Thorne MediClear-SGS™ - Vanilla Review

Thorne MediClear-SGS is presented as an all-in-one daily detox product with protein, multi-vitamin, and multi-mineral support in a vanilla flavour. The page describes it as a powerhouse of daily nutrition that combines two plant-based proteins, a complete multi-vitamin and multi-mineral complex, antioxidants, broccoli seed extract, and liver-supportive botanicals, intended to help the body balance life in a toxic world. The product is described as having more protein, more detox factors, fewer carbohydrates, and added special nutrients than other daily detox alternatives, and is positioned as a more affordable and more complete formula. The powder is said to mix easily with water, juice, or a favourite beverage for on-the-go nutritional support, or to be blended into a smoothie with fruits and greens. The benefits listed include powerhouse nutrition with all-in-one daily protein and multi-vitamin and mineral support with added antioxidant support, daily support with a choice of chocolate or vanilla flavour, detox benefits that support the body's defences against modern toxic insults, and a powdered alternative to capsules that mixes with a favourite beverage. The features section states that rice and pea proteins are less likely to trigger an allergic reaction or cause digestive discomfort than common protein sources. It describes the vitamins and minerals as the most absorbable, best utilised forms, including the active forms of vitamins B6, B12, and folate, along with mineral chelates from Albion Laboratories. Reduced glutathione is presented as a well-absorbed form of the body's most abundant antioxidant. Glycine, glutamine, and taurine, along with vitamins A, C, and E, and minerals such as zinc and selenium, are described as building blocks the body uses to make and recycle antioxidants. Green tea and milk thistle extracts are said to promote healthy liver function, while curcumin and grape seed phytosomes are said to support a healthy inflammatory response. Sulforaphane glucosinolate from broccoli seed extract is described as helping to protect cells for up to 72 hours. The page states that the product has been third-party tested and certified to verify that what is in the package matches the label and that it contains no unsafe levels of contaminants such as heavy metals, pesticides, and microorganisms. The warnings section includes a California Proposition 65 lead warning, and notes that the product is contraindicated for anyone with a history of hypersensitivity to its ingredients. It states that the grape seed phytosome uses phospholipids derived from soy, although the phospholipids contain no soy protein. It also advises caution for people with a known, serious peanut allergy because the product contains pea protein. Pregnant individuals are advised to consult a health-care practitioner before use. Interaction warnings cover a med with 5-MTHF folate and curcumin with cyclophosphamide, camptothecin-related agents, and irinotecan. The page lists a serving size of 2 scoops with 21 servings per container and a price of $90, or $81 with a subscription.

Product Focus: Liver HealthAlso covers:DigestionMetabolism
Tier ⓘ
Tier 3 · Rank 4
Tier 3 · Reviewed. Strong review agreement, with limited or early support from human studies. Rank 4 within Tier 3 for Liver Health; 24 of 39 overall. Tiers run from 1, the strongest evidence, to 5. How we grade →
Evidence ⓘ
70 /100
How strongly the evidence says this product works: human studies count most, then real reviews, then our biohacker panel.
Positive Reviews
86% of 481
Biohacker Mentions
9 of 10
Cost per month
$386 at 3 servings

Study, Trial or Testing Result Summary

Members Only647 human studies · 281 improved

32 of these 647 human studies gave the ingredient by drip or injection, not by mouth.

647 human studies281 improved272 no effect1,158,770 people studied

This shake has several liver-studied ingredients at the doses used in studies. Curcumin, here as a phytosome, lowered liver enzymes and improved liver scans in pooled trials of people with fatty liver [1]. In one trial of a phytosome form, 75% improved on ultrasound versus 4.7% on placebo [2]. A 2026 pooled analysis said the benefits were not clearly meaningful [3]. Milk thistle lowered liver enzymes across 55 trials [4] and improved liver fat in fatty liver disease [5], though it did not help alcohol-related hepatitis. Vitamin E improved liver tissue in non-diabetic adults with fatty liver inflammation [6][7], but results were weaker in people with diabetes [8]. Vitamin D reduced liver fat in a 12-month trial [9]. Grape seed extract lowered liver enzymes in small trials [10]. Vitamin A, niacin, chromium, boron and betaine taken alone did not help the liver in the better studies [11][12][13][14][15]. Taurine, betaine and vanadium are present only in trace amounts, far below the studied doses [16][17]. Sulforaphane and glutathione have only thin evidence [18][19]. Animal and cell studies are never counted.

See all 647 studies →Hide the studies

Review Totals and Summary

Members Only481 reviews · 86% positive
481 reviews · Amazon 285 · Thorne 126 · Vitacost 32 · Google.com listing 32 · Walmart 6
86% positive7% neutral7% negative

Overall, buyers rate Thorne MediClear-SGS Vanilla favorably, with about 449 ratings across the stores. Most of the written feedback is positive and centers on trust in the brand and an easy-to-drink shake, but a few people find it too sweet or dislike the taste. This summary covers the powder only. Feedback on other forms of the product was left out. **What buyers say it did for them:** Several people use it as a quick meal or daily shake and say they feel better for it. One calls it a go-to when rushed: "something quick until lunch." Another says, "I feel better starting my day with a shake." A diabetic reviewer says it "checks all the boxes." The Vitacost page describes reviewers reporting more energy, better sleep, less sluggishness, clearer skin, and no bloating. One reviewer says it supports liver health. These come from the store summary, not from a quote. **What buyers complain about:** The main complaints are sweetness, the sweetener, and mixing. One reviewer wants a "flavorless or unsweetened one," saying the vanilla is too sweet. Another gave two stars after a formula change: "Causes GI upset. Artificial sweeteners." That reviewer preferred the earlier version sweetened only with monk fruit. The Vitacost page notes one customer who found the powder hard to mix in a blender bottle and will not repurchase. The Thorne page also mentions a need for a scooper. Some low and middling star ratings on the Thorne page have no written explanation. **Taste, smell, and form:** Opinions on the vanilla flavor split. Some find it easy: "goes down easy," and one person likes it "ice cold." They also sometimes mix it with a protein drink. The Vitacost page describes the taste as quite neutral with a little vanilla sweetness, more palatable than the unflavored version, and says you get used to it. Others struggle. One reviewer found the vanilla "a bit of a challenge to choke down" and recommends the chocolate instead. The product is a powder, and one Vitacost reviewer mentions how big the container is. **Value for money:** Price comes up only once in the reviews. A reviewer who liked the nutrition profile said, "if it weren't so expensive," they would take it daily as a multivitamin. The store summaries say little about price. **Who it seems to suit and who it did not:** It seems to suit people who want a convenient breakfast or on-the-go shake, trust Thorne, and like a mild vanilla flavor. One person on a very restrictive diet was glad to find it, and a diabetic reviewer was happy with it. It suited others less if they dislike sweet flavors, are sensitive to artificial sweeteners, or dislike powders that clump in a shaker. One reviewer thought the chocolate flavor was the better pick. Written reviews are few and often short, so treat these themes as indicative rather than definitive.

Biohacker Summary

Members Only9 of 10 recommend it
9 of 10 biohackers on our panel recommend it
See all 10 biohackers →Hide the biohackers
  • Dave Asprey · Curcumin · uses
    • 29 Oct 2026 · uses · YouTube ↗
      Says CallaCurcumin is like "mommy's little helper" and he takes it when he knows he's going to eat late at night, around 5:00 or 6:00, to avoid overeating.
    • 1 Nov 2026 · Vitamin D · uses · Facebook ↗
      Takes Vitamin DAKE from Suppgrade Labs.
    • 31 Oct 2026 · Magnesium · neutral · YouTube ↗
      Mentions magnesium in the context of sleep but states that it doesn't address the core issue of waking up during the night.
    • 25 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Suggests that vitamin D supports brain health, muscle function, and focus.
    • 25 Oct 2026 · Magnesium · recommends · Podcast ↗
      Suggests that magnesium may help slow aging, support cellular repair, and improve sleep.
    • 24 Oct 2026 · Glutathione · recommends · Facebook ↗
      Recommends detoxing with glutathione.
    • 24 Oct 2026 · Vitamin C · recommends · Facebook ↗
      Recommends taking vitamin C for better skin health.
    • 17 Oct 2026 · Magnesium · neutral · Facebook ↗
      States that magnesium can affect how the body responds to a supplement.
    • 17 Oct 2026 · Folate · neutral · Facebook ↗
      States that folate can affect how the body responds to a supplement.
    • 9 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Host Dave Asprey explains why correcting a vitamin D deficiency still makes sense for male fertility, even though supplementation did not improve overall semen parameters in a randomized trial.
    • 7 Oct 2026 · recommends · YouTube ↗
      Recommends Tetrahydro Curcuminoids, stating they lower inflammation.
    • 7 Oct 2026 · Vitamin D · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin C · uses · YouTube ↗
      States that currently, he is only taking vitamin C and vitamin D.
    • 7 Oct 2026 · Vitamin E · uses · YouTube ↗
      Dave Asprey's kids get a little bit of vitamin E every day, which helps to stabilize the bad oils they get when eating at restaurants.
  • Dr. Eric Berg · Curcumin · neutral
    • 25 Oct 2026 · neutral · Facebook ↗
      Mentions that turmeric contains curcumin, which has been studied for its effects on inflammation, joint discomfort, mood, and blood sugar.
    • 2 Nov 2026 · Vitamin D · warns · Facebook ↗
      Dr. Berg warns that the recommended daily intake for vitamin D is based on a massive error and that the actual necessary amount is closer to 8,895 IU, with millions remaining deficient.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends getting vitamin D levels tested to ensure they are between 50 and 70, as vitamin D is intimately involved in regulating prostate size.
    • 31 Oct 2026 · Zinc · recommends · YouTube ↗
      Recommends ensuring sufficient zinc intake because the prostate needs enough zinc for the conversion from testosterone to DHT to be smooth and optimized.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking at least 10,000 IUs of vitamin D3 every single day in the winter, stating it is the most important vitamin to lower cancer risk.
    • 30 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends vitamin D to support the immune system, aiming for blood levels between 80 to 100 ng per ml.
    • 30 Oct 2026 · Magnesium · neutral · Instagram ↗
      Dr. Eric Berg states that magnesium supports energy, muscle function, and sleep, and that most of it is stored inside cells, making deficiencies harder to detect with a standard blood test.
    • 30 Oct 2026 · Sulforaphane · recommends · YouTube ↗
      Recommends adding sulforaphane, a phytonutrient found in broccoli sprouts or radish sprouts, to the diet for its studied effects against cancer.
    • 29 Oct 2026 · Potassium · recommends · Podcast ↗
      States that people need more potassium than any other mineral, yet most people aren’t getting enough.
    • 28 Oct 2026 · Magnesium · neutral · YouTube ↗
      Notes that magnesium could also be a factor in preventing muscle cramps.
    • 28 Oct 2026 · Potassium · recommends · YouTube ↗
      Explains that potassium is essential for peristalsis, the pumping action through the colon, and without it, things can sit there, leading to constipation.
    • 26 Oct 2026 · Vitamin C · neutral · YouTube ↗
      Mentions that lemon is loaded with vitamin C, and when combined with coffee, vitamin C significantly increases the bioavailability of antioxidants in the coffee.
    • 25 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Recommends taking no less than 10,000 IU's of vitamin D3 for osteoporosis, alongside magnesium and K2.
    • 25 Oct 2026 · Vitamin D · recommends · X ↗
      Recommends increasing vitamin D to restore balance and support healthy blood pressure.
  • Thomas DeLauer · Milk Thistle · neutral
    • 16 Oct 2026 · neutral · YouTube ↗
      Notes that Dose Daily contains organic milk thistle, highlighting its significant data supporting liver health benefits.
    • 28 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's cans which contain 30 milligram magnesium, finding that electrolytes help his workout performance.
    • 28 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's cans which contain 100 milligram potassium, finding that electrolytes help his workout performance.
    • 27 Oct 2026 · Glycine · neutral · YouTube ↗
      Explains that glycine is critical for collagen synthesis, which supports the intestinal wall, and deficiency can slow down the repair process.
    • 26 Oct 2026 · Glycine · recommends · YouTube ↗
      Explains that the body needs roughly 10g more of glycine per day than a typical modern diet provides, and that this deficit can lead to issues with creatine production, connective tissue repair, and sleep. He recommends increasing glycine intake.
    • 26 Oct 2026 · Vitamin C · recommends · YouTube ↗
      Recommends taking vitamin C along with collagen about an hour before a workout for connective tissue benefits.
    • 24 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses Element's 30 mg magnesium cans first thing in the morning to prime his day and help with workout performance.
    • 24 Oct 2026 · Potassium · uses · YouTube ↗
      Uses Element's 100 mg potassium cans first thing in the morning to prime his day and help with workout performance.
    • 23 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends magnesium around the time one would normally break a fast to calm the brain and dull feelings of conditioned hunger.
    • 23 Oct 2026 · Vitamin C · uses · YouTube ↗
      Uses vitamin C as part of their immunity duo, stating it is important for boosting the immune system, especially during cold and flu season.
    • 23 Oct 2026 · Zinc · uses · YouTube ↗
      Adds zinc to their immunity duo because it helps them absorb vitamin C, considering the two together a fantastic combination for fall and winter.
    • 23 Oct 2026 · Vitamin D · uses · YouTube ↗
      Uses vitamin D3 in the fall and winter months when getting less sun, as it's important to supplement it then.
    • 22 Oct 2026 · Taurine · recommends · YouTube ↗
      Recommends taurine, stating it raises the stress threshold, acts as a GABA and glycine receptor modulator, and protects neurons from stress, ultimately lowering cortisol release.
    • 21 Oct 2026 · Sulforaphane · recommends · YouTube ↗
      Recommends rotating thymoquinone with other NRF2 activators like sulforaphane instead of stacking it daily to maintain sensitivity and preserve intensity.
  • Siim Land · Curcumin · recommends
    • 7 Oct 2026 · recommends · Instagram ↗
      Recommends Curcumin for joint pain and inflammation, based primarily on human research, especially randomized controlled trials showing measurable benefits.
    • 31 Oct 2026 · Glycine · recommends · Instagram ↗
      Suggests that a higher glycine to methionine ratio appears to preferentially target visceral fat and improve insulin sensitivity.
    • 31 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Advises against taking vitamin D in the morning with other supplements because it is fat soluble and requires dietary fat for better absorption.
    • 29 Oct 2026 · Glycine · recommends · Instagram ↗
      Recommends pairing NAC with glycine to support antioxidant activity in your sleep.
    • 29 Oct 2026 · Vitamin D · recommends · Instagram ↗
      Recommends taking Vitamin D with fat for better absorption.
    • 29 Oct 2026 · Vitamin C · recommends · Instagram ↗
      Recommends taking vitamin C with collagen to support joint collagen synthesis.
    • 26 Oct 2026 · Glycine · recommends · YouTube ↗
      Believes glycine is the best longevity supplement and encourages viewers to learn more about its longevity benefits.
    • 25 Oct 2026 · Glycine · recommends · Instagram ↗
      States that Glycine can be a useful addition for some people for sleep.
    • 25 Oct 2026 · Magnesium · recommends · Instagram ↗
      States that Magnesium can be a useful addition for some people for sleep.
    • 24 Oct 2026 · Vitamin D · neutral · Instagram ↗
      States that Vitamin D connects biology to light and that UVB reaching the skin enables its production.
    • 21 Oct 2026 · Glycine · uses · YouTube ↗
      Increased his glycine supplementation to 10g a day, noting that it balances methionine and improves blood sugar and glycation.
    • 19 Oct 2026 · Glycine · uses · YouTube ↗
      Personally uses glycine for its health benefits, including glutathione, blood sugar glycation, and potentially sleep, and notes that it appears to have some autophagy benefits by increasing autophagy through its role in methionine metabolism.
    • 14 Oct 2026 · Glycine · neutral · Instagram ↗
      Notes that glycine is one of the most important building blocks for collagen synthesis, making up 30% of collagen, and that 12g of glycine a day is needed for collagen turnover.
    • 14 Oct 2026 · Vitamin C · neutral · Instagram ↗
      States that vitamin C is needed for initiating collagen synthesis and that higher vitamin C intake appears to increase vitamin C content in the skin.
  • Dr. Mark Hyman · Curcumin · recommends
    • 5 Oct 2026 · recommends · YouTube ↗
      States that curcumin is great for immune support and is anti-inflammatory, suggesting making curries.
    • 1 Nov 2026 · Magnesium · uses · Facebook ↗
      Recommends considering magnesium glycinate before bed for nervous system support, deeper sleep quality, and to help the body transition into rest, and states that they take it every night.
    • 28 Oct 2026 · Glutathione · recommends · YouTube ↗
      Recommends Rosen Nutrition Liposomal Glutathione to support immunity through colder months, noting it helps maintain healthy immune cell function, supports natural detoxification, and neutralizes free radicals.
    • 26 Oct 2026 · Vitamin D · recommends · Facebook ↗
      Recommends Vitamin D for health, stating that amazing things happen when patients' vitamin D statuses reach optimal levels.
    • 21 Oct 2026 · Magnesium · recommends · YouTube ↗
      Recommends Magnesium Breakthrough Advanced 10 from Bioptimizers for restful sleep, muscle recovery, stress resilience, and metabolic health, especially during stressful times of the year.
    • 21 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Mentions vitamin D as an existing biomarker that plays a role in mental health, which Function Health includes in their measurements.
    • 21 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that taking folate can lower homocysteine levels, which has shown health benefits and physical improvements in brain scans in clinical trials.
    • 19 Oct 2026 · Glutathione · neutral · YouTube ↗
      Mentions that sulforaphane helps the body make glutathione, an amazing nutrient that helps the body get rid of toxins.
    • 19 Oct 2026 · Vitamin D · neutral · YouTube ↗
      Notes that vitamin D plays a role in immune function.
    • 19 Oct 2026 · Folate · neutral · YouTube ↗
      Notes that some people may need a little bit extra folate with a supplement.
    • 19 Oct 2026 · Sulforaphane · neutral · YouTube ↗
      Notes that sulforaphane, found in cruciferous vegetables, is excellent for general detoxification, helps the body produce glutathione, and assists with estrogen metabolism.
    • 19 Oct 2026 · Vitamin A · neutral · YouTube ↗
      Mentions that vitamin A levels can be looked at to get a deep sense of what's happening with nutrient levels.
    • 16 Oct 2026 · Potassium · warns · Facebook ↗
      Warns that potassium bromate, a dough conditioner banned in the EU, UK, and Canada, is still allowed in U.S. bread.
    • 14 Oct 2026 · Magnesium · recommends · TikTok ↗
      Recommends magnesium because it is involved in over 600 reactions in the body and up to 80% of people may have low levels that never get flagged on a standard blood test.
  • Dr. Rhonda Patrick · Curcumin · neutral
    • 5 Aug 2026 · neutral · Facebook ↗
      Curcumin may be one of the most powerful naturally occurring dietary compounds for lowering age-related inflammation. The phytosomal form is preferred because standard curcumin is rapidly broken down by the liver, while phytosomal delivery makes it far more bioavailable.
    • 29 Oct 2026 · Magnesium · neutral · Facebook ↗
      Magnesium supplementation has lowered blood pressure in randomized controlled trials. An analysis of 34 trials involving over 2,000 participants found modest reductions in both systolic and diastolic pressure, with a median dose of 368 mg/day.
    • 21 Oct 2026 · Sulforaphane · uses · YouTube ↗
      Takes sulforaphane every day to activate enzymes that make plastic-associated chemicals like BPA and phthalates water soluble for excretion, noting it's the biggest dietary activator of the NRF2 detox system.
    • 16 Oct 2026 · Magnesium · warns · Facebook ↗
      Warns that some magnesium supplements make the dose look much larger than it really is and that labels can fool people.
    • 12 Oct 2026 · Taurine · neutral · YouTube ↗
      Mentions that taurine depletion is a concern raised in long-term animal studies regarding Beta Alanine, though not observed in human trials, and notes that one can supplement with taurine, which is a beneficial compound.
    • 5 Oct 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D supplementation was linked to a 40% lower risk of dementia in an observational study of more than 12,000 older adults.
    • 30 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Mentions that vitamin D also plays a role in maintaining muscle mass.
    • 29 Sep 2026 · Magnesium · recommends · YouTube ↗
      Mentions magnesium as an important nutrient component for testosterone.
    • 29 Sep 2026 · Zinc · recommends · YouTube ↗
      Notes that not getting enough zinc can affect testosterone, as zinc is very important for testosterone synthesis.
    • 28 Sep 2026 · Magnesium · warns · YouTube ↗
      Warns that some supplement companies mislead consumers by listing the total compound weight of magnesium citrate as the elemental magnesium dose, when the actual elemental magnesium content is much lower, potentially around 44-66 milligrams.
    • 28 Sep 2026 · Vitamin D · recommends · YouTube ↗
      Recommends ensuring adequate vitamin D intake for men's sperm health.
    • 28 Sep 2026 · Zinc · recommends · YouTube ↗
      Recommends men take a 30 milligram zinc supplement for sperm health when preparing for IVF.
    • 28 Sep 2026 · Folate · recommends · YouTube ↗
      Recommends ensuring adequate methyl folate intake, ideally through a prenatal vitamin, for women preparing for IVF.
    • 24 Sep 2026 · Vitamin D · neutral · Facebook ↗
      Vitamin D and strength training alone did not, but adding them strengthened the effect on one clock, with the full combination slowing that measure by ~3.8 months.
  • Ben Greenfield · Curcumin · neutral
    • 13 Jun 2026 · neutral · Facebook ↗
      Mentions curcumin as another Nrf2 activator, but notes that sulforaphane outperforms it.
    • 29 Oct 2026 · Glutathione · uses · YouTube ↗
      Will do glutathione for some patients after surgery.
    • 29 Oct 2026 · Magnesium · uses · YouTube ↗
      Uses magnesium during surgery because it is neuroprotective.
    • 29 Oct 2026 · Zinc · warns · YouTube ↗
      Ben Greenfield's formulation includes 30 grams of zinc a day, taken for one week before surgery and two weeks after, as it is an important cofactor for wound healing.
    • 29 Oct 2026 · Vitamin E · neutral · YouTube ↗
      Mentions a recent study showing no significant increase in bleeding for patients on Vitamin E supplementation during open heart surgery, which was interesting for him to learn.
    • 29 Oct 2026 · Vitamin C · recommends · YouTube ↗
      States that vitamin C is extremely important for collagen turnover and cites orthopedic data showing that 500 mg to 1 g of vitamin C can reduce the rate of complex regional pain in total knee replacements and wrist fractures.
    • 29 Oct 2026 · Vitamin D · recommends · YouTube ↗
      Notes that Vitamin D is actually a hormone and recommends patients aim for levels around 40 to 50, or even 60 for fracture healing, for optimal healing, as opposed to just above 20 which is considered normal.
    • 22 Oct 2026 · Magnesium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 22 Oct 2026 · Potassium · uses · YouTube ↗
      Says he is drinking LMNT, which contains sodium, potassium, and magnesium, and states that he actually drinks this stuff.
    • 21 Oct 2026 · Vitamin A · neutral · Instagram ↗
      Notes that Vitamin A is a fat-soluble vitamin that supports healthy skin cell turnover.
    • 15 Oct 2026 · Magnesium · recommends · Podcast ↗
      Mentions magnesium as part of a bare-minimum protocol.
    • 15 Oct 2026 · Magnesium · recommends · YouTube ↗
      Advises getting red blood cell magnesium levels to the high end of the range as a minimum step for overall health and to slow down heart disease.
    • 15 Oct 2026 · Vitamin C · recommends · Podcast ↗
      Mentions vitamin C as part of a bare-minimum protocol.
    • 15 Oct 2026 · Vitamin D · recommends · Podcast ↗
      Mentions vitamin D as part of a bare-minimum protocol.
  • Andrew Huberman · Curcumin · neutral
    • 13 Apr 2026 · neutral · Podcast ↗
      Discusses curcumin as a supplement for prenatal care and sperm health.
    • 29 Oct 2026 · Zinc · uses · YouTube ↗
      Zinc carnosine to support and improve the lining of your gut.
    • 26 Oct 2026 · Zinc · uses · YouTube ↗
      Notes that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 22 Oct 2026 · Magnesium · neutral · Podcast ↗
      Discusses Magnesium Threonate as a tool for falling asleep.
    • 19 Oct 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut.
    • 12 Oct 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 28 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of the gut, and he was already taking some of these ingredients separately.
    • 21 Sep 2026 · Zinc · uses · YouTube ↗
      States that AG1 Pro includes zinc carnosine, which he was already taking separately, to support and improve the lining of the gut.
    • 21 Sep 2026 · Vitamin D · neutral · YouTube ↗
      Notes that most people are probably deficient in vitamin D and benefit from supplementing, but there's no point in doing it unless you're deficient for most things.
    • 14 Sep 2026 · Zinc · uses · YouTube ↗
      Personally takes zinc carnosine, which is included in AG1 Pro to support and improve the lining of the gut.
    • 31 Aug 2026 · Zinc · uses · YouTube ↗
      AG1 Pro has zinc carnosine to support and improve the lining of your gut. Some of these ingredients I personally was already taking separate from the AG1 formula.
    • 24 Aug 2026 · Zinc · recommends · YouTube ↗
      States that AG1 Pro contains zinc carnosine to support and improve the lining of your gut.
    • 17 Aug 2026 · Zinc · uses · YouTube ↗
      Uses AG1 Pro, which contains zinc carnosine to support and improve the lining of the gut.
    • 13 Aug 2026 · Glutathione · neutral · YouTube ↗
      Dr. Gottfried looks at glutathione in nutritional testing, considering it an important lever.
  • Bryan Johnson · Vitamin D · uses
    • 22 Oct 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 22 Oct 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 22 Oct 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 15 Aug 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for general health.
    • 15 Aug 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 15 Aug 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium L-Threonate before bed for sleep.
    • 3 Jul 2026 · neutral · X ↗
      Mentions that the sunlight assessment claims low vitamin D levels cause the immune system to misfire, and notes that their vitamin D has been measured.
    • 4 May 2026 · uses · X ↗
      Takes 5000 IU of Vitamin D3 in the morning for longevity.
    • 4 May 2026 · Glycine · uses · X ↗
      Takes 2 grams of Glycine before bed for sleep.
    • 4 May 2026 · Magnesium · uses · X ↗
      Takes 400 mg of Magnesium Threonate before bed for sleep.
    • 4 May 2026 · Boron · uses · X ↗
      Takes 2 mg of Boron in the morning for longevity.
    • 4 May 2026 · Zinc · uses · X ↗
      Takes 15 mg of Zinc in the morning for longevity.
    • 2 May 2026 · uses · X ↗
      He takes 5000 IU of Vitamin D3 in the morning for general health.
    • 2 May 2026 · Glycine · uses · X ↗
      He takes 2 g of Glycine before bed for sleep.
  • Peter Attia · Potassium · recommends
    • 6 Sep 2026 · recommends · YouTube ↗
      States there is some evidence that increasing dietary potassium through potassium-rich foods like bananas and potatoes, rather than supplements, can lower blood pressure.
    • 1 Jun 2026 · Magnesium · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 1 Jun 2026 · Glycine · neutral · Podcast ↗
      Peter reviews the evidence for select off-label medications and supplements commonly used for sleep, including glycine, magnesium, ashwagandha, and phosphatidylserine.
    • 4 Jan 2026 · Magnesium · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 4 Jan 2026 · Vitamin D · uses · YouTube ↗
      Lists vitamin D as one of her staple supplements.
    • 4 Jan 2026 · Zinc · recommends · YouTube ↗
      Suggests that zinc and magnesium could potentially help with vasodilation and sleep, particularly for women experiencing severe symptoms in the luteal phase.
    • 16 Nov 2025 · Vitamin D · neutral · YouTube ↗
      Notes that several studies show patients taking vitamin D can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 16 Nov 2025 · Selenium · neutral · YouTube ↗
      Notes that several studies show patients taking selenium can reduce TPO levels and prolong the honeymoon period of Hashimoto's disease.
    • 15 Sep 2025 · Magnesium · recommends · Podcast ↗
      Peter discusses electrolytes and fiber and the ketogenic diet, specifically preventing magnesium loss.
    • 6 Aug 2025 · Vitamin D · neutral · YouTube ↗
      States that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin D for both sexes.
    • 6 Aug 2025 · Vitamin A · neutral · YouTube ↗
      Notes that in mouse studies, there was a combined effect of alpha ketoglutarate with vitamin A for male mice.
    • 3 Aug 2025 · Vitamin D · neutral · YouTube ↗
      Uses vitamin D as an example of how people might dismiss its efficacy due to failed clinical trials that didn't adjust the dose or measure levels.
    • 20 Jul 2025 · Glycine · neutral · YouTube ↗
      Mentions that they also see positive effects of glycine, among other things.
    • 20 Jul 2025 · Vitamin D · neutral · YouTube ↗
      In mouse studies, Peter Attia's team found a combined effect of AKG with Vitamin D for both sexes.

RAL Summary

Members OnlyTier 3 for Liver Health

481 reviews are 86% positive. Vitamin E, curcumin and milk thistle at full doses have human studies showing better liver enzymes, liver fat or liver tissue, which gives the some study support that tier 3 needs [6][1][4].

Take 3 servings a day (6 scoops) to match the dose that worked in the studies.

Where the evidence disagrees: 272 of the 647 human studies found no effect.

More Details

Members OnlyBody systems · Combine with · Possible side effects

Body systems: Digestive system, Liver, Metabolic system

Combine with: For liver and detox support, MediClear-SGS pairs well with milk thistle (silymarin), additional NAC or glutathione, alpha-lipoic acid, and a high-quality fish oil. Fiber such as psyllium or PGX helps bind toxins and supports regular elimination. If the goal is blood sugar support, consider adding berberine, chromium picolinate, or magnesium glycinate, and consult a healthcare provider, especially if taking glucose-lowering medication.

Possible side effects: Some reviewers report stomach upset, which they put down to the sweeteners, and some find the shake too sweet. Studies link high-dose green tea extract and rare high-dose curcumin products to raised liver enzymes, at amounts far above what this product contains.

Supplement Facts

Includes 5 g Added Sugars 0 · Vitamin A 1.5 mg · Vitamin C 300 mg
Supplement Facts
Serving Size Two Scoops (46.5 g)
Servings Per Container 21
Amount Per Serving% Daily Value
Calories190
Total Fat5 g
Saturated Fat2 g
Total Carbohydrate10 g
Dietary Fiber1 g
Total Sugars5 g
Includes 5 g Added Sugars
Protein20 g
Vitamin A1.5 mg
Vitamin C300 mg
Vitamin D10 mcg
Vitamin E80.6 mg
Thiamin12 mg
Riboflavin5 mg
Niacin38 mg
Vitamin B610 mg
Folate500 mcg DFE
Vitamin B1250 mcg
Biotin150 mcg
Pantothenic Acid50 mg
Choline11 mg
Calcium300 mg
Magnesium150 mg
Zinc10 mg
Selenium70 mcg
Manganese1.5 mg
Chromium100 mcg
Molybdenum50 mcg
Potassium100 mg
Proprietary Blend26.12 g†
Glycine†††1.65 g†
Medium Chain Triglycerides (MCTs)1.5 g†
L-Glutamine†††500 mg†
L-Lysine500 mg†
Curcumin Phytosome††††400 mg†
Milk Thistle extract250 mg†
Taurine†††110 mg†
Methyl Sulfonyl Methane (MSM)100 mg†
Grape Seed Phytosome††††50 mg†
Green Tea Phytosome††††50 mg†
Betaine Anhydrous (Trimethylglycine)50 mg†
Sulforaphane Glucosinolate30 mg†
Glutathione (Reduced)†††30 mg†
Boron100 mcg†
Lutein60 mcg†
Vanadium50 mcg†
† Daily Value not established.

Other ingredients: Cane Sugar, Flavor, Rebaudioside A, Silicon Dioxide.

Directions: For adults and children 12 or more years of age. Mix one serving (two scoops) with at least 10 ounces of cold water, juice, rice milk, or nut milk as recommended by your health-care practitioner.

Label source: Reverseagelab · Report a label change

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Graded November 6, 2026 by the Reverse Age Lab evidence engine, from human studies, real reviews and our biohacker panel. How we grade. Is this medical advice? No. Rala organizes the published evidence; go over any change with your doctor, especially if you take meds.