Researchers found that directly activating AMP-activated protein kinase (AMPK) with compound 991 extended the lifespan of yeast, worms, and flies. The compound also induced a pro-longevity proteomic profile in mice.
Source: Animal study, Yeast, worms, flies, and mice. The result is in animals. Many animal results do not hold up in people, so this is early evidence.
What was found
Direct activation of AMP-activated protein kinase (AMPK) with compound 991 extended the lifespan of Drosophila melanogaster (flies), Caenorhabditis elegans (worms), and Schizosaccharomyces pombe (yeast).
In mice, treatment with compound 991 induced a proteomic profile associated with longevity.
How it was done
Researchers used the compound 991 to directly activate AMPK in yeast, worms, and flies to study its effect on their lifespan.
They also investigated the proteomic changes in mice treated with compound 991.
What it does not show
This study was conducted in yeast, worms, flies, and mice, not in humans.
The study in mice observed changes in proteomic profiles, not lifespan extension.
Who was talking about it
- SciTechDaily on the news (2026-10-06): SciTechDaily reported that scientists extended lifespan by more than 25% by switching on a cellular energy sensor. See the post
The source
This is news, reported from the source above. It is not medical advice and not a recommendation. Talk to your doctor or pharmacist before you change any medicine or supplement.