A systematic review and meta-analysis of 24 studies reports that vitamin D supplementation increased IGF-1 levels in children. Combined vitamin D and recombinant human growth hormone therapy also promoted growth and development in children with short stature.
Source: Pooled analysis of studies, children. It combines earlier studies, so its strength depends on the studies it pooled.
What was found
A systematic review and meta-analysis found that levels of insulin-like growth factor 1 (IGF-1) increased after vitamin D supplementation in children. When vitamin D was combined with recombinant human growth hormone (rhGH) therapy, IGF-1 levels were higher than with rhGH alone.
The analysis also reported that children with growth hormone deficiency (GHD) had lower vitamin D levels. Treatment with rhGH increased vitamin D levels. The researchers concluded that combined vitamin D and rhGH therapy can better promote growth and development in children with short stature.
How it was done
This was a systematic review and meta-analysis of relevant studies. Researchers searched PubMed/MEDLINE, Web of Science, SCOPUS, Embase, and CNKI databases for articles on the effect of vitamin D on IGF-1 levels. They also meta-analyzed the effect of rhGH supplementation on 25-hydroxyvitamin D levels.
The meta-analysis included 24 studies.
What it does not show
The meta-analysis showed high variability (I² = 99%) in the results for vitamin D levels increasing after rhGH treatment, which indicates significant differences between the included studies.
The source
This is news, reported from the source above. It is not medical advice and not a recommendation. Talk to your doctor or pharmacist before you change any medicine or supplement.