- In 50 adults with fatty liver disease, 1500 mg of cinnamon daily for 12 weeks lowered insulin resistance, blood sugar, cholesterol, liver enzymes and C-reactive protein more than placebo.Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-react…
- In 50 overweight women, 8 weeks of a supplement with 25 mg capsaicin plus green tea and ginger lowered insulin and insulin resistance, improved insulin sensitivity and raised glutathione compared with placebo.The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profi…
- In 50 adults with type 2 diabetes, 4 days of bell pepper juice plus yoga did not lower fasting blood sugar more than yoga alone, but lowered blood sugar after meals and systolic blood pressure.Short-term effect of add on bell pepper (Capsicum annuum var. grossum) juice with integrated approach of yoga therapy on…
- In 50 people with fatty liver disease, 1200 mg daily of alpha-lipoic acid for 12 weeks lowered insulin and leptin and raised adiponectin and an insulin sensitivity index compared with placebo, but liver fat did not differ significantly between groups.Oral α-lipoic acid supplementation in patients with non-alcoholic fatty liver disease: effects on adipokines and liver h…
- In 48 people with type 1 or type 2 diabetes, 10 days of sugar-free zinc gluconate lozenges did not change blood sugar control compared with placebo, and did not harm it.Sugar-free zinc gluconate glycine lozenges (Cold-Eeze) do not adversely affect glucose control in patients with type 1 o…
- In 48 postmenopausal women with type 2 diabetes, 40 mg per day of zinc for 12 weeks, given with flaxseed oil, did not significantly change glucose, insulin, HbA1c or HOMA-IR compared with placebo.Zinc transporter gene expression and glycemic control in post-menopausal women with Type 2 diabetes mellitus.
- In 48 pregnant women, a combination supplement containing manganese taken for 60 days lowered blood sugar, cholesterol, LDL and triglycerides versus placebo, and systolic blood pressure fell within the treated group; manganese was not tested alone.Myo-inositol, D-chiro-inositol, folic acid and manganese in second trimester of pregnancy: a preliminary investigation.
- In 46 young adults who exercised three times a week for 12 weeks, taking 250 or 500 mg of vitamin C before each session did not change blood sugar or cholesterol compared with no vitamin C.Ascorbic acid supplementation does not alter oxidative stress markers in healthy volunteers engaged in a supervised exer…
- In 46 postmenopausal women with insulin resistance, vitamin C alone or with resveratrol lowered markers of cell damage from oxidative stress, but insulin resistance did not change between groups.The Administration of Resveratrol and Vitamin C Reduces Oxidative Stress in Postmenopausal Women-A Pilot Randomized Clin…
- In 46 adults with fatty liver disease, 400 mcg of chromium picolinate daily for 3 months lowered triglycerides, insulin, insulin resistance, and inflammatory markers compared with placebo, without changing fasting blood sugar or HbA1c.A pilot study of the effects of chromium picolinate supplementation on serum fetuin-A, metabolic and inflammatory factor…
- In 46 adults with type 2 diabetes, 3,000 mg of taurine daily for 8 weeks lowered fasting blood sugar, HbA1c, insulin, insulin resistance, cholesterol, pentosidine and methylglyoxal compared with placebo.The Effects of Taurine Supplementation on Metabolic Profiles, Pentosidine, Soluble Receptor of Advanced Glycation End Pr…
- In 45 women with polycystic ovary syndrome, 1,500 mg of cinnamon daily for 6 months improved menstrual cycle frequency, but insulin resistance did not change compared with placebo.Preliminary evidence that cinnamon improves menstrual cyclicity in women with polycystic ovary syndrome: a randomized co…
- In 45 adults with type 2 diabetes, 3,000 mg of taurine daily for 8 weeks lowered fasting blood sugar, insulin, insulin resistance, total cholesterol and LDL cholesterol compared with placebo, with no change in HbA1c.The effects of taurine supplementation on glycemic control and serum lipid profile in patients with type 2 diabetes: a r…
- In 44 people with type 2 diabetes who all took 53.6 mg of vitamin E daily, adding fish oil for 8 weeks did not change blood sugar control, so vitamin E itself was not tested against a control.Influence of fish oil supplementation on in vivo and in vitro oxidation resistance of low-density lipoprotein in type 2 …
- In 44 adults with type 2 diabetes, 3 grams of cinnamon daily for 8 weeks did not change blood sugar, insulin, or antioxidant measures compared with placebo.Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type …
- In 44 adults with type 2 diabetes, 3 g of cinnamon per day for 8 weeks did not lower blood levels of two artery-wall adhesion molecules more than placebo.A randomized controlled trial to determining the effect of cinnamon on the plasma levels of soluble forms of vascular ad…
- In 44 adults with type 2 diabetes, 3 g of cinnamon per day for 8 weeks produced a between-group difference in one inflammation-related factor (NF-kB), but levels of other inflammation markers and SIRT1 did not improve, and the authors concluded no overall benefit.Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type …
- In 44 pregnant women with gestational diabetes, 5 mg of capsaicin daily for 4 weeks lowered blood sugar and insulin after meals plus fasting total cholesterol and triglycerides compared with placebo.Capsaicin-containing chili improved postprandial hyperglycemia, hyperinsulinemia, and fasting lipid disorders in women w…
- In 44 obese people with type 2 diabetes, 0.9 mg daily of vanadium from enriched yeast for 12 weeks lowered blood sugar measures and body measurements and improved insulin sensitivity compared with placebo.Insulin Receptor Substrates Regulation and Clinical Responses Following Vanadium-Enriched Yeast Supplementation in Obese…
- In 44 obese men over 12 weeks, combining aerobic and resistance training with 3 g of taurine daily produced larger reductions in the fat-producing hormone asprosin, body weight, and body fat than training alone, with a small group size making the results preliminary.Combined Aerobic-Resistance Training and Taurine Supplementation Reduce Asprosin and Elevate Spexin in Men with Obesity:…
- In 43 people with poorly controlled type 2 diabetes, 4 weeks of chromium plus 2 mg biotin lowered blood sugar after a glucose drink by 9.7% while placebo rose 5.1%, and also improved fructosamine and triglycerides.The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type…
- In 43 adults with sleep complaints, a blend with 750 mg mulberry leaf extract taken with the evening meal for 14 days cut the after-meal blood sugar response at 1 hour by 21% and reduced nighttime glucose variation versus control.Mulberry leaf extract combined with tryptophan improves sleep and post wake mood in adults with sleep complaints - A ran…
- In 42 healthy Asian adults, eating two kiwifruit before breakfast daily for 7 weeks raised vitamin C intake but did not change fasting blood sugar or insulin compared with the control group.Metabolic and Blood Pressure Effects of Consuming Two Kiwifruit Daily for 7 Weeks: A Randomised Controlled Trial.
- In 42 adults with low HDL cholesterol, 4 mg of capsaicin daily for 3 months raised HDL cholesterol and lowered triglycerides and C-reactive protein compared with control, with no change in glucose.Capsaicin Supplementation Improved Risk Factors of Coronary Heart Disease in Individuals with Low HDL-C Levels.
- In 42 adults with impaired glucose tolerance, a single 300 mg dose of alpha-lipoic acid before a glucose drink reduced the blood vessel dysfunction caused by the sugar spike compared with placebo.The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impair…
- In 41 teenagers with poorly controlled type 1 diabetes, an antioxidant mix with vitamin C for 3 to 6 months did not improve blood antioxidant levels or oxidative stress compared with placebo, though blood sugar control improved similarly in both groups.Improved glycemic control either alone, or combined with antioxidant supplementation, fails to restore blood glutathione…
- In 40 healthy young men, 1,000 mg of vitamin C plus 400 IU of vitamin E daily for 4 weeks of training raised blood levels of vaspin, a marker linked to poorer insulin sensitivity, whereas levels fell in men who took no antioxidants.Serum vaspin concentrations are decreased after exercise-induced oxidative stress.
- In 40 women with polycystic ovary syndrome, 250 mg a day of magnesium oxide for 2 months lowered fasting insulin and insulin resistance and improved cholesterol and fasting blood sugar compared with placebo.The Effect of Magnesium Supplementation on Insulin Resistance and Metabolic Profiles in Women with Polycystic Ovary Synd…
- In 40 adults with newly diagnosed type 2 diabetes, 3 months of chromium-enriched brewer's yeast lowered fasting blood sugar and long-term blood sugar control markers more than placebo yeast, and also reduced cholesterol and triglycerides.Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type…
- In 40 adults with high fasting glucose, an 8-week combination product containing banaba lowered insulin by 13% and insulin resistance by 25% and improved triglycerides versus placebo.Nutraceutical Effects on Glucose and Lipid Metabolism in Patients with Impaired Fasting Glucose: A Pilot, Double-Blind, …
- In a 3-month placebo-controlled trial of 40 adults with type 2 diabetes, bitter melon capsules did not significantly change HbA1c or fasting blood sugar compared with placebo.The effect of Momordica charantia capsule preparation on glycemic control in type 2 diabetes mellitus needs further stud…
- In 40 women with type 2 diabetes, taurine alone for 8 weeks did not lower blood sugar or lipids, but taurine combined with suspension training improved HbA1c, insulin resistance, triglycerides and HDL cholesterol more than training alone.The Effects of TRX Suspension Training Combined with Taurine Supplementation on Body Composition, Glycemic and Lipid Mar…
- In 39 people with Parkinson's disease, licorice syrup taken for 6 months did not change blood glucose or blood pressure, though Parkinson's symptoms improved.Efficacy of oral administration of licorice as an adjunct therapy on improving the symptoms of patients with Parkinson's…
- In 38 healthy adults, a single dose of white mulberry leaf extract taken with 75 g sucrose lowered the blood sugar rise by 42% and the insulin rise by 40% compared with sucrose alone.Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a r…
- In 38 obese women on a weight-loss diet, 3 g of taurine daily for 8 weeks lowered total cholesterol, bad (LDL) cholesterol, leptin, adiponectin and C-reactive protein compared with the diet plus placebo, with no significant change in good (HDL) cholesterol or blood sugar measures.Effect of weight-loss diet combined with taurine supplementation on body composition and some biochemical markers in obe…
- In 37 adults with type 2 diabetes taking a med drug, 1000 mcg of chromium picolinate daily for 6 months improved insulin sensitivity and average blood sugar and reduced weight gain and belly fat compared with placebo.Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type …
- In 37 healthy adults, single normal and double doses of mulberry leaf extract taken with 50 g maltodextrin lowered the blood sugar rise by 14% and 22% and the insulin rise by about 24% versus placebo, while the half dose did not significantly differ.Mulberry-extract improves glucose tolerance and decreases insulin concentrations in normoglycaemic adults: Results of a …
- In 37 healthy adults eating a full meal, 200, 225 or 250 mg of Reducose mulberry leaf extract lowered blood sugar rise by about 30 to 33 percent and insulin rise by about 31 to 38 percent compared with placebo.Understanding the Impact of Different Doses of Reducose® Mulberry Leaf Extract on Blood Glucose and Insulin Responses af…
- In 36 obese people with type 2 diabetes, 4 weeks of chromium plus biotin lowered the artery-clogging blood fat index, triglycerides, glucose and fructosamine compared with placebo.Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus…
- In a placebo-controlled trial of 36 pregnant women with gestational diabetes, 250 mg of magnesium oxide daily for 6 weeks reduced inflammatory gene activity compared with placebo and lowered newborn hyperbilirubinemia and hospitalization rates.The effects of magnesium supplementation on gene expression related to inflammatory markers, vascular endothelial growth…
- In 36 adults with type 2 diabetes, a single drink of aqueous cinnamon extract taken with a glucose drink did not change the blood sugar rise after the drink compared with the glucose drink alone.Effect of Aqueous Cinnamon Extract on the Postprandial Glycemia Levels in Patients with Type 2 Diabetes Mellitus: A Rand…
- In 36 people with impaired fasting glucose, 5 grams a day of mulberry leaf extract for 4 weeks reduced blood sugar and insulin rises after a carbohydrate load compared with placebo.Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo…
- In 36 healthy adults given a high sugar and fat drink, a single dose of mulberry twig extract lowered blood sugar at 4 hours compared with placebo and changed insulin levels.Effect of Mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected…
- In 18 diabetic and 15 non-diabetic adults, 28 days of biotin lowered triglycerides and VLDL cholesterol but did not change blood glucose, insulin or cholesterol.Biotin supplementation reduces plasma triacylglycerol and VLDL in type 2 diabetic patients and in nondiabetic subjects w…
- In 32 adults with metabolic syndrome, 600 mcg of chromium with magnesium and zinc daily for 24 weeks did not change blood sugar, lipids, or blood pressure compared with placebo, though C-reactive protein fell more than with placebo.Effects of zinc, magnesium, and chromium supplementation on cardiometabolic risk in adults with metabolic syndrome: A do…
- In 31 adults, two weeks of mulberry leaf and water chestnut tea before meals reduced daily blood sugar swings and the one-hour post-meal blood sugar compared with placebo, with no safety concerns found.Evaluation of the Postprandial-Hyperglycemia-Suppressing Effects and Safety of Short-Term Intake of Mulberry Leaf and Wa…
- In 30 men, 15 of them obese, 80 mg of vitamin C sprayed into the nose daily for 8 days acutely reduced the insulin response in the obese men, and the authors describe this as improved insulin sensitivity; food intake was not changed.Metabolic and Neuroenergetic Effects of Intranasal Vitamin C Application in the Human Brain.
- In 30 women with type 2 diabetes on a med, 400 IU of vitamin E daily for 12 weeks lowered insulin resistance and serum insulin compared with placebo.Read the study on PubMed (35291435) →
- In 30 elderly non-diabetic people with angina, 900 mg of vitamin E daily for 4 months lowered fasting and 2-hour insulin and triglycerides and raised glucose use in the clamp test compared with placebo, while blood glucose stayed similar.Chronic intake of pharmacological doses of vitamin E might be useful in the therapy of elderly patients with coronary he…
- In 30 adults with moderately high cholesterol, a 6-week combination containing banaba improved cholesterol and inflammation but showed no change in insulin resistance or other glucose measures versus placebo.Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hyper…
- In 30 young adults, adding 6 g of ground cinnamon to a farina cereal lowered blood sugar at several points and reduced the 2-hour blood sugar total, in both normal-weight and obese people.Effect of ground cinnamon on postprandial blood glucose concentration in normal-weight and obese adults.
- In 30 people with impaired glucose tolerance, 300 mg of Gymnema sylvestre twice daily lowered 2-hour glucose tolerance test results and long-term blood sugar (A1C), and raised insulin sensitivity; 46.7% reached normal A1C.Effect of Gymnema sylvestre Administration on Glycemic Control, Insulin Secretion, and Insulin Sensitivity in Patients w…
- In 30 people with borderline diabetes, a 3 g serving of mulberry leaf and water chestnut tea (containing 10.2 mg DNJ) lowered blood sugar 30 and 60 minutes after rice and lowered insulin compared with placebo tea.Mulberry leaves and water chestnut tea reduces postprandial blood glucose in borderline diabetic Japanese: A randomized,…
- In 30 adults with type 2 diabetes, 21 days of daily 600 mg alpha-lipoic acid given intravenously improved blood vessel dilation in response to acetylcholine, while the placebo group showed no change.Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomiz…
- In 30 children and teens with type 1 diabetes, 600 mg a day of lipoic acid added to insulin for four months improved heart pumping function and lowered oxidative stress and inflammation compared with insulin alone.Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes.
- In 30 overweight or obese college students taking 3 grams of taurine daily for 7 weeks, triglycerides and the atherogenic index fell compared with placebo, and body weight dropped.Beneficial effects of taurine on serum lipids in overweight or obese non-diabetic subjects.
- In 28 healthy non-diabetic adults, 1 gram per day of vitamin C for 4 months did not change HbA1c, a three-month blood sugar marker, on any of three test methods.Read the study on PubMed (16698007) →
- In 28 adults with type 1 diabetes, 12 months of oral magnesium hydroxide (20-30 mmol daily) did not change kidney function or most blood fats compared with placebo, though triglycerides rose in three treated patients.Magnesium therapy in type 1 diabetes. A double blind study concerning the effects on kidney function and serum lipid lev…
- In 27 adults, a milk rice meal with 4 g of cinnamon plus acetic acid lowered blood sugar at 15 minutes and increased early fullness, but total blood sugar over 2 hours did not differ from the plain meal.Additive postprandial blood glucose-attenuating and satiety-enhancing effect of cinnamon and acetic acid.
- In 26 healthy young adults, 220 mcg of chromium nicotinate daily for 90 days did not change fasting blood sugar, insulin, or cholesterol compared with placebo overall.Effects of chromium supplementation on fasting insulin levels and lipid parameters in healthy, non-obese young subjects.
- In 25 healthy adults, a single dose of mulberry leaf extract taken with cornflakes and milk reduced how much starch was digested and absorbed compared with placebo.Mulberry leaf extract decreases digestion and absorption of starch in healthy subjects-A randomized, placebo-controlled,…
- In 24 adults with hypertension, 600 mg of vitamin E daily for 4 weeks increased whole-body glucose uptake during a clamp test compared with placebo, along with higher glutathione ratios and intracellular magnesium.Effects of vitamin E and glutathione on glucose metabolism: role of magnesium.
- In 24 people with type 1 diabetes, 100 IU of vitamin E daily for 3 months lowered a blood clotting marker by 51 percent and a lipid peroxidation marker by 30 percent compared with placebo.Relationship of blood thromboxane-B2 (TxB2) with lipid peroxides and effect of vitamin E and placebo supplementation on …
- In 24 adults with metabolic syndrome and normal magnesium levels, 400 mg of magnesium citrate daily for 12 weeks lowered average blood sugar and blood pressure compared with placebo.Magnesium citrate supplementation decreased blood pressure and HbA1c in normomagnesemic subjects with metabolic syndrome…
- In 24 overweight adults with binge-eating disorder, 600 mcg of chromium picolinate daily for 6 months improved blood sugar control compared with placebo, but the higher 1000 mcg dose did not.A Double-Blind, Randomized Pilot Trial of Chromium Picolinate for Overweight Individuals with Binge-Eating Disorder: Eff…
- In 24 adults with metabolic syndrome, taking 500 mg of banaba twice a day for 12 weeks lowered fasting blood sugar, triglycerides, systolic blood pressure and insulin levels, and 8 of 12 (67%) no longer met the criteria for metabolic syndrome.Effect of Banaba (Lagerstroemia speciosa) on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.
- In 24 adults with type 2 diabetes, 2000 mg per day of bitter melon for 3 months lowered long-term blood sugar and two-hour blood sugar and increased early insulin release, with no change in insulin sensitivity.Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus.
- In 24 adults with metabolic syndrome, 600 mg a day of Gymnema sylvestre for 12 weeks lowered body weight, BMI and VLDL cholesterol but did not change insulin secretion, insulin sensitivity or the components of metabolic syndrome.Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.
- In 24 overweight men, a single 0.15 mg dose of nonivamide in a glucose drink reduced hunger and food intake at the next meal; the abstract reports no blood sugar or insulin difference.The capsaicin analog nonivamide decreases total energy intake from a standardized breakfast and enhances plasma serotoni…
- In 24 adults with type 2 diabetes, adding 0.75 g of mulberry fruit extract to a rice meal lowered the two-hour blood sugar rise by about 22% and the insulin response by about 18% compared with the same meal without it.Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Ind…
- In 24 healthy volunteers, a single 600 mg dose of thioctic acid did not change blood sugar or insulin levels or interact with glibenclamide or a med.Read the study on PubMed (10594485) →
- In 24 obese adults with impaired glucose tolerance, 1 gram of alpha-lipoic acid daily for 12 weeks did not improve blood sugar regulation, and alone it increased LDL cholesterol oxidation, while combined with exercise this effect was prevented.Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance.
- In 23 people with early rheumatoid arthritis who completed a feasibility trial, diet and exercise counselling produced only non-significant trends toward lower LDL cholesterol and better vitamin C intake over 6 months.Personalized diet and exercise recommendations in early rheumatoid arthritis: A feasibility trial.
- In a placebo-controlled trial of 23 competitive triathletes taking magnesium orotate for 4 weeks, race times improved and stress hormone levels were lower, but blood sugar rose more during the race than with placebo.On the significance of magnesium in extreme physical stress.
- In 22 overweight or obese adults with impaired fasting glucose, 500 mg of a water-based cinnamon extract daily for 12 weeks increased antioxidant levels and lowered a marker of cell damage in the blood.Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese.
- In 22 obese adults with impaired glucose tolerance, two weeks of 600 mg lipoic acid given by IV daily improved insulin sensitivity by 41% and lowered blood fats, oxidation markers and inflammatory markers.Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects.
- In a 12-week placebo-controlled trial of 21 adults with impaired glucose tolerance, 6 g of Cassia cinnamon twice daily did not change insulin sensitivity, fasting glucose, blood lipids or liver enzymes compared with placebo.Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance…
- In 20 children with obesity, a daily mixed carotenoid supplement containing gamma-tocopherol for 6 months reduced BMI and belly fat more than placebo and raised blood adiponectin, a hormone linked to insulin sensitivity.Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study.
- In a double-blind crossover trial of 20 dialysis patients, zinc supplements markedly improved taste and appetite compared with placebo, but the abstract does not report a blood sugar result for supplemented patients.Hypogeusia and zinc depletion in chronic dialysis patients.
- In college wrestlers, 200 mcg of chromium picolinate daily for 14 weeks did not change body composition or performance beyond training alone or placebo.Chromium picolinate effects on body composition and muscular performance in wrestlers.
- In overweight adults eating a high-fat meal, a spice blend that included cinnamon lowered blood fats after the meal only when they were resting, not when stressed, and had no effect on blood sugar.Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized…
- In 20 overweight men with a family history of type 2 diabetes, taking 1.5 g of taurine daily for 8 weeks did not change insulin secretion, insulin sensitivity, or blood lipid levels compared with placebo.Effect of taurine treatment on insulin secretion and action, and on serum lipid levels in overweight men with a genetic …
- In 20 overweight men with a family history of type 2 diabetes, 1.5 g of taurine daily for 8 weeks did not change platelet clumping compared with placebo, although blood taurine levels rose.No effect of taurine on platelet aggregation in men with a predisposition to type 2 diabetes mellitus.
- In 19 adults with type 2 diabetes, a single dose of raw cinnamon stirred into water blunted the blood sugar spike after a meal, but the same cinnamon taken in capsules lost most of that effect.Suppression of the postprandial hyperglycemia in patients with type 2 diabetes by a raw medicinal herb powder is weakene…
- Healthy volunteers who took 1 g of a Ceylon cinnamon extract before a meal had a 21 percent lower blood sugar rise over the first hour compared with placebo, though the two-hour difference was not significant.Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rat…
- In a randomized crossover trial of 18 adults with prediabetes, 4 g of cinnamon spice daily for 4 weeks lowered 24-hour blood glucose and glucose peaks compared with placebo, as measured by continuous glucose monitoring.Effect of cinnamon spice on continuously monitored glycemic response in adults with prediabetes: a 4-week randomized con…
- In a small placebo-controlled trial of 17 people with type 2 diabetes, 1000 mg of mulberry leaf extract three times daily lowered after-meal blood sugar over 3 months but did not significantly change A1C, and it raised serum creatinine by 15%.Impact of mulberry leaf extract on type 2 diabetes (Mul-DM): A randomized, placebo-controlled pilot study.
- In 16 obese women taking 3 grams of taurine daily for 8 weeks, inflammation (C-reactive protein) and fat oxidation (TBARS) fell compared with placebo, and adiponectin rose.Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study.
- In 16 female rugby players given a single 4 or 6 gram dose of taurine an hour before a sprint test, blood glucose changed little compared with placebo, though the same doses improved power output.The effects of taurine ingestion on anaerobic and physiological performance in female rugby players.
- In 15 people with type 2 diabetes, a daily pack with 500 mg vitamin C per pack plus Cassia tora fiber for 2 months showed only trend-level drops in total cholesterol versus placebo, with blood sugar unchanged.Effects of Cassia tora fiber supplement on serum lipids in Korean diabetic patients.
- In hypercholesterolemic adults, 200 mg daily of a tocotrienol-enriched palm oil fraction (a vitamin E family form, not alpha-tocopherol) lowered total cholesterol by 15 percent and LDL cholesterol by 8 percent over 4 weeks compared with corn oil.Lowering of serum cholesterol in hypercholesterolemic humans by tocotrienols (palmvitee).
- In a small 8-week trial of 15 women with polycystic ovary syndrome, daily cinnamon extract significantly reduced insulin resistance compared with their starting levels, while placebo did not.The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study.
- Healthy adults who ate 3 g of cinnamon in rice pudding had lower post-meal insulin and higher GLP-1 levels, but no change in blood sugar, satiety or stomach emptying.Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent i…
- In 15 healthy adults, rinsing the mouth with Gymnema sylvestre before sweet foods reduced sweet taste but did not change blood glucose, insulin, or stomach emptying compared with water.Suppression of Oral Sweet Sensations during Consumption of Sweet Food in Humans: Effects on Gastric Emptying Rate, Glyce…
- In 14 obese young men, 100 mg a day of zinc sulfate for one month raised blood zinc and leptin but did not change insulin sensitivity compared with placebo.[Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males].
- In 14 overweight people with impaired glucose tolerance, 100 mg daily of vanadyl sulfate for 4 weeks did not change insulin sensitivity and raised triglycerides compared with placebo.Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance.
- In 12 adults with type 2 diabetes and low magnesium, magnesium supplementation reduced some immune cell activity compared with placebo, but did not change immune cell counts or inflammatory proteins significantly.Magnesium Supplementation Modulates T-cell Function in People with Type 2 Diabetes and Low Serum Magnesium Levels.
- In 12 healthy volunteers given a single 5 gram dose of capsicum in a crossover sugar-tolerance test, blood sugar was lower than with placebo at 30 and 45 minutes and insulin stayed higher later on.Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level.
- In 12 young adults, mulberry leaf extract taken with a meal in the evening improved blood sugar control compared with placebo, while taking it in the morning lowered insulin levels but did not improve blood sugar.Effects of the timing of acute mulberry leaf extract intake on postprandial glucose metabolism in healthy adults: a rand…
- In 12 adults with obesity, 100 g of concentrated mulberry drink daily for 6 weeks lowered blood pressure, triglycerides and C-reactive protein compared with placebo, but did not change cholesterol levels.Nutraceutical Properties of Thai Mulberry (Morus alba L.) and Their Effects on Metabolic and Cardiovascular Risk Factors…
- In 12 healthy young men, taking powdered Morus australis leaves before 75 g of sucrose lowered blood sugar at 30 minutes and prevented the temporary rise in arterial stiffness seen at 60 minutes in the control trial.Effect of Powdered Morus australis Leaves on Arterial Stiffness Response after Sucrose Ingestion in Healthy Young Men: A…
- In a placebo-controlled crossover pilot of 12 prediabetic adults, 600 mg of alpha-lipoic acid daily for 30 days reduced fasting insulin and insulin resistance compared with placebo, but blood sugar and blood lipids did not change.Metabolic effects of α-lipoic acid supplementation in pre-diabetics: a randomized, placebo-controlled pilot study.
- In 11 healthy adults, 4-week periods of supplemental cinnamon did not change fasting blood sugar or cholesterol, while turmeric raised urinary oxalate.Effect of cinnamon and turmeric on urinary oxalate excretion, plasma lipids, and plasma glucose in healthy subjects.
- In 11 men, a single 500 mg dose of cayenne pepper did not increase energy burning or fat burning at rest or during exercise compared with placebo.Capsaicin and evodiamine ingestion does not augment energy expenditure and fat oxidation at rest or after moderately-int…
- In 10 healthy men, 500 mg per day of vitamin C for 8 weeks improved the LDL to HDL cholesterol ratio but did not change fasting or 2-hour blood sugar, and the cholesterol gain was smaller than with Chyawanprash.Effect of Chyawanprash and vitamin C on glucose tolerance and lipoprotein profile.
- In 10 people with impaired glucose tolerance, a single 6 g dose of Ceylon cinnamon taken with a sugar drink did not change blood sugar or insulin levels compared with placebo.Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance.
- Obese young women who took 5 g of Cassia cinnamon before a sugar drink had a lower peak blood sugar at 30 minutes, but overall blood sugar and insulin resistance did not improve compared with placebo.Cassia Cinnamon Supplementation Reduces Peak Blood Glucose Responses but Does Not Improve Insulin Resistance and Sensiti…
- In 9 healthy young adults, 2 grams per day of vitamin C for 2 weeks raised blood sugar 1 hour after a glucose drink and delayed the insulin response compared with placebo.Megadose of vitamin C delays insulin response to a glucose challenge in normoglycemic adults.
- In 9 women with gestational diabetes, 2000 mg of vitamin C over an 8-day test period raised blood sugar about the same as a placebo capsule.Blood glucose rise following prenatal vitamins in gestational diabetes.
- In 9 people with type 1 diabetes, 1000 mg of vitamin E daily for 35 days reduced platelet clumping and a marker of platelet oxidative damage compared with placebo.Platelet function in type I diabetes: effects of supplementation with large doses of vitamin E.
- In 9 people, rinsing with a Gymnema solution before drinking glucose slowed stomach emptying and lowered the blood sugar and insulin rise after the glucose drink.Suppression of sweet sensing with glucose, but not aspartame, delays gastric emptying and glycemic response.
- In 9 healthy young men, a single 12 mg dose of capsinoids taken after exercise shifted fuel use toward fat burning during recovery but did not speed muscle glycogen refilling or change post-meal blood sugar and insulin compared with placebo.Effect of Capsinoids Supplementation on Fat Oxidation and Muscle Glycogen Restoration During Post-exercise Recovery in H…
- In 8 active men during intermittent high-intensity exercise, adding 400 mg of chromium picolinate to a carbohydrate drink did not improve running endurance beyond the carbohydrate drink alone.Effects of carbohydrate and chromium ingestion during intermittent high-intensity exercise to fatigue.
- In 8 healthy men, 3 grams of cinnamon daily for 14 days lowered the blood sugar response to a sugar drink and improved insulin sensitivity, but these effects reversed after stopping.Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans.
- In 8 healthy young men, 475 mg of Capsicum annuum fruit powder taken after a high-sugar meal brought blood sugar back to near fasting levels within 15 minutes, compared with about 120 minutes on placebo, over 7 days of testing.Both caffeine and Capsicum annuum fruit powder lower blood glucose levels and increase brown adipose tissue temperature …
- In 7 healthy lean men, 5 g of cinnamon taken with a sugar drink reduced total blood sugar rise by about 13% and improved insulin sensitivity compared with placebo, with effects lasting up to 12 hours.Effects of short-term cinnamon ingestion on in vivo glucose tolerance.
- In healthy adults, 1 gram of vitamin C taken twice daily for 10 days prevented the drop in blood vessel function caused by a sugar drink, while placebo did not.Ascorbic acid prevents vascular dysfunction induced by oral glucose load in healthy subjects.
- In children with fatty liver disease, hydroxytyrosol combined with vitamin E for about four months lowered interleukin-6 and a DNA damage marker, raised the anti-inflammatory marker interleukin-10, and improved triglyceride levels more than placebo.Antioxidant activity of Hydroxytyrosol and Vitamin E reduces systemic inflammation in children with paediatric NAFLD.
- In a randomized blinded study of women in preterm labor, adding magnesium sulfate infusion to ritodrine did not change potassium, glucose, or other metabolic markers compared with ritodrine plus placebo.Adjunctive magnesium sulfate infusion does not alter metabolic changes associated with ritodrine tocolysis.
- In a short study of liquid meals, adding soy fiber slowed gut transit and lowered zinc and folate levels in the blood, but did not change blood sugar.Apparent nutrient absorption and upper gastrointestinal transit with fiber-containing enteral feedings.
- In Tunisian adults with type 2 diabetes, 400 mcg of chromium daily for 6 months reduced a marker of lipid oxidation by about 14%, but blood sugar and HbA1c did not change significantly.Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus.
- In adults with type 2 diabetes and higher blood sugar, 1000 mcg of chromium daily for 6 months lowered markers of oxidative stress compared with placebo, while in euglycemic adults the effect ran in the opposite direction.Antioxidant effects of chromium supplementation with type 2 diabetes mellitus and euglycemic subjects.
- In women with polycystic ovary syndrome, 200 mcg of chromium picolinate daily improved blood sugar control compared with placebo, but did not improve ovulation or hormone levels.Effect of chromium supplementation on insulin resistance and ovarian and menstrual cyclicity in women with polycystic ov…
- In people with pre-diabetes, a daily tablet containing chromium picolinate with Ilex paraguariensis and white mulberry for three months lowered fasting glucose and triglycerides and improved insulin resistance compared with placebo.Ilex paraguariensis, white mulberry and chromium picolinate in patients with pre-diabetes.
- In adults with type 2 diabetes on a med, adding a supplement containing chromium picolinate, berberine, and hesperidin for 12 weeks lowered HbA1c and fasting blood sugar more than a med alone, and reduced markers of lipid peroxidation.Read the study on PubMed (34371883) →
- In adults aged 40 to 60 with uncontrolled type 2 diabetes, 200 mcg of daily chromium added to regular medication over four months lowered average long-term blood sugar and fasting blood sugar more than medication alone.A comparative study to assess the use of chromium in type 2 diabetes mellitus.
- In a randomized trial of people with type 2 diabetes, a standardized banaba leaf extract taken daily for 2 weeks significantly lowered blood sugar, with the soft gel form lowering it about 30 percent compared with about 20 percent for the powder capsule form.Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A do…
- In overweight adults with mildly high blood sugar, 300 mg a day of banaba extract for 12 weeks lowered blood glucose, HbA1c, insulin resistance, body fat, waist size and triglycerides compared with placebo.The beneficial effect of soybean (Glycine max (L.) Merr.) leaf extracts in adults with prediabetes: a randomized placebo…
- In a randomized trial of a combined product with probiotics, vitamin D and banaba leaf extract, blood sugar and glycosylated hemoglobin levels improved; the abstract attributes the effect mainly to the probiotic strains and does not report participant numbers, duration or banaba dose.Evaluation of a Nutraceutical Product with Probiotics, Vitamin D, Plus Banaba Leaf Extracts (Lagerstroemia speciosa) in …
- In women with type 2 diabetes and high blood fats, taking a three-herb capsule containing guggul three times a day for 3 months lowered fasting blood sugar compared with placebo, though long-term blood sugar (glycosylated hemoglobin) did not change significantly.Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Pl…
- In a 4-week trial of people with newly diagnosed type 2 diabetes, 2,000 mg daily of bitter melon significantly lowered fructosamine, while 500 and 1,000 mg did not, and a med 1,000 mg lowered it more.Read the study on PubMed (21211558) →
- In two small studies of overweight or obese adults, 8 weeks of licorice flavonoid oil produced no significant differences from placebo in blood lipids, insulin sensitivity, or body measures, apart from a non-significant trend toward less fat gain when overfed.A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemi…
- In a randomized trial of nondiabetic adults given a glucose drink with or without cinnamon tea, cinnamon tea slightly lowered postprandial blood glucose and significantly reduced the peak postprandial glucose concentration.Effect of Cinnamon Tea on Postprandial Glucose Concentration.
- In adults with type 2 diabetes, taking 600 mg of cinnamon with 1200 mg of berberine daily for 12 weeks lowered fasting blood sugar, HbA1c and LDL cholesterol compared with placebo.The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a ra…
- In overweight adults, a single meal containing about 5.8 mg of chilli capsaicinoids produced lower insulin levels over two hours after eating than the same meal without chilli, with a trend toward lower blood sugar.The metabolic effects of a commercially available chicken peri-peri (African bird's eye chilli) meal in overweight indiv…
- In healthy volunteers, single doses of mulberry leaf powder enriched with DNJ (12 to 18 mg DNJ) before 50 g of sucrose significantly reduced the rise in blood sugar and insulin after eating.Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in hu…
- In obese adults with borderline diabetes, 12 mg of mulberry leaf DNJ three times daily for 12 weeks lowered fasting blood sugar and HbA1c, with mainly mild stomach side effects such as bloating and loose stools.A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese per…
- In crossover studies, 250 mg of mulberry leaf extract taken with a full meal reduced the blood sugar rise after eating by 34%, and it worked less well when taken 5 minutes before the meal.Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies.
- Adding mulberry leaf extract to white bread reduced the rise in blood sugar after eating it, with a stronger effect at higher amounts, lowering the bread's glycemic index from 77 to 43 at the highest level tested.The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread.
- In adults with fatty liver inflammation (NASH), a diet plan plus a specialized food containing lipoic acid for 14 days lowered cholesterol and an insulin resistance index more than diet alone.[Modification of dietary patterns in patients with non-alcoholic steatohepatitis].
- In 142 people with diabetes, those taking a bitter melon peptide (64 people) lowered their average long-term blood sugar (HbA1c) from 7.8% to 7.4%, while the control group (78 people) stayed at 7.5%.mcIRBP-19 of Bitter Melon Peptide Effectively Regulates Diabetes Mellitus (DM) Patients' Blood Sugar Levels.
- In 100 people with moderate type 2 diabetes, drinking a bitter melon pulp suspension significantly lowered fasting and after-meal blood sugar, with 86 people showing this effect.Effect of Momordica charantia (Karolla) extracts on fasting and postprandial serum glucose levels in NIDDM patients.
- In 100 women with polycystic ovary syndrome over 6 months, adding gymnemic acid and L-methylfolate to myo-inositol improved blood sugar and insulin after a glucose test more than myo-inositol with folic acid alone.Effects of myo-inositol, gymnemic acid, and L-methylfolate in polycystic ovary syndrome patients.
- In 70 patients with metabolic syndrome and impaired glucose tolerance taking 300 mcg of chromium-enriched yeast daily in a placebo-controlled trial, resting heart rate fell, but blood sugar, blood fats and other lab markers did not change.Chromium Supplementation Reduces Resting Heart Rate in Patients with Metabolic Syndrome and Impaired Glucose Tolerance.
- In 65 people with abnormal blood sugar taking a seaweed extract with chromium picolinate for 6 months against placebo, fasting and after-meal blood sugar, HbA1c and insulin resistance improved, and markers of inflammation dropped.Ascophyllum nodosum and Fucus vesiculosus on glycemic status and on endothelial damage markers in dysglicemic patients.
- In 59 adults at high risk of type 2 diabetes taking chromium picolinate for 6 months against placebo, blood sugar, insulin levels, insulin resistance and other measures did not improve.Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus.
- In 59 adults with polycystic kidney disease, 1.6 g of alpha-lipoic acid daily for 6 months lowered blood sugar, insulin and insulin resistance, C-reactive protein and uric acid compared with a control group, and improved mental test scores.α-lipoic acid in patients with autosomal dominant polycystic kidney disease.
- In a crossover trial of 52 adults with prediabetes, taking 2.5 grams of bitter gourd powder daily for 8 weeks lowered fasting blood sugar more than cucumber juice did, with a difference of about 0.31 mmol/L.Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania.
- In people with type 2 diabetes, 55 ml of bitter melon daily did not significantly change serum sialic acid or blood sugar compared with control subjects, while rosiglitazone raised sialic acid, blood sugar, and cholesterol.Serum sialic acid changes in non-insulin-dependant diabetes mellitus (NIDDM) patients following bitter melon (Momordica …
- In 50 adults with obesity given Gymnema sylvestre or berberine for 3 months, Gymnema lowered fasting glucose and a gene marker linked to insulin resistance, while berberine did better on weight and blood pressure.Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obes…
- In smokers and people with impaired glucose tolerance, a vitamin C infusion improved insulin sensitivity and blood vessel function, while controls showed no change.Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C.
- In 44 healthy adults taking 200 mg of chromium daily for 8 weeks in a double-blind crossover trial against placebo, blood sugar control and blood fat levels improved, with higher good cholesterol and lower triglycerides, though total cholesterol did not change.Effect of chromium supplementation on glucose tolerance and lipid profile.
- In 43 men with diabetes taking chromium supplements for 4 months each in a double-blind crossover trial, fasting blood sugar, blood fats and blood sugar response to a meal were not changed compared with placebo.Effects of chromium and yeast supplements on carbohydrate and lipid metabolism in diabetic men.
- In 39 healthy young men, 1000 mg vitamin C plus 400 IU vitamin E daily for 4 weeks blocked the insulin-sensitivity gains that exercise otherwise produced.Antioxidants prevent health-promoting effects of physical exercise in humans.
- In 39 people with insulin-dependent diabetes, plasma and platelet taurine levels were low at the start; 1.5 g of taurine daily for 90 days raised them to the level of healthy controls and normalized platelet clumping tendency.Plasma and platelet taurine are reduced in subjects with insulin-dependent diabetes mellitus: effects of taurine supplem…
- In a randomized crossover trial of 38 young adults, taurine alone given in a control drink did not raise blood pressure or prolong the QT interval, and the abstract does not report a taurine-specific blood sugar effect. Caffeine, not taurine, caused the blood pressure rise.Energy Drinks Induce Acute Cardiovascular and Metabolic Changes Pointing to Potential Risks for Young Adults: A Randomiz…
- In 31 people, a single 10 mg dose of corosolic acid taken before a glucose challenge lowered blood sugar from 60 to 120 minutes compared with placebo, reaching significance at 90 minutes.Effect of corosolic acid on postchallenge plasma glucose levels.
- In 25 postmenopausal women with type 2 diabetes, 1.5 grams of cinnamon daily for 6 weeks did not improve insulin sensitivity, glucose tolerance, or blood lipids compared with placebo.Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients.
- In 22 people with vasospastic angina, a single intravenous magnesium sulfate infusion reduced acetylcholine-induced coronary artery spasm in 10 of 14 patients, compared with no change after glucose infusion.The preventive effect of magnesium on coronary spasm in patients with vasospastic angina.
- In a 90-day study of 22 adults with type 2 diabetes, 200 ml of bitter melon juice daily added to usual meds significantly lowered fasting and after-meal blood sugar, while medicines alone gave a smaller, non-significant change.Effects of Momordica Charantia (Karela/bitterguord) in Type 2 Diabetic Patients Taking Allopathic Drugs: A pilot study.
- In 10 people with type 2 diabetes and 10 without, a vitamin C infusion into the arm artery at 24 mg per minute improved blood vessel widening in response to methacholine in the diabetic group only, while it had no effect in the non-diabetic group.Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.
- In 20 adults with type 2 diabetes and nerve damage, lipoic acid taken for four months along with usual meds eased nerve symptoms, and the benefit appeared larger in those with better blood sugar control; the abstract does not clearly report a blood sugar lowering effect.Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment.
- In a small pilot of 19 patients with high cholesterol, a daily herbal tablet containing 200 mg of Commiphora mukul (guggul) with garlic, fenugreek, picrorhiza and black pepper for about 15 weeks was followed by reduced total cholesterol, triglycerides and LDL cholesterol and raised HDL cholesterol, compared with placebo tablets.A Comparative Study on Clinical Evaluation of the Hypolipidemic Effects of Allium sativum, Trigonella foenum-graecum, Co…
- In 7 adults with type 2 diabetes, a 4-week combination of evening primrose oil, sardine oil, and 200 mg of vitamin E lowered fasting blood sugar and HbA1c compared with 11 people who did not take the oils, though the vitamin E effect cannot be separated from the oils.Evening primrose oil and fish oil in non-insulin-dependent-diabetes.
- In a small study of people with and without type 2 diabetes, taking biotin for 14 to 28 days raised enzyme activity in white blood cells but did not change blood glucose, insulin, triglycerides, or cholesterol.Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose an…
- In a small pilot study of 17 adults with diabetic nerve damage, 1200 mg of lipoic acid taken daily for 6 weeks shortened the time for blood flow in tiny finger vessels to peak after a brief blockage, a sign of better blood flow reserve; resting blood flow and blood sugar control did not change.Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy.
- In 16 healthy older adults over 28 days, chromium alone did not change blood sugar, but chromium taken with nicotinic acid lowered glucose tolerance and fasting glucose.Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans.
- In a pilot study of 14 diabetic patients with a specific gene variant, 750 mg a day of licorice for 3 weeks lowered serum insulin compared with placebo, with no other clinical changes.Effect of licorice on patients with HSD11B1 gene polymorphisms- a pilot study.
- In 14 healthy adults given a 75 gram glucose drink, adding oral capsaicin raised blood sugar levels between 30 and 150 minutes and increased glucagon release, suggesting faster glucose absorption.Capsaicin and glucose absorption and utilization in healthy human subjects.
- In 14 healthy volunteers, an energy drink containing taurine did not improve exercise performance or change the heart and blood effects of alcohol during a single test session.Does an energy drink modify the effects of alcohol in a maximal effort test?
- In 13 healthy young men, a single meal with 400 or 800 mcg of chromium picolinate produced a lower blood sugar rise overall, which was only borderline significant, and a clear reduction in most responders.Effects of acute chromium supplementation on postprandial metabolism in healthy young men.
- In 7 people with type 2 diabetes and 6 without, 100 mg daily of vanadyl sulfate for 3 weeks lowered fasting blood sugar and HbA1c and improved insulin sensitivity in those with diabetes only.Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects.
- In 12 normal-blood-sugar adults, bread made with chromium-enriched yeast produced a smaller rise in blood sugar after eating than white bread, though the study had no placebo group.Cr-enriched yeast: beyond fibers for the management of postprandial glycemic response to bread.
- In 11 people with type 1 diabetes and low magnesium, 10 weeks of intravenous plus oral magnesium raised body magnesium stores but did not normalize magnesium levels, and lipids and blood sugar control were unchanged.Effect of intensive i.v. + oral magnesium supplementation on circulating ion levels, lipid parameters and metabolic cont…
- In 10 adults with non-insulin-dependent diabetes, 200 mcg of trivalent chromium daily for 6 weeks did not significantly change glucose tolerance or fasting insulin compared with placebo.Effect of inorganic chromium supplementation on glucose tolerance, insulin response, and serum lipids in noninsulin-depe…
- In 9 adults with diabetes, a water-soluble bitter melon fruit extract lowered blood sugar during a glucose tolerance test, and eating fried bitter melon daily produced a small improvement in glucose tolerance without raising insulin.Improvement in glucose tolerance due to Momordica charantia (karela).
- In eight obese adults on a low-calorie, high-calcium diet, more carbohydrates were linked to better zinc balance and higher insulin, and thyroid hormone raised zinc loss, but blood sugar was not measured as an outcome.Changes in bone and muscle constituents during dieting for obesity.
- In 8 women with symptoms of low blood sugar, 200 mcg of chromium daily for three months eased symptoms and raised their lowest blood glucose readings after a glucose load in a double-blind crossover study.Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia.
- In 8 people with type 2 diabetes, 100 mg daily of vanadyl sulfate for 4 weeks lowered fasting blood glucose by about 20% and liver glucose output, though six of eight had stomach side effects in the first week.Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus…
- In 7 healthy adults, a vitamin C infusion fully restored blood vessel widening that high insulin had impaired during a 4-hour insulin clamp, without affecting vessel response to a nitroglycerin control.Insulin causes endothelial dysfunction in humans: sites and mechanisms.
- In 6 people with type 2 diabetes, 100 mg daily of vanadyl sulfate for 3 weeks lowered fasting blood sugar and HbA1c and improved liver and muscle insulin sensitivity, with effects lasting 2 weeks after stopping.Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes…
- In a small single-dose study of 5 overweight men, one dose of freeze-dried bitter melon before a sugar drink did not change blood sugar, insulin, energy use, or appetite compared with placebo.No effect of acute, single dose oral administration of Momordica charantia Linn., on glycemia, energy expenditure and ap…
- In young adults with type 1 diabetes, 100 or 600 mg of vitamin C daily for 58 days normalized red blood cell sorbitol, a marker of sugar-related damage that was about double normal levels, regardless of blood sugar control.Vitamin C: an aldose reductase inhibitor that normalizes erythrocyte sorbitol in insulin-dependent diabetes mellitus.
- Adding soluble gums to the diet did not change blood sugar response to a glucose test in two small studies, though guar gum lowered C-peptide in people with type 2 diabetes. Carboxymethylcellulose fiber caused a negative manganese balance, while the other fibers did not change manganese balance.Effect of soluble fibers on plasma lipids, glucose tolerance and mineral balance.
- In adults with high cholesterol not on meds, 4 weeks of a combination containing Morus alba leaf extract, red yeast rice and berberine lowered glycated hemoglobin, fasting glucose, insulin and HOMA index more than another combination.Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endotelial func…
- In 112 people with type 2 diabetes and a prior heart attack, 4 months of alpha lipoic acid lowered inflammation markers (CRP, IL-6, TNF-alpha); blood sugar was not reported.Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myoca…
- In a 6-month open-label trial of 82 adults with prediabetes, adding a Gymnema sylvestre mother tincture to homeopathic medicines improved fasting blood sugar, glucose tolerance test results and HbA1c more than homeopathic medicines alone, but the differences were not statistically significant.Plant Extracts as Add-On Therapeutics in Homeopathy: An Open-Label, Randomized Trial Using Mother Tinctures in Prediabet…
- In 78 adults with metabolic syndrome, taking Kepar, a multi-herb supplement that contains guggul, for 4 months alongside their usual treatment was followed by lower body weight, waist size, fasting glucose and total cholesterol, but the study had no placebo group and the guggul dose was not stated.Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrom…
- In 72 people with painful diabetic nerve damage, 600 mg a day of lipoic acid for 40 days reduced nerve symptoms and triglycerides and improved quality of life, with no control group.Effect of α-lipoic acid on symptoms and quality of life in patients with painful diabetic neuropathy.
- In 61 Korean adults with diabetic nerve damage in the feet and legs, 600 mg daily of thioctic acid for 8 weeks improved symptoms such as pain, burning and numbness in 71.4% of patients, with no change in blood sugar or HbA1c.Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabet…
- In 46 adults with type 1 diabetes and nerve damage affecting the heart and blood vessel reflexes, 600 mg of lipoic acid daily for about 60 days (first 10 days by IV) improved heart rate and blood pressure reflex scores and raised blood antioxidant levels, while a comparison group did not improve.Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).
- In 42 adults with metabolic syndrome, 4.8 grams per day of wild bitter gourd powder for 3 months reduced the rate of metabolic syndrome and waist size, with the benefit fading after stopping, and it was well tolerated.Wild bitter gourd improves metabolic syndrome: a preliminary dietary supplementation trial.
- In 35 people with rheumatoid arthritis, taking 300 mg of magnesium sulfate daily for six months on top of usual treatment lowered fasting blood sugar, insulin, and insulin resistance compared with the period before, in an uncontrolled study.Magnesium supplementation and insulin resistance in patients with rheumatoid arthritis.
- In 31 healthy Chinese adults, milk supplemented with mulberry leaf extract, vegetable oil and inulin lowered early blood sugar (first 60 minutes, by 25%) and insulin responses compared with skimmed milk, but did not change blood sugar over 180 minutes.Milk with Mulberry Leaf Extract, Vegetable Oil, and Inulin Reduce Early Glucose and Insulin Response in Healthy Adults i…
- Healthy adults taking up to 500 mg of Ceylon cinnamon water extract daily for 3 months had lower total and LDL cholesterol and lower blood pressure, with no serious side effects and no uncontrolled control group.Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phas…
- Adults with insulin-dependent diabetes taking 400 mg daily of a Gymnema leaf extract needed less insulin, and their fasting blood sugar and long-term blood sugar markers fell.Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus.
- In 26 adults with type 2 diabetes and nerve damage, 600 mg of alpha-lipoic acid daily for 3 months lowered average blood glucose without a control group.Effects of 3-month treatment with the antioxidant alpha-lipoic acid in diabetic peripheral neuropathy.
- In 13 healthy men with diet-induced high triglycerides and 11 postmenopausal women with type 2 diabetes, alpha-lipoic acid treatment improved blood vessel dilation and reduced oxidative stress from neutrophils, with no placebo group.Prevention and treatment of macroangiopathy: focusing on oxidative stress.
- Adults with type 2 diabetes taking 400 mg daily of a Gymnema leaf extract for 18 to 20 months, alongside their usual meds, had lower blood sugar and long-term blood sugar markers, and five of 22 could stop their drugs.Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients.
- In 21 adults with type 2 diabetes, up to 1200 mg daily of controlled-release alpha-lipoic acid for 12 weeks was well tolerated and lowered plasma fructosamine, a measure of average blood sugar over recent weeks, from 313 to 283 micromol/L in 15 patients who were analysed.Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lip…
- In 18 people with schizophrenia, 500 mg of alpha-lipoic acid daily for 3 months lowered fasting blood sugar and raised adiponectin, without a control group.Effects of Alpha-Lipoic Acid Supplementation on Plasma Adiponectin Levels and Some Metabolic Risk Factors in Patients wi…
- In 16 adults with type 2 diabetes given vanadyl sulfate for 6 weeks at three doses, fasting blood sugar and HbA1c fell at the 150 and 300 mg doses, but insulin sensitivity did not improve across all doses and the sugar-lowering effect was not dramatic.Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studie…
- In 16 adults with type 2 diabetes given 25, 50 or 100 mg vanadium daily for 6 weeks, total blood vanadium levels did not correlate with insulin response, suggesting other vanadium pools drive the effect.Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients…
- In 15 healthy volunteers, taking mulberry leaf extract with sucrose, maltose or maltodextrin lowered the glycemic index of those sugars by 31 to 53 percent, and was well tolerated.Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates.
- In 12 adults with type 2 diabetes, 53.5 grams daily of honey formulated with cinnamon, chromium and magnesium for 40 days did not improve blood sugar compared with plain honey, though weight and cholesterol fell.The effect of a cinnamon-, chromium- and magnesium-formulated honey on glycaemic control, weight loss and lipid paramete…
- In 11 adults with type 2 diabetes given 150 mg vanadyl sulfate daily for 6 weeks, fasting blood sugar fell from 194 to 155 mg/dL, HbA1c fell from 8.1% to 7.6%, and insulin sensitivity modestly improved.Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.
- In 9 adolescents with type 1 diabetes, six weeks of combined vitamin C and vitamin E did not improve blood vessel function or other blood markers of vascular risk compared with before treatment.Effect of Vitamins C and E on Endothelial Function in Type 1 Diabetes Mellitus.
- In 9 adults with mild type 2 diabetes, 30 days of magnesium-rich salt lake water lowered fasting insulin and blood pressure, in a study without a placebo group.Clinical efficacy of magnesium supplementation in patients with type 2 diabetes.
- In 9 men with type 1 diabetes, four weeks of benfotiamine combined with slow-release lipoic acid normalised several blood markers of damage-causing pathways, but blood sugar measures did not change.Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
- In 8 people with human immunodeficiency virus on antiretroviral therapy, taking 1000 mcg of chromium picolinate daily for 8 weeks raised insulin sensitivity by about 25% on a clamp test, with some liver function abnormalities reported.Chromium picolinate for insulin resistance in subjects with HIV disease: a pilot study.
- People with type 2 diabetes still above target on two meds had their average blood sugar marker drop by 0.65 percentage points after taking 100 mg daily of a banaba-containing fraction for 12 weeks, though this open-label study had no placebo group.Read the study on PubMed (27451997) →
- Adults with type 2 diabetes taking 500 mg daily of Gymnema for 3 months had less fatigue and extra eating, lower fasting and after-meal blood sugar, lower long-term blood sugar markers, and better blood fats, in a non-randomized open-label study.An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics.
- In a large study of about 84,000 postmenopausal women, those in the highest fifth of dietary manganese intake had about a 30% lower risk of developing type 2 diabetes than those in the lowest fifth, and part of this link appeared to run through lower inflammation in the blood.Dietary Manganese, Plasma Markers of Inflammation, and the Development of Type 2 Diabetes in Postmenopausal Women: Findi…
- In a 30-year study of 29,092 men, those with higher blood levels of vitamin E had lower overall death rates and lower death rates from heart disease and stroke, though this was observational and not a trial.Relationship Between Serum Alpha-Tocopherol and Overall and Cause-Specific Mortality.
- In a cohort of 20,490 adults in southwestern China followed for about 4.5 years, people who ate spicy food had a 34% lower risk of developing type 2 diabetes than non-consumers, especially at 3 to 5 days per week and with mild spiciness.Consuming spicy food and type 2 diabetes incidence in Southwestern Chinese aged 30-79: a prospective cohort study.
- In a large national survey of US adults, people with diabetes ate about the same nutrients as those without, though those with the highest blood sugar levels ate about 4% less magnesium from food.Dietary intake of adults with and without diabetes: results from NHANES 2013-2016.
- In a large Women's Health Initiative subset, higher estimated vitamin E intake from blood levels was linked to somewhat higher risk of certain heart outcomes, while the link to diabetes risk was not clearly positive.Application of blood concentration biomarkers in nutritional epidemiology: example of carotenoid and tocopherol intake i…
- In a large Tehran cohort followed for a median of about 5.8 years, spice and pepper intake was not linked to developing type 2 diabetes or metabolic syndrome, but the highest spice intake quartile had higher risk of high triglycerides and high blood pressure, while higher pepper intake was linked to lower risk of low good cholesterol.Associations between spice or pepper (Capsicum annuum) consumption and diabetes or metabolic syndrome incidence.
- In a case-control study of 4,443 Chinese adults, people with the highest blood chromium levels had about 42% lower odds of having newly diagnosed type 2 diabetes than those with the lowest levels.Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study.
- In a 23-year study of 3,648 young American adults, those with the highest chromium levels in their toenails were 20% less likely to develop metabolic syndrome than those with the lowest levels.Chromium exposure and incidence of metabolic syndrome among American young adults over a 23-year follow-up: the CARDIA T…
- In 2,045 American adults with diabetes followed for about six years, those eating 250 mg or less of magnesium daily from food had higher risk of death from all causes, and higher magnesium intake reduced the added risk linked to poor blood sugar control.Association of dietary magnesium intake and glycohemoglobin with mortality risk in diabetic patients.
- In 1,843 middle-aged men followed for 30 years, higher dietary vitamin C intake was not clearly linked to lower stroke risk; the apparent decrease was not statistically significant.Dietary vitamin C, beta-carotene and 30-year risk of stroke: results from the Western Electric Study.
- In a cross-sectional study of 1571 Iranian adults, those eating the most high glycemic index foods met the recommended vitamin C intake less often, but this is a diet pattern association and not a supplement test.The association between dietary glycemic index, glycemic load and diet quality indices in Iranian adults: results from I…
- In 1,276 Mexican adults, those with the highest blood magnesium had lower odds of type 2 diabetes and of coronary artery calcification (a marker of heart disease) than those with the lowest levels.Serum magnesium is inversely associated with coronary artery calcification in the Genetics of Atherosclerotic Disease (G…
- In a cohort of 1148 pregnant women in China, higher air pollution exposure to vanadium and other PM2.5 components was linked to gestational diabetes or impaired glucose tolerance, with vanadium among the more important exposures in the second trimester.Association of abnormal-glucose tolerance during pregnancy with exposure to PM2.5 components and sources.
- In 1046 diabetic dialysis patients, blood levels of vitamin E were not independently linked to heart events, infection deaths, or overall death after adjustment for confounders.Low plasma α-tocopherol concentrations and adverse clinical outcomes in diabetic hemodialysis patients.
- In 998 US adults with type 2 diabetes, blood levels of vitamin E and vitamin C were not significantly linked to diabetic eye damage (retinopathy) once supplement users were removed from the analysis.Relations of serum ascorbic acid and alpha-tocopherol to diabetic retinopathy in the Third National Health and Nutrition…
- Among 582 diabetic outpatients and 140 controls, diabetic patients had lower plasma magnesium, and lower magnesium tracked with higher blood glucose, with about a quarter of diabetics falling below nearly all controls.Hypomagnesaemia in diabetes.
- In 623 pregnant women in France, blood manganese levels were not clearly linked to gestational diabetes or impaired glucose tolerance, while higher blood cadmium was.Exposure to heavy metals during pregnancy related to gestational diabetes mellitus in diabetes-free mothers.
- In a Chinese case-control study of 122 people with type 2 diabetes and 429 controls, higher plasma vanadium was associated with greater diabetes risk.Association between Plasma Metal Levels and Diabetes Risk: a Case-control Study in China.
- In 408 Iranian girls aged 12 to 18, serum zinc was only weakly correlated with dietary zinc intake, and this study did not test zinc supplementation; high serum copper, not zinc, was linked to higher fasting blood glucose.Serum and dietary zinc and copper in Iranian girls.
- In 373 people with type 2 diabetes, 11 percent had low blood magnesium, which was more common in women and in those with HbA1c of 8 percent or higher, and was linked to diabetic eye disease.Hypomagnesemia and Poor Glycemic Control among Type 2 Diabetic Patients: A Cross-Sectional Study.
- In 345 Iranian women, higher dietary magnesium intake was linked to better insulin sensitivity, but this link disappeared after accounting for endothelial dysfunction, and other blood sugar measures were not significantly related.Magnesium intake, insulin resistance and markers of endothelial function among women.
- In a cross-sectional study of 329 adults with type 2 diabetes in Oman, low and high magnesium levels were common, and a higher ratio of ionized to total magnesium was linked to poorer blood sugar control and some diabetes complications.Ionized and total magnesium levels and health outcomes in patients with type 2 diabetes mellitus.
- Adults with type 1 or type 2 diabetes had lower blood manganese levels than control adults, suggesting a possible link between manganese deficiency and diabetes.Blood metals concentration in type 1 and type 2 diabetics.
- In a cross-sectional study of 285 adults with type 2 diabetes in Saudi Arabia, about 28% had low blood magnesium, and these people had worse blood sugar control than those with normal magnesium levels.Type 2 diabetes control and complications and their relation to serum magnesium level.
- In 205 pregnant women taking daily multivitamins, higher vitamin E intake from food during the second trimester was linked to lower fasting blood sugar, lower insulin resistance, and better insulin sensitivity later in pregnancy.Lower dietary vitamin E intake during the second trimester is associated with insulin resistance and hyperglycemia later…
- In 182 Saudi women, 65 with diabetes and obesity, 47 with obesity only, and 70 of normal weight, hair manganese was lower in obese women, but the abstract did not report a manganese difference linked to diabetes; this was a one-time comparison, not a supplement trial.Trace Element Alterations in the Hair of Diabetic and Obese Women.
- This study of a telephone weight-loss coaching service in adults with prediabetes did not test zinc supplementation; objectively measured weight and BMI changes over 12 months were modest, and nutrition and activity barely changed.Effectiveness of NSW health get healthy telephone coaching in adults screened from general practices.
- In a cross-sectional study of 147 adults with type 2 diabetes in Brazil, low blood magnesium was linked to a higher chance of elevated HbA1c, a marker of poor blood sugar control.Magnesium Status and Dietary Patterns Associated with Glycemic Control in Individuals with Type 2 Diabetes Mellitus.
- In this comparison of 100 people with diabetes and 45 matched people without diabetes, people with diabetes had much lower blood vitamin C levels, and the lowest levels were in those with eye damage from diabetes.Role of plasma ascorbate in diabetic microangiopathy.
- Adults with type 2 diabetes had lower vitamin E levels and higher oxidative stress markers in plasma than healthy controls.Relationships between plasma measures of oxidative stress and metabolic control in NIDDM.
- People with type 2 diabetes had plasma chromium levels about 33% lower than healthy volunteers and urinary chromium almost double, suggesting chromium losses in diabetes.Chromium homeostasis in patients with type II (NIDDM) diabetes.
- In 116 Korean women with prior gestational diabetes, the lowest postpartum blood magnesium was seen in the eight who developed type 2 diabetes, though magnesium was only a possible predictor and did not clearly separate prediabetes from normal glucose tolerance.Serum magnesium level is associated with type 2 diabetes in women with a history of gestational diabetes mellitus: the K…
- Overweight children aged 4 to 14 had lower blood magnesium than normal-weight children despite eating more magnesium, and lower levels were linked to higher body weight, blood pressure, waist size and insulin.Serum magnesium in overweight children.
- In 106 adults, dietary vitamin E intake did not differ between people with and without fatty liver disease.The TyG Index, Dietary Vitamin E Intake, and LRP5 rs4988321 in Adults with MASLD: A Case-Control Study.
- In 100 adults with type 2 diabetes compared with 112 healthy adults, plasma ascorbic acid (vitamin C) was relatively higher in the diabetic group, while many of them had other vitamin and mineral deficiencies.Vitamins and trace metals status in non insulin dependent diabetes mellitus.
- In 99 pregnant women in Saudi Arabia, blood magnesium was slightly lower in those who developed gestational diabetes, but the difference was not statistically significant.Modification of Total Magnesium level in pregnant Saudi Women developing gestational diabetes mellitus.
- In a cross-sectional study of 96 Brazilian adults with fatty liver disease, most patients ate less vitamin C than recommended, but the study did not measure any effect on heart or blood sugar.Dietary patterns in Brazilian patients with nonalcoholic fatty liver disease: a cross-sectional study.
- In 88 adults with type 2 diabetes, lower blood magnesium was linked to poorer blood sugar control and more complications; this study did not test magnesium supplements.Low magnesium level as an indicator of poor glycemic control in type 2 diabetic patients with complications.
- In 72 matched people, higher blood vitamin E was found in those with coronary artery disease, and it was not useful for judging heart disease risk once cholesterol was accounted for.Vitamin E compared with other potential risk factor concentrations in patients with and without coronary artery disease:…
- Middle-aged men with newly impaired glucose tolerance had lower serum magnesium than healthy controls, suggesting mineral imbalance may appear early in blood sugar problems.Indices of mineral metabolism in subjects with an impaired glucose tolerance.
- In 20 young adults with type 2 diabetes, serum chromium was significantly lower than in 20 non-diabetic controls.Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus.
- Children newly diagnosed with type 1 diabetes (37 children, compared with 13 controls) excreted more magnesium in urine, which may help explain why they had low magnesium despite normal blood levels.Hypermagnesiuria in children with newly diagnosed insulin-dependent diabetes mellitus.
- In 31 overweight postmenopausal women, 12 weeks of 48 mg banaba extract (1% corosolic acid) with 2 g myo-inositol reduced fasting insulin and insulin resistance and improved how the liver clears insulin, though there was no control group.Combined myo-inositol and Banaba (1% Corosolic Acid) improve HOMA-IR and hepatic insulin extraction index in overweight …
- In 21 patients with coronary artery disease, higher blood vitamin E levels were linked to better blood vessel widening in response to acetylcholine, a measure of vessel lining health.Plasma alpha-tocopherol and coronary endothelium-dependent vasodilator function.
- Higher blood vitamin C levels were linked to lower glycohemoglobin readings, so high vitamin C intake may make average blood sugar appear lower than it really is.Ascorbic acid, glycation, glycohemoglobin and aging.
- In large U.S. national surveys, adults with higher blood levels of vitamin C had lower odds of metabolic syndrome and insulin resistance, but this cross-sectional association does not show that vitamin C prevents these conditions.Serum antioxidant status is associated with metabolic syndrome among U.S. adults in recent national surveys.
- A register-based study in Finland found no clear link between magnesium in local well water and type 2 diabetes rates among young adults, though weak signals appeared in young women.The regional association of rising type 2 diabetes incidence with magnesium in drinking water among young adults.
- Whole blood manganese was measured in normal and diabetic people, and the abstract reports no difference for manganese. Cobalt, chromium, selenium and zinc were lower in diabetes.Determination of trace elements in normal and diabetic whole blood by neutron activation analysis.
- Urinary chromium excretion rose as pregnancy advanced, and in nine late-pregnancy women it usually fell after an intravenous glucose test, suggesting diet may not meet the higher chromium needs of pregnancy.Urinary chromium excretion during pregnancy and its relationship with intravenous glucose loading.
- In a Beijing cross-sectional analysis of blood metals, vanadium was among nine metals significantly associated with glucose homeostasis, though the direction of effect for vanadium was not clearly stated.Associations of metals and metal mixtures with glucose homeostasis: A combined bibliometric and epidemiological study.
- In a survey of 6,587 adults in Bangladesh, fasting blood sugar was not linked to arsenic in nearby well water, and manganese and 13 other water minerals did not significantly change this result; manganese itself was not given as a supplement.Arsenic and fasting blood glucose in the context of other drinking water chemicals: a cross-sectional study in Banglades…
- In an uncontrolled 1992 report of 2,365 people with age-related conditions, most who received chelation therapy with chromium and antioxidants had good results, but chromium could not be assessed alone.Antioxidant therapy in the aging process.
- In a lab study of fat cells, low magnesium reduced insulin-driven sugar uptake by about half, and a cohort of 395 people with type 2 diabetes showed lower magnesium linked to more insulin resistance; magnesium supplementation itself was not tested.Magnesium increases insulin-dependent glucose uptake in adipocytes.
- In hypertensive people with glucose intolerance, a single dose of vitamin C improved blood vessel dilation and reduced clot-related markers, but had no such effect in people with normal glucose metabolism.Influences of increased oxidative stress on endothelial function, platelets function, and fibrinolysis in hypertension a…
- In 38 people with type 2 diabetes and low zinc, zinc supplementation lowered a marker of oxidative DNA damage (8-OHdG) by 26% and raised serum zinc by 42%.Relationship Between Zinc Status and DNA Oxidative Damage in Patients with Type 2 Diabetes Mellitus.
- In 32 adults with type 2 diabetes, Gymnema sylvestre capsules at 1 g per day for 30 days reduced blood glucose by 37 percent in the Gymnema group, with smaller effects on triglycerides and cholesterol.EFFECT OF-GYMNEMA SYLVESTRE, CITRULLUS COLOCYNTHIS AND ARTEMISIA ABSINTHIUM ON BLOOD GLUCOSE AND LIPID PROFILE IN DIABET…
- In 22 healthy volunteers, a 2.5% aqueous cinnamon tea extract had a glycemic index of 63 on a single occasion, lower than green tea or ginger alone, while a blend of green tea, cinnamon and ginger gave the lowest index of 60.Synergistic effect of green tea, cinnamon and ginger combination on enhancing postprandial blood glucose.
- In 20 patients with type 2 diabetes, adding Dibicor (taurine) to usual medicine for 3 months lowered fasting and after-meal blood sugar, and reduced protein in the urine.[The antioxidant Dibicor in the treatment of vascular complications of type 2 diabetes].
- In 19 insulin-dependent people with diabetes, a short hospital course of 2,000 mg vitamin C per day produced lower blood sugar readings across the day, but this effect was not statistically confirmed, and blood fats (triglycerides, cholesterol, free fatty acids, glycerol) were not changed.[The effect of high dosage vitamin C treatment on the carbohydrate and lipid metabolism in diabetics using insulin].
- In 16 adults with type 2 diabetes given vanadyl sulfate for 6 weeks, blood vanadium levels did not track blood sugar response, and animal experiments added that vanadium binding to blood proteins may limit its effect.Effect of vanadium(IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis…
- In 15 adults with type 2 diabetes, 200 mg of a bitter melon fruit extract taken twice daily with half doses of a med or glibenclamide lowered blood sugar more than full doses of those drugs alone over 7 days.Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypogl…
- After a 75 gram glucose drink in 14 healthy people, vitamin E levels in blood fell and white blood cell oxidative stress rose over 3 hours.Glucose challenge stimulates reactive oxygen species (ROS) generation by leucocytes.
- In 11 obese adults with type 2 diabetes, 600 mg of vitamin E daily for 3 months reduced how well insulin moved glucose out of the blood and worsened clot breakdown.Insulin action and fibrinolysis influenced by vitamin E in obese Type 2 diabetes mellitus.
- In 10 healthy volunteers, a single 2.0 g dose of magnesium sulfate raised blood magnesium and lowered the insulin response to a sugar load without changing blood glucose, suggesting better insulin sensitivity.[The effect of a single administration of magnesium sulfate on glucose tolerance and insulinemia in healthy volunteers].
- In 9 adults with diabetes, a purified plant protein from bitter melon lowered blood sugar significantly, with effects starting within 30 to 60 minutes and peaking around six hours, and no allergic reactions occurred.Clinical trial in patients with diabetes mellitus of an insulin-like compound obtained from plant source.
- In 8 people, rinsing with a Gymnema sylvestre solution before drinking a glucose solution reduced sweet taste and delayed stomach emptying, and blood sugar and insulin rises were lower early after the drink.Suppression of Oral Sweet Taste Sensation with Gymnema sylvestre Affects Postprandial Gastrointestinal Blood Flow and Ga…
- In a small uncontrolled case series of 7 people with schizophrenia gaining weight on antipsychotic drugs, lipoic acid taken for 12 weeks was linked to lower total cholesterol and a weak, non-significant trend toward better insulin resistance.A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with sc…
- In five obese women with polycystic ovary syndrome, 1000 mcg of chromium picolinate taken without diet or activity changes improved how well their bodies cleared glucose by about 38 percent.Chromium picolinate improves insulin sensitivity in obese subjects with polycystic ovary syndrome.
- In three people with diabetes and severe nerve damage in the feet and legs, high-dose biotin taken for one to two years was followed by marked clinical and laboratory improvement within 4 to 8 weeks; this was an uncontrolled report of three patients.Biotin for diabetic peripheral neuropathy.
- A cost model based on a trial found that magnesium chloride taken for at least 4 months by adults with prediabetes and low magnesium was estimated to cost less and prevent more complications than placebo over 10 years.Cost-effectiveness analysis of using oral magnesium supplementation in the treatment of prediabetes.
- Fruit juice of bitter melon improved blood sugar handling in 73% of adults with maturity-onset diabetes, while the other 27% did not respond.Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes.
- In a small group of adults with type 2 diabetes taking 1 gram daily for 60 days, this Gymnema extract raised circulating insulin and C-peptide and lowered fasting and after-meal blood sugar.A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro.
- In rats with high parathyroid hormone, two weeks of capsiate injections at 2 mg/kg lowered parathyroid hormone and phosphate, improved insulin sensitivity markers and bone measures, and reduced oxidative stress; this is animal data, not human.Capsiate ameliorates secondary hyperparathyroidism by improving insulin sensitivity and inhibiting angiogenesis.
- In people with prediabetes or early type 2 diabetes, 12 weeks of mulberry leaf powder lowered two blood proteins linked to insulin resistance and inflammation and increased markers of mitochondrial energy production, though the study had no control group.Mulberry-Derived 1-Deoxynojirimycin Prevents Type 2 Diabetes Mellitus Progression via Modulation of Retinol-Binding Prot…
- In a Korean national survey of adults over 75, higher dietary taurine intake was linked to a lower atherogenic index in men but a higher diastolic blood pressure in women; this was a food-intake survey, not a supplement trial.Relationship Between Taurine Intake and Cardiometabolic Risk Markers in Korean Elderly.
- In mice fed a high-fat diet, cinnamaldehyde given at 40 mg per kilogram of body weight reduced weight gain, insulin resistance, and blood fats compared with untreated high-fat mice. Cell experiments also showed less fat buildup in fat cells. This was an animal and cell study, not a human trial.Cinnamaldehyde prevents adipocyte differentiation and adipogenesis via regulation of peroxisome proliferator-activated r…
- In rats with chemically induced high blood sugar, a cinnamon oil tablet formulation lowered blood glucose and HbA1c and raised insulin levels, and partly restored damaged insulin-producing cells. This was an animal study, not a human trial.Improvement of the bioavailability and glycaemic metabolism of cinnamon oil in rats by liquid loadable tablets.
- In diabetic mice, feeding a diet containing 0.02 percent cinnamaldehyde for 12 weeks reduced oxidative stress and improved blood vessel function and kidney function compared with mice on normal chow. This was an animal study, not a human trial.Cinnamaldehyde Ameliorates Vascular Dysfunction in Diabetic Mice by Activating Nrf2.
Review Totals and Summary
Members OnlyWhat buyers say
I could not find enough genuine customer feedback on this exact product to give you a reliable thematic summary. I found no Amazon or retailer review text for the Just Ripe Nutrition 8-bottle listing. The Trustpilot pages for similarly named "GlucoPure" products were nearly empty. One had no reviews at all. Another had two short reviews, which said the product was easy to take daily and seemed to support stable blood sugar. Both reviews were lukewarm, rating it 3 to 4 stars. Two reviews are too few to draw real conclusions, and they may not be about the Just Ripe product. The other material I found was promotional press releases and "review" articles. Those are marketing, not customer experience. Independent write-ups did raise some cautions. The supplement may suit people whose main concern is sugar cravings more than blood glucose numbers. It could interact with meds. The evidence for the ingredients is mixed. I would be inventing the usual themes about pill size, taste, side effects or visible results if I wrote them as customer findings. For real feedback, read the verified-purchase reviews on the Amazon listing itself, and look at the low-star ones first.
Biohacker Summary
Members Only10 of 10 recommend it
Magnesium is the main ingredient, and the panel is broadly positive: four of the ten say they use it, and others recommend it or discuss it favorably, mostly for sleep. Bryan Johnson's style of use stands out, with one panelist taking 400 mg of the threonate form before bed, and others also point to threonate or glycinate forms for sleep and deeper rest, while one panelist takes glycinate every night. Other reasons given include muscle function and cramps, blood pressure, bone support, stress, recovery, workout performance with electrolyte drinks, and calming hunger when breaking a fast, with one citing a median dose of 368 mg a day in trials. The cautions are that one panelist says magnesium does not fix waking in the night, and another warns that labels can make the dose look much larger than it really is. Zinc, vitamin C, taurine, cinnamon and vitamin E are smaller ingredients in this product, and several panelists mention vitamin C and zinc favorably.
See all 10 biohackers →Hide the biohackers
Dr. Mark Hyman · Magnesium · uses
- Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
- Recommends adding cinnamon to coffee as a way to enjoy fall flavors without the high sugar content.
- Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
- Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
- Recommends magnesium as a basic supplement during detoxification to support pathways, help with constipation, and provide electrolytes.
- Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
- Recommends Magnesium Breakthrough Advanced 10 from Biooptimizers, which contains 10 bioavailable forms and 550 mg of elemental magnesium, to support restful sleep, restorative sleep, muscle recovery, stress resilience, and metabolic health.
- Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
- Mentions topical vitamin C as an antioxidant that can help skin with aging.
- Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
- Mentions that what they do when a cold comes on is not just vitamin C.
- Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
- Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
- Has recommended magnesium breakthrough from bioptimizers for years and now uses Magnesium Breakthrough Advanced 10 as part of his evening routine, especially during periods of travel, training, and higher stress, to support sleep, muscle recovery, and metabolic health.
Dave Asprey · Magnesium · neutral
- Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
- Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
- Recommends taking vitamin C for better skin health.
- States that magnesium can affect how the body responds to a supplement.
- States that currently, he is only taking vitamin C and vitamin D.
- Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
- Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
- Recommends fixing sleep with 300mg of Magnesium 101 before bed if diet and exercise aren't melting stubborn belly fat.
- Dave Asprey explains that a 2017 study in rats found taurine pretreatment reduced several behavioral and biochemical effects of chronic unpredictable stress, but notes this does not show that taurine treats depression in humans.
- Mentions that taurine, a common longevity molecule, affects the sense of smell, but they do not know why it works.
- Dave Asprey says his daily routine includes magnesium as part of a carefully developed combination for longevity.
- Recommends magnesium glycinate for sleep, stating that trials show it helps people fall asleep about 17 minutes faster and that he finds it incredibly effective.
- Mentions magnesium glycinate as one of the five gut-friendly, extensively researched ingredients in Kill Switch that helps with natural sleep.
- Emphasizes the importance of having enough zinc before trying advanced longevity strategies like peptides.
Dr. Eric Berg · Magnesium · neutral
- Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
- Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
- Notes that magnesium could also be a factor in preventing muscle cramps.
- Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
- Recommends magnesium, specifically magnesium glycinate, stating it is key for D3 and K2 to work and is probably more important than calcium for building bone.
- Recommends increasing magnesium to restore balance and support healthy blood pressure.
- Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
- Dr. Eric Berg suggests that magnesium could help support deeper, more restful sleep.
- Recommends Magnesium Glycinate, noting that the combination of magnesium and glycine is helpful for connective tissue, sleep, and reducing stress.
- Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
- Recommends Vitamin C as a cofactor, especially for collagen.
- Recommends taking magnesium 90 minutes to 2 hours before bedtime to support better sleep.
- Suggests that magnesium glycinate can help support the missing 'break pads' on the nervous system, which contribute to constant pain.
- Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
Ben Greenfield · Magnesium · uses
- Uses magnesium during surgery because it is neuroprotective.
- Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
- Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
- States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
- Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
- Mentions magnesium as part of a bare-minimum protocol.
- Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
- Mentions chromium as a secondary ingredient in blood sugar control products, along with vanadium and bittermelon extract.
- Mentions vitamin C as part of a bare-minimum protocol.
- Mentions bittermelon extract as an ingredient in blood sugar control products, along with vanadium and chromium.
- Put himself on a diet of chelated vanadium to help regenerate his pancreas, as vanadium was historically used for diabetes.
- Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
- Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
- Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
Dr. Rhonda Patrick · Magnesium · neutral
- Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
- Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
- Mentions that taurine depletion is a concern raised in long-term animal studies regarding Beta Alanine, though not observed in human trials, and notes that one can supplement with taurine, which is a beneficial compound.
- Mentions magnesium as an important nutrient component for testosterone.
- Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
- Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
- Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
- States there is not yet strong, consistent evidence that magnesium supplementation reliably improves sleep, noting that while some meta-analyses suggest it can improve sleep quality scores, sleep efficiency, and sleep duration, individual studies are inconsistent and several have found no meaningful effect.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Lutein and zeaxanthin can also be obtained from certain multivitamins.
- Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
- States that magnesium may help modestly lower blood pressure by playing an important role in regulating vascular tone and influencing calcium signaling, with studies showing a reduction in systolic and diastolic blood pressure by 2 mmHg at a dose of around 370 mg/day for about 3 months.
- Recommends considering magnesium to improve mood.
- Recommends Magnesium, stating that roughly half of Americans don’t get enough and it is a cofactor for over 300 biological processes, including DNA repair and energy production.
Thomas DeLauer · Magnesium · uses
- Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
- Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
- Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
- Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
- Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
- Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
- Recommends taurine, stating it raises the stress threshold, acts as a GABA and glycine receptor modulator, and protects neurons from stress, ultimately lowering cortisol release.
- Recommends magnesium, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
- Notes that modern agricultural practices have led to soils depleted of trace minerals like magnesium, resulting in widespread magnesium deficiency.
- Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
- Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
- Recommends taking some magnesium glycinate tonight to help calm down and sleep.
- Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
Siim Land · Magnesium · recommends
- States that Magnesium can be a useful addition for some people for sleep.
- Recommends taking vitamin C with collagen to support joint collagen synthesis.
- States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
- Recommends magnesium for sleep, especially deep sleep, and suggests trying better types like Threonate, Biscinate, or Torate, referencing a study where magnesium supplementation improved deep sleep.
- States that taurine supports normal muscle, nerve, and heart function, and supplement trials suggest benefits for some metabolic markers, exercise performance and blood pressure.
- Recommends Magnesium for blood pressure, migraines and deficiency, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Recommends Taurine for blood pressure and metabolic health, based primarily on human research, especially randomized controlled trials showing measurable benefits.
- Lists Magnesium as one of 15 supplements backed by human studies.
- Lists Taurine as one of 15 supplements backed by human studies.
- States that magnesium is a fundamental mineral governing over 600 enzymes and metabolic reactions, and recommends that most people need at least 400-500 mg/d for health, with some needing up to 600 mg/d.
- Lists seafood and pumpkin seeds as sources of Magnesium.
- Lists sauerkraut and fruit as sources of Vitamin C.
- Thinks magnesium has some of the strongest evidence and is worth considering.
- Notes that Vitamin C is one of several supplements with human evidence.
Andrew Huberman · Magnesium · neutral
- Discusses Magnesium Threonate as a tool for falling asleep.
- Zinc carnosine to support and improve the lining of your gut.
- Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
- States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
- Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
- AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
- States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
- Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Uses Element, an electrolyte drink with sodium, magnesium, and potassium in correct ratios and no sugar, to ensure adequate hydration and electrolytes, especially when starting days fast or during physical exercise.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
Bryan Johnson · Magnesium · uses
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 15 mg of Zinc in the morning for longevity.
- He takes 400 mg of Double Wood Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of Magnesium Threonate before bed for sleep.
- Takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 15 mg of Zinc in the morning.
- Takes 400 mg of magnesium L-threonate before bed for sleep.
- He takes 400 mg of Magnesium L-Threonate before bed for sleep.
- Takes 400 mg of magnesium threonate before bed for sleep.
- Takes 15 mg of Zinc in the morning for longevity.
- Uses Vitamin C as an example of how it would be great if people knew that when they took it, it had a measurable amount and wasn't polluted, which is what Brian ensures with his products.
Peter Attia · Magnesium · neutral
- Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
- Uses cinnamon in his keto mousse in the evening.
- Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
- Recommends magnesium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 300 to 500 milligrams as a minimum, and personally aims for about a gram of supplemental magnesium.
- Recommends magnesium for optimizing bone mineral density, suggesting a daily intake of 300 to 500 milligrams as a minimum, but personally aims for about a gram.
- Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
- Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
- Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
- Mentions that taurine supplementation in mice and other species appears to prolong life, referencing V.J. Adav's work, but notes that it is unclear if the same applies to humans.
- Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
- States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
- Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.
RAL Summary
Members OnlyTier 4 for Blood Sugar
Tier 4 fits: several full-dose ingredients such as chromium and magnesium have human support for blood sugar [2][4]. However, only 10 reviews were counted, and just 60% of them were positive, which is too few to rank higher.
Take 3 servings a day (3 capsules) to match the dose that worked in the studies.
- Emerging: not enough evidence to rank higher yet.
Where the evidence disagrees: 140 of the 493 human studies found no effect.
More Details
Members OnlyBody systems · Combine with · Possible side effects
Body systems: Endocrine system, Metabolic system, Cardiovascular system
Combine with: For blood sugar support, this product pairs well with magnesium glycinate, which aids insulin sensitivity, plus omega-3 fish oil for heart and metabolic health, and soluble fiber such as psyllium or glucomannan to blunt post-meal glucose spikes. If thyroid support is the real goal, look at a separate thyroid formula with selenium (about 100-200 mcg), zinc, and iodine only if intake is low, and have TSH and free T4 checked first. Vitamin D and B12 are also commonly low in people with thyroid issues. Because blood sugar agents like berberine or chromium can lower glucose and may interact with diabetes or meds (a med should be separated from minerals by about 4 hours), consult a healthcare provider before combining them.
Possible side effects: Mild stomach upset, such as bloating and loose stools, was reported with mulberry leaf. Stomach side effects were also common with vanadium, but only at doses far higher than this product contains.
Supplement Facts
Vitamin C 50 mg · Vitamin E 7 mg · Biotin 300 mcg
| Vitamin C | 50 mg | |
| Vitamin E | 7 mg | |
| Biotin | 300 mcg | |
| Magnesium | 125 mg | |
| Zinc | 8 mg | |
| Manganese | 1 mg | |
| Chromium | 67 mcg | |
| Banaba Extract | 25 mg | † |
| Guggul | 50 mg | † |
| Bitter Melon Extract | 20 mg | † |
| Licorice Extract | 25 mg | † |
| Cinnamon Powder | 50 mg | † |
| Gymnema Extract | 3 mg | † |
| Yarrow Powder | 25 mg | † |
| Cayenne Pepper Powder | 10 mg | † |
| Juniper Extract | 13 mg | † |
| White Mulberry Extract | 3 mg | † |
| Vanadium | 2 mcg | † |
| Alpha Lipoic Acid | 30 mg | † |
| L-Taurine | 25 mg | † |
Other ingredients: Hypromellose (vegetable capsule), Rice Flour.
Directions: SUGGESTED USE: As a dietary supplement, take one (1) veggie capsule once a day. If desired, take two capsules daily. For best results, take 20-30 min before a meal with an 8 fl oz. glass of water or as directed by your healthcare professional.
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Our articles on this subject
- How to Lower Blood Sugar Naturally: A Comprehensive GuideArticle · Sep 9, 2026
- Magnesium Glycinate vs Citrate: What the Studies ShowArticle · Oct 30, 2026
Graded November 4, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.
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