Mason Natural Ultra Collagen with Horsetail Concentrate Review

Mason Natural Ultra Collagen with Horsetail Concentrate, 100 Capsules, is listed on this Vitacost page as a dietary supplement from the Mason Natural brand, which the page describes as established in 1967. The product is labelled as supporting healthy hair, skin and nails. It is listed as gluten free, soy free, and cGMP certified, and it is described as Mason Guarantee laboratory tested. The page explains that collagen is a type of protein that makes up about 25% of the total protein in the body and is often described as the glue that holds the body together. It says collagen also supports other body tissues, including skin, bone, tendons, muscles and cartilage. The description notes that as people age, collagen degradation occurs and can lead to wrinkles, so the product is presented as an option for people looking to address the visible effects of aging. The supplement facts list a serving size of 2 capsules with 50 servings per container, while the key info section lists 100 count total. Each serving provides a collagen complex of 725 mg, horsetail concentrate of 200 mg from a 4:1 concentrate, and fo ti concentrate of 100 mg from a 12:1 concentrate. The formula also includes vitamin C, calcium, vitamin E, D-biotin, zinc, selenium, copper, manganese, choline, L-methionine, N-acetyl L-cysteine, and silicon. The page says the product is guaranteed to contain no added sugar, sodium, yeast, soy, wheat, dairy, gluten, fish, tree nuts, peanuts, egg, fragrance, or artificial colours or flavours. The suggested use is to take two capsules daily, preferably with food. The page includes standard warnings advising pregnant or nursing women, people taking medication, and anyone with a medical condition to consult a physician before use. It also says to keep out of reach of children, not to use the product if the tamper evident seal appears broken, and to store it in a dry place at controlled room temperature. The expiration date is listed as 02/28/2027, and the UPC is listed as 311845149114.

Tier ⓘ
Tier 2 · Rank 3
Tier 2 · Researched. Human studies show improvement in an aging-related function or a specific goal, and the reviews agree. Rank 3 within Tier 2 for Younger-Looking Skin for Women; 3 of 41 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
79 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
82% of 312
Biohacker Mentions
8 of 10
Cost per month
$25 at 2 servings

Study, Trial or Testing Result Summary

Members Only124 human studies · 88 improved

15 of these 124 human studies gave the ingredient by injection, not by mouth.

124 human studies88 improved21 no effect10,787 people studied

The main ingredient, collagen, has the strongest support. At two servings a day it reaches the studied dose. A review of 26 trials with 1721 people found collagen taken by mouth improved skin hydration and elasticity [1]. Another review of 19 trials, mostly in women, found about 90 days improved hydration, elasticity and wrinkles [2]. One trial cut eye wrinkle volume by 20 percent [3]. A 2025 review found the highest-quality and non-company-funded trials showed no clear effect [4]. Silicon is at a full dose; 10 milligrams a day for 20 weeks reduced roughness and improved firmness in women with sun-damaged skin [5]. Vitamin E and selenium are at full doses, but were only tested in mixes, which improved skin density and roughness [6][7]. Vitamin C helped wrinkles mainly as a skin cream, not as a pill [8]. Horsetail was tested only in a cream mixed with soybean, with no placebo group [9]. Fo Ti has only animal studies [10]. The calcium evidence comes from injected fillers, not pills [11]. The copper evidence comes from creams and fabrics [12]. Animal and cell studies are never counted.

See all 124 studies →Hide the studies

Review Totals and Summary

Members Only312 reviews · 82% positive
312 reviews · Amazon 153 · PureFormulas 133 · Vitacost 22 · Walmart 4
82% positive6% neutral12% negative

Buyers are generally happy with Mason Natural Ultra Collagen with Horsetail Concentrate capsules. The ratings, about 175 across the stores, lean strongly positive, with mostly five-star and four-star scores and very few low ones. **What buyers say it did for them:** The clearest benefit reported is better skin. One user in their late sixties used it with the same brand's cream and noticed a change after a couple of bottles: "I see the difference/improvement in my skin and I'll be 70." Another says "I get good benefit," though without saying what the benefit was. Several reviews are simply general praise, such as "Excellent product" and "Amazing products good quality." One reviewer wants to use it longer before judging how well it works. **What they complain about:** Complaints are few and mild. The main one is a strong smell, mentioned by one buyer who otherwise liked the product. One review is lukewarm: the brand is usually good, but the supplements are "okay," and that buyer had stopped taking supplements. The store summary also notes that many reviews are very short and say little about long-term results. **Taste, smell, pill size and form:** Smell is the only point in this group with a comment: "the smell was strong." Nobody wrote about taste or capsule size. One buyer praised the packaging, saying "I love the packaging." **Value for money:** Opinions are mixed but mostly relaxed. One buyer calls it "Reasonable priced," and another hopes it "remains at an affordable price." A third finds it "A bit costly for hair/skin/nails vitamins," while also calling the ingredients "Interesting and unique." The store summary treats price as a hope for the future rather than a real complaint. **Who it seems to suit and who it did not:** It seems to suit people looking for a hair, skin and nails supplement with an unusual ingredient mix, especially those who already like the brand or use its cream alongside it. Patient buyers who will take it for a while before judging seem the best fit. It seems less convincing for people who are sensitive to smell, for those who want a very cheap option, and for those who are not convinced supplements do anything for them. No reviews give enough detail to say how it works for hair or nails, or for particular age groups beyond the one user in their late sixties. **Other forms:** Reviews of any other forms of this product, such as gummies or powder, were left out. This summary covers the capsules only.

Biohacker Summary

Members Only8 of 10 recommend it
8 of 10 biohackers on our panel recommend it

Collagen gets a mostly positive response from the panel: three of the ten recommend it and four more say they use it, two are neutral, and one has stopped taking it. People take it for skin, joints and connective tissue, muscle, and gut care, and two of them suggest taking it about an hour before exercise, with vitamin C alongside it. Doses came up a few times, with 10 grams in the morning from three panelists, 15 grams suggested by one, and 2.5 to 5 grams of collagen peptides a day for skin elasticity from another. Cautions came from one panelist who warns that collagen will not repair a damaged gut wall, and from another who says it is a weaker choice than whey for building muscle. Vitamin C is a smaller ingredient in this product, and the panel often pairs it with collagen because it is needed to make collagen.

See all 10 biohackers →Hide the biohackers
  • Dr. Eric Berg · Collagen · recommends
    • 31 Oct 2026 · recommends · Podcast ↗
      Recommends collagen as it is critical for healthy aging, supporting connective tissues, skin health, and cardiovascular health.
    • 31 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Dr. Berg states that Vitamin C helps fight biofilms and is essential for making collagen in gums, teeth, and capillaries.
    • 25 Oct 2026 · Calcium · warns · YouTube ↗
      Warns that bone loss cannot be fixed with just calcium, as bone is primarily collagen with other essential minerals.
    • 24 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends taking zinc carnosine for an ulcer or some type of gastric problem.
    • 24 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends Vitamin C as a cofactor, especially for collagen.
    • 23 Oct 2026 · Zinc · recommends · YouTube ↗
      Emphasizes the importance of zinc for decreasing viral replication and recommends taking 40 to 60 mg every single day.
    • 23 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that high doses of vitamin C, like 2 to 4 grams, can greatly reduce inflammation and support the immune system.
    • 21 Oct 2026 · recommends · YouTube ↗
      Recommends collagen powder as an alternative to bone broth, to be put in coffee, for its benefits in building connective tissue and providing glycine for sleep.
    • 19 Oct 2026 · Zinc · neutral · YouTube ↗
      Notes that birth control pills deplete the body of zinc, which is needed for the brain to make serotonin.
    • 18 Oct 2026 · neutral · YouTube ↗
      Mentions that grass-fed liver is loaded with collagen.
    • 18 Oct 2026 · Zinc · uses · YouTube ↗
      Added zinc to his creatine product because a deficiency in zinc might make creatine not work as well.
    • 18 Oct 2026 · Zinc · neutral · YouTube ↗
      Mentions that grass-fed liver is loaded with zinc.
  • Siim Land · Collagen · recommends
    • 29 Oct 2026 · recommends · Instagram ↗
      Recommends taking Collagen 1 hour before exercise with vitamin C to support joint collagen synthesis.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 19 Oct 2026 · Methionine · recommends · YouTube ↗
      Recommends keeping methionine intake slightly lower to support autophagy.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
    • 14 Oct 2026 · Copper · neutral · Instagram ↗
      Mentions that copper is a mineral necessary for making collagen.
    • 13 Oct 2026 · Methionine · uses · Instagram ↗
      Lowered his methionine intake as part of an amino acid strategy.
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Collagen for joints, skin and connective tissue, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 6 Oct 2026 · neutral · X ↗
      Lists Collagen as one of 15 supplements backed by human studies.
    • 30 Sep 2026 · Vitamin C · neutral · X ↗
      Lists sauerkraut and fruit as sources of Vitamin C.
    • 30 Sep 2026 · Calcium · neutral · X ↗
      Lists dairy and sardines as sources of Calcium.
    • 21 Sep 2026 · uses · YouTube ↗
      Takes 10 grams of collagen peptides a day, which provides 3 grams of glycine.
    • 8 Sep 2026 · neutral · X ↗
      30% of collagen is glycine, as glycine is every third amino acid in the collagen triple helix.
    • 6 Sep 2026 · Vitamin C · neutral · X ↗
      Notes that Vitamin C is one of several supplements with human evidence.
    • 2 Sep 2026 · recommends · YouTube ↗
      Recommends marine collagen peptides, citing a study where 5g daily for 12 weeks reduced AGE levels and improved insulin sensitivity.
  • Thomas DeLauer · Collagen · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says he takes collagen to take care of his gut.
    • 26 Oct 2026 · recommends · YouTube ↗
      Recommends collagen as a direct dietary source of glycine, suggesting a 15g serving of pure collagen. He advises taking it an hour before a workout for connective tissue benefits or before bed on rest days to help with sleep.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Zinc · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 19 Oct 2026 · recommends · YouTube ↗
      Recommends taking 15 grams of collagen an hour before working out to target connective tissue, as it has been shown to double a marker of collagen synthesis and help rebuild tendons and ligaments that are loaded harder with age.
    • 14 Oct 2026 · uses · YouTube ↗
      Always eats collagen, considering it one of the most underrated things they do for sustainability and recovery, as it supports connective tissue protein synthesis.
    • 9 Oct 2026 · neutral · YouTube ↗
      Mentions that if curling fingers are due to a collagen issue, there's a case for taking collagen peptides to help rebuild connective tissue.
    • 8 Oct 2026 · Zinc · recommends · Facebook ↗
      Recommends zinc, noting it is a cofactor for enzymes that build neurotransmitters, and deficiency can affect mood, happiness, and motivation.
    • 4 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends consuming vitamin C to aid in NADPH recycling, which is necessary for glutathione to be reused after neutralizing oxidative stress.
    • 4 Oct 2026 · Selenium · recommends · YouTube ↗
      Recommends adding selenium to the diet, found in Brazil nuts (two or three a day), eggs, shellfish, and mushrooms, as the glutathione recycling process is very selenium dependent and it helps protect against feroptosis.
    • 3 Oct 2026 · Zinc · neutral · YouTube ↗
      Mentions that more zinc could be beneficial for testosterone, but it's not working on the axis that most people need help with.
    • 29 Sep 2026 · Vitamin C · uses · YouTube ↗
      Takes Purity's liquid liposomal vitamin C for immune support and overall wellness, finding it easy to add to water, juice, or take straight up due to its good taste.
    • 25 Sep 2026 · Choline · neutral · Facebook ↗
      Mentions that choline from avocado (and eggs) contributes to the liver's ability to tag and process toxins, focusing on phase II detox.
  • Dave Asprey · Collagen · uses
    • 27 Oct 2026 · uses · YouTube ↗
      States he made collagen into a billion-dollar industry because he needed it for his joints due to Ehlers-Danlos syndrome.
    • 24 Oct 2026 · recommends · Facebook ↗
      Recommends taking collagen for better skin health.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 10 Oct 2026 · warns · YouTube ↗
      Dave Asprey agrees with taking collagen, but warns that using bone broth and collagen to repair a compromised gut wall is like trying to rebuild a collapsed house using nothing but craft glue, as it doesn't provide the rapid high demand energy gut cells need.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Developed a nonnano zinc sunscreen over five years, stating her skin is probably better now than it's ever been.
    • 29 Sep 2026 · Choline · recommends · YouTube ↗
      Recommends increasing choline intake, noting that it is missing in most people's diets and is important for cell membranes and liver function. He switched to a new American-made, plant-based choline called Vitacoline, which has prenatal clinical studies.
    • 24 Sep 2026 · neutral · Podcast ↗
      Mentions Puori CP1 Pure Collagen as a sponsor, offering a discount on a subscription.
    • 20 Sep 2026 · neutral · YouTube ↗
      Notes that eating collagen can break down into amino acids and create a signaling molecule that tells the body the skin has been injured, leading to thicker skin.
    • 15 Sep 2026 · uses · YouTube ↗
      Explains that One Skin uses collagen amino acids in their formula because they are hygroscopic and help hold water, acting as natural moisturizing factors.
    • 12 Sep 2026 · Choline · recommends · YouTube ↗
      Dave Asprey recommends eating eggs or taking a supplement that raises acetylcholine when taking racetams, as racetams can burn through choline, which the brain needs for focus.
    • 9 Sep 2026 · stopped · YouTube ↗
      Has updated his stance on collagen, now believing there may be some benefit for certain populations in having collagen peptides, especially since they are small and get absorbed.
    • 3 Sep 2026 · neutral · Podcast ↗
      Dave and Jenny walk through the biohacking protocol that helped her son recover from autism, including collagen and hypermobility support.
  • Ben Greenfield · Collagen · recommends
    • 22 Oct 2026 · recommends · Facebook ↗
      Mentions that two separate meta-analyses found real improvement in skin elasticity when people consumed 2.5 to 5 g of collagen peptides a day for eight weeks.
    • 29 Oct 2026 · Copper · neutral · YouTube ↗
      Mentions that overshooting zinc can lead to a copper deficiency, highlighting the interplay between these elements.
    • 29 Oct 2026 · Zinc · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 22 Oct 2026 · recommends · YouTube ↗
      Recommends 2.5 to 5 grams a day of hydrolyzed collagen peptides for at least 8 weeks to improve skin elasticity and address sagging skin.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Selenium · recommends · YouTube ↗
      Recommends taking sufficient selenium to ensure free T3 levels are right, which is important for the reverse calcium transport system.
    • 10 Oct 2026 · Zinc · recommends · YouTube ↗
      Emphasizes that zinc sufficiency is crucial for immunity because the thymus-derived peptide thymulin, which trains lymphocytes, requires zinc to be active.
    • 4 Oct 2026 · recommends · Facebook ↗
      Recommends 2.5-5 g/day of hydrolyzed collagen for at least 8 weeks, citing a meta-analysis that found real improvement in skin elasticity.
    • 27 Sep 2026 · recommends · X ↗
      Recommends starting with collagen for body remodeling.
    • 24 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Notes that while vitamin C has significant value, the optimal dose is a vexed question, and high doses might not always be beneficial, potentially blunting the hormetic effects of exercise.
    • 19 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends adding zinc into one's stack because it is a co-factor for enzymes involved in testosterone synthesis and sperm maturation, and zinc deficiency is a reproducible cause of low sperm count.
    • 19 Sep 2026 · Zinc · neutral · Podcast ↗
      He mentions zinc as a supplement with real human data behind it for male fertility.
  • Bryan Johnson · Collagen · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 22 Jul 2026 · uses · X ↗
      Consumes collagen peptides at 4:55 am.
    • 1 Jul 2026 · uses · X ↗
      Uses collagen peptides as an ingredient in Nutty Pudding.
    • 4 May 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 4 May 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 10 g of Collagen in the morning for muscle.
    • 21 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for skin health.
    • 15 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 14 Apr 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 14 Apr 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning.
    • 8 Apr 2026 · uses · X ↗
      Takes 10 grams of collagen in the morning for muscle.
    • 7 Apr 2026 · uses · X ↗
      He takes 10 grams of Collagen in the morning for muscle.
    • 2 Apr 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 2 Apr 2026 · Copper · uses · X ↗
      Takes 2 mg of Copper in the morning for longevity.
  • Dr. Mark Hyman · Collagen · neutral
    • 7 Oct 2026 · neutral · Podcast ↗
      Dr. Hyman mentions collagen supplements in the context of skin aging.
    • 12 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends vitamin C as a basic supplement during detoxification to help with inflammation and detoxification.
    • 7 Oct 2026 · recommends · YouTube ↗
      Is on 'team collagen' and believes there's enough data to support collagen consumption, noting that it sends signals to help the body build better collagen, though lifestyle factors are more important.
    • 7 Oct 2026 · Vitamin C · neutral · Podcast ↗
      Dr. Hyman mentions vitamin C as an advanced therapy for skin repair.
    • 7 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Mentions topical vitamin C as an antioxidant that can help skin with aging.
    • 7 Oct 2026 · Zinc · uses · YouTube ↗
      Gave a patient with psoriatic arthritis a little zinc, which contributed to significant improvement in her condition.
    • 6 Oct 2026 · Vitamin C · neutral · X ↗
      Mentions that what they do when a cold comes on is not just vitamin C.
    • 5 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends ensuring adequate vitamin C intake on a regular basis for immune support, stating it's important for healthy immune function despite mixed data on its effectiveness for colds.
    • 5 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring adequate zinc intake on a regular basis for immune support, noting some data on zinc lozenges for early cold.
    • 5 Oct 2026 · Selenium · recommends · YouTube ↗
      Includes selenium in a formula he uses to support health during the winter season.
    • 30 Sep 2026 · uses · YouTube ↗
      Adds Peak's marine collagen to his routine for a powerful longevity ritual, supporting skin elasticity, hydration, hair, nails, and whole body vitality.
    • 30 Sep 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that vitamin C was the very first vitamin discovered, isolated, and synthesized in 1932, and its deficiency caused scurvy.
    • 22 Sep 2026 · Zinc · recommends · Instagram ↗
      Recommends correcting nutrient deficiencies with zinc.
    • 14 Sep 2026 · Vitamin C · recommends · Facebook ↗
      Recommends nutrient-dense foods rich in vitamin C, such as guavas and parsley, to reduce inflammation.
  • Andrew Huberman · Collagen · uses
    • 7 Aug 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 29 Oct 2026 · Zinc · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · Zinc · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 19 Oct 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 14 Sep 2026 · Zinc · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · Zinc · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 17 Aug 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 6 Aug 2026 · Choline · recommends · Podcast ↗
      Recommends choline-rich foods to enhance focus and acetylcholine.
    • 20 Jul 2026 · uses · X ↗
      Takes 10 grams of Collagen in the morning for muscle.
    • 20 Jul 2026 · Choline · recommends · YouTube ↗
      Mentions choline as a structural lipid component, obtainable from nuts, seeds, or eggs, that seems related to cognitive function, though with slightly less evidence for brain changes over time and dementia risk.
  • Dr. Rhonda Patrick · Collagen · stopped
    • 5 Aug 2025 · stopped · Podcast ↗
      Is no longer taking collagen.
    • 29 Sep 2026 · Zinc · recommends · YouTube ↗
      Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
    • 28 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
    • 25 Aug 2026 · Vitamin E · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 25 Aug 2026 · Vitamin C · neutral · Facebook ↗
      Lutein and zeaxanthin can also be obtained from certain multivitamins.
    • 21 Aug 2026 · Zinc · neutral · Instagram ↗
      Discusses findings from a meta-analysis on zinc supplementation, noting it improved insulin resistance, inflammation, and oxidative stress in people with diabetes or prediabetes, and explains its biological role in the pancreas.
    • 29 Jun 2026 · Calcium · neutral · Facebook ↗
      Mentions that kale delivers calcium, a micronutrient many diets fall short on.
    • 18 Jun 2026 · Choline · neutral · Facebook ↗
      States that choline helps make acetylcholine for cognition and phosphatidylcholine for cell membranes, and can be converted into betaine to help clear homocysteine.
    • 5 Jun 2026 · Zinc · recommends · Instagram ↗
      Recommends nutrients like zinc for men to prioritize sperm mitochondrial health.
    • 5 Jun 2026 · Vitamin C · recommends · Instagram ↗
      Recommends nutrients like vitamin C for men to prioritize sperm mitochondrial health.
    • 4 May 2026 · Vitamin C · uses · YouTube ↗
      Dr. Rhonda Patrick's daughter chugs an Emergency fizzy drink in the morning to ensure she gets some vitamin C and micronutrients before school.
    • 5 Feb 2026 · Vitamin E · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 5 Feb 2026 · Vitamin C · recommends · Facebook ↗
      Choosing a multivitamin that includes lutein and zeaxanthin ensures you get meaningful amounts every day.
    • 9 Jan 2026 · Vitamin E · neutral · Facebook ↗
      Notes that ~60% of Americans are low in vitamin E.
  • Peter Attia · Collagen · neutral
    • 20 Jun 2024 · neutral · YouTube ↗
      Explains that collagen has a much lower quality amino acid composition than whey and tends to be rich in only a handful of amino acids like glycine and proline, making it less effective for muscle protein synthesis.
    • 4 Jan 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 9 Jul 2025 · Calcium · recommends · YouTube ↗
      Recommends calcium as one of the 'big three' micronutrients for bone health, suggesting a daily intake of 1,000 to 1,200 milligrams, which can be supplemented with calcium carbonate or calcium citrate.
    • 6 Jul 2025 · Calcium · neutral · YouTube ↗
      Explains that bone is 50 to 70% mineral, predominantly calcium, and that virtually all of the body's calcium is contained within bone, making bone important for calcium homeostasis.
    • 3 Jul 2025 · Vitamin C · stopped · YouTube ↗
      Recommends vitamin C as an important molecule for skin, noting its role as a precursor for collagen synthesis, a powerful antioxidant, and a regulator of complexion for even skin tone.
    • 29 Jun 2025 · Vitamin C · stopped · YouTube ↗
      Tried a vitamin C serum mixed with ferulic acid but stopped using it because she hated the smell. She notes that topical application of vitamin C far exceeds the levels achievable by ingestion for skin benefits.
    • 11 May 2025 · Biotin · warns · YouTube ↗
      Warns that biotin, found in many supplements, can completely obscure findings and render a non-LCMS test for estradiol and testosterone irrelevant due to interference with ELISA-based assays.
    • 22 Oct 2024 · Calcium · recommends · YouTube ↗
      Recommends calcium for bone health, stating that teenagers probably need about 1000 milligrams a day.
    • 21 Oct 2024 · Calcium · recommends · YouTube ↗
      Discusses bone acting as a reservoir for calcium and how resorption and formation release calcium into the blood when needed.
    • 6 Sep 2024 · Zinc · neutral · YouTube ↗
      Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
    • 6 Sep 2024 · Vitamin C · neutral · YouTube ↗
      States that vitamin C deficiency is associated with an elevated risk of cataract, but supplementation to supranormal levels has not been shown to protect against cataract formation.
    • 6 Sep 2024 · Copper · neutral · YouTube ↗
      Discusses the AREDS formula, which initially included C and beta-carotene with zinc and copper, and later replaced beta-carotene with lutein and zeaxanthin, showing it could delay or reduce the conversion of mild to severe macular degeneration.
    • 19 Aug 2024 · Vitamin C · recommends · YouTube ↗
      Mentions the elimination of scurvy through the work of James Lind and the eventual understanding that it was due to vitamin C, initially thought to be just citrus.

RAL Summary

Members OnlyTier 2 for Younger-Looking Skin for Women

Tier 2: several reviews of placebo-controlled trials show oral collagen, given here at a full dose over two servings, improves skin hydration, elasticity and wrinkles [1][2]. In addition, 82% of 312 reviews are positive.

Take 2 servings a day (4 capsules) to match the dose that worked in the studies.

Where the evidence disagrees: 21 of the 124 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Skin, Hair and nails, Connective tissue

Combine with: For skin, hair, nail, and joint support, collagen pairs well with vitamin C (needed for collagen synthesis), hyaluronic acid for hydration, biotin for hair and nails, and silica or MSM for connective tissue. Vitamin E and astaxanthin add antioxidant protection for skin. If heartburn is the real concern, use a separate product such as calcium carbonate or magnesium-based antacids, or an alginate, for fast relief. Long-term support may include DGL licorice, zinc-carnosine, or aloe vera, ideally after consulting a healthcare provider if symptoms are frequent. Because horsetail has a med effect, stay hydrated and check with a clinician if you take meds, lithium, or have kidney issues.

Possible side effects: Collagen trials reported no related side effects. One buyer noted a strong smell.

Supplement Facts

Vitamin C 60 mg · Vitamin E 27 mg · D-Biotin 2500 mcg
Supplement Facts
Serving Size 2 Capsule(s)
Servings Per Container 50
Amount Per Serving% Daily Value
Vitamin C60 mg
Vitamin E27 mg
D-Biotin2,500 mcg†
Calcium225 mg
Zinc15 mg
Selenium150 mcg
Copper2 mg
Manganese4 mg
Choline100 mg
Collagen Complex725 mg†
Horsetail concentrate200 mg†
Fo Ti concentrate100 mg†
L-Methionine25 mg†
N-Acetyl L-Cysteine25 mg†
Silicon12 mg†
† Daily Value not established.

Other ingredients: Gelatin, Maltodextrin, Magnesium Stearate.

Directions: Directions: Adults - Take two capsules daily, preferably with food, as a dietary supplement.

Barcode (UPC) 311845149114 · Label source: NIH label database · Report a label change

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Our articles on this subject

Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.